Takuto Takahashi, MD, PhD

Dr. Takahashi received his MD from the University of Yamanashi in Japan. He completed pediatric residency at SUNY Downstate Medical Center, and a pediatric hematology/oncology fellowship at the University of Minnesota, where he also completed PhD in Experimental and Clinical Pharmacology with a focus on PKPD modeling and pharmacogenetics. He joined Dana-Farber Cancer Institute in 2021 as a stem cell transplantation fellow before he became a faculty member in 2022.

Pharmacometrics, Pharmacogenomics, Stem cell transplantation, Pediatric oncology

• American Society of Hematology
• American Society of Transplant and Cellular Therapy
• American Society of Pediatric Hematology and Oncology

My specific research interest is to improve utilization of drugs used in hematopoietic stem cell transplantation through application of pharmacometrics and pharmacogenomics approaches. These advanced research methodologies can be useful in optimization of critical drug use. However, application of such methods are rarely done because it requires expertise in both clinical and research fields, both of which are highly specialized.

Clinical Interests

Stem cell transplantation, oncology, pediatrics

Japanese

26. Takahashi T, Jaber MM, Brown SJ, Al-Kofahi M Population pharmacokinetic model of intravenous busulfan in hematopoietic cell transplantation: Systematic review and comparative simulations Clinical Pharmacokinetics, in press

25. Takahashi T, Al-Kofahi M, Jaber MM, Bratrude B, Betz K, Suessmuth Y, Yu A, Neuberg DS, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Blazar BR, Horan JT, Watkins B, Langston A, Qayed M, Kean LS Higher Abatacept Exposure After Transplant Decreases Acute GVHD Risk Without Increasing Adverse Events Blood. 2023 Jun 15:blood.2023020035. doi: 10.1182/blood.2023020035

24. Takahashi T, Teramoto M, Matsumoto K, Jaber MM, Tamaki H, Ikegame K, Yoshihara S, Kaida K Population pharmacokinetics of total rabbit anti-thymocyte globulin in non-obese adult patients undergoing hematopoietic cell transplantation for hematologic malignancy Clin Pharmacokinet. 2023 Jun 7. doi: 10.1007/s40262-023-01252-4

23. Takahashi T, Jaber MM, Al-Kofahi M, Weisdorf D, Brunstein C, Bachanova V, Brundage RC, Jacobson P, Kirstein MN Comparison of Dose Adjustment Strategies for Obesity in High-dose Cyclophosphamide Among Adult Hematopoietic Cell Transplantation Recipients: Pharmacokinetic Analysis Transplantation and Cellular Therapy, 2022 Dec;28(12):845.e1-845.e8.

22. Takahashi T, Prockop S T-cell depleted haploidentical hematopoietic cell transplantation for pediatric malignancy Frontiers in Pediatrics, 2022 Oct 14;10:987220.

21. Jaber MM, Takahashi T, Kirstein MN, Jacobson P, Brundage RC Influence of renal function on phosphoramide mustard exposure: A nonlinear mixed-effects analysis Journal of Clinical Pharmacology, 2022 Sep 5. doi: 10.1002/jcph.2144

20. Takahashi T, Jaber MM, Smith AR, Jacobson P, Fisher J, Kirstein M Predictive value of C-reactive protein and albumin for temporal within-individual pharmacokinetic variability of voriconazole in pediatric hematopoietic cell transplant patients Journal of Clinical Pharmacology, 2021 December. PMID: 34970774. DOI: 10.1002/jcph.2024.

19. Takahashi T, Pearson R, Cao Q, Scheilbner A, Sanghavi K, Weisdorf D, Brunstein C, Rogoskeske J, Bachanova V, Warlick ED, Wiseman A, Jacobson P Effects of cyclophosphamide related genetic variants on clinical outcomes of adult hematopoietic cell transplant patients Cancer Chemotherapy and Pharmacology, 2022 April. PMID: 35083501. DOI: 10.1007/s00280-021-04389-w.

18. Takahashi T, Illamola SM, Jennissen CA, Long SE, Lung TC, Orchard PJ, Gupta AO, Long-Boyle JR Busulfan dose recommendation in inherited metabolic disorders: Population pharmacokinetic analysis Transplantation and Cellular Therapy, 2021 December. DOI: https://doi.org/10.1016/j.jtct.2021.11.018

17. Takahashi T, Mohamud M, Smith AR, Jacobson P, Jaber M, Alharbi A, Fisher J, Kirstein M CYP2C19 phenotype and body-weight-guided voriconazole initial dose in infants and children after hematopoietic cell transplantation Antimicrobial Agent and Chemotherapy, 2021 Jun. PMID: 34097481. DOI: 10.1128/AAC.00623-21

16. Takahashi T, Scheibner A, Cao Q, Pearson R, Sanghavi K, Weisdorf DJ, Brunstein C, Rogosheske J, Bachanova V, Warlick ED, Wiseman A, Jacobson PA Higher Fludarabine and Cyclophosphamide Exposures Lead to Worse Outcomes in Reduced Intensity Hematopoietic Cell Transplant for Adult Hematologic Malignancy Transplantation and Cellular Therapy, 2021 May. PMID: 34044184. DOI: 10.1016/j.jtct.2021.05.013

