Curbside Consult Volume 16, Issue 2 - Second Quarter 2018

Research Updates 

Serotonin Syndrome: What is the Risk When Co-Prescribing a Triptan With a Selective Serotonin Reuptake Inhibitor (SSRI) or Selective Norepinephrine Reuptake Inhibitor (SNRI)?
Brittany Bailey, Pharm.D., Avera Marshall Regional Medical Center
Serotonin syndrome can be a serious diagnosis and has been reported through FDA advisory to be of increased risk when combining tripan therapy with SSRI/SNRI therapy. A retrospective database study spanning 14 years reviews the risk.  

Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout
Kaity Kuske, Pharm.D., Smiley’s Family Medicine Clinic
Could serum urate level lowering therapy have an effect on cardiovascular and all-cause mortality?

Primary Literature Review: Effect of Opioid vs Non-opioid Medications on Pain-Related Function in Patients with Chronic Back Pain or Hip or Knee Osteoarthritis Pain – The SPACE Randomized Clinical Trial
Logane Kiehnau, Pharm.D., Allina Health
How effective are opioids at controlling chronic musculoskeletal pain and improving function? Are non-opioid medications more effective?

Two is Company, but is Three Really a Crowd? Once Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD
Roberta Dume, Pharm.D., GuidePoint Pharmacy—Northern Pines Mental Health Center
So many inhalers, so little time. A recent study investigates triple vs. dual inhaler therapy options. Which group of patients came out with the least exacerbations? Read on to find out.

Therapeutic Thoughts

A Closer Look at the Updated ADA Standards of Medical Care Recommendations for Patients with Diabetes and ASCVD
Kirstin Gramith, Pharm.D., Essentia Health – Duluth, MN
The updated 2018 Standards of Medical Care in Diabetes recommend adding a second agent with evidence of cardiovascular risk reduction in patients with ASCVD who are already on metformin and need additional therapy. Are all potential options considered equal?

Benefit of Adding Ezetimibe to Statin
Courtney Murphy, Pharm.D., Essentia Health - Duluth, MN
What is ezetimibe’s place in therapy? Let’s consider the IMPROVE-IT trial and one of its recently published subanalyses that analyzes use in patients who have diabetes.

From the Pharmacy Press  

Cost of Prescription Drug-Related Morbidity and Mortality
Stephanie Swanson, Pharm.D., North Memorial Health Camden Family Medicine Clinic
Comprehensive medication management can be an effective way to reduce the growing price of avoidable medication costs related to non-optimized medication use. 

A Pilot Study for Antimicrobial Stewardship Post-Discharge: Avoiding Pitfalls at the Transitions of Care
Barbara Truskolawski, Pharm.D., CashWise Clinic Pharmacy/ ACMC
Pharmacists’ involvement and interventions during transitions of care are well established and have proven to be effective at reducing hospital readmissions and medication errors. Can similar follow up and interventions be applied to antimicrobial stewardship?

Increasing Access to Hepatitis C Medications: A Program Model to Obtain Prior Authorization Approval
Joelle Ayoub, Pharm.D., Coborn’s Pharmacy-CHI St. Gabriel’s Health Family Medical Center
Can increased expertise and interprofessional teamwork improve insurance PA approval for hepatitis C medications?

Miscellaneous News  

Reducing Nicotine Content of Cigarettes- Public Health Implications
Hannah Schmidt, Pharm.D., FirstLight Health System
Tobacco is the leading cause of preventable death in the United States. The FDA recently proposed a new rule requiring reduction in the nicotine content of cigarettes to reduce the public health burden of smoking. If this law is enacted, will it actually have a positive effect on public health? 

Improving Medication Adherence Through Smartphone Apps
Elizabeth So, Pharm.D., MBA, Cub Pharmacy