Research
Advancing the science of human pharmacology and therapeutics through translational research
Faculty in the Department of Experimental and Clinical Pharmacology conduct clinical and translational research. This cross-disciplinary paradigm translates basic scientific discoveries into safe and effective therapeutic uses by providers and patients, through laboratory experiments and clinical studies. Clinical data can also prompt new questions and investigations, leading back to the bench and beginning a new cycle of translational research.
Research conducted by department faculty can focus on a range of topics, diseases/conditions, and investigational methods. Some current and recent projects are highlighted here:
Alzheimer's Disease
Alzheimer's Disease
HDL Mimetic Peptide Mediated Enhancement of Neurovascular Function to Mitigate Cerebral Amyloid Angiopathy and Alzheimer's Disease
The primary goal of this project is to elucidate the mechanisms by which HDL mimetic peptides modulate the function of blood-brain barrier and trafficking of amyloid-β in transgenic mouse models of cerebral amyloid angiopathy and Alzheimer’s disease.
PI: Ling Li, PhD
Funding: NIH, National Institute on Aging
Dysregulation of Protein Prenylation in the Pathogenesis of Alzheimer's Disease
The main objective is to unravel the mechanistic relationship between dynamics of protein prenylation and the development of Alzheimer’s disease in mouse models and humans.
PI: Ling Li, PhD (contact) and Mark Distefano, PhD
Funding: NIH, National Institute on Aging
Testing a Unique HDL Mimetic Peptide to Reverse ApoE4 Lipidation Deficiency and Alzheimer's Neuropathology
This project investigates the potential of a clinically tested HDL-mimetic peptide to enhance apoE lipidation in human apoE4 vs. apoE3 mice with or without amyloid pathology.
PI: Ling Li, PhD
Funding: NIH, National Institute on Aging
Cancer
Cancer
Combating Cellular Senescence to Prevent Anthracycline Cardiotoxicity
PI: Beshay Zordoky
Funding: St. Baldrick’s Foundation for Childhood Cancer Research
Psychosocial Stress Unmasks Juvenile Doxorubicin-Induced Latent Cardiotoxicity
PI: Beshay Zordoky
Funding: American Cancer Society - Institutional Research Grant (ACS-IRG)
Molecular Mechanisms of Sexual Dimorphism in Delayed Doxorubicin-Induced Cardiomyopathy
PI: Beshay Zordoky
Funding: Masonic Cancer Center, University of Minnesota
Community Health and Clinical Care
Community Health and Clinical Care
Treatment of Acute Pain: An Evidence Map
Co-PI: Shellina Scheiner
Funding: Agency for Healthcare Research and Quality
A Community Pharmacy Coordinated Program to Enhance Control of High Blood Pressure and Diabetes in a Suburban Minnesota Community
PI: Jeannine M. Conway
Funding: Centers for Disease Control/MN Department of Health
Creating a 21st Century Precision Medicine Intensive Care Unit
Co-I: Pamala A. Jacobson
Funding: College of Pharmacy
Reducing Health Disparities through Precision Medicine
Co-PI: Pamala A. Jacobson
Funding: University Grand Challenge
A Path to Identifying Effective Treatments for Hmong Adults with Gout-Related Comorbidities
Co-PI: Robert Straka
Funding: Patient-Centered Outcome Research Institute
Drug Dependence
Drug Dependence
Vaccines for Prescription Opioid and Heroin Abuse
PI: Angela K. Birnbaum (Co-PI)
Funding: Minneapolis Medical Research Foundation/NIH
Use of Medicinal Nicotine for Preventing Cue-Induced Craving and Withdrawal Symptoms
PI: Michael Kotlyar
Funding: Clearway MN
Use of Medicinal Nicotine for Preventing Cue-Induced Craving and Withdrawal Symptoms
About the project:
This study tests whether using nicotine lozenges prior to exposure to smoking cues attenuates the increase in craving and withdrawal symptoms that occur during cue presentation. Data from the study should determine if instructions to smokers regarding how to properly use nicotine lozenges should be modified from those currently used.
PI: Michael Kotlyar, PharmD
Funding: 2012 Global Research Award for Nicotine Dependence (GRAND), sponsored by Pfizer
Smoker Response to Banning of Menthol-Flavored Cigarettes
About the project:
This study investigates the impact of eliminating menthol cigarettes on smoking behavior, on motivation to quit smoking, and on biomarkers of tobacco-related carcinogen exposure in African-American menthol smokers.
