Curbside Consult Volume 18, Issue 1 - First Quarter 2020

Research Updates 

The HUNT Study: Proton Pump Inhibitors and Fracture Risk
Kaylin Maddy, PharmD, Park Nicollet Health Services
Does the use of PPIs increase fracture risk? A large Norwegian study adds to the supply of conflicting evidence.

A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke
Kelly Beneke, PharmD, New Ulm Medical Center
The Treat Stroke to Target trial investigates if a target LDL cholesterol level less than 70 mg/dL has a lower risk of composite cardiovascular events compared to a target LDL cholesterol level of 90-110 mg/dL.

Therapeutic Thoughts

Migraine Pharmacotherapy and Novel Agents
Anna K Hanson, PharmD, Essentia Health
Many of our current treatment modalities for migraine focus on medications originally developed for alternative indications. Will newer agents specifically targeted at the pathophysiology of migraine provide promising new strategies?

Antihypertensive Treatment Update
Sarah Shockley, PharmD, Fairview
The current guidelines recommend any drug in five different pharmaceutical classes as first-line treatment for hypertension. A recent study published in The Lancet shakes up the guidelines with new recommendations for first-line agents. 

Who Should Receive PCV13?
Analisa Buysse, PharmD, Avera Marshall Regional Medical Center
The Advisory Committee on Immunization Practices now recommends against the routine administration of Prevnar13Ⓡ (PCV13) in adults ≥65 years old. Instead, a shared clinical decision making process considering several patient-specific factors should now be used when recommending for or against vaccination with PCV13 in this population. 

From the Pharmacy Press  

Direct Oral Anticoagulant Therapy in Cancer
Sara Massey, PharmD, MOBE 
Could a direct oral anticoagulant be a new therapy indicated for VTE prophylaxis in cancer patients? Check out this recent study comparing DOACs to LMWH! 

Examining the Medicare Part D Medication Therapy Management Program in the Context of Mental Health
Kyle Walburg, PharmD, North Memorial Camden Clinic
Despite coverage for medication therapy management services, a large disparity exists in Medicare beneficiaries that receive the service; how can pharmacists help?

Safety Comparison of High-Intensity Atorvastatin vs. High-Intensity Rosuvastatin
Emily Hulke, PharmD, Goodrich Pharmacy
Are all high-intensity statins created equal?

Miscellaneous News  

OTC Tamiflu: Coming Soon to an Aisle Near You?
Meg Tapp, PharmD, Essentia Health
Sanofi recently purchased exclusive over-the-counter (OTC) rights for Tamiflu® from manufacturer Roche Pharmaceuticals. What will it mean for pharmacists and patients when this medication hits OTC shelves?

FDA Issues Warning of Respiratory Depression with Gabapentinoids
Amanda Bisel, PharmD, Allina Health
Gabapentin is commonly prescribed for several indications including neuropathic pain, insomnia, and seizures. What patients should pharmacists second guess using gabapentinoids in?

New Manufacturer: State of California?
Amanda Bisel, PharmD, Allina Health
Drug prices have increasingly become a major concern in the healthcare industry, sparking the need for creative solutions. An unlikely team, California state and drug manufacturers, join forces to tackle the issue.