Curbside Consult Volume 26 - Fall Edition 2025

Resident Editors: Joyce Hu, PharmD; Jenna Knutson, PharmD; Rose Yang, PharmD
Faculty Editor: Maggie Ricco, PharmD; MS; BCACP

This edition was published November 17, 2025.

Updates in Research

Once a Week for Better Control? Efsitora Challenges Daily Insulin in Type 2 Diabetes
Sarah Pinkley, PharmD, Geritom Medical
Can a once-weekly basal insulin reduce treatment burden and improve safety compared to daily regimens in type 2 diabetes? Explore the latest findings with insulin efsitora.

Keeping an Eye on GLP-1s: Risk of Age-Related Macular Degeneration
Elizabeth Wolkow, PharmD, New Ulm Medical Center
GLP-1 Receptor Agonists, used to treat diabetes, may increase the risk of neurovascular age-related macular degeneration (nAMD) in older adults with diabetes.

Therapeutic Thought

ACC 2025: Obesity Management in Heart Failure—Emerging Therapies and Key Pharmacy Practice Considerations
Lauren Terp, PharmD, Park Nicollet Health Services
The 2025 ACC Scientific Statement recognizes obesity as a modifiable risk factor in heart failure. Growing evidence suggests that GLP-1 and GIP/GLP-1 receptor agonists may, when used in evidence-based practice, enhance quality of life and functional capacity while reducing heart failure events among individuals with both heart failure and obesity.

Statins for People with HIV: Necessary for Primary Prevention?
John Kastner, PharmD, Goodrich Pharmacy
As the overall mortality rates among people with HIV have declined, the rates of ASCVD-related death have increased, leaving an opportunity for providers and clinical pharmacists. Statin therapy decisions can now be guided by recent recommendations from the U.S. Department of HHS Panel for the Use of Antiretroviral Agents in Adults and Adolescents with HIV.

Miscellaneous News  

RSV Vaccine Now Recommended for At-Risk Adults Aged 50–59 Years 
Mai Dang, PharmD, Community-University Health Care Center (CUHCC)

A Preventative Look: Evaluating Cardiovascular Risk in Adults
Rose Yang, PharmD, Combined PGY1 Residency & Practice Advancement Fellowship - Smiley’s Clinic (Year 1)