PI: Michael Kotlyar, PharmD
Co-investigators: Dorothy Hatsukami, PhD; Kola Okuyemi, M.D., M.P.H.
Funding: ClearWay Minnesota
Medicinal Nicotine for Preventing Stress-Induced Craving and Withdrawal Symptoms
About the project:
By measuring craving and withdrawal symptoms prior and subsequent to a stress task, this laboratory study will identify the optimal time-frame (relative to the stressor) during which a nicotine lozenge should be used. Data from this study could be used to assess if counseling smokers to use nicotine lozenge in anticipation of a smoking trigger results in higher cessation rates than the current practice of counseling smokers to use these products when they need them (i.e. after symptoms of craving or withdrawal have already occurred). Ultimately this line of research should lead to more effective use of medicinal nicotine and higher smoking cessation success rates.
PI: Michael Kotlyar
Funding: NIH / National Institute on Drug Abuse
Infectious Diseases
Infectious Diseases
Outcomes of Immunocompromised Patients Treated with Ceftolozane/Tazobactam
Activity of Ceftolozane/Tazobactam and Ceftazidime/Avibactam Against Multidrug-Resistant Clinical Isolates
A Retrospective, Multi-Center Study to Assess Patient Outcomes Following Treatment with Ceftolozane/Tazobactam
Program to Improve Quality and Safety of Outpatient Parenteral Antibiotic Treatment (OPAT) at UMMC
Pharmacology of Antiretrovirals in Anatomical Brain Tissue among Persons with Chronic HIV Infection
Co-PI: Melanie Nicol
Funding: NIH, National Institute of Neurological Disorders and Stroke
Evaluating Antiretroviral Pharmacology in the Female Genital Tract to Optimize HIV Prevention
PI: Melanie Nicol
Funding: NIH, National Institute of for Allergies and Infectious Diseases
Pharmacogenomics
Pharmacogenomics
Pharmacogenomics and Pharmacokinetics of Lamotrigine in Early Pregnancy
PI: Angela K. Birnbaum (Co-PI)
Funding: Epilepsy Foundation of America, Inc.
Epigenetics of PTSD Treatment Response
PI: Jeffrey Bishop
Funding: National Institutes of Health
Medication Therapy Management and Pharmacogenetic Evaluation in Mental Health
PI: Jeffrey Bishop
Funding: University of Minnesota
Pharmacogenetics and Drug Interactions
PI: Richard C. Brundage
Funding: NIH National Institute of General Medical Sciences
Drug Repurposing in Breast Cancer
PI: R. Stephanie Huang
Funding: NIH/National Cancer Institute
Whole Genome Expression Based Drug Reposition in Metastatic Breast Cancer
PI: R. Stephanie Huang
Funding: Avon Foundation
Repurposing Drugs to Treat Androgen Receptor Independent Prostate Cancer
Co-PI: R. Stephanie Huang
Funding: Academic Health Center, University of Minnesota
Genetic Mechanisms Underlying Sexual Dimorphism in Cancer and Response to Therapy
Co-PI: R. Stephanie Huang
Funding: NIH/National Cancer Institute
Pharmacogenomics of Transplantation
PI: Pamala A. Jacobson
Funding: NIH National Institute of Allergy and Infectious Diseases
Microbiome and Immunesuppressants in Hematopoietic Cell Transplantation
PI: Pamala A. Jacobson
Funding: Masonic Cancer Center Chainbreaker Award
Pharmacogenomics of Once Daily Tacrolimus
PI: Pamala A. Jacobson
Funding: Industry
Pharmacogenomics of Cyclophosphamide
PI: Pamala A. Jacobson
Funding: Internal Funding
Pharmacogenomics in Minnesota Native Americans
Co-PI: Pamala A. Jacobson
Funding: University Grand Challenge
Genomics of Kidney Transplantation – Genomics Core
PI: William S. Oetting
Funding: NIH National Institute of Allergy and Infectious Diseases
Pharmacometrics/ Pharmacokinetic modeling
Pharmacometrics/ Pharmacokinetic modeling
Novel Targeted Chemo/Immunotherapy Approach for Localized and Metastatic Prostate Cancer
Co-I: Mark N. Kirstein
Funding: NIH National Cancer Institute
Innovative Drug Discovery Pipeline for Preclinical Development of Novel Drugs
Co-I: Mark N. Kirstein
Funding: Children's Tumor Foundation/Synodos
Cancer Center Support Grant
Co-I: Mark N. Kirstein
Funding: NIH National Cancer Institute
Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs – Pharmacokinetics Laboratory Core
PI: Angela K. Birnbaum
Funds: Epilepsy Foundation of America, Inc.
