Ronald A. Siegel, ScD

Professor, Department of Pharmaceutics

Ronald A. Siegel

Contact Info

Office Phone 612-624-6164

Fax 612-626-2125

Office Address:
Room 9-127E
Weaver-Densford Hall

Mailing Address:
University of Minnesota
College of Pharmacy
Department of Pharmaceutics
Room 9-177 WDH
308 Harvard St. SE
Minneapolis, MN 55455

ScD, MIT (Electrical Engineering and Computer Science)

MS, Massachusetts Institute of Technology (Electrical Engineering and Computer Science)

BS, University of Oregon (Mathematics-cum laude)


Prof. Siegel received his ScD degree in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology in 1984. From 1984-1998 he was on the faculty of the School of Pharmacy at the University of California, San Francisco. He moved to UMn in 1998, and was Department Head of Pharmaceutics from 1999-2009. He is also on the faculty of the Department of Biomedical Engineering.

Awards & Recognition

  • Fellow, CRS, 2010
  • CRS/Jorge Heller Journal of Controlled Release Outstanding Paper Award, 2003
  • CRS/Ethypharm Best Pharmaceutical Paper Award, 2001
  • Fellow, American Association of Pharmaceutical Scientists, 1999
  • Fellow, American Institute for Medical and Biological Engineering, 1999
  • Controlled Release Society (CRS) Young Investigator Research Award, 1989
  • American Association of Pharmaceutical Scientists (AAPS)/Pfizer Young Investigator Grant Award, 1988

Professional Associations

  • President, Controlled Release Society, 1997-1998
  • Editorial Boards: Journal of Controlled Release, AAPS Journal


Research Summary/Interests

Intranasal prodrugs and delivery systems for treatment of epilepsy; hydrogels and polymer-drug interactions; development of inert biodegradable polymers for implants; physical and mathematical modeling of processes governing drug disposition.

Research Methods/Techniques

Polymer synthesis and characterization; UV/Vis spectroscopy; HPLC; Mathematical and computational modeling

Research Funding Grants

MN-REACH: Intranasal delivery of benzodiazepine prodrug/enzyme combinations for seizure rescue

Genentech, Inc.: Artificial gut simulator for evaluation of supersaturated drug formulations with simultaneous dissolution and absorption


