Graduate Faculty Research Interests
Distinguished McKnight Professor & Merck Professor
Research interests: Bioorganic chemistry, enzymology, organic synthesis, protein prenylataion, sesquiterpene biosynthesis, rubber biosynthesis, protein labeling and immobilization, photoaffinity labeling, caged substrates.
Research interests: Quantum mechanics, molecular mechanics/dynamics, computer graphics techniques, molecular interactions, investigation of inter- and intramolecular interactions to gain insight for drug design and protein engineering
Regents Professor and Head
Research interests: Design, synthesis, and evaluation of synthetic and natural product-derived medicinal agents; drug discovery by HTS; new synthetic methods; combinatorial chemistry. Therapeutic areas: cancer, male contraception, Alzheimer's disease.
Northrop Professor and Director of Graduate Studies
Research interests: Synthesis, biophysical characterization, and biological efficacy evaluation of novel small molecules that influence cellular function. Applications for these molecules range from anticancer drug discovery to new tools for modern biotechnology research.
Professor & Philip S. Portoghese Endowed Chair in Chemical Neuroscience, Associate Department Head
Research interests: Peptide Chemistry, Medicinal Chemistry, G-protein Coupled Receptor (GPCR) Pharmacology, Human Receptor Polymorphisms, Neuroscience, Voluntary Exercise of Mice, Obesity, Diabetes, Feeding Behavior
Research interests: Development of novel non-viral vector transfection agents for use in human gene therapy, strategies for eliminating carcinogenic and estrogenic mycotoxins from the human food supply, exploration of the drug potential of betulins and other natural products
Distinguished McKnight University Professor
Research interests: Structural basis for promutagenic and anticancer activity of DNA-modifying agents, DNA damage by tobacco carcinogens and lung cancer, DNA-DNA and DNA-protein cross-linking agents as carcinogens and drugs, DNA oxidation by endogenous reactive oxygen species
Distinguished University Teaching Professor and Endowed Chair in Medicinal Chemistry
Research interests: Chemical Biology, design and development of targeted drug delivery approaches, design and study of chemical inducers of protein oligomerization, mechanistic and structural studies of biocatalyis and protein translation