Publications

Publications

Angela Birnbaum, PhD

Angela Birnbaum, PhD

Link to PubMed

Pharmacokinetic-pharmacodynamic modeling of intravenous and oral topiramate and its effect on the symbol digit modalities test in adult healthy volunteers.
Lim CN, Birnbaum AK, Brundage RC, Leppik IE, Cloyd JC, Clark A, Marino SE. J Clin Pharmacol. 2015 Sep 23. doi: 10.1002/jcph.646. [Epub ahead of print] PMID: 26395889

Pharmacokinetic-pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers.
Ahmed GF, Marino SE, Brundage RC, Pakhomov SV, Leppik IE, Cloyd JC, Clark A, Birnbaum AK. Br J Clin Pharmacol. 2015 May;79(5):820-30. doi: 10.1111/bcp.12556. PMID: 25403343

Jeffrey Bishop

Jeffrey Bishop

Link to PubMed

Catechol-O-Methyltransferase Val158Met Polymorphism and Clinical Response to Antipsychotic Treatment in Schizophrenia and Schizo-Affective Disorder Patients: a Meta-Analysis.
Huang E, Zai CC, Lisoway A, Maciukiewicz M, Felsky D, Tiwari AK, Bishop JR, Ikeda M, Molero P, Ortuno F, Porcelli S, Samochowiec J, Mierzejewski P, Gao S, Crespo-Facorro B, Pelayo-Terán JM, Kaur H, Kukreti R, Meltzer HY, Lieberman JA, Potkin SG, Müller DJ, Kennedy JL.  Int J Neuropsychopharmacol. 2016 Apr 29;19(5). pii: pyv132. doi: 10.1093/ijnp/pyv132.  Print 2016 May. PubMed PMID: 26745992; PubMed Central PMCID: PMC4886669.

Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes. 
Stevenson JM, Reilly JL, Harris MS, Patel SR, Weiden PJ, Prasad KM, Badner JA, Nimgaonkar VL, Keshavan MS, Sweeney JA, Bishop JR.  Transl Psychiatry. 2016  Feb 23;6:e739. doi: 10.1038/tp.2016.10. PubMed PMID: 26905411; PubMed Central PMCID: PMC4872428.

Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. 
Hicks JK, Bishop JR, Sangkuhl K, Müller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A;  Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29.  Review. PubMed PMID: 25974703; PubMed Central PMCID: PMC4512908.

Escitalopram pharmacogenetics: CYP2C19 relationships with dosing and clinical outcomes in autism spectrum disorder.
Bishop JR, Najjar F, Rubin LH, Guter SJ, Owley T, Mosconi MW, Jacob S, Cook EH. Pharmacogenet Genomics. 2015 Nov;25(11):548-54. doi: 10.1097/FPC.0000000000000173. PMID: 26313485

Pharmacogenetic Study of Serotonin Transporter and 5HT2A Genotypes in Autism.
Najjar F, Owley T, Mosconi MW, Jacob S, Hur K, Guter SJ, Sweeney JA, Gibbons RD, Cook EH, Bishop JR. J Child Adolesc Psychopharmacol. 2015 Aug;25(6):467-74. doi: 10.1089/cap.2014.0158. PMID: 26262902

SNP genotyping using TaqMan technology: the CYP2D6*17 assay conundrum.
Gaedigk A, Freeman N, Hartshorne T, Riffel AK, Irwin D, Bishop JR, Stein MA, Newcorn JH, Jaime LK, Cherner M, Leeder JS. Sci Rep. 2015 Mar 19;5:9257. doi: 10.1038/srep09257.
PMID: 25788121

Genetic predictor of working memory and prefrontal function in women with HIV.
Sundermann EE, Bishop JR, Rubin LH, Little DM, Meyer VJ, Martin E, Weber K, Cohen M, Maki PM. J Neurovirol. 2015 Feb;21(1):81-91. doi: 10.1007/s13365-014-0305-z. Epub 2014 Dec 17. PMID: 25515329

Jacob Brown

Jacob Brown

Link to PubMed

J Palliat Med. 2017 Jul;20(7):793. doi: 10.1089/jpm.2017.0059. Epub 2017 Mar 2. No abstract available.  PMID:28253048

Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA.
Kemp PJ, Rushton DJ, Yarova PL, Schnell C, Geater C, Hancock JM, Wieland A, Hughes A, Badder L, Cope E, Riccardi D, Randall AD, Brown JT, Allen ND, Telezhkin V.  J Physiol. 2016 Nov 15;594(22):6583-6594. doi: 10.1113/JP270655.

Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.
Brown JT, Abdel-Rahman SM, van Haandel L, Gaedigk A, Lin YS, Leeder JS. Clin Pharmacol Ther. 2016 Jun;99(6):642-50. doi: 10.1002/cpt.319. Epub 2016 Jan 12.PMID: 26660002

Single-dose pharmacokinetics of atomoxetine in children stratified by CYP2D6 activity score
Brown JT, Abdel-Rahman SM, Van Haandel L, Gaedigk A, Leeder JS.Clin Pharm and Ther 2015 [Epub ahead of print].

