Institute of Personalized Medicine - PUMA IPM


Institute of Personalized Medicine - Pharmacogenomics U of M Alliance (PUMA-IPM)


Fairview Health Services: Can Genetic Tests Improve High Blood Pressure Care?

Fairview Health Services is working with a local genetics research firm to determine if DNA tests can steer patients to more effective treatment for high blood pressure. Researchers hope the genetic testing and customized treatment will result in more patients getting their blood pressure under control in less time. Read more about the genetic testing.

 U-PGx: Treatment Optimization Accessible to Every European Citizen

A new project titled "U-PGx" aims to make effective treatment optimization accessible to every European citizen. The U-PGx consortium will examine whether pre-emptive genotyping of an entire panel of genetic markers is cost-effective and results in a better outcome for patients. Read more about the project.

21st Century Cures Initiative Passed

Congress passed the 21st Century Cures Initiative, a $6.3 billion medial research bill. The bill authorizes significant funding for various health care related programs over the next 10 years, including $1.5 billion for Obama's Precision Medicine Initiative.

U of M Grand Challenge Collaboration Research Grant Awarded to Precision Medicine

"Minnesota Precision Medicine Collaborative: Transforming health and advancing equity," was named one of eight U of M Grand Challenges Research collaboration grants to advance the research goals of the TC Campus Strategic Plan over the next ten years.

The Interdisciplinary Work Group, comprised of 14 faculty across the University, proposed precision medicine as a means to transform health and address health disparities.  The initiative will use genomics, informatics, bioengineering, analysis of environmental exposures, and behavioral sciences, to tailor health care to the challenges facing individuals and their communities. This ambitious approach will fundamentally alter our understanding of health, disease prevention, and treatment. Core to this project is partnering across the state of Minnesota with citizens, patients, and healthcare providers to understand and effectively address major health problems.  

Co-PIs: Ellen Demerath, Epidemiology & Community Health; Pamala Jacobson, Experimental & Clinical Pharmacology; Kingshuk Sinha, Supply Chain & Operations; Susan M. Wolf, Law, Medicine & Public Policy

Team Members: Gerald August, Family Social Science; Marilyn Bruin, Design, Housing, & Apparel; Michael Conzemius, Veterinary Clinical Sciences; Jigna Desai, Gender, Women, & Sexuality Studies; Joseph Gaugler, Nursing; Christy Haynes, Chemistry; Bin He, Biomedical Engineering; Dan Knights, Computer Science & Engineering; Alex Rothman, Psychology; Paula Termuhlen, Surgery; Jakub Tolar, Pediatrics, Stem Cell Biology, Genetics & Genomics

Read more on the Grand Challenge Research Grants awards

U of M Grand Challenges Exploratory Research Grants Awarded to Precision Medicine

Development of a clinical precision medicine program in ovarian cancer as a paradigm for 21st century tailored health care solutions 

Co-PIs: Boris Winterhoff, Obstetrics, Gynecology & Women’s health, Andrew Nelson, Laboratory Medicine & Pathology; Joshua Baller, Supercomputing Institute; Constantin Aliferis, Medicine; Pamala Jacobson, Experimental & Clinical Pharmacology 

Team Members: Ahmad Abusalah, Institute for Health Informatics; Peter Argenta, Obstetrics, Gynecology & Women’s Health; Subbaya Subramanian, Surgery; Martina Bazzaro, Obstetrics, Gynecology & Women’s Health; Linda Carson, Obstetrics, Gynecology & Women’s Health; Melissa Geller, Obstetrics, Gynecology & Women’s Health; Mahmoud Khalifa, Laboratory Medicine & Pathology; Sally Mullany, Obstetrics, Gynecology & Women’s Health; Steve Shen, Institute for Health Informatics; Tim Starr, Obstetrics, Gynecology & Women’s Health; Gyorgy Simon, Institute for Health Informatics

A community-based approach toward advancing personalized medicine in underserved populations 

Co-PIs: Kathleen A. Culhane-Pera, Family Medicine; Robert J. Straka, Experimental & Clinical Pharmacology; Bharat Thyagarajan, Laboratory Medicine & Pathology

Team Members: Jeffrey Bishop, Experimental & Clinical Pharmacology; Muaj Lo, West Side Community Health Services; Heather Zierhut, Genetics, Cell Biology, & Development

Read more on the Grand Challenge Research Grants awards 

David GregornikWelcome to Our Newest Member, David Gregornik!

David joined the Department of Medical Genetics and Genomics at Children's Hospitals and Clinics of Minnesota in August, where he will be working with the department and pharmacy services to implement a clinical pharmacogenomics service across the health-system.  He completed his B.S and PharmD at the U of M and has previously worked at St Jude Children's Research Hospital in Memphis, TN and Memorial Sloan - Kettering Cancer Center in New York City.

University of Minnesota Genomics Center (UMGC) GenoFest 2016: Annual Open House and Festival of Genomics Held on October 7th, 2016

Highlighting the arrival of three new technologies: Pacific Biosciences Sequel, 10X Genomics Chromium System, and Illumina HiSeq 4000.

NIH: Survey shows broad support for national precision medicine study

In a recent survey designed to measure public attitudes about the Precision Medicine Initiative (PMI) Cohort Program, a majority of respondents expressed willingness to participate in the nationwide research effort.  Read more about the National Institutes of Health survey

Organizations named in NIH $55 million award to build million-person precision medicine study 

The research effort that aims to engage 1 million or more U.S. participants to improve our ability to prevent and treat disease based on individual differences in lifestyle, environment and genetics. Read more about the National Institutes of Health award.

Pamala JacobsonWhat Drives Professor Pam Jacobson To Match Medications To Genes?

Her research focus is for every person who needs medical treatment will receive drugs that work for them. Read more about Pam Jacobson.

Moving Toward Precision Healthcare in Children’s Mental Health: New Perspectives, Methodologies, and Technologies in Therapeutics and Prevention

The UMN College of Education and Human Development hosted a 3 day conference on precision healthcare and childrens mental health, October 5-7. Read More about the conference

 Precision Medicine Health Symposium 20162016 Precision Medicine Conference Completed June 20th

This year's Precision Medicine Conference had 300 attendees and the first 150 registrants were genotyped.

CPIC Guideline Videos

See the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Videos, taken from the PharmGKB YouTube channel.

Codeine and CYP2D6

Clopidogrel and CYP2C19

Simvastatin and SLCO1B1

Phenytoin, HLA-B and CYP2C9

Carbamazepine and HLA-B

Allopurinol and HLA-B

Abacavir and HLA-B

Weekly Genomics Scan

This weekly update features emerging roles of human genomics, testing and interventions in a wide variety of noncommunicable diseases across the life span.

Health Impact Weekly Scan