Carrie Haskell-Luevano, PhD
Professor & Philip S. Portoghese Endowed Chair in Chemical Neuroscience, Department of Medicinal Chemistry
Contact
Office Address
8-102 Weaver Densford Hall
308 Harvard St. SE
Minneapolis, MN 55455
United States
Titles
Professor & Philip S. Portoghese Endowed Chair in Chemical Neuroscience, Department of Medicinal Chemistry
Faculty, PhD Program in Integrative Biology and Physiology
Faculty, MS and PhD Programs in Molecular Pharmacology and Therapeutics (MPaT)
Education
Doctorate of Philosophy, Chemistry, University of Arizona, 1995
Bachelor of Chemistry, California State University Fresno, 1990
Biography
Summary
Our laboratory focuses on the understanding of peptide hormone endocrine systems in the brain, and their involvement in feeding behavior, exercise, diabetes, and obesity. We utilize multidisciplinary approaches including chemistry, chemical biology, biochemistry, molecular biology, pharmacology, physiology, and neuroscience to study endocrine systems. The techniques we use to answer different research questions include combinatorial chemistry, peptide design and synthesis, receptor pharmacology and compound analysis, computer assisted molecular modeling (CAMM), NMR spectroscopy, receptor mutagenesis and pharmacology, use of knock-out mice, real-time PCR (qRT-PCR, mRNA expression in the brain), and administration of compounds into mice.
Research Interests
- Peptide chemistry
- Chemical biology
- Small molecule medicinal chemistry
- Positional scanning combinatorial chemistry and libraries
- G-protein coupled receptor (GPCR) pharmacology
- Human receptor polymorphisms
- Neuroscience
- Obesity
- Diabetes
- Feeding behavior
- Pain
Publications
- Ericson MD, Larson CM, Freeman KT, Nicke L, Geyer A, Haskell-Luevano C. Incorporation of Indoylated Phenylalanine Yields a Sub-Micromolar Selective Melanocortin-4 Receptor Antagonist Tetrapeptide. ACS Omega. 2022 Jul 29;7(31):27656-27663. doi: 10.1021/acsomega.2c03307. PMID: 35967074; PMCID: PMC9366794.