The Department of Medicinal Chemistry's STEAM Team attended a science-focused poster session hosted by Thomas Edison High School as part of a continued outreach program that focuses on student mentoring in the sciences.
Over the past decades we have learned that cancer is a very complex disease. There are many forms of cancer arising from organ specific malignancies that can further metastasize to other organs. Tumors themselves are now recognized to not just be one type of cell but a community of many different types of cells, including many types of tumor cells. Key among these cells are what are being called cancer stem cell like cells or CSCs.
High-throughput screening is a reliable method for discovering compounds that interact with novel therapeutic targets to improve human health. “Nuisance compounds” interfere with drug discovery by confounding screening results.
Mycobacterium abscessus is an opportunistic pathogen that causes severe lung infections, particularly in patients with underlying lung disorders such as cystic fibrosis or chronic pulmonary disease and is intrinsically resistant to most antibiotics. The high pH in the airway lumen environment serves as a natural barrier, in