Pharmacogenomic Publications

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Angela Birnbaum, PhD

Angela Birnbaum, PhD

Link to PubMed

Pharmacokinetic-pharmacodynamic modeling of intravenous and oral topiramate and its effect on the symbol digit modalities test in adult healthy volunteers.
Lim CN, Birnbaum AK, Brundage RC, Leppik IE, Cloyd JC, Clark A, Marino SE. J Clin Pharmacol. 2015 Sep 23. doi: 10.1002/jcph.646. [Epub ahead of print] PMID: 26395889

Pharmacokinetic-pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers.
Ahmed GF, Marino SE, Brundage RC, Pakhomov SV, Leppik IE, Cloyd JC, Clark A, Birnbaum AK. Br J Clin Pharmacol. 2015 May;79(5):820-30. doi: 10.1111/bcp.12556. PMID: 25403343

Jeffrey Bishop

Jeffrey Bishop

Link to PubMed

Pharmacogenetics of Treating Pediatric Anxiety and Depression.
Ramsey LB, Bishop JR, Strawn JR. Pharmacogenomics. 2019 Aug;20(12):867-870. doi: 10.2217/pgs-2019-0088. PubMed PMID: 31453769.

Gene-Based Dose Optimization in Children.
Ramsey LB, Brown JT, Vear SI, Bishop JR, Van Driest SL. Annu Rev Pharmacol Toxicol. 2019 Jul 5. doi: 10.1146/annurev-pharmtox-010919-023459. [Epub ahead of print] PubMed PMID: 31283429.

Multi-Site Investigation of Strategies for the Clinical Implementation of CYP2D6 Genotyping to Guide Drug Prescribing.
Cavallari LH, Van Driest SL, Prows CA, Bishop JR, Limdi NA, Pratt VM, Ramsey LB, Smith DM, Tuteja S, Duong BQ, Hicks JK, Lee JC, Obeng AO, Beitelshees AL, Bell GC, Blake K, Crona DJ, Dressler L, Gregg RA, Hines LJ, Scott SA, Shelton RC, Weitzel KW, Johnson JA, Peterson JF, Empey PE, Skaar TC; IGNITE Network.Genet Med. 2019 Mar 21. doi: 10.1038/s41436-019-0484-3. [Epub ahead of print] PubMed PMID: 30894703.

A Systematic Review of Genome-wide Association Studies of Antipsychotic Response.
Allen JD, Bishop JR. Pharmacogenomics. 2019 Mar;20(4):291-306. doi: 10.2217/pgs-2018-0163. Epub 2019 Mar 18. PubMed PMID: 30883267; PubMed Central PMCID: PMC6563266.

Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Brown JT, Bishop JR, Sangkuhl K, Nurmi EL, Mueller DJ, Dinh JC, Gaedigk A, Klein TE, Caudle KE, McCracken JT, de Leon J, Leeder JS. Clin Pharmacol Ther. 2019 Jul;106(1):94-102. doi: 10.1002/cpt.1409. Epub 2019 Apr 13. Review. PubMed PMID: 30801677; PubMed Central PMCID: PMC6612570.

Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder.
Bishop JR, Lee AM, Mills LJ, Thuras PD, Eum S, Clancy D, Erbes CR, Polusny MA, Lamberty GJ, Lim KO.Front Psychiatry. 2018 Sep 18;9:418. doi: 10.3389/fpsyt.2018.00418. eCollection 2018. PubMed PMID: 30279666; PubMed Central PMCID: PMC6153325.

Beneficial and Adverse Effects of Antipsychotic Medication on Cognitive Flexibility are Related to COMT Genotype in First Episode Psychosis.
Nelson CLM, Amsbaugh HM, Reilly JL, Rosen C, Marvin RW, Ragozzino ME, Bishop JR, Sweeney JA, Hill SK. Schizophr Res. 2018 Dec;202:212-216. doi:10.1016/j.schres.2018.06.029. Epub 2018 Jun 23. PubMed PMID: 29941295.

Polygenic Risk for Schizophrenia and Measured Domains of Cognition in Individuals with Psychosis and Controls.
Shafee R, Nanda P, Padmanabhan JL, Tandon N, Alliey-Rodriguez N, Kalapurakkel S, Weiner DJ, Gur RE, Keefe RSE, Hill SK, Bishop JR, Clementz BA, Tamminga CA, Gershon ES, Pearlson GD, Keshavan MS, Sweeney JA, McCarroll SA, Robinson EB. Transl Psychiatry. 2018 Apr 12;8(1):78. doi:10.1038/s41398-018-0124-8. PubMed PMID: 29643358; PubMed Central PMCID: PMC5895806.

Pharmacogenetics.
Bishop JR. Handb Clin Neurol. 2018;147:59-73. doi:10.1016/B978-0-444-63233-3.00006-3. Review. PubMed PMID: 29325628.

Genome-wide Association Studies of Smooth Pursuit and Antisaccade Eye Movements in Psychotic Disorders: Findings from the B-SNIP Study.
Lencer R, Mills LJ, Alliey-Rodriguez N, Shafee R, Lee AM, Reilly JL, Sprenger A, McDowell JE, McCarroll SA, Keshavan MS, Pearlson GD, Tamminga CA, Clementz BA, Gershon ES, Sweeney JA, Bishop JR.  Transl Psychiatry. 2017 Oct 24;7(10):e1249. doi:10.1038/tp.2017.210. PubMed PMID: 29064472; PubMed Central PMCID: PMC5682604.

Genetic Analysis of Deep Phenotyping Projects in Common Disorders.
Gershon ES, Pearlson G, Keshavan MS, Tamminga C, Clementz B, Buckley PF, Alliey-Rodriguez N, Liu C, Sweeney JA, Keedy S, Meda SA, Tandon N, Shafee R, Bishop JR, Ivleva EI.  Schizophr Res. 2018 May;195:51-57. doi: 10.1016/j.schres.2017.09.031. Epub 2017 Oct 20. Review. PubMed PMID: 29056493; PubMed Central PMCID:PMC5910299.

Precision Pharmacotherapy Enables Precision Medicine.
Bishop JR, Ellingrod VL. Pharmacotherapy. 2017 Sep;37(9):985-987. doi: 10.1002/phar.1998. Epub 2017 Aug 23. PubMed PMID: 28836287.

Pharmacogenetic Evaluation to Assess Breakthrough Psychosis with Aripiprazole Long-Acting Injection: A Case Report.
Eum S, Schneiderhan ME, Brown JT, Lee AM, Bishop JR.BMC Psychiatry. 2017 Jul 3;17(1):238. doi: 10.1186/s12888-017-1396-x. PubMed PMID: 28673279; PubMed Central PMCID: PMC5496345.

Collaborative Counseling Considerations for Pharmacogenomic Tests.
Zierhut HA, Campbell CA, Mitchell AG, Lemke AA, Mills R, Bishop JR. Pharmacotherapy. 2017 Sep;37(9):990-999. doi: 10.1002/phar.1980. Epub 2017 Aug 7. Review. PubMed PMID: 28672074.

Serum Clomipramine and Desmethylclomipramine Levels in a CYP2C19 and CYP2D6 Intermediate Metabolizer.
Brown JT, Schneiderhan M, Eum S, Bishop JR. Pharmacogenomics. 2017 May;18(7):601-605. doi: 10.2217/pgs-2017-0015. Epub 2017 May 4. Review. PubMed PMID: 28470111.

Pharmacogenomics of Autism Spectrum Disorder.
Brown JT, Eum S, Cook EH, Bishop JR. Pharmacogenomics. 2017 Mar;18(4):403-414. doi: 10.2217/pgs-2016-0167. Epub 2017 Feb 22. Review. PubMed PMID: 28244813.

Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants: 2016 Update.
Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC.Clin Pharmacol Ther. 2017 Jul;102(1):37-44. doi: 10.1002/cpt.597. Epub 2017 Feb 13. No abstract available. PMID:27997040; PMCID: PMC5478479

Pharmacogenetic Tests for Antipsychotic Medications: Clinical Implications and Considerations.
Eum S, Lee AM, Bishop JR. Dialogues Clin Neurosci. 2016 Sep;18(3):323-337. Review. PMID:27757066

Antipsychotic Pharmacogenomics in First Episode Psychosis: A Role for Glutamate Genes.
Stevenson JM, Reilly JL, Harris MS, Patel SR, Weiden PJ, Prasad KM, Badner JA, Nimgaonkar VL, Keshavan MS, Sweeney JA, Bishop JR. Transl Psychiatry. 2016 Feb 23;6:e739. doi: 10.1038/tp.2016.10. PMID: 26905411

Catechol-O-Methyltransferase Val158Met Polymorphism and Clinical Response to Antipsychotic Treatment in Schizophrenia and Schizo-Affective Disorder Patients: a Meta-Analysis.
Huang E, Zai CC, Lisoway A, Maciukiewicz M, Felsky D, Tiwari AK, Bishop JR, Ikeda M, Molero P, Ortuno F, Porcelli S, Samochowiec J, Mierzejewski P, Gao S, Crespo-Facorro B, Pelayo-Terán JM, Kaur H, Kukreti R, Meltzer HY, Lieberman JA, Potkin SG, Müller DJ, Kennedy JL.  Int J Neuropsychopharmacol. 2016 Apr 29;19(5). pii: pyv132. doi: 10.1093/ijnp/pyv132.  Print 2016 May. PubMed PMID: 26745992; PubMed Central PMCID: PMC4886669.

Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes. 
Stevenson JM, Reilly JL, Harris MS, Patel SR, Weiden PJ, Prasad KM, Badner JA, Nimgaonkar VL, Keshavan MS, Sweeney JA, Bishop JR.  Transl Psychiatry. 2016  Feb 23;6:e739. doi: 10.1038/tp.2016.10. PubMed PMID: 26905411; PubMed Central PMCID: PMC4872428.

Clinical Pharmacogenetics Implementation Consortium. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors. 
Hicks JK, Bishop JR, Sangkuhl K, Müller DJ, Ji Y, Leckband SG, Leeder JS, Graham RL, Chiulli DL, LLerena A, Skaar TC, Scott SA, Stingl JC, Klein TE, Caudle KE, Gaedigk A;  Clin Pharmacol Ther. 2015 Aug;98(2):127-34. doi: 10.1002/cpt.147. Epub 2015 Jun 29.  Review. PubMed PMID: 25974703; PubMed Central PMCID: PMC4512908.

Escitalopram pharmacogenetics: CYP2C19 relationships with dosing and clinical outcomes in autism spectrum disorder.
Bishop JR, Najjar F, Rubin LH, Guter SJ, Owley T, Mosconi MW, Jacob S, Cook EH. Pharmacogenet Genomics. 2015 Nov;25(11):548-54. doi: 10.1097/FPC.0000000000000173. PMID: 26313485

Pharmacogenetic Study of Serotonin Transporter and 5HT2A Genotypes in Autism.
Najjar F, Owley T, Mosconi MW, Jacob S, Hur K, Guter SJ, Sweeney JA, Gibbons RD, Cook EH, Bishop JR. J Child Adolesc Psychopharmacol. 2015 Aug;25(6):467-74. doi: 10.1089/cap.2014.0158. PMID: 26262902

SNP genotyping using TaqMan technology: the CYP2D6*17 assay conundrum.
Gaedigk A, Freeman N, Hartshorne T, Riffel AK, Irwin D, Bishop JR, Stein MA, Newcorn JH, Jaime LK, Cherner M, Leeder JS. Sci Rep. 2015 Mar 19;5:9257. doi: 10.1038/srep09257.
PMID: 25788121

Genetic predictor of working memory and prefrontal function in women with HIV.
Sundermann EE, Bishop JR, Rubin LH, Little DM, Meyer VJ, Martin E, Weber K, Cohen M, Maki PM. J Neurovirol. 2015 Feb;21(1):81-91. doi: 10.1007/s13365-014-0305-z. Epub 2014 Dec 17. PMID: 25515329

Jacob Brown

Jacob Brown

Link to PubMed

Gene-Based Dose Optimization in Children.
Ramsey LB, Brown JT, Vear SI, Bishop JR, Van Driest SL. Annu Rev Pharmacol Toxicol. 2019 Jul 5. doi: 10.1146/annurev-pharmtox-010919-023459. [Epub ahead of print] PubMed PMID: 31283429.

PharmGKB Summary: Methylphenidate Pathway, Pharmacokinetics/Pharmacodynamics.
Stevens T, Sangkuhl K, Brown JT, Altman RB, Klein TE. Pharmacogenet Genomics. 2019 Aug;29(6):136-154. doi: 10.1097/FPC.0000000000000376. PubMed PMID: 30950912; PubMed Central PMCID: PMC6581573.

Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Brown JT, Bishop JR, Sangkuhl K, Nurmi EL, Mueller DJ, Dinh JC, Gaedigk A, Klein TE, Caudle KE, McCracken JT, de Leon J, Leeder JS. Clin Pharmacol Ther. 2019 Jul;106(1):94-102. doi: 10.1002/cpt.1409. Epub 2019 Apr 13. Review. PubMed PMID: 30801677; PubMed Central PMCID: PMC6612570.

The Role of the Pediatric Pharmacist in Precision Medicine and Clinical Pharmacogenomics for Children.
Brown JT, Gregornik D, Kennedy MJ; Advocacy and Research Committees. J Pediatr Pharmacol Ther. 2018 Nov-Dec;23(6):499-501. doi: 10.5863/1551-6776-23.6.499. PubMed PMID: 30697138; PubMed Central PMCID: PMC6336182.

Pharmacogenetic Evaluation to Assess Breakthrough Psychosis with Aripiprazole Long-Acting Injection: A Case Report.
Eum S, Schneiderhan ME, Brown JT, Lee AM, Bishop JR. BMC Psychiatry. 2017 Jul 3;17(1):238. doi: 10.1186/s12888-017-1396-x. PubMed PMID: 28673279; PubMed Central PMCID: PMC5496345.

Serum Clomipramine and Desmethylclomipramine Levels in a CYP2C19 and CYP2D6 Intermediate Metabolizer.
Brown JT, Schneiderhan M, Eum S, Bishop JR. Pharmacogenomics. 2017 May;18(7):601-605. doi: 10.2217/pgs-2017-0015. Epub 2017 May 4. Review. PubMed PMID: 28470111.

Pharmacogenomics of Autism Spectrum Disorder.
Brown JT, Eum S, Cook EH, Bishop JR.Pharmacogenomics. 2017 Mar;18(4):403-414. doi: 10.2217/pgs-2016-0167. Epub 2017 Feb 22. Review. PubMed PMID: 28244813.

Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA.
Kemp PJ, Rushton DJ, Yarova PL, Schnell C, Geater C, Hancock JM, Wieland A, Hughes A, Badder L, Cope E, Riccardi D, Randall AD, Brown JT, Allen ND, Telezhkin V.  J Physiol. 2016 Nov 15;594(22):6583-6594. doi: 10.1113/JP270655.

