Biological and chemical warfare agent mitigation; BSL-2, BSL-3 and select agent research; Homeland security; High-throughput and fragment screening, lead optimization; Psychiatric pharmacy and neuropharmacology
Quantum mechanics, molecular mechanics/dynamics, computer graphics techniques, molecular interactions, investigation of inter- and intramolecular interactions to gain insight for drug design and protein engineering
Design, synthesis, and evaluation of synthetic and natural product-derived medicinal agents; drug discovery by HTS; new synthetic methods; combinatorial chemistry. Therapeutic areas: cancer, male contraception, Alzheimer's disease.
Synthesis, biophysical characterization, and biological efficacy evaluation of novel small molecules that influence cellular function. Applications for these molecules range from anticancer drug discovery to new tools for modern biotechnology research.
Development of novel non-viral vector transfection agents for use in human gene therapy, strategies for eliminating carcinogenic and estrogenic mycotoxins from the human food supply, exploration of the drug potential of betulins and other natural products
Structural basis for promutagenic and anticancer activity of DNA-modifying agents, DNA damage by tobacco carcinogens and lung cancer, DNA-DNA and DNA-protein cross-linking agents as carcinogens and drugs,DNA oxidation by endogenous reactive oxygen species
Chemical Biology, design and development of targeted drug delivery approaches, design and study of chemical inducers of protein oligomerization, mechanistic and structural studies of biocatalyis and protein translation