Atomoxetine pharmacogenetics: associations with pharmacokinetics, treatment response, and tolerability. 
Brown JT, Bishop JR. Pharmacogenomics. 2015. 16(13);1513-20.

Individualized Factor IX Dosing in Two Brothers: Application of Longitudinal Pharmacokinetic Modeling to Optimize Therapeutic Benefit.
Brown JT, Wicklund B, Abdel-Rahman SM.Haemophilia, 2015; 21: e125-7.

Atomoxetine pharmacogenetics: associations with pharmacokinetics, treatment response and tolerability.
Brown JT, Bishop JR.  Pharmacogenomics. 2015 Aug;16(13):1513-20. doi: 10.2217/PGS.15.93. Epub 2015 Aug 28. PMID: 26314574

David Gregornik

David Gregornik

Link to PubMed

Ajay Israni

Ajay Israni

Link to PubMed
Effect of Replacing Race With Apolipoprotein L1 Genotype in Calculation of Kidney Donor Risk Index.
Julian BA, Gaston RS, Brown WM, Reeves-Daniel AM, Israni AK, Schladt DP, Pastan SO, Mohan S, Freedman BI, Divers J. Am J Transplant. 2017 Jun;17(6):1540-1548. doi: 10.1111/ajt.14113. Epub 2017 Jan 3.

Validation Is Critical for Genome-Wide Association Study-Based Associations.
Oetting WS, Jacobson PA, Israni AKAm J Transplant. 2017 Feb;17(2):318-319. doi: 10.1111/ajt.14051. Epub 2016 Oct 12. No abstract available. PMID: 27640398

Deceased-Donor Apolipoprotein L1 Renal-Risk Variants Have Minimal Effects on Liver Transplant Outcomes.
Dorr CR, Freedman BI, Hicks PJ, Brown WM, Russell GB, Julian BA, Pastan SO, Gautreaux MD, Muthusamy A, Chinnakotla S, Hauptfeld V, Bray RA, Kirk AD, Divers J, Israni AKPLoS One. 2016 Apr 7;11(4):e0152775. doi: 10.1371/journal.pone.0152775. eCollection 2016. PMID: 27054572

Genotype-guided tacrolimus dosing in African-American kidney transplant recipients.
Sanghavi K, Brundage RC, Miller MB, Schladt DP, Israni AK, Guan W, Oetting WS, Mannon RB, Remmel RP, Matas AJ, Jacobson PA. Pharmacogenomics J. 2017 Jan;17(1):61-68. doi: 10.1038/tpj.2015.87. Epub 2015 Dec 15 .PMID:26667830
 
APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors.
Freedman BI, Pastan SO, Israni AK, Schladt D, Julian BA, Gautreaux MD, Hauptfeld V, Bray RA, Gebel HM, Kirk AD, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Mohan S, Ma L, Langefeld CD, Bowden DW, Hicks PJ, Palmer ND, Palanisamy A, Reeves-Daniel AM, Brown WM, Divers J. Transplantation. 2016 Jan;100(1):194-202. doi: 10.1097/TP.0000000000000969. PMID:26566060

Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles.
Oetting WS, Schladt DP, Guan W, Miller MB, Remmel RP, Dorr C, Sanghavi K, Mannon RB, Herrera B, Matas AJ, Salomon DR, Kwok PY, Keating BJ, Israni AK, Jacobson PA; DeKAF Investigators. Am J Transplant. 2016 Feb;16(2):574-82. doi: 10.1111/ajt.13495. Epub 2015 Oct 20. PMID: 26485092

Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies.
Li YR, van Setten J, Verma SS, Lu Y, Holmes MV, Gao H, Lek M, Nair N, Chandrupatla H, Chang B, Karczewski KJ, Wong C, Mohebnasab M, Mukhtar E, Phillips R, Tragante V, Hou C, Steel L, Lee T, Garifallou J, Guettouche T, Cao H, Guan W, Himes A, van Houten J, Pasquier A, Yu R, Carrigan E, Miller MB, Schladt D, Akdere A, Gonzalez A, Llyod KM, McGinn D, Gangasani A, Michaud Z, Colasacco A, Snyder J, Thomas K, Wang T, Wu B, Alzahrani AJ, Al-Ali AK, Al-Muhanna FA, Al-Rubaish AM, Al-Mueilo S, Monos DS, Murphy B, Olthoff KM, Wijmenga C, Webster T, Kamoun M, Balasubramanian S, Lanktree MB, Oetting WS, Garcia-Pavia P, MacArthur DG, de Bakker PI, Hakonarson H, Birdwell KA, Jacobson PA, Ritchie MD, Asselbergs FW, Israni AK, Shaked A, Keating BJ.  Genome Med. 2015 Oct 1;7(1):90. doi: 10.1186/s13073-015-0211-x. PMID:26423053