  • Drug-Device Combinations for Chronic Diseases, S. Lyu and R.A. Siegel, eds., Wiley, 2016
  • M. Kapoor, J.C. Cloyd, and R.A. Siegel, "A Review of Intranasal Formulations for the Treatment of Seizure Emergencies," J. Control. Rel., 237, 147-159 (2016). DOI: 10.1016/j.jconrel.2016.07.001
  • M. Kapoor, N. Cheryala, D. Rautiola, G. Georg, J.C. Cloyd, and R.A. Siegel, "Chirally Pure Prodrugs and Their Converting Enzymes Lead to High Supersaturation and Rapid Transcellular Permeation of Benzodiazepines," J Pharm Sci, 105, 2365-2371 (2016). DOI: 10.1016/j.xphs.2016.05.011
  • W. Wang, R.A. Siegel, and C. Wang, "Nanocomposite Polymers with "Slimy" Surfaces that Refresh Following Abrasion," ACS Biomaterials Science & Engineering, 2, 180-187 (2016). DOI: 10.1021/acsbiomaterials.5b00182
  • A.R. Kirtane, R.A. Siegel, and J. Panyam, "A Pharmacokinetic Model for Quantifying the Effect of Vascular Permeability on the Choice of Drug Carrier: A Framework for Personalized Nanomedicine," J. Pharm. Sci., 104, 1174-1186 (2015) DOI: 10.1002/jps.24302. PMID: 25583443 [PubMed - in process]
  • A.S. Bhalla and R.A. Siegel, "Mechanistic Studies of an Autonomously Pulsing Hydrogel/Enzyme System for Rhythmic Hormone Delivery Journal of Controlled Release," J. Control. Rel., 196, 261-271 (2014). NIHMS640330. DOI: 10.1016/j.jconrel.2014.10.019. PMC4268432
  • M. Kapoor, T. Winter, L. Lis, G.I. Georg, and R.A. Siegel, "Rapid Delivery of Diazepam from Supersaturated Solutions Prepared Using Prodrug-Enzyme Mixtures: Toward Intranasal Treatment of Seizure Emergencies," AAPS J., 16, 577-585 (2014). DOI: 10.1208/s12248-014-9596-5. PMID: 24700272
  • S.H. Song, J.H. Park, G. Chitnis, R.A. Siegel, and B. Ziaie, "A Wireless Chemical Sensor with Iron Oxide Nanoparticles Embedded Hydrogel," Sens. Act. B, 193, 925-930 (2014). DOI:10.1016/j.snb.2013.12.012
  • I. Koonar, C. Zhou, M.A. Hillmyer, T.P. Lodge, and R.A. Siegel, “ABC TriblockTerpolymers Exhibiting Both Temperature- and pH-Sensitive Micellar Aggregation and Gelation in Aqueous Solution,” Langmuir, 28, 17785-17794 (2012).
  • G. Khushf and R.A. Siegel, “What is Unique about Nanomedicine? The Significance of the Mesoscale,” J. Law Med. Ethics, 40, 780-794 (2012).
  • J.P.M. Motion, G.H. Huynh, F.C. Szoka, and R.A. Siegel, “Convection and Retro-Convection Enhanced Delivery: Some Theoretical Considerations Related to Drug Targeting,” Pharmaceut. Res., 28, 472-479 (2011).
  • R.A. Siegel and J.L. Linstad, “Cooperative Binding Isotherms for Nearest Neighbor Interacting Ligands on Platonic Solids: A Simple Model for Viral Capture Nanotherapy,” J. Phys. Chem. B, 114, 14071-14076 (2010).
  • R.A. Siegel. Oscillatory Systems Created with Polymer Membranes, in Nonlinear Dynamics with Polymers (J. Pojman and T-Q. Miyata, eds.), Wiley-VCH, Weinheim, pp 189-217 (2010).
  • R.A. Siegel, Y. Gu, M. Lei, A. Baldi, E.E. Nuxoll and B. Ziaie. Hard and Soft Micro- and Nanofabrication: An Integrated Approach to Hydrogel Based Biosensing and Drug Delivery. J. Controlled Release 141, 303-313 (2010).
  • T. Vermonden, S.S. Jena, D. Barriet, R. Censi, J. van der Gucht, W.E. Hennink and R.A. Siegel. Macromolecular Diffusion in Self-Assembling Biodegradable Thermosensitive Hydrogels. Macromolecules 43, 782-789 (2010).
  • E.E. Nuxoll, M.A. Hillmyer, R. Wang, C. Leighton and R.A. Siegel. Composite Block Polymer-Microfabricated Silicon Nanoporous Membrane. ACS Appl. Mater. Interf. 1, 888-893 (2009).
  • V.D. Ivaturi, J.R. Riss, R.L. Kriel, R.A. Siegel and J.C. Cloyd. Bioavailability and Tolerability of Intranasal Diazepam in Healthy Adult Volunteers. Epilepsy Research 84, 120-126 (2009).
  • D.F. Bayramov, P. Singh, G.W. Cleary, R.A. Siegel, A.E. Chalykh and M.M. Feldstein. Noncovalently Crosslinked Hydrogels Displaying a Unique Combination of Water Absorbing, Elastic and Adhesive Properties. Polym. Int. 57, 785-790 (2008)."
  • H. Hou and R.A. Siegel. Enhanced Permeation of Diazepam through Artificial Membranes from Supersaturated Solutions. J. Pharm. Sci. 95, 896-905 (2006).
  • M. Lei, A. Baldi, E. Nuxoll, R.A. Siegel and B. Ziaie. A Hydrogel-Based Implantable Micromachined Transponder for Wireless Glucose Measurement. Diabetes Tech. Therap. 8, 112-122 (2006).
  • B. Ziaie, A. Baldi, M. Lei, Y. Gu and R.A. Siegel. Hard and Soft Micromachining for BioMEMS: Review of Techniques and Examples of Applications in Microfluidics and Drug Delivery. Adv. Drug Deliv. Revs. 56, 145-172 (2004).
  • G.P. Misra and R.A. Siegel. A New Mode of Drug Delivery: Long-Term Autonomous Rhythmic Hormone Release Across a Hydrogel Membrane. J. Controlled Release 81, 1-6 (2002).


Academic Interests and Focus

Drug delivery, mathematical modeling

Teaching Areas

Graduate course in controlled drug and gene delivery, and graduate physical chemistry/physical pharmacy module.


Phm/BMEn 8431
Phm 8295
Phm 8110