Single dose, CYP2D6 genotype-stratified pharmacokinetic study of atomoxetine in children with ADHD.
Brown JT, Abdel-Rahman SM, van Haandel L, Gaedigk A, Lin YS, Leeder JS. Clin Pharmacol Ther. 2016 Jun;99(6):642-50. doi: 10.1002/cpt.319. Epub 2016 Jan 12.PMID: 26660002

David Gregornik

David Gregornik

Link to PubMed

The Role of the Pediatric Pharmacist in Precision Medicine and Clinical Pharmacogenomics for Children.
Brown JT, Gregornik D, Kennedy MJ; Advocacy and Research Committees. J Pediatr Pharmacol Ther. 2018 Nov-Dec;23(6):499-501. doi: 10.5863/1551-6776-23.6.499. PubMed PMID: 30697138; PubMed Central PMCID: PMC6336182.

R. Stephanie Huang

R. Stephanie Huang

Link to PubMed

Using Differential Threshold Effects of Individual and Combined Periconceptional Methyl Donor Status on Maternal Genomic LINE-1 and Imprinted H19 DNA Methylation to Predict Birth Weight Variance in the Taiwan Pregnancy-Newborn Epigenetics (TPNE) Cohort Study. 
Huang KT, Shen YL, Lee CN, Chu KY, Ku WC, Liu CY, Huang RS. J Nutr. 2019 Sep 10. pii: nxz204. doi: 10.1093/jn/nxz204. [Epub ahead of print] PubMed PMID: 31504733.

Long Non-Coding RNA Transcriptome of Uncharacterized Samples Can Be Accurately Imputed Using Protein-Coding Genes.
Nath A, Geeleher P, Huang RS.Brief Bioinform. 2019 Jan 17. doi: 10.1093/bib/bby129. [Epub ahead of print] PubMed PMID: 30657858.

Pharmacogenomics of MedicationsCommonly Used in the Intensive Care Unit.
Zhou S, Skaar DJ, Jacobson PA, Huang RS. Front Pharmacol. 2018 Dec 4;9:1436. doi: 10.3389/fphar.2018.01436. eCollection 2018. Review. PubMed PMID: 30564130; PubMed Central PMCID: PMC6289166.

More Than Fishing for a Cure: The Promises and Pitfalls of High Throughput Cancer Cell Line Screens.
Ling A, Gruener RF, Fessler J, Huang RS. Pharmacol Ther. 2018 Nov;191:178-189. doi: 10.1016/j.pharmthera.2018.06.014. Epub 2018 Jun 25. Review. PubMed PMID: 29953899.

Cancer-Testis Antigen GAGE-1 Expression and Serum Immunoreactivity in Hepatocellular Carcinoma.
Chao NX, Li LZ, Luo GR, Zhong WG, Huang RS, Fan R, Zhao FL. Niger J Clin Pract. 2018 Oct;21(10):1361-1367. doi: 10.4103/njcp.njcp_73_18. PubMed PMID: 30297572.

MicroRNA-485-5p Suppresses Growth and Metastasis in Non-Small Cell Lung Cancer Cells by Targeting IGF2BP2.
Huang RS, Zheng YL, Li C, Ding C, Xu C, Zhao J. Life Sci. 2018 Apr 15;199:104-111. doi: 10.1016/j.lfs.2018.03.005. Epub 2018 Mar 3. PubMed PMID: 29510198.

MicroRNA-381 Suppresses the Growth and Increases Cisplatin Sensitivity in Non-Small Cell Lung Cancer Cells Through Inhibition of Nuclear Factor-κB Signaling.
Huang RS, Zheng YL, Zhao J, Chun X. Biomed Pharmacother. 2018 Feb;98:538-544. doi: 10.1016/j.biopha.2017.12.092. Epub 2017 Dec 27. PubMed PMID: 29287202.

Low Folate Metabolic Stress Reprograms DNA Methylation-Activated Sonic Hedgehog Signaling to Mediate Cancer Stem Cell-Like Signatures and Invasive Tumour Stage-Specific Malignancy of Human Colorectal Cancers.
Feng HC, Lin JY, Hsu SH, Lan WY, Kuo CS, Tian YF, Sun DP, Huang RS. Int J Cancer. 2017 Dec 15;141(12):2537-2550. doi: 10.1002/ijc.31008. Epub 2017 Sep 23. PubMed PMID: 28833104.

Discovering Drugs to Overcome Chemoresistance in Ovarian Cancers Based on the Cancer Genome Atlas Tumor Transcriptome Profile.
Oncotarget. Wang F, Chang JT, Zhang Z, Morrison G, Nath A, Bhutra S, Huang RS. 2017 Dec 4;8(70):115102-115113. doi: 10.18632/oncotarget.22870. eCollection 2017 Dec 29. PubMed PMID: 29383145; PubMed Central PMCID: PMC5777757.

Discovering Novel Pharmacogenomic Biomarkers by Imputing Drug Response in Cancer Patients from Large Genomics Studies.
Geeleher P, Zhang Z, Wang F, Gruener RF, Nath A, Morrison G, Bhutra S, Grossman RL, Huang RS. Genome Res. 2017 Oct;27(10):1743-1751. doi: 10.1101/gr.221077.117. Epub 2017 Aug 28. PubMed PMID: 28847918; PubMed Central PMCID: PMC5630037.

Exploring the Link between the Germline and Somatic Genome in Cancer.
Geeleher P, Huang RS. Cancer Discov. 2017 Apr;7(4):354-355. doi: 10.1158/2159-8290.CD-17-0192. PubMed PMID: 28373166; PubMed Central PMCID: PMC5404740.

The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment.
Rudin S, Marable M, Huang RS. Genomics Proteomics Bioinformatics. 2017 Apr;15(2):82-93. doi: 10.1016/j.gpb.2016.11.003. Epub 2017 Apr 6. Review. PubMed PMID: 28391009; PubMed Central PMCID: PMC5414888.

Institutional Profile: Pharmacogenomic research in R Stephanie Huang Laboratory.
Geeleher P, Nath A, Huang RS. Pharmacogenomics. 2017 Apr;18(6):519-522. doi: 10.2217/pgs-2017-0031. Epub 2017 Mar 14. PubMed PMID: 28290771.

Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas.
Chang JT, Wang F, Chapin W, Huang RS. PLoS One. 2016 Dec13;11(12):e0168284. doi: 10.1371/journal.pone.0168284. eCollection 2016. PubMed PMID: 27959953; PubMed Central PMCID: PMC5154569.

Consistency in Large Pharmacogenomic Studies.
Geeleher P, Gamazon ER, Seoighe C, Cox NJ, Huang RS. Nature. 2016 Nov 30;540(7631):E1-E2. doi: 10.1038/nature19838. PubMed PMID: 27905415; PubMed Central PMCID: PMC6290674.

Cancer Biomarker Discovery is Improved by Accounting for Variability in General Levels of Drug Sensitivity in Pre-Clinical Models.
Geeleher P, Cox NJ, Huang RS. Genome Biol. 2016 Sep 21;17(1):190. PubMed PMID: 27654937; PubMed Central PMCID: PMC5031330.

Utility of Patient-Derived Lymphoblastoid Cell Lines as an Ex Vivo Capecitabine Sensitivity Prediction Model for Breast Cancer Patients.
Morrison G, Lenkala D, LaCroix B, Ziliak D, Abramson V, Morrow PK, Forero A, Van Poznak C, Rugo HS, Nanda R, O'Donnell PH, Huang RS. Oncotarget. 2016 Jun 21;7(25):38359-38366. doi: 10.18632/oncotarget.9521. PubMed PMID: 27224917; PubMed Central PMCID: PMC5122395.

High Expression of miR-532-5p, a Tumor Suppressor, Leads to Better Prognosis in Ovarian Cancer Both In Vivo and In Vitro.
Wang F, Chang JT, Kao CJ, Huang RS. Mol Cancer Ther. 2016 May;15(5):1123-31. doi: 10.1158/1535-7163.MCT-15-0943. Epub 2016 Feb 12. PubMed PMID: 26873729; PubMed Central PMCID: PMC4873383.