Multigene predictors of tacrolimus exposure in kidney transplant recipients.
Pulk RA, Schladt DS, Oetting WS, Guan W, Israni AK, Matas AJ, Remmel RP, Jacobson PA; DeKAF Investigators. Pharmacogenomics. 2015 Jul;16(8):841-54. doi: 10.2217/pgs.15.42. Epub 2015 Jun 12. PMID: 26067485

Differentially expressed gene transcripts using RNA sequencing from the blood of immunosuppressed kidney allograft recipients.
Dorr C, Wu B, Guan W, Muthusamy A, Sanghavi K, Schladt DP, Maltzman JS, Scherer SE, Brott MJ, Matas AJ, Jacobson PA, Oetting WS, Israni AK. PLoS One. 2015 May 6;10(5):e0125045. doi: 10.1371/journal.pone.0125045. eCollection 2015. PMID: 25946140

Deceased donor multidrug resistance protein 1 and caveolin 1 gene variants may influence allograft survival in kidney transplantation.
Ma J, Divers J, Palmer ND, Julian BA, Israni AK, Schladt D, Pastan SO, Chattrabhuti K, Gautreaux MD, Hauptfeld V, Bray RA, Kirk AD, Brown WM, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Guan M, Palanisamy A, Reeves-Daniel AM, Bowden DW, Langefeld CD, Hicks PJ, Ma L, Freedman BI. Kidney Int. 2015 Sep;88(3):584-92. doi: 10.1038/ki.2015.105. Epub 2015 Apr 8. PMID: 25853335

Pamala Jacobson

Pamala Jacobson

Link to PubMed

CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism.
Dorr CR, Remmel RP, Muthusamy A, Fisher J, Moriarity BS, Yasuda K, Wu B, Guan W, Schuetz EG, Oetting WS, Jacobson PA, Israni AK. Drug Metab Dispos. 2017 Aug;45(8):957-965. doi: 10.1124/dmd.117.076307. Epub 2017 May 22. PMID:28533324

Rifampin-sirolimus-voriconazole interaction in a hematopoietic cell transplant recipient.   Wasko J, Westholder JS, Jacobson PA. J Oncol Pharm Pract. 2017 Jan;23(1):75-79.[ PMID: 2676300]

Editorial: Validation is critical for genome wide association study based associations.  Oetting WA, Jacobson PA, Israni AK. Am J Transplant. 2017:17: 318-319. doi: 10.1111/ajt.14051

Validation is critical for Genome Wide Association Study-Based Associations. Oetting WS, Jacobson PA, Israni AK.  Am J Transplant. 2017 Feb;17(2):318-319. doi: 10.1111/ajt.14051. Epub 2016 Oct 12. PMID:27640398

Genome wide association study of tacrolimus concentrations in African American kidney transplant recipients identifies multiple CYP3A5 alleles. Oetting WS, Schladt DP, Guan W, Miller MB, Remmel RP, Dorr C*, Sanghavi K*, Mannon RB, Herrera B, Matas AJ, Salomon DR, Kwok PY, Keating BJ, Israni AK, Jacobson PA for the DeKAF Investigators. Am J Transplant  2016 Feb;16(2):574-82. [PMID 26485092]

Personalized Fludarabine Dosing To Reduce Non-Relapse Mortality In Hematopoietic Stem Cell Transplant Recipients Receiving Reduced Intensity Conditioning. R, Jensen K, Rosgosheske J, Kurtzweil A, Long-Boyle J, Wagner J, Warlick E, Brunstein CG, Weisdorf D, Jacobson PA. 2016 Sep;175:103-115.e4. Epub 2016 Mar 31. [PMID 27094990]

Pharmacokinetic-pharmacodynamic modeling of  acute N-terminal pro B-type natriuretic peptide after doxorubicin infusion in breast cancer. Liang S*, BrundageRC, Jacobson PA,  Blaes, A,  Kirstein, MN.  Br J Clin Pharmacol. (2016) 82, 773–783. [PMID 27128712]

Sirolimus and Mycophenolate Mofetil as Calcineurin Inhibitor-Free GVHD Prophylaxis for Reduced Intensity Umbilical Cord Blood Transplantation. Bejanyan N, Rogosheske J, DeFor TE, Lazaryan A, Arora M, Holtan SG, Jacobson PA, MacMillan ML, Verneris MR, Blazar BR, Weisdorf DJ, Wagner JE, Brunstein CG. Biol Blood and Marrow Transplant.  2016 Nov;22(11):2025-2030 [PMID:27519278]

Genotype-guided tacrolimus dosing in African American kidney transplant recipients.
Sanghavi K, Brundage RC, Miller MB, Schladt DP,  Israni AK, Guan W, Oetting WS, Mannon RB, Remmel RP,  Matas AJ,  Jacobson PA. The Pharmacogenomics Journal. Accepted. advance online publication 15 December 2015; (PMID:26667830)

Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS.
Oetting W, Schladt D, Guan W, Israni A, Remmel R, Dorr C, Sanghavi K, Mannon R, Herrera B, Matas A, Salomon D, Kwok P, Jacobson P. Am J Transplant. 2015. Online ahead of print October 20, 2015. (PMID:26485092)

