Carrie Haskell-Luevano, PhD
Doctorate of Philosophy, Chemistry, University of Arizona, 1995
Bachelor of Chemistry, California State University Fresno, 1990
Our laboratory focuses on the understanding of peptide hormone endocrine systems in the brain, and their involvement in feeding behavior, exercise, diabetes, and obesity. We utilize multidisciplinary approaches including chemistry, chemical biology, biochemistry, molecular biology, pharmacology, physiology, and neuroscience to study endocrine systems. The techniques we use to answer different research questions include combinatorial chemistry, peptide design and synthesis, receptor pharmacology and compound analysis, computer assisted molecular modeling (CAMM), NMR spectroscopy, receptor mutagenesis and pharmacology, use of knock-out mice, real-time PCR (qRT-PCR, mRNA expression in the brain), and administration of compounds into mice.
- Peptide Chemistry
- Medicinal Chemistry
- G-protein Coupled Receptor (GPCR) Pharmacology
- Human Receptor Polymorphisms
- Voluntary Exercise of Mice
- Feeding Behavior
- Ericson MD, Larson CM, Freeman KT, Nicke L, Geyer A, Haskell-Luevano C. Incorporation of Indoylated Phenylalanine Yields a Sub-Micromolar Selective Melanocortin-4 Receptor Antagonist Tetrapeptide. ACS Omega. 2022 Jul 29;7(31):27656-27663. doi: 10.1021/acsomega.2c03307. PMID: 35967074; PMCID: PMC9366794.