Evgenyi Shalaev, PhD

Dr. Evgenyi Shalaev's research efforts are focused on applications of physical chemical principles to drug development and manufacturing, covering a broad range of pharmaceutical R&D such as pre-formulation and formulation development for immediate and controlled release dosage forms, lyophilization development and scale-up, and solid state characterization and stability of proteins and small molecular weight drugs. Current research interests include:

• Role of water in solid-state chemical stability of proteins and small molecules
• Advanced analytical methods (e.g., small-angle neutron and X-ray scattering) for characterization of various pharmaceuticals including small molecules and proteins, drug substance and drug product, and solutions, solids, and dispersed systems
• Phase transitions during freezing and drying
• Optimization of lyophilization processes 

Dr. Shalaev is an Executive Director at Allergan, Inc.

• E Shalaev, W Wang, LA Gatlin (2008). Rational choice of excipients for use in lyophilized formulations. in: EJ. McNally, JE. Hastedt, Eds, Drugs and the Pharmaceutical Sciences (2008), 175 (Protein Formulation and Delivery (2nd Edition)), pp. 197-217
• SG Chou, AK Soper, S Khodadadi, JE Curtis, S Krueger, MT Cicerone, A Fitch, E Shalaev (2012). Pronounced Micro-Heterogeneity in a Sorbitol-Water Mixture Observed Through Variable Temperature Neutron Scattering. J Phys Chem B, 116 (15) 4439–4447
• C Wu, S Shamblin, D Varshney, E Shalaev (2015). Advance Understanding of Buffer Behavior during Lyophilization. In: Lyophilized Biologics and Vaccines: Modality-Based Approaches. D Varshney, M Singh (Eds), Springer, pp. 25-42
• E Shalaev, AK Soper (2016). Water in a Soft Confinement: Structure of Water in Amorphous Sorbitol. J Phys Chem B, DOI: 10.1021/acs.jpcb.6b06157
• E Shalaev, K Wu, S Shamblin, JF Krzyzaniak, M Descamps (2016). Crystalline mesophases: Structure, mobility, and pharmaceutical properties. Advanced Drug Delivery Reviews, 100, 194–211