Design and Implementation of the International Genetics & Translational Research in Transplantation Network (iGeneTRAIN).
Keating BJ, van Setten J, Jacobson PA, Holmes MV, Verma SS, Chandrupatla H, Nair N, Gao H, Phillips R, Wong C, Mukhtar E, Zhang W, Li YR, Cao H, Li C, Lee T, Steel L, Garifallou J, Miller MB, Karczewski KJ, Lek M, Fu Y, Pawashe M, Guettouche T, Thomas K, Almoguera B, Snyder J, Wang T, Himes A, Guan W, Wu B, Schladt D, Menon M, Zhang Z, Gonzalez A, Tragante V, Malkki M, De Vlaminck I, Piening BD, Strehl C, Shaw M, Snieder H, Klintmalm GB, O'Leary JG, Amaral S, Goldfarb S, Rand E, Rossano JW, Kohli U, Heeger P, Stahl E, Christie JD, Hernandez M, Levine JE, Aplenc R, Schadt EE, Stranger BE, Kluin J, Potena L, Zuckermann A, Khush K, Al-Muhanna FA, Al-Ali AK, Al-Rubaish AM, Potena L, Suthanthiran M, Tedesco H, Saw CL, Ragoussis J, Wijmenga C, Palmer S, de Borst MH, Naesens M, Hao K, de Bakker PI.W, MacArthur DG, Balasubramanian S, Lord G, Ritchie MD, Snyder M, Olthoff KM, Moore J, Petersdorf EW, Kamoun M, Wang J, Monos DS, Hakonarson H, Lankree MB, Murphy B, Garcia-Pavia P, Oetting WS, Birdwell KA, Bakker SJL, Israni AK, Shaked A, Asselbergs FW.Transplantation.  Volume 99(11), November 2015, p 2401–2412

Concept and Design of a Genome-wide Association Genotyping Array Tailored for Transplantation-Specific Studies.
Li YR, van Setten J, Lu Y, Holmes MV, Verma SS, Lek M, Nair N, Gao H, Chandrupatla H, Karczewski KJ, Wong C, Mukhtar E, Tragante V, Li C, Steel L, Lee T, Garifallou J, Guettouche T, Almoguera B, Cao H, Guan W, Himes A, Miller MB, Schladt D, Snyder J, Thomas K, Wang T, Wu B, Al-Ali AK, Al-Muhanna FA, Al-Rubaish AM, Monos DS, Murphy B, Olthoff KM, Wijmenga C, Webster T, Kamoun M, Balasubramanian S, Hakonarson H, Lanktree MB, Oetting WS, Garcia-Pavia P, MacArthur DG, Birdwell KA, Jacobson PA, Ritchie MD, Asselbergs FW, Israni AK, Shaked A, Keating BJ.  Genomic Medicine. 2015 Oct 1, 7(1):90  (PMID:26423053)

Multi-Gene Pharmacogenomics of Tacrolimus Troughs in Kidney Transplant Recipients.  
Pulk R, Schladt D, Weihau, G, Oetting W, Israni A, Matas A, Jacobson PA. Pharmacogenomics 2015. Accepted  doi: 10.2217/pgs.15.42.  (PMID 26067485)

Genotype-guided tacrolimus dosing in African American kidney transplant recipients.  Sanghavi K*, Brundage RC, Miller MB, Schladt DP, Israni AK, Guan W, Oetting WS, Mannon RB, Remmel RP, Matas AJ, Jacobson PA.  The Pharmacogenomics Journal. 2015, 1–8 [PMID: 26667830]

Differentially expressed gene transcripts using RNA sequencing from the blood of immunosuppressed kidney allograft recipients.
Door C, Wu B, Guan W, Muthusamy A, Sanghavi K, Schladt DP, Maltzman JS, Scherer SE, Brott MJ, Matas AJ, Jacobson PA, Oetting WS, Israni AK.  PLoS One. 2015 May 6;10(5);e012545. doi: 10.1371/journal.pone.0125045. (PMID: 25946140, PMCID: PMC4422721)

Higher dose of mycophenolate mofetil reduces acute graft-versus-host disease in reduced-intensity conditioning double umbilical cord blood transplantation.
Bejanyan N, Rogosheske J, DeFor T, Lazaryan A, Esbaum K, Holtan S, Arora M, MacMillan ML, Weisdorf D, Jacobson P, Wagner J, Brunstein CG. Biol Blood Marrow Transplant. 2015 May;21(5):926-33. (PMID: 25655791)

Angiotensin Converting Enzyme Inhibitors (ACEI) and doxorubicin pharmacokinetics in women receiving adjuvant breast cancer treatment.
Blaes A, Duprez D, Defor T, Shanley R, Beckwith H, Haddad T, Potter D, Yee D, Sanghavi K, Jacobson P. Springerplus. 2015 Jan 23;4:32. (PMID:25646154)

 