The Impact of the Cancer Genome Atlas on Lung Cancer. Chang JT, Lee YM, Huang RS. Transl Res. 2015 Dec;166(6):568-85. doi: 10.1016/j.trsl.2015.08.001. Epub 2015 Aug 10. Review. PubMed PMID: 26318634; PubMed Central PMCID: PMC4656061.

Predicting Response to Histone Deacetylase Inhibitors Using High-Throughput Genomics.
Geeleher P, Loboda A, Lenkala D, Wang F, LaCroix B, Karovic S, Wang J, Nebozhyn M, Chisamore M, Hardwick J, Maitland ML, Huang RS. J Natl Cancer Inst. 2015 Aug 21;107(11). pii: djv247. doi: 10.1093/jnci/djv247. Print 2015 Nov. PubMed PMID: 26296641; PubMed Central PMCID: PMC4643634.

Pharmacogenomics of EGFR-Targeted Therapies in Non-Small Cell Lung Cancer: EGFR and Beyond.
Delaney C, Frank S, Huang RS. Chin J Cancer. 2015 Apr 8;34(4):149-60. doi: 10.1186/s40880-015-0007-9. Review. PubMed PMID: 25962919; PubMed Central PMCID: PMC4593375.

Carcinosarcoma of the Parotid: Investigating Its Biology with Morphoproteomics.
Vélez-Pérez A, Huang RS, Everett JM, Guo S, Buryanek J, Karni RJ, Brown RE. Int J Surg Pathol. 2015 Apr;23(2):116-21. doi: 10.1177/1066896914562278. Epub 2014 Dec 16. PubMed PMID: 25515562.

Peripheral Blood IRF1 Expression as a Marker for Glucocorticoid Sensitivity.
Chapin WJ, Lenkala D, Mai Y, Mao Y, White SR, Huang RS. Pharmacogenet Genomics. 2015 Mar;25(3):126-33. doi: 10.1097/FPC.0000000000000116. PubMed PMID: 25564375; PubMed Central PMCID: PMC4315702.

Identifying and Validating a Combined mRNA and microRNA Signature in Response to Imatinib Treatment in a Chronic Myeloid Leukemia Cell Line.
Bhutra S, Lenkala D, LaCroix B, Ye M, Huang RS. PLoS One. 2014 Dec 15;9(12):e115003. doi: 10.1371/journal.pone.0115003. eCollection 2014. PubMed PMID: 25506832; PubMed Central PMCID: PMC4266614.

Isolated Mesenteric CD20-Positive Myeloid Sarcoma.
Ohanian M, Huang RS, Yakoushina TV, Estrov Z, Juneja H, Chen L, Idowu M, Abruzzo LV. Clin Lymphoma Myeloma Leuk. 2014 Dec;14(6):e217-20. doi: 10.1016/j.clml.2014.06.027. Epub 2014 Jun 26. PubMed PMID: 25131853; PubMed Central PMCID: PMC4257057.

Pharmacogenomics of Cisplatin Sensitivity in Non-Small Cell Lung Cancer.
Rose MC, Kostyanovskaya E, Huang RS. Genomics Proteomics Bioinformatics. 2014 Oct;12(5):198-209. doi: 10.1016/j.gpb.2014.10.003. Epub 2014 Oct 28. Review. PubMed PMID: 25449594; PubMed Central PMCID: PMC4411417.

pRRophetic: an R Package for Prediction of Clinical Chemotherapeutic Response from Tumor Gene Expression Levels.
Geeleher P, Cox N, Huang RS. PLoS One. 2014 Sep 17;9(9):e107468. doi: 10.1371/journal.pone.0107468. eCollection 2014. PubMed PMID: 25229481; PubMed Central PMCID: PMC4167990.

Genome-Wide Interrogation of Longitudinal FEV1 in Children with Asthma.
Wu K, Gamazon ER, Im HK, Geeleher P, White SR, Solway J, Clemmer GL, Weiss ST, Tantisira KG, Cox NJ, Ratain MJ, Huang RS.Am J Respir Crit Care Med. 2014 Sep 15;190(6):619-27. doi: 10.1164/rccm.201403-0460OC. PubMed PMID: 25221879; PubMed Central PMCID: PMC4214107.

Ajay Israni

Ajay Israni

Link to PubMed

Tacrolimus Troughs and Genetic Determinants of Metabolism in Kidney Transplant Recipients: A Comparison of Four Ancestry Groups.
Mohamed ME, Schladt DP, Guan W, Wu B, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Oetting WS, Jacobson PA; DeKAF Genomics and GEN03 Investigators.Am J Transplant. 2019 Apr 6. doi: 10.1111/ajt.15385. [Epub ahead of print] PubMed PMID: 30953600.

The Impact of Donor and Recipient Common Clinical and Genetic Variation on Estimated Glomerular Filtration Rate in a European Renal Transplant Population.
Stapleton CP, Heinzel A, Guan W, van der Most PJ, van Setten J, Lord GM, Keating BJ, Israni AK, de Borst MH, Bakker SJL, Snieder H, Weale ME, Delaney F, Hernandez-Fuentes MP, Reindl-Schwaighofer R, Oberbauer R, Jacobson PA, Mark PB, Chapman FA, Phelan PJ, Kennedy C, Sexton D, Murray S, Jardine A, Traynor JP, McKnight AJ, Maxwell AP, Smyth LJ, Oetting WS, Matas AJ, Mannon RB, Schladt DP, Iklé DN, Cavalleri GL, Conlon PJ; UK Ireland Renal Transplant Consortium; DeKAF Genomics and GEN03 Studies; International Genetics and Translational Research in Transplantation Network.Am J Transplant. 2019 Aug;19(8):2262-2273. doi: 10.1111/ajt.15326. Epub 2019 Mar 28. PubMed PMID: 30920136.

Genetic Variants Associated With Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome-wide Association Studies.
Oetting WS, Wu B, Schladt DP, Guan W, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN-03 Investigators. Transplantation. 2019 Jun;103(6):1131-1139. doi: 10.1097/TP.0000000000002625. PubMed PMID: 30801552; PubMed Central PMCID:
PMC6597284.

Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A.
Oetting WS, Schladt DP, Dorr CR, Wu B, Guan W, Remmel RP, Iklé D, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN03 Investigators. Transplantation. 2019 Aug;103(8):1591-1602. doi: 10.1097/TP.0000000000002659. PubMed PMID: 30801535.

Identification of Genetic Variants Associated with Tacrolimus Metabolism in Kidney Transplant Recipients by Extreme Phenotype Sampling and Next Generation Sequencing.
Dorr CR, Wu B, Remmel RP, Muthusamy A, Schladt DP, Abrahante JE, Guan W, Mannon RB, Matas AJ, Oetting WS, Jacobson PA, Israni AK; for DeKAF Genomics. Pharmacogenomics J. 2019 Aug;19(4):375-389. doi: 10.1038/s41397-018-0063-z. Epub 2018 Nov 16. PubMed PMID: 30442921; PubMed Central PMCID: PMC6522337.

Urinary Microbiome Associated with Chronic Allograft Dysfunction in Kidney Transplant Recipients.
Wu JF, Muthusamy A, Al-Ghalith GA, Knights D, Guo B, Wu B, Remmel RP, Schladt DP, Alegre ML, Oetting WS, Jacobson PA, Israni AK. Clin Transplant. 2018 Dec;32(12):e13436. doi: 10.1111/ctr.13436. Epub 2018 Nov 18. PubMed PMID: 30372560.