15. Takahashi T, Arora M, Okoev G, DeFor TE, Weisdorf DJ, MacMillan ML Late-onset Acute and Chronic Graft-Versus-Host Disease in Children: Clinical features and Response to Therapy Transplantation and Cellular Therapy, 2021 May. PMID: 34077812. DOI: 10.1016/j.jtct.2021.05.022

14. Takahashi T, Turcotte LM, Gordon PM, Johnson AD, Rubin N, Spector LG Therapeutic Leukapheresis in Pediatric Leukemia: Utilization Trend and Early Outcomes in a US Nationwide Cohort Journal of Pediatric Hematology/Oncology, 2021 May. PMID: 33735152. DOI: 10.1097/MPH.0000000000002140

13. Takahashi T, Smith AR, Jacobson PA, Alharbi AF, Fisher J, Rubin NT, Kirstein MN CYP51A1 polymorphism and voriconazole-associated hepatotoxicity in children undergoing hematopoietic cell transplant International Journal of Clinical Pharmacology and Therapeutics, 2021 Feb. PMID: 33560212. DOI: 10.5414/CP203920

12. Okoev G, Weisdorf DJ, Wagner EJ, Blazar BR, MacMillan ML, DeFor T, Lazaryan A, Jurdi NE, Holtan SG, Brunstein CG, Betts BC, Takahashi T, Bachanova V, Warlick ED, Rashidi A, Arora M Outcomes of chronic graft-versus-host disease following matched sibling donor versus umbilical cord blood transplant Bone Marrow Transplant, 2021 Jan. PMID: 33420387. DOI: 10.1038/s41409-020-01195-5

11. Takahashi T, Smith AR, Jacobson PA, Fisher J, Rubin NT, Kirstein MN Impact of obesity on voriconazole pharmacokinetics among pediatric hematopoietic cell transplant recipients Antimicrobial Agent and Chemotherapy, 2020 Nov. PMID: 32988816. DOI:

10.1128/AAC.00653-20 10. Takahashi T, John Prensner, Caroline Robson, Katherine Janeway, Brenda Weigel Safety and efficacy of Gamma-Secretase Inhibitor Nirogacestat (PF-03084014) in Desmoid Tumor: Report of Four Pediatric/Young Adult Cases Pediatric Blood and Cancer, 2020 Oct. PMID: 32762028. DOI: 10.1002/pbc.28636

9. Takahashi T, Pamala Jacobson, Jasmine Luzum, Melanie Nicol Pharmacogenomics of COVID-19 therapy npj Genomic Medicine, 5, 35, 2020 August. PMID: 32864162. DOI: 10.1038/s41525-020-00143-y

8. Takahashi T, Patricia M. Hobday, Tamara C. Pozos, Peter M. Gordon Successful Rituximab Monotherapy in Advanced-Stage, Epstein-Barr Virus Positive Diffuse Large B-cell Lymphoma in an Adolescent with Systemic Juvenile Idiopathic Arthritis Journal of Pediatric Hematology/Oncology, 2021 May. PMID: 32590419. DOI: 10.1097/MPH.0000000000001869

7. Takahashi T, Pereda MA, Bala N, Nagarajan S In-hospital Mortality of Hematopoietic Stem Cell Transplantation among Children with Non-malignancies: A nationwide study in the United States from 2000 to 2012 Pediatric Blood and Cancer, 2019 Jun. PMID: 30740860. DOI: 10.1002/pbc.27626

6. Takahashi T, Okubo Y, Pereda MA, Handa A, Miller S. Factors Associated with Mechanical Ventilation Use in Children with Sickle Cell Disease and Acute Chest Syndrome Pediatr Crit Care Med. 2018 Sep. PMID: 29923940. DOI: 10.1097/PCC.0000000000001643

5. Tomari K, Toyokawa T, Takahashi T, Kakita T, Okano S, Kyan H, Tonegawa N, Okawa T, Matsuoka T, Matsumora T Childhood leptospirosis in an industrialized country: Population-based study in Okinawa, Japan PLoS Negl Trop Dis. 2018 Mar. PMID: 29518084. DOI: 10.1371/journal.pntd.0006294

4. Takahashi T, Okubo Y, Handa A Acute chest syndrome among children hospitalized with vaso-occlusive crisis: A nationwide study in the United States Pediatric Blood and Cancer, 2018 Mar. PMID: 29134776. DOI: 10.1002/pbc.26885

3. Takahashi T, Inoue N, Shimizu N, Terakawa T, Ran D. Goldman ‘Down-triage’ for Children with Abnormal Vital Signs: Evaluation of a New Triage Practice at a Pediatric Emergency Department in Japan Emergency Medicine Journal, 2016 Aug. PMID: 27044947. DOI: 10.1136/emermed-2015-204968

2. Takahashi T, Morikawa Y, Akiba K, Akatsuka S, Ikari Y, Kishibe S, Kitami Y, Kuroda J, Takemoto N, Miwa N, Kono T, Hasegawa T Efficacy of oral chloral sedatives in combination with intravenous midazolam for pediatric sedation in MRI The Journal of Japan Pediatric Society, 2016, 120:5 (in Japanese)

1. Takahashi T, Sakakibara H, Morikawa Y, Miura M. Development of coronary artery lesions in indolent kawasaki disease following initial spontaneous defervescence: a retrospective cohort study Pediatric Rheumatology Online Journal, 2015 Nov. PMID: 26530040. DOI: 10.1186/s12969-015-0042-8