Susan Marino

Susan Marino

Link to PubMed

Pharmacokinetic-pharmacodynamic modeling of intravenous and oral topiramate and its effect on the symbol digit modalities test in adult healthy volunteers.
Lim CN, Birnbaum AK, Brundage RC, Leppik IE, Cloyd JC, Clark A, Marino SE.
J Clin Pharmacol. 2015 Sep 23. doi: 10.1002/jcph.646. [Epub ahead of print]
PMID: 26395889

Pharmacokinetic-pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers.
Ahmed GF, Marino SE, Brundage RC, Pakhomov SV, Leppik IE, Cloyd JC, Clark A, Birnbaum AK.
Br J Clin Pharmacol. 2015 May;79(5):820-30. doi: 10.1111/bcp.12556.
PMID: 25403343

William Oetting

William Oetting

Link to PubMed

CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism.
Dorr CR, Remmel RP, Muthusamy A, Fisher J, Moriarity BS, Yasuda K, Wu B, Guan W, Schuetz EG, Oetting WS, Jacobson PA, Israni AK. Drug Metab Dispos. 2017 Aug;45(8):957-965. doi: 10.1124/dmd.117.076307. Epub 2017 May 22. PMID:28533324

Non-Coding Variation: The 2016 Annual Scientific Meeting of the Human Genome Variation Society.
Oetting WS, Béroud C, Brenner SE, Greenblatt M, Karchin R, Mooney SD, Sunyaev S. Hum Mutat. 2017 Apr;38(4):460-463. doi: 10.1002/humu.23169. Epub 2017 Feb 14. No abstract available. PMID: 28054414


Validation Is Critical for Genome-Wide Association Study-Based Associations.
Oetting WS, Jacobson PA, Israni AK. Am J Transplant. 2017 Feb;17(2):318-319. doi: 10.1111/ajt.14051. Epub 2016 Oct 12. No abstract available. PMID:27640398
 
Clinical Interpretation of Variants from Next-Generation Sequencing: The 2016 Scientific Meeting of the Human Genome Variation Society.
Oetting WS, Brookes AJ, Béroud C, Taschner PE. Hum Mutat. 2016 Oct;37(10):1110-3. doi: 10.1002/humu.23059. Epub 2016 Aug 21. PMID: 27492570

Pathogenicity Interpretation in the Age of Precision Medicine: The 2015 Annual Scientific Meeting of the Human Genome Variation Society.
Oetting WS, Brenner SE, Brookes AJ, Greenblatt MS, Hart RK, Karchin R, Sunyaev SR, Taschner PE. Hum Mutat. 2016 Apr;37(4):406-11. doi: 10.1002/humu.22958. Epub 2016 Feb 12. No abstract available. PMID: 26791113

Genotype-guided tacrolimus dosing in African-American kidney transplant recipients.
Sanghavi K, Brundage RC, Miller MB, Schladt DP, Israni AK, Guan W, Oetting WS, Mannon RB, Remmel RP, Matas AJ, Jacobson PA. Pharmacogenomics J. 2017 Jan;17(1):61-68. doi: 10.1038/tpj.2015.87. Epub 2015 Dec 15. PMID: 26667830

Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles. 
Oetting WS, Schladt DP, Guan W, Miller MB, Remmel RP, Dorr C, Sanghavi K, Mannon RB, Herrera B, Matas AJ, Salomon DR, Kwok PY, Keating BJ, Israni AK, Jacobson PA; DeKAF Investigators. Am J Transplant. 2016 Feb;16(2):574-82. doi: 10.1111/ajt.13495. Epub 2015 Oct 20.  PMID: 26485092


Pharmacogenetic Allele Nomenclature: International Workgroup Recommendations for Test Result Reporting.
Kalman LV, Agúndez JA, Appell ML, Black JL, Bell GC, Boukouvala S, Bruckner C, Bruford E, Bruckner C, Caudle K, Coulthard S, Daly AK, Del Tredici AL, den Dunnen JT, Drozda K, Everts R, Flockhart D, Freimuth R, Gaedigk A, Hachad H, Hartshorne T, Ingelman-Sundberg M, Klein TE, Lauschke VM, Maglott DR, McLeod HL, McMillin GA, Meyer UA, Müller DJ, Nickerson DA, Oetting WS, Pacanowski M, Pratt VM, Relling MV, Roberts A, Rubinstein WS, Sangkuhl K, Schwab M, Scott SA, Sim SC, Thirumaran RK, Toji LH, Tyndale R, van Schaik RH, Whirl-Carrillo M, Yeo KJ, Zanger UM.Clin Pharmacol Ther. 2015 Oct 19. doi: 10.1002/cpt.280. [Epub ahead of print] Review. PMID:26479518

Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies.
Li YR, van Setten J, Verma SS, Lu Y, Holmes MV, Gao H, Lek M, Nair N, Chandrupatla H, Chang B, Karczewski KJ, Wong C, Mohebnasab M, Mukhtar E, Phillips R, Tragante V, Hou C, Steel L, Lee T, Garifallou J, Guettouche T, Cao H, Guan W, Himes A, van Houten J, Pasquier A, Yu R, Carrigan E, Miller MB, Schladt D, Akdere A, Gonzalez A, Llyod KM, McGinn D, Gangasani A, Michaud Z, Colasacco A, Snyder J, Thomas K, Wang T, Wu B, Alzahrani AJ, Al-Ali AK, Al-Muhanna FA, Al-Rubaish AM, Al-Mueilo S, Monos DS, Murphy B, Olthoff KM, Wijmenga C, Webster T, Kamoun M, Balasubramanian S, Lanktree MB, Oetting WS, Garcia-Pavia P, MacArthur DG, de Bakker PI, Hakonarson H, Birdwell KA, Jacobson PA, Ritchie MD, Asselbergs FW, Israni AK, Shaked A, Keating BJ.
Genome Med. 2015 Oct 1;7(1):90. doi: 10.1186/s13073-015-0211-x.  PMID: 26423053

Multigene predictors of tacrolimus exposure in kidney transplant recipients.
Pulk RA, Schladt DS, Oetting WS, Guan W, Israni AK, Matas AJ, Remmel RP, Jacobson PA; DeKAF Investigators. Pharmacogenomics. 2015 Jul;16(8):841-54. doi: 10.2217/pgs.15.42. Epub 2015 Jun 12. PMID: 26067485

Differentially expressed gene transcripts using RNA sequencing from the blood of immunosuppressed kidney allograft recipients.
Dorr C, Wu B, Guan W, Muthusamy A, Sanghavi K, Schladt DP, Maltzman JS, Scherer SE, Brott MJ, Matas AJ, Jacobson PA, Oetting WS, Israni AK.  PLoS One. 2015 May 6;10(5):e0125045. doi: 10.1371/journal.pone.0125045. eCollection 2015. PMID: 25946140

Germline & somatic mosaicism: the 2014 annual scientific meeting of the Human Genome Variation Society.
Oetting WS, Greenblatt MS, Brookes AJ, Karchin R, Mooney SD. Hum Mutat. 2015 Mar;36(3):390-3. doi: 10.1002/humu.22757. No abstract available. PMID: 25597405

Serguei Pakhomov

Serguei Pakhomov

Link to PubMed

Corpus Domain Effects on Distributional Semantic Modeling of Medical Terms 
Pakhomov, S., Finley, G., McEwan, R. Wang, Y. Melton, G. (2016) Bioinformatics, (in press).

Mining Biomedical Literature to Explore Interactions between Cancer Drugs and Dietary Supplements.
Zhang R, Adam TJ, Simon G, Cairelli MJ, Rindflesch T, Pakhomov S, Melton GB.
AMIA Jt Summits Transl Sci Proc. 2015 Mar 23;2015:69-73. eCollection 2015.
PMID: 26306241

Evaluation of Herbal and Dietary Supplement Resource Term Coverage.
Manohar N, Adam TJ, Pakhomov SV, Melton GB, Zhang R.
Stud Health Technol Inform. 2015;216:785-9.
PMID:26262159

Ease of adoption of clinical natural language processing software: An evaluation of five systems. Zheng K, Vydiswaran VG, Liu Y, Wang Y, Stubbs A, Uzuner O, Gururaj AE, Bayer S, Aberdeen J, Rumshisky A, Pakhomov S, Liu H, Xu H. J Biomed Inform. 2015 Jul 22. pii: S1532-0464(15)00148-3. doi: 10.1016/j.jbi.2015.07.008. [Epub ahead of print]
PMID:26210361

Zachary Rivers

Zachary Rivers

Link to Pubmed

 

David Stenehjem

David Stenehjem

Link to Pubmed

Neutrophil-lymphocyte ratio as a predictive biomarker for response to high dose interleukin-2 in patients with renal cell carcinoma.
Kuzman JA, Stenehjem DD, Merriman J, Agarwal AM, Patel SB, Hahn AW, Alex A, Albertson D, Gill DM, Agarwal N. BMC Urol. 2017 Jan 5;17(1):1. doi: 10.1186/s12894-016-0192-0.PMID: 28056941

BRCA testing, treatment patterns and survival in platinum-sensitive recurrent ovarian cancer - an observational cohort study.
Unni SK, Schauerhamer MB, Deka R, Tyczynski JE, Fernandes AW, Stevens V, Brixner DI, Stenehjem DDJ Ovarian Res. 2016 Mar 22;9:18. doi: 10.1186/s13048-016-0227-x. PMID:27004793

Cost-Utility of a Prognostic Test Guiding Adjuvant Chemotherapy Decisions in Early-Stage Non-Small Cell Lung Cancer.