Tacrolimus Trough and Dose Intra-Patient variability and CYP3A5 Genotype: Effects on Acute Rejection and Graft Failure in European American and African American Kidney Transplant Recipients.
Seibert SR, Schladt DP, Wu B, Guan W, Dorr C, Remmel RP, Matas AJ, Mannon RB, Israni AK, Oetting WS, Jacobson PA. Clin Transplant. 2018 Dec;32(12):e13424. doi: 10.1111/ctr.13424. Epub 2018 Oct 31. PubMed PMID: 30318646; PubMed Central PMCID: PMC6317347.

NPHP1 (Nephrocystin-1) Gene Deletions Cause Adult-Onset ESRD.
Snoek R, van Setten J, Keating BJ, Israni AK, Jacobson PA, Oetting WS, Matas AJ, Mannon RB, Zhang Z, Zhang W, Hao K, Murphy B, Reindl-Schwaighofer R, Heinzl A, Oberbauer R, Viklicky O, Conlon PJ, Stapleton CP, Bakker SJL, Snieder H, Peters EDJ, van der Zwaag B, Knoers NVAM, de Borst MH, van Eerde AM.J Am Soc Nephrol. 2018 Jun;29(6):1772-1779. doi: 10.1681/ASN.2017111200. Epub 2018 Apr 13. PubMed PMID: 29654215; PubMed Central PMCID: PMC6054334.

Attempted Validation of 44 Reported SNPs Associated with Tacrolimus Troughs in a Cohort of Kidney Allograft Recipients.
Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Dorr C, Mannon RB, Matas AJ, Israni AK, Jacobson PA. Pharmacogenomics. 2018 Feb;19(3):175-184. doi: 10.2217/pgs-2017-0187. Epub 2018 Jan 10. PubMed PMID: 29318894; PubMed Central PMCID: PMC6021962.

Genome-Wide Association Study Identifies the Common Variants in CYP3A4 and CYP3A5 Responsible for Variation in Tacrolimus Trough Concentration in Caucasian Kidney Transplant Recipients.
Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Mannon RB, Matas AJ, Israni AK, Jacobson PA. Pharmacogenomics J. 2018 May 22;18(3):501-505. doi: 10.1038/tpj.2017.49. Epub 2017 Nov 21. PubMed PMID: 29160300.

Concepts of Genomics in Kidney Transplantation.
Oetting WS, Dorr C, Remmel RP, Matas AJ, Israni AK, Jacobson PA. Curr Transplant Rep. 2017 Jun;4(2):116-123. doi: 10.1007/s40472-017-0153-x. Epub 2017 May 24. PubMed PMID: 29123971; PubMed Central PMCID: PMC5673265.

Genetics of Acute Rejection after Kidney Transplantation.
Dorr CR, Oetting WS, Jacobson PA, Israni AK. Transpl Int. 2018 Mar;31(3):263-277. doi: 10.1111/tri.13084. Epub 2017 Nov 8. Review. PubMed PMID: 29030886; PubMed Central PMCID: PMC6260834.

CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism.
Dorr CR, Remmel RP, Muthusamy A, Fisher J, Moriarity BS, Yasuda K, Wu B, Guan  W, Schuetz EG, Oetting WS, Jacobson PA, Israni AK. Drug Metab Dispos. 2017 Aug;45(8):957-965. doi: 10.1124/dmd.117.076307. Epub 2017 May 22. PubMed PMID: 28533324; PubMed Central PMCID: PMC5518718.

Effect of Replacing Race With Apolipoprotein L1 Genotype in Calculation of Kidney Donor Risk Index.
Julian BA, Gaston RS, Brown WM, Reeves-Daniel AM, Israni AK, Schladt DP, Pastan SO, Mohan S, Freedman BI, Divers J. Am J Transplant. 2017 Jun;17(6):1540-1548. doi: 10.1111/ajt.14113. Epub 2017 Jan 3.

Validation Is Critical for Genome-Wide Association Study-Based Associations.
Oetting WS, Jacobson PA, Israni AKAm J Transplant. 2017 Feb;17(2):318-319. doi: 10.1111/ajt.14051. Epub 2016 Oct 12. No abstract available. PMID: 27640398

Deceased-Donor Apolipoprotein L1 Renal-Risk Variants Have Minimal Effects on Liver Transplant Outcomes.
Dorr CR, Freedman BI, Hicks PJ, Brown WM, Russell GB, Julian BA, Pastan SO, Gautreaux MD, Muthusamy A, Chinnakotla S, Hauptfeld V, Bray RA, Kirk AD, Divers J, Israni AKPLoS One. 2016 Apr 7;11(4):e0152775. doi: 10.1371/journal.pone.0152775. eCollection 2016. PMID: 27054572

Genotype-guided tacrolimus dosing in African-American kidney transplant recipients.
Sanghavi K, Brundage RC, Miller MB, Schladt DP, Israni AK, Guan W, Oetting WS, Mannon RB, Remmel RP, Matas AJ, Jacobson PA. Pharmacogenomics J. 2017 Jan;17(1):61-68. doi: 10.1038/tpj.2015.87. Epub 2015 Dec 15 .PMID:26667830

APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors.
Freedman BI, Pastan SO, Israni AK, Schladt D, Julian BA, Gautreaux MD, Hauptfeld V, Bray RA, Gebel HM, Kirk AD, Gaston RS, Rogers J, Farney AC, Orlando G, Stratta RJ, Mohan S, Ma L, Langefeld CD, Bowden DW, Hicks PJ, Palmer ND, Palanisamy A, Reeves-Daniel AM, Brown WM, Divers J. Transplantation. 2016 Jan;100(1):194-202. doi: 10.1097/TP.0000000000000969. PMID:26566060

Pamala Jacobson

Pamala Jacobson

Link to PubMed

Tacrolimus Troughs and Genetic Determinants of  Metabolism in Kidney Transplant Recipients: A Comparison of Four Ancestry Groups.
Mohamed ME, Schladt DP, Guan W, Wu B, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Oetting WS, Jacobson PA; DeKAF Genomics and GEN03 Investigators.Am J Transplant. 2019 Apr 6. doi: 10.1111/ajt.15385. [Epub ahead of print] PubMed PMID: 30953600.

The Impact of Donor and Recipient Common Clinical and Genetic Variation on Estimated Glomerular Filtration Rate in a European Renal Transplant Population.
Stapleton CP, Heinzel A, Guan W, van der Most PJ, van Setten J, Lord GM, Keating BJ, Israni AK, de Borst MH, Bakker SJL, Snieder H, Weale ME, Delaney F, Hernandez-Fuentes MP, Reindl-Schwaighofer R, Oberbauer R, Jacobson PA, Mark PB, Chapman FA, Phelan PJ, Kennedy C, Sexton D, Murray S, Jardine A, Traynor JP, McKnight AJ, Maxwell AP, Smyth LJ, Oetting WS, Matas AJ, Mannon RB, Schladt DP, Iklé DN, Cavalleri GL, Conlon PJ; UK Ireland Renal Transplant Consortium; DeKAF Genomics and GEN03 Studies; International Genetics and Translational Research in
Transplantation Network. Am J Transplant. 2019 Aug;19(8):2262-2273. doi: 10.1111/ajt.15326. Epub 2019 Mar 28. PubMed PMID: 30920136.

Genetic Variants Associated With Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome-wide Association Studies.
Oetting WS, Wu B, Schladt DP, Guan W, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN-03 Investigators. Transplantation. 2019 Jun;103(6):1131-1139. doi: 10.1097/TP.0000000000002625. PubMed PMID: 30801552; PubMed Central PMCID: PMC6597284.

Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A.
Oetting WS, Schladt DP, Dorr CR, Wu B, Guan W, Remmel RP, Iklé D, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN03 Investigators. Transplantation. 2019 Aug;103(8):1591-1602. doi: 10.1097/TP.0000000000002659. PubMed PMID: 30801535.

Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit.
Zhou S, Skaar DJ, Jacobson PA, Huang RS. Front Pharmacol. 2018 Dec 4;9:1436. doi: 10.3389/fphar.2018.01436. eCollection 2018. Review. PubMed PMID: 30564130; PubMed Central PMCID: PMC6289166.

Identification of Genetic Variants Associated with Tacrolimus Metabolism in Kidney Transplant Recipients by Extreme Phenotype Sampling and Next Generation Sequencing.
Dorr CR, Wu B, Remmel RP, Muthusamy A, Schladt DP, Abrahante JE, Guan W, Mannon RB, Matas AJ, Oetting WS, Jacobson PA, Israni AK; for DeKAF Genomics.Pharmacogenomics J. 2019 Aug;19(4):375-389. doi:10.1038/s41397-018-0063-z. Epub 2018 Nov 16. PubMed PMID: 30442921; PubMed Central PMCID: PMC6522337.

Urinary Microbiome Associated with Chronic Allograft Dysfunction in Kidney Transplant Recipients.
Wu JF, Muthusamy A, Al-Ghalith GA, Knights D, Guo B, Wu B, Remmel RP, Schladt DP, Alegre ML, Oetting WS, Jacobson PA, Israni AK. Clin Transplant. 2018 Dec;32(12):e13436. doi: 10.1111/ctr.13436. Epub 2018 Nov 18. PubMed PMID: 30372560.

Tacrolimus Trough and Dose Intra-Patient variability and CYP3A5 Genotype: Effects on Acute Rejection and Graft Failure in European American and African American Kidney Transplant Recipients.
Seibert SR, Schladt DP, Wu B, Guan W, Dorr C, Remmel RP, Matas AJ, Mannon RB, Israni AK, Oetting WS, Jacobson PA. Clin Transplant. 2018 Dec;32(12):e13424. doi: 10.1111/ctr.13424. Epub 2018 Oct 31. PubMed PMID: 30318646; PubMed Central PMCID: PMC6317347.

Tacrolimus Elimination in Four Patients With a CYP3A5*3/*3 CYP3A4*22/*22 Genotype Combination.
Scheibner A, Remmel R, Schladt D, Oetting WS, Guan W, Wu B, Dorr C, Israni A, Jacobson PA.
Pharmacotherapy. 2018 May 26. doi: 10.1002/phar.2131. [Epub ahead of print]
PMID:29804290

Genome-wide association study identifies the common variants in CYP3A4 and CYP3A5 responsible for variation in tacrolimus trough concentration in Caucasian kidney transplant recipients.
Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Mannon RB, Matas AJ, Israni AK, Jacobson PA.
Pharmacogenomics J. 2018 May 22;18(3):501-505. doi: 10.1038/tpj.2017.49. Epub 2017 Nov 21.
PMID:29160300

NPHP1 (Nephrocystin-1) Gene Deletions Cause Adult-Onset ESRD.
Snoek R, van Setten J, Keating BJ, Israni AK, Jacobson PA, Oetting WS, Matas AJ, Mannon RB, Zhang Z, Zhang W, Hao K, Murphy B, Reindl-Schwaighofer R, Heinzl A, Oberbauer R, Viklicky O, Conlon PJ, Stapleton CP, Bakker SJL, Snieder H, Peters EDJ, van der Zwaag B, Knoers NVAM, de Borst MH, van Eerde AM.
J Am Soc Nephrol. 2018 Jun;29(6):1772-1779. doi: 10.1681/ASN.2017111200. Epub 2018 Apr 13.
PMID:29654215

Mycophenolic Acid and Its Metabolites in Kidney Transplant Recipients: A Semimechanistic Enterohepatic Circulation Model to Improve Estimating Exposure.
Okour M, Jacobson PA, Ahmed MA, Israni AK, Brundage RC.
J Clin Pharmacol. 2018 May;58(5):628-639. doi: 10.1002/jcph.1064. Epub 2018 Jan 12.
PMID:29329489

Genetics of acute rejection after kidney transplantation.
Dorr CR, Oetting WS, Jacobson PA, Israni AK.
Transpl Int. 2018 Mar;31(3):263-277. doi: 10.1111/tri.13084. Epub 2017 Nov 8. Review.
PMID:29030886

Concepts of Genomics in Kidney Transplantation.
Oetting WS, Dorr C, Remmel RP, Matas AJ, Israni AK, Jacobson PA.
Curr Transplant Rep. 2017 Jun;4(2):116-123. doi: 10.1007/s40472-017-0153-x. Epub 2017 May 24

Influence of Kidney Transplant Status on Warfarin Dose, Anticoagulation Control, and Risk of Hemorrhage.
Yanik MV, Irvin MR, Beasley TM, Jacobson PA, Julian BA, Limdi NA.
Pharmacotherapy. 2017 Nov;37(11):1366-1373. doi: 10.1002/phar.2032. Epub 2017 Nov 2.
PMID:28949423

CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism.
Dorr CR, Remmel RP, Muthusamy A, Fisher J, Moriarity BS, Yasuda K, Wu B, Guan W, Schuetz EG, Oetting WS, Jacobson PA, Israni AK. Drug Metab Dispos. 2017 Aug;45(8):957-965. doi: 10.1124/dmd.117.076307. Epub 2017 May 22. PMID:28533324

Rifampin-sirolimus-voriconazole interaction in a hematopoietic cell transplant recipient.   Wasko J, Westholder JS, Jacobson PA. J Oncol Pharm Pract. 2017 Jan;23(1):75-79.[ PMID: 2676300]

Editorial: Validation is critical for genome wide association study based associations.  Oetting WA, Jacobson PA, Israni AK. Am J Transplant. 2017:17: 318-319. doi: 10.1111/ajt.14051

Validation is critical for Genome Wide Association Study-Based Associations. Oetting WS, Jacobson PA, Israni AK.  Am J Transplant. 2017 Feb;17(2):318-319. doi: 10.1111/ajt.14051. Epub 2016 Oct 12. PMID:27640398

Genome wide association study of tacrolimus concentrations in African American kidney transplant recipients identifies multiple CYP3A5 alleles. Oetting WS, Schladt DP, Guan W, Miller MB, Remmel RP, Dorr C*, Sanghavi K*, Mannon RB, Herrera B, Matas AJ, Salomon DR, Kwok PY, Keating BJ, Israni AK, Jacobson PA for the DeKAF Investigators. Am J Transplant  2016 Feb;16(2):574-82. [PMID 26485092]

Personalized Fludarabine Dosing To Reduce Non-Relapse Mortality In Hematopoietic Stem Cell Transplant Recipients Receiving Reduced Intensity Conditioning. R, Jensen K, Rosgosheske J, Kurtzweil A, Long-Boyle J, Wagner J, Warlick E, Brunstein CG, Weisdorf D, Jacobson PA. 2016 Sep;175:103-115.e4. Epub 2016 Mar 31. [PMID 27094990]

Pharmacokinetic-pharmacodynamic modeling of  acute N-terminal pro B-type natriuretic peptide after doxorubicin infusion in breast cancer. Liang S*, BrundageRC, Jacobson PA,  Blaes, A,  Kirstein, MN.  Br J Clin Pharmacol. (2016) 82, 773–783. [PMID 27128712]

Sirolimus and Mycophenolate Mofetil as Calcineurin Inhibitor-Free GVHD Prophylaxis for Reduced Intensity Umbilical Cord Blood Transplantation. Bejanyan N, Rogosheske J, DeFor TE, Lazaryan A, Arora M, Holtan SG, Jacobson PA, MacMillan ML, Verneris MR, Blazar BR, Weisdorf DJ, Wagner JE, Brunstein CG. Biol Blood and Marrow Transplant.  2016 Nov;22(11):2025-2030 [PMID:27519278]

