Curbside Consult Volume 19, Issue 1 - First Quarter 2021

Research Updates 

Association Between Benzodiazepine Use With or Without Opioid Use and All-Cause Mortality in the United States, 1999-2015
Atuobi Nana Yiadom, PharmD, CentraCare Hospital, Paynesville
Are you thinking of prescribing or dispensing benzodiazepines with opioids? Wait! Did you know that taking benzodiazepines and opioids together may lead to increased mortality risk?

Once-Weekly vs Once-Daily Basal Insulin for Treatment of Type 2 Diabetes
Elizabeth Tupper, PharmD, St. Cloud VA
Once-weekly glucagon-like peptide-1 receptor agonists have gained favor with healthcare professionals and patients due to fewer pokes, better treatment acceptance, and improved adherence. What if there was a once-weekly basal insulin injection instead of once-daily? Presenting insulin icodec - a once-weekly basal insulin for treatment of type 2 diabetes!

Therapeutic Thoughts

Clinical Impact of Removing Race from Estimates of Kidney Function
Paige Behrend, PharmD, Park Nicollet Health Services
Despite increasing evidence that race is not a reliable indicator of genetic difference, many clinical algorithms and practice guidelines still contain race-based adjustments or recommendations. In the case of estimating kidney function, the inclusion of race-based coefficients may be underestimating the prevalence of chronic kidney disease among Black adults, thus perpetuating healthcare disparities.

Digoxin, Dig-ya think I was gone? Not yet!
Ann K. E. Nagle, PharmD, Pharmaceutical Care Leadership PGY1 Resident
Digoxin has been around for centuries, yet it appears low on treatment algorithms and out of many clinicians’ consideration. Atrial fibrillation and heart failure are two conditions for which digoxin and beta blockers are both indicated and often seen as comorbidities. For patients with these coexisting conditions, should digoxin be prioritized for symptomatic or quality of life improvements? Or are beta blockers supreme? The RATE-AF Trial explores these questions.

From the Pharmacy Press  

Analysis of Provider-Generated Revenue and Impact on Medication Reconciliation from a Pharmacist-Led Chronic Care Management Service
Alexandra Vecchia, PharmD, M Health Fairview
Do pharmacist-led chronic care management services provide economic benefits for pharmacies and resolve medication discrepancies?

Assessment of Racial Differences in Pharmacotherapy Efficacy for Smoking Cessation
Katherine Anderson, PharmD, Cash Wise Clinic Pharmacy/Carris Health
Tobacco consumption is the leading cause of preventable morbidity and mortality in the U.S. with 480,000 deaths annually. Is there a racial difference in self-identified White vs Black smokers when selecting pharmacotherapy for smoking cessation?

Pharmacists: Essential Partners in Shared Decision-Making for Schizophrenia and Schizoaffective Disorder
Tim Isdahl, PharmD, Minnesota Community Care
Pharmacists are becoming directly involved in caring for patients living with schizophrenia and schizoaffective disorder. ASHP’s new Therapeutic Position Statement helps pharmacists hoping to become more involved in this area of care.

Miscellaneous News  

FDA Warning on Male Enhancement and Weight Loss Products Sold Online
Ashton Forst, PharmD, Hennepin Healthcare
Recently, the Food and Drug Administration (FDA) released a warning statement regarding certain products purchased through online marketplaces, such as Amazon and eBay, due to their potentially dangerous, hidden ingredients. This article will take a closer look at the FDA warning and how to safely purchase products online.

Amazon Launches a New Online Pharmacy Service
Ashton Forst, PharmD, Hennepin Healthcare
At the end of 2020, Amazon launched an online pharmacy for delivering prescription medications within the United States. Read on to find out how this new service could impact patients and pharmacies.

Minnesota Board of Pharmacy Approves Protocol for Pharmacist Prescribing of Self-administered Hormonal Contraceptives
Brianna Ferrell, PharmD, Essentia Health
Advances in pharmacist prescriptive authority of contraceptive medications: Minnesota Board of Pharmacy approves a pharmacist prescribing protocol for self-administered hormonal contraceptives.