Stenehjem DD, Bellows BK, Yager KM, Jones J, Kaldate R, Siebert U, Brixner DI. Oncologist. 2016 Feb;21(2):196-204. doi: 10.1634/theoncologist.2015-0162. Epub 2015 Nov 27. PMID: 26614710

Assessment of HER2 testing patterns, HER2+ disease, and the utilization of HER2-directed therapy in early breast cancer.
Stenehjem DD, Yoo M, Unni SK, Singhal M, Bauer H, Saverno K, Quah C, Masaquel A, Brixner DI. Breast Cancer (Dove Med Press). 2014 Oct 29;6:169-77. doi: 10.2147/BCTT.S69416. eCollection 2014. PMID: 25378949

Application of decision-analytic models in personalized medicine for CML treatment decisions made by payers, providers, and patients. Saverno KR, Rochau U, Stenehjem DD, Morley K, Siebert U, Brixner DI.J Manag Care Pharm. 2012 Jul-Aug;18(6):457-63. No abstract available. PMID: 22839687

 

Robert Straka

Robert Straka

Link to PubMed

Engaging Hmong adults in genomic and pharmacogenomic research: Toward reducing health disparities in genomic knowledge using a community-based participatory research approach.
Culhane-Pera KA, Straka RJ, Moua M, Roman Y, Vue P, Xiaaj K, Lo MX, Lor M. J Community Genet. 2017 Apr;8(2):117-125. doi: 10.1007/s12687-017-0292-x. Epub 2017 Jan 10. PMID:28074382

Leaves imitate trees: Minnesota Hmong concepts of heredity and applications to genomics research.
Culhane-Pera KA, Moua M, Vue P, Xiaaj K, Lo MX, Straka RJJ Community Genet. 2017 Jan;8(1):23-34. doi: 10.1007/s12687-016-0284-2. Epub 2016 Nov 7. PMID:27822876

A genome-wide study of lipid response to fenofibrate in Caucasians: a combined analysis of the GOLDN and ACCORD studies.
Irvin MR, Rotroff DM, Aslibekyan S, Zhi D, Hidalgo B, Motsinger-Reif A, Marvel S, Srinivasasainagendra V, Claas SA, Buse JB, Straka RJ, Ordovas JM, Borecki IB, Guo X, Chen IY, Rotter JI, Wagner MJ, Arnett DK. Pharmacogenet Genomics. 2016 Jul;26(7):324-33. doi: 10.1097/FPC.0000000000000219. PMID: 27002377

A family-specific linkage analysis of blood lipid response to fenofibrate in the Genetics of Lipid Lowering Drug and Diet Network.
Hidalgo B, Aslibekyan S, Wiener HW, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Ordovas JM, Arnett DK. Pharmacogenet Genomics. 2015 Oct;25(10):511-4. doi: 10.1097/FPC.0000000000000162.PMID: 26203732

A family-specific linkage analysis of blood lipid response to fenofibrate in the Genetics of Lipid Lowering Drug and Diet Network. Hidalgo B, Aslibekyan S, Wiener HW, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Ordovas JM, Arnett DK. Pharmacogenet Genomics. 2015 Oct;25(10):511-4. doi: 10.1097/FPC.0000000000000162. PMID: 26203732

Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FA, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JM; CHARGE Nutrition Study Group. Diabetes Care. 2015 Aug;38(8):1456-66. doi: 10.2337/dc14-2709. Epub 2015 Jun 17. PMID: 26084345

Natalia Tretyakova

Natalia Tretyakova

Link to PubMed

Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells.
Pang J, Shen N, Yan F, Zhao N, Dou L, Wu LC, Seiler CL, Yu L, Yang K, Bachanova V, Weaver E, Tretyakova NY, Liu S.Oncotarget. 2017 May 23;8(21):34453-34467. doi: 10.18632/oncotarget.16431. PMID: 28415607

Mass Spectrometry Based Proteomics Study of Cisplatin-Induced DNA-Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells. Ming X, Groehler A 4th, Michaelson-Richie ED, Villalta PW, Campbell C, Tretyakova NYChem Res Toxicol. 2017 Apr 17;30(4):980-995. doi: 10.1021/acs.chemrestox.6b00389. Epub 2017 Mar 29. PMID: 28282121

Mass Spectrometry-Based Tools to Characterize DNA-Protein Cross-Linking by Bis-Electrophiles.  Groehler A 4th, Degner A, Tretyakova NYBasic Clin Pharmacol Toxicol. 2016 Dec 29. doi: 10.1111/bcpt.12751. [Epub ahead of print] Review. PMID: 28032943

Mutagenicity of a Model DNA-Peptide Cross-Link in Human Cells: Roles of Translesion Synthesis DNA Polymerases.
Pande P, Ji S, Mukherjee S, Schärer OD, Tretyakova NY, Basu AK. Chem Res Toxicol. 2017 Feb 20;30(2):669-677. doi: 10.1021/acs.chemrestox.6b00397. Epub 2016 Dec 21. PMID: 27951635

Synthesis of DNA Oligodeoxynucleotides Containing Site-Specific 1,3-Butadiene-Deoxyadenosine Lesions. Wickramaratne S, Seiler CL, Tretyakova NY.Curr Protoc Nucleic Acid Chem. 2015 Jun 3;61:4.61.1-22. doi: 10.1002/0471142700.nc0461s61. PMID:26344227

 

Brian Van Ness

Brian Van Ness

Link to PubMed

Development of expression-based biomarkers of dasatinib response in hematologic malignancies.
Akre, M, Mitra, A.,  Wang, W, Myers, C, and Van Ness, B. (2017) Blood Cancer J.  In press.