Genotype-guided tacrolimus dosing in African American kidney transplant recipients.
Sanghavi K, Brundage RC, Miller MB, Schladt DP,  Israni AK, Guan W, Oetting WS, Mannon RB, Remmel RP,  Matas AJ,  Jacobson PA. The Pharmacogenomics Journal. Accepted. advance online publication 15 December 2015; (PMID:26667830)

Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS.
Oetting W, Schladt D, Guan W, Israni A, Remmel R, Dorr C, Sanghavi K, Mannon R, Herrera B, Matas A, Salomon D, Kwok P, Jacobson P. Am J Transplant. 2015. Online ahead of print October 20, 2015. (PMID:26485092)

Design and Implementation of the International Genetics & Translational Research in Transplantation Network (iGeneTRAIN).
Keating BJ, van Setten J, Jacobson PA, Holmes MV, Verma SS, Chandrupatla H, Nair N, Gao H, Phillips R, Wong C, Mukhtar E, Zhang W, Li YR, Cao H, Li C, Lee T, Steel L, Garifallou J, Miller MB, Karczewski KJ, Lek M, Fu Y, Pawashe M, Guettouche T, Thomas K, Almoguera B, Snyder J, Wang T, Himes A, Guan W, Wu B, Schladt D, Menon M, Zhang Z, Gonzalez A, Tragante V, Malkki M, De Vlaminck I, Piening BD, Strehl C, Shaw M, Snieder H, Klintmalm GB, O'Leary JG, Amaral S, Goldfarb S, Rand E, Rossano JW, Kohli U, Heeger P, Stahl E, Christie JD, Hernandez M, Levine JE, Aplenc R, Schadt EE, Stranger BE, Kluin J, Potena L, Zuckermann A, Khush K, Al-Muhanna FA, Al-Ali AK, Al-Rubaish AM, Potena L, Suthanthiran M, Tedesco H, Saw CL, Ragoussis J, Wijmenga C, Palmer S, de Borst MH, Naesens M, Hao K, de Bakker PI.W, MacArthur DG, Balasubramanian S, Lord G, Ritchie MD, Snyder M, Olthoff KM, Moore J, Petersdorf EW, Kamoun M, Wang J, Monos DS, Hakonarson H, Lankree MB, Murphy B, Garcia-Pavia P, Oetting WS, Birdwell KA, Bakker SJL, Israni AK, Shaked A, Asselbergs FW.Transplantation.  Volume 99(11), November 2015, p 2401–2412

Concept and Design of a Genome-wide Association Genotyping Array Tailored for Transplantation-Specific Studies.
Li YR, van Setten J, Lu Y, Holmes MV, Verma SS, Lek M, Nair N, Gao H, Chandrupatla H, Karczewski KJ, Wong C, Mukhtar E, Tragante V, Li C, Steel L, Lee T, Garifallou J, Guettouche T, Almoguera B, Cao H, Guan W, Himes A, Miller MB, Schladt D, Snyder J, Thomas K, Wang T, Wu B, Al-Ali AK, Al-Muhanna FA, Al-Rubaish AM, Monos DS, Murphy B, Olthoff KM, Wijmenga C, Webster T, Kamoun M, Balasubramanian S, Hakonarson H, Lanktree MB, Oetting WS, Garcia-Pavia P, MacArthur DG, Birdwell KA, Jacobson PA, Ritchie MD, Asselbergs FW, Israni AK, Shaked A, Keating BJ.  Genomic Medicine. 2015 Oct 1, 7(1):90  (PMID:26423053)

Multi-Gene Pharmacogenomics of Tacrolimus Troughs in Kidney Transplant Recipients.  
Pulk R, Schladt D, Weihau, G, Oetting W, Israni A, Matas A, Jacobson PA. Pharmacogenomics 2015. Accepted  doi: 10.2217/pgs.15.42.  (PMID 26067485)

Genotype-guided tacrolimus dosing in African American kidney transplant recipients.  Sanghavi K*, Brundage RC, Miller MB, Schladt DP, Israni AK, Guan W, Oetting WS, Mannon RB, Remmel RP, Matas AJ, Jacobson PA.  The Pharmacogenomics Journal. 2015, 1–8 [PMID: 26667830]

Differentially expressed gene transcripts using RNA sequencing from the blood of immunosuppressed kidney allograft recipients.
Door C, Wu B, Guan W, Muthusamy A, Sanghavi K, Schladt DP, Maltzman JS, Scherer SE, Brott MJ, Matas AJ, Jacobson PA, Oetting WS, Israni AK.  PLoS One. 2015 May 6;10(5);e012545. doi: 10.1371/journal.pone.0125045. (PMID: 25946140, PMCID: PMC4422721)

Higher dose of mycophenolate mofetil reduces acute graft-versus-host disease in reduced-intensity conditioning double umbilical cord blood transplantation.
Bejanyan N, Rogosheske J, DeFor T, Lazaryan A, Esbaum K, Holtan S, Arora M, MacMillan ML, Weisdorf D, Jacobson P, Wagner J, Brunstein CG. Biol Blood Marrow Transplant. 2015 May;21(5):926-33. (PMID: 25655791)

Angiotensin Converting Enzyme Inhibitors (ACEI) and doxorubicin pharmacokinetics in women receiving adjuvant breast cancer treatment.
Blaes A, Duprez D, Defor T, Shanley R, Beckwith H, Haddad T, Potter D, Yee D, Sanghavi K, Jacobson P. Springerplus. 2015 Jan 23;4:32. (PMID:25646154)

 

Susan Marino

Susan Marino

Link to PubMed

Pharmacokinetic-Pharmacodynamic Modeling of Intravenous and Oral Topiramate and Its Effect on the Symbol Digit Modalities Test in Adult Healthy Volunteers.
Lim CN, Birnbaum AK, Brundage RC, Leppik IE, Cloyd JC, Clark A, Marino SE.
J Clin Pharmacol. 2015 Sep 23. doi: 10.1002/jcph.646. [Epub ahead of print]
PMID: 26395889

Pharmacokinetic-Pharmacodynamic Modelling of Intravenous and Oral Topiramate and Its Effect on Phonemic Fluency in Adult Healthy Volunteers.
Ahmed GF, Marino SE, Brundage RC, Pakhomov SV, Leppik IE, Cloyd JC, Clark A, Birnbaum AK.
Br J Clin Pharmacol. 2015 May;79(5):820-30. doi: 10.1111/bcp.12556.
PMID: 25403343

Genetic and Environmental Correlates of Topiramate-Induced Cognitive Impairment.
Cirulli ET, Urban TJ, Marino SE, Linney KN, Birnbaum AK, Depondt C, Attix DK,  Radtke RA, Goldstein DB. Epilepsia. 2012 Jan;53(1):e5-8. doi: 10.1111/j.1528-1167.2011.03322.x. Epub 2011 Nov 16. PubMed PMID: 22091778; PubMed Central PMCID: PMC3253145.

William Oetting

William Oetting

Link to PubMed

Tacrolimus Troughs and Genetic Determinants of  Metabolism in Kidney Transplant Recipients: A Comparison of Four Ancestry Groups.
Mohamed ME, Schladt DP, Guan W, Wu B, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Oetting WS, Jacobson PA; DeKAF Genomics and GEN03 Investigators.Am J Transplant. 2019 Oct;19(10):2795-2804. doi: 10.1111/ajt.15385. Epub 2019 May 13. PubMed PMID: 30953600; PubMed Central PMCID: PMC6763344.