Pharmacogenetics and Drug Interactions
PI: Richard C. Brundage
Funding: NIH National Institute of General Medical Sciences
Neuropharmacology
Neuropharmacology
Pilot Study of Inflammatory Markers and Neurocognitive Phenotypes in Psychosis
PI: Jeffrey Bishop
Funding: University of Minnesota
Characterizing and Predicting Drug Effects on Cognition
About the project:
The study will examine the relationship among exposure to TPM (a second-generation, broad-spectrum antiepileptic drug) as measured by plasma drug levels, its neurophysiological effects, and consequent effect on the cognitive processes observable in everyday language. The long-term goal of the project is to enhance clinical strategies and inform drug development in order to maximize the benefits of individual medication therapy while minimizing adverse cognitive/language-related side effects.
PI: Susan Marino, PhD
Co-investigators: Angela Birnbaum, PhD; Ilo Leppik, M.D.; Serguei Pakhomov, PhD, M.A., M.S.
Funding: NIH / National Institute of Neurological Disorders and Stroke
Rare Diseases
Rare Diseases
Use of Antioxidant or Anti-inflammatory Medications to Mitigate Oxidative Stress and Inflammation in Type 1 Gaucher Disease (GD1)
PI: Reena Kartha
Funding: Pfizer
Seizure Disorders
Seizure Disorders
Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs – Pharmacokinetics Laboratory Core
PI: Angela K. Birnbaum
Funding: NIH National Institute of Neurological Disorders and Stroke
Maternal Outcomes and Neurodevelopmental Effects of Anti-Epileptic Drugs (Pharmacokinetics Core)
About the project:
Part of a 19-site national study exploring drug exposure in women with epilepsy and their children. The goal is to study several populations of women with and without epilepsy in order to compare the effect of antiepileptic drug exposure on the woman and child during pregnancy. Dr. Angela Birnbaum’s research team is performing the pharmacokinetic analyses for this project.
PIs: Kimford J. Meador, M.D.; Page B. Pennell, M.D.; Nancy Browning, PhD (EMMES)
PI of Pharmacokinetics Core: Angela Birnbaum, PhD
Co-investigators of Pharmacokinetics Core: Rory Remmel, PhD; Richard C. Brundage, PhD, PharmD
Funding: NIH / National Institute of Child Health and Human Development
Identifying New Therapies for Infantile Spasms
About the project:
Infantile spasms are epileptic seizures in infants which often lead to emergence of other types of seizures, cognitive deficits, and neurodevelopmental disabilities. This project will evaluate the efficacy and tolerability of drug therapies in mouse models of infantile spasms, in order to identify treatments that achieve rapid and sustained suppression of spasms and determine whether these are effective and safe in infantile spasms of various pathologies. The goal of this project is to identify new treatments for infantile spasms that have rapid onset and stop spasms early with anti-epileptic and disease-modifying effects that persist through adulthood.
PIs: Aristea Galanopoulou, M.D., PhD; Rodney Scott, M.D.; Gregory Holmes, M.D.; James Cloyd, PharmD
Co-investigators: Lisa Coles, PhD; Krista Johnson, ECP graduate student
Funding: Citizens United for Research in Epilepsy; Department of Defense
Facilities
The Department of Experimental and Clinical Pharmacology (ECP) is located within one of the largest academic health centers in the United States, with nationally recognized programs in public health, medicine, nursing, dentistry, and veterinary medicine. Major campus research facilities include a Clinical and Translational Science Institute, the Biomedical Genomics Center, and the Masonic Cancer Center. In addition, numerous affiliated health care systems with exceptional research and educational programs partner with the COP. The Twin Cities also has a large number of cutting-edge biomedical companies eager to collaborate with the academic community.
Our regular faculty and staff are located in four buildings within the University of Minnesota's Academic Health Center on the Twin Cities campus:
- Weaver-Densford Hall
- McGuire Translational Research Facility
- 717 Delaware
- Phillips-Wangensteen Building
Several ECP faculty also work at clinical sites around the Twin Cities, directing experiential clinical residencies of fourth-year students in the College's PharmD program. These include North Memorial Medical Center and University of Minnesota Medical Center.