A gene expression signature distinguishes innate response and resistance to proteasome inhibitors in multiple myeloma.
Mitra AK, Harding T, Mukherjee UK, Jang JS, Li Y, HongZheng R, Jen J, Sonneveld P, Kumar S, Kuehl WM, Rajkumar V, Van Ness BBlood Cancer J. 2017 Jun 30;7(6):e581. doi: 10.1038/bcj.2017.56. PMID: 28665416

A de novo splice site mutation in EHMT1 resulting in Kleefstra syndrome with pharmacogenomics screening and behavior therapy for regressive behaviors.
Mitra AK, Dodge J, Van Ness J, Sokeye I, Van Ness BMol Genet Genomic Med. 2016 Dec 26;5(2):130-140. doi: 10.1002/mgg3.265. eCollection 2017 Mar. PMID:28361099

Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide Polymorphisms Associated with Nonsyndromic Cleft Lip with or without Cleft Palate.
Mitra AK, Stessman HA, Schaefer RJ, Wang W, Myers CL, Van Ness BG, Beiraghi S. Front Genet. 2016 May 23;7:88. doi: 10.3389/fgene.2016.00088. eCollection 2016. PMID: 27242896

PIAS1 Promotes Lymphomagenesis through MYC Upregulation.
Rabellino A, Melegari M, Tompkins VS, Chen W, Van Ness BG, Teruya-Feldstein J, Conacci-Sorrell M, Janz S, Scaglioni PP. Cell Rep. 2016 Jun 7;15(10):2266-78. doi: 10.1016/j.celrep.2016.05.015. Epub 2016 May 26. PMID: 27239040

Single-cell analysis of targeted transcriptome predicts drug sensitivity of single cells within human myeloma tumors. 
Mitra AK, Mukherjee UK, Harding T, Jang JS, Stessman H, Li Y, Abyzov A, Jen J, Kumar S, Rajkumar V, Van Ness BLeukemia. 2016 May;30(5):1094-102. doi: 10.1038/leu.2015.361. Epub 2015 Dec 29. PMID: 26710886

Polymerase Bypass of N(6)-Deoxyadenosine Adducts Derived from Epoxide Metabolites of 1,3-Butadiene. Kotapati S, Wickramaratne S, Esades A, Boldry EJ, Quirk Dorr D, Pence MG, Guengerich FP, Tretyakova NY. Chem Res Toxicol. 2015 Jul 20;28(7):1496-507. doi: 10.1021/acs.chemrestox.5b00166. Epub 2015 Jul 6. PMID: 26098310

DNA-Protein Cross-Links: Formation, Structural Identities, and Biological Outcomes. Tretyakova NY, Groehler A 4th, Ji S. Acc Chem Res. 2015 Jun 16;48(6):1631-44. doi: 10.1021/acs.accounts.5b00056. Epub 2015 Jun 2. PMID:26032357

Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide. McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD. Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29. PMID:26025730

High throughput HPLC-ESI--MS/MS methodology for mercapturic acid metabolites of 1,3-butadiene: Biomarkers of exposure and bioactivation. Kotapati S, Esades A, Matter B, Le C, Tretyakova N. Chem Biol Interact. 2015 Feb 26. pii: S0009-2797(15)00071-X. doi: 10.1016/j.cbi.2015.02.009. [Epub ahead of print] PMID: 25727266

Single-cell analysis of targeted transcriptome (SCATTome) predicts drug sensitivity of single cells within human myeloma tumors.  
Mitra, A, Mukherjee, U, Jang, J, Harding, T, Stessman, H, Li, Y, Abyzov, A, Jen, J, Kumar, S, Rajkumar, V, Van Ness, B.  (2016)  Leukemia.  In press.

Risk of multiple myeloma in a case-spouse study.
Andrrotti, G, Katz, M, Hoering, A, Van Ness, B, Crowley, J, Morgan, G, Hoover RN, Baris D, Durie, B. (2015) Leuk Lymphoma DOI: 10.3109/10428194.2015.1094693

Returning a Research Participant's Genomic Results to Relatives: Perspectives from Managers of Two Distinct Research Biobanks.
Petersen GM, Ness BV. J Law Med Ethics. 2015 Sep;43(3):523-8. doi: 10.1111/jlme.12294. PMID: 26479561

Returning a Research Participant's Genomic Results to Relatives: Analysis and Recommendations.
Wolf SM, Branum R, Koenig BA, Petersen GM, Berry SA, Beskow LM, Daly MB, Fernandez CV, Green RC, LeRoy BS, Lindor NM, O'Rourke PP, Breitkopf CR, Rothstein MA, Van Ness B, Wilfond BS. J Law Med Ethics. 2015 Sep;43(3):440-63. doi: 10.1111/jlme.12288. PMID: 26479555

Applications and limitations in translating genomics to clinical practice.
Van Ness B. Transl Res. 2015 May 4. pii: S1931-5244(15)00138-3. doi: 10.1016/j.trsl.2015.04.012. [Epub ahead of print] Review. PMID:26001594