The Impact of Donor and Recipient Common Clinical and Genetic Variation on Estimated Glomerular Filtration Rate in a European Renal Transplant Population.
Stapleton CP, Heinzel A, Guan W, van der Most PJ, van Setten J, Lord GM, Keating BJ, Israni AK, de Borst MH, Bakker SJL, Snieder H, Weale ME, Delaney F, Hernandez-Fuentes MP, Reindl-Schwaighofer R, Oberbauer R, Jacobson PA, Mark PB, Chapman FA, Phelan PJ, Kennedy C, Sexton D, Murray S, Jardine A, Traynor JP, McKnight AJ, Maxwell AP, Smyth LJ, Oetting WS, Matas AJ, Mannon RB, Schladt DP, Iklé DN, Cavalleri GL, Conlon PJ; UK Ireland Renal Transplant Consortium; DeKAF Genomics and GEN03 Studies; International Genetics and Translational Research in Transplantation Network.Am J Transplant. 2019 Aug;19(8):2262-2273. doi: 10.1111/ajt.15326. Epub 2019 Mar 28. PubMed PMID: 30920136.

Genetic Variants Associated With Immunosuppressant Pharmacokinetics and Adverse Effects in the DeKAF Genomics Genome-wide Association Studies.
Oetting WS, Wu B, Schladt DP, Guan W, van Setten J, Keating BJ, Iklé D, Remmel RP, Dorr CR, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN-03 Investigators. Transplantation. 2019 Jun;103(6):1131-1139. doi: 10.1097/TP.0000000000002625. PubMed PMID: 30801552; PubMed Central PMCID: PMC6597284.

Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A.
Oetting WS, Schladt DP, Dorr CR, Wu B, Guan W, Remmel RP, Iklé D, Mannon RB, Matas AJ, Israni AK, Jacobson PA; DeKAF Genomics and GEN03 Investigators.Transplantation. 2019 Aug;103(8):1591-1602. doi: 10.1097/TP.0000000000002659. PubMed PMID: 30801535.

Identification of Genetic Variants Associated with Tacrolimus Metabolism in Kidney Transplant Recipients by Extreme Phenotype Sampling and Next Generation Sequencing.
Dorr CR, Wu B, Remmel RP, Muthusamy A, Schladt DP, Abrahante JE, Guan W, Mannon RB, Matas AJ, Oetting WS, Jacobson PA, Israni AK; for DeKAF Genomics.Pharmacogenomics J. 2019 Aug;19(4):375-389. doi: 10.1038/s41397-018-0063-z. Epub 2018 Nov 16. PubMed PMID: 30442921; PubMed Central PMCID: PMC6522337.

Tacrolimus Elimination in Four Patients With a CYP3A5*3/*3 CYP3A4*22/*22 Genotype Combination.
Scheibner A, Remmel R, Schladt D, Oetting WS, Guan W, Wu B, Dorr C, Israni A, Jacobson PA.Pharmacotherapy. 2018 May 26. doi: 10.1002/phar.2131. [Epub ahead of print] PubMed PMID: 29804290; PubMed Central PMCID: PMC6265082.

NPHP1(Nephrocystin-1) Gene Deletions Cause Adult-Onset ESRD.
Snoek R, van Setten J, Keating BJ, Israni AK, Jacobson PA, Oetting WS, Matas AJ, Mannon RB, Zhang Z, Zhang W, Hao K, Murphy B, Reindl-Schwaighofer R, Heinzl A, Oberbauer R, Viklicky O, Conlon PJ, Stapleton CP, Bakker SJL, Snieder H, Peters EDJ, van der Zwaag B, Knoers NVAM, de Borst MH, van Eerde AM.J Am Soc Nephrol. 2018 Jun;29(6):1772-1779. doi: 10.1681/ASN.2017111200. Epub 2018 Apr 13. PubMed PMID: 29654215; PubMed Central PMCID: PMC6054334.

Tacrolimus Trough and Dose Intra-Patient Variability and CYP3A5 Genotype: Effects on Acute Rejection and Graft Failure in European American and African American Kidney Transplant Recipients.
Seibert SR, Schladt DP, Wu B, Guan W, Dorr C, Remmel RP, Matas AJ, Mannon RB, Israni AK, Oetting WS, Jacobson PA.Clin Transplant. 2018 Dec;32(12):e13424. doi: 10.1111/ctr.13424. Epub 2018 Oct 31. PubMed PMID: 30318646; PubMed Central PMCID: PMC6317347.

Attempted Validation of 44 Reported SNPs Associated with  Tacrolimus Troughs in a Cohort of Kidney Allograft Recipients.
Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Dorr C, Mannon RB, Matas AJ, Israni AK, Jacobson PA. Pharmacogenomics.  2018 Feb;19(3):175-184. doi: 10.2217/pgs-2017-0187. Epub 2018 Jan 10. PubMed PMID: 29318894; PubMed Central PMCID: PMC6021962.

Methods and Tools for Assessing the Impact of Genetic Variations: The 2017 Annual Scientific Meeting of the Human Genome Variation Society.
Oetting WS, Béroud C, Brenner SE, Greenblatt MS, Karchin R, Mooney SD. Hum Mutat. 2018 Mar;39(3):454-458. doi: 10.1002/humu.23393. Epub 2018 Jan 15. PubMed PMID: 29282786; PubMed Central PMCID: PMC5805595.

Genome-Wide Association Study Identifies the Common Variants in CYP3A4 and CYP3A5 Responsible for Variation in Tacrolimus Trough Concentration in Caucasian Kidney Transplant Recipients.
Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Mannon RB, Matas AJ, Israni AK, Jacobson PA. Pharmacogenomics J. 2018 May22;18(3):501-505. doi: 10.1038/tpj.2017.49. Epub 2017 Nov 21. PubMed PMID: 29160300.

Concepts of Genomics in Kidney Transplantation.
Oetting WS, Dorr C, Remmel RP, Matas AJ, Israni AK, Jacobson PA. Curr Transplant Rep. 2017 Jun;4(2):116-123. doi: 10.1007/s40472-017-0153-x. Epub 2017 May 24. PubMed PMID: 29123971; PubMed Central PMCID: PMC5673265.

Genetics of Acute Rejection After Kidney Transplantation.
Dorr CR, Oetting WS, Jacobson PA, Israni AK.Transpl Int. 2018 Mar;31(3):263-277. doi: 10.1111/tri.13084. Epub 2017 Nov 8. Review. PubMed PMID: 29030886; PubMed Central PMCID: PMC6260834.

Implementing Pharmacogenomics in Modern Health Care: The 2017 scientific meeting of the Human Genome Variation Society.
Lanting P, Oetting WS. Hum Mutat. 2017 Nov;38(11):1606-1610. doi: 10.1002/humu.23300. Epub 2017 Aug 3. PubMed PMID: 28748604.

CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism.
Dorr CR, Remmel RP, Muthusamy A, Fisher J, Moriarity BS, Yasuda K, Wu B, Guan W, Schuetz EG, Oetting WS, Jacobson PA, Israni AK. Drug Metab Dispos. 2017 Aug;45(8):957-965. doi: 10.1124/dmd.117.076307. Epub 2017 May 22. PMID:28533324

Non-Coding Variation: The 2016 Annual Scientific Meeting of the Human Genome Variation Society.
Oetting WS, Béroud C, Brenner SE, Greenblatt M, Karchin R, Mooney SD, Sunyaev S. Hum Mutat. 2017 Apr;38(4):460-463. doi: 10.1002/humu.23169. Epub 2017 Feb 14. No abstract available. PMID: 28054414


Validation Is Critical for Genome-Wide Association Study-Based Associations.
Oetting WS, Jacobson PA, Israni AK. Am J Transplant. 2017 Feb;17(2):318-319. doi: 10.1111/ajt.14051. Epub 2016 Oct 12. No abstract available. PMID:27640398
 
Clinical Interpretation of Variants from