Curbside Consult Volume 20, Issue 1 - First Quarter 2022

Research Updates 

Apixaban, is it a One-Size-Fits-All Anticoagulant? Using Apixaban to Treat VTE in Individuals of Higher Body Weight
Yesenia Lopez-Mendoza, PharmD, Community-University Health Care Center
Apixaban is blazing a trail for direct oral anticoagulants (DOACs) everywhere in the pursuit of superior anticoagulation therapy. The evidence supporting DOACs continues to impress by displaying noteworthy versatility among a variety of patient populations.

Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction
Makoto Hang, PharmD, Minnesota Community Care
How does sacubitril-valsartan compare to ramipril to reduce the rate of heart failure after myocardial infarction? This study aims to determine whether or not one is superior to the other in a head-to-head comparison.

Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
Erica Hanson, PharmD, Cash Wise Clinic Pharmacy
Efficacy of thiazide diuretics is thought to decrease with worsening renal function and is often avoided in CKD patients when eGFR drops below 30 mL/min/1.73 m2. Is this class of medications actually safe and effective for patients with stage 4 CKD?

Therapeutic Thoughts

Pregnancy and Medication Safety
Bobby LeDuff, PharmD, Essentia Health
Medication use in pregnancy is common, even though data for medication safety in this population is limited. Clinicians should be aware of the FDA’s guidance for medication use in pregnancy in addition to available resources to help guide decision making with patients.

Addressing High Elder Suicide Rates: A Call to Action
Hayley Kytta, PharmD, Allina Health
Suicidal ideation is a growing concern among older adults. Pharmacists are well positioned to identify and respond to warning signs, but suicide prevention training programs geared toward the pharmacist profession are still lacking.

Young Women with Premature ASCVD are at Risk for Worse Outcomes
Debesai Hailemicael, PharmD, Minnesota Community Care
Cardiovascular events and mortality rate has not declined in young women despite down trending in the general population. New evidence suggests sex-based disparities exist within the health system. Can increasing awareness, education, and healthcare access be the pathway to equity?

From the Pharmacy Press  

Medical Pedagogy Beyond the Boundaries of a Textbook: Teaching Intellectual Humility
Athena Cannon, PharmD, Indian Health Board Medical and Dental Center
Do the tools needed to prepare student pharmacists for successful interprofessional collaboration lie between the covers of a textbook? Maybe not.

Combating Polypharmacy: A Deprescribing Tool within the VA
Abigail Sirek, PharmD, CentraCare - Paynesville
Many patients feel they are on too many medications. This article illustrates how pharmacists can effectively combat polypharmacy.

A Scoping Review Evaluating the Effect of SGLT-2 Inhibitors on Insulin Dose Requirements in Insulin-Dependent Patients With Type 2 Diabetes
Anna Lange, PharmD, Goodrich Pharmacy
How do SGLT2 inhibitors affect total daily insulin requirements in insulin-dependent patients with type 2 diabetes?

Miscellaneous News  

Social Determinants of Health - New Resources in 2022
Ann Nagle, PharmD, MPH, M Health Fairview - Entira Family Clinics
Pharmacists continue to be among the most accessible members of the healthcare team. As such, they are often tasked to not only connect patients with resources to help with affordability of medications, but also assist with other social determinants of health. Read on to learn more about two programs in 2022 that aim to help with medication and food access.

In the Fine Print - Safety First!
Sonal Parmar, PharmD, Community-University Health Care Center
Medication safety is a shared responsibility that begins with the manufacturer and ends in the hands of the consumer. Despite our best intentions, safety gets buried in the fine print that attempts to provide consumer education.

Virtual Reality for Chronic Pain
Lauren Ostlund, PharmD, Broadway Family Medicine
Is virtual reality the future of chronic low back pain treatment?