Samuel Callisto, PhD

Adjunct Assistant Professor, Department of Experimental and Clinical Pharmacology (ECP)
Samuel Callisto



Adjunct Assistant Professor, Department of Experimental and Clinical Pharmacology (ECP)
Senior Scientist, Metrum Research Group


PhD, Experimental and Clinical Pharmacology (Pharmacometrics Emphasis), University of Minnesota, College of Pharmacy, Minneapolis, MN

BA, Biology, Computer Science Minor, Saint Mary's University of Minnesota, Winona, MN

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Bio Summary

Samuel currently works as a Senior Scientist at Metrum Research Group in the modeling and simulation group. He has expertise in developing population pharmacokinetic and pharmacokinetic-pharmacodynamic models using NONMEM in therapeutic areas such as CNS, inflammation, and oncology. Other duties include writing reports for regulatory agencies, researching new methodologies in pharmacometrics, and developing software tools to assist pharmacometricians. 

In addition to his work at Metrum Research Group, he also holds the position of Adjunct Assistant Professor in the Experimental and Clinical Pharmacology Department at the University of Minnesota College of Pharmacy. In this role, he develops and presents content for graduate-level pharmacometrics courses and leads discussions of research articles for pharmacometrics student discussion sections. 

Samuel holds a Ph.D. in Experimental and Clinical Pharmacology with a Pharmacometrics Emphasis Track from the University of Minnesota, where he was advised by Dr. Susan Marino and co-advised by Dr. Angela Birnbaum. The topic of his Ph.D. thesis was "Linking topiramate exposure to changes in electrophysiological activity and behavioral deficits through quantitative pharmacological modeling." Samuel also holds a B.A. with honors in Biology and a minor in Computer Science from Saint Mary's University of Minnesota. When not conducting research or teaching, hobbies include camping, running, and reading.


Pharmacometrics; population PK/PK-PD modeling; clinical trial simulations

Professional Associations

International Society of Pharmacometrics (ISoP)