Curbside Consult Volume 19, Issue 2 - Second Quarter 2021

Research Updates 

Antihypertensive Drug Targets and the Potential Effects on Psychiatric Disorders
David Bunch, PharmD, Geritom Medical, Inc.
Could antihypertensive agents worsen mental health conditions? Further, could our genes tell us the answer?

Comparing Efficacy and Safety of Different Doses of Dulaglutide in Metformin-Treated Patients with Type 2 Diabetes
Larissa Yehle, PharmD, Coborns CSC
Learn about the potential benefits of increasing dulaglutide dosing in those with type 2 diabetes previously inadequately treated with metformin.

Effectiveness of Vitamin D Supplementation on Preventing Acute Respiratory Infections
Sami Russo, PharmD, Goodrich Pharmacy
Does vitamin D supplementation significantly help protect against acute respiratory infections?

Therapeutic Thoughts

Safety and Efficacy of Direct Oral Anticoagulants (DOACs) versus Warfarin for Valvular Atrial Fibrillation
Anna Insley, PharmD, Welia Health
The safety and efficacy of direct oral anticoagulants (DOACs) in patients with valvular heart disease is an ongoing area of study. Read on as we examine the 2018 CHEST guidelines as well as newly published evidence to consider the risks versus benefits of DOACs for patients with valvular heart disease.

To Crush or Not to Crush: Novel Drug Formulations
Bridget Williams, PharmD, Allina Health
The Institute for Safe Medicine Practices “Do Not Crush” list has not been updated since 2016. Innovative nanocrystal and amorphous solid dispersion technologies have been appearing on the market for the past several years, and healthcare providers need to be aware that these cutting-edge drug formulations should remain intact during administration.

From the Pharmacy Press  

Effects of Pharmacist Interventions on Heart Failure Outcomes
Taylor Grupa, PharmD, Essentia Health
Heart failure is a complex condition associated with many adverse outcomes. Pharmacist interventions demonstrate a reduction in mortality and hospitalization rates as well as increased quality of life for patients with heart failure, highlighting the importance of including pharmacists as part of the integrated, collaborative heart failure care team.

Pharmacist-led Diabetes Care Associated with Improved Outcomes
Sara Maki, PharmD, North Memorial Blaine Clinic
Previous literature has demonstrated that pharmacist-led diabetes care can improve patient outcomes, but read this new study to learn more about which patients are most likely to benefit in a primary care setting.

The Effect of Ambulatory Care Pharmacists on Clinic Attendance and Patient Engagement
Caitlin Pederson, PharmD, M Health Fairview
Patient engagement is important for improving patient outcomes. Pharmacists may be able to help improve patient attendance to initial primary care provider visits, which may lead to improved patient engagement and patient outcomes.

Miscellaneous News  

Bringing Awareness of Performance Enhancing Drug Use to the Family Medicine Practitioner
Athena Cannon, PharmD, Broadway Family Medicine
Performance enhancing drugs (PEDs) are thought to be widely used in elite athletes; however, a recent editorial published in American Family Physician brings awareness to the use of PEDs in recreational and masters level athletes and outlines the family medicine practitioner’s role in this public health issue.

Old Drug, New Indication? An expanded approval for the use of Entresto™
Lauren Martens, PharmD, CentraCare St. Cloud
Entresto™ was originally approved for use only in patients with heart failure with reduced ejection fraction; however, with the recent approval of an expanded indication, see who may be appropriate for the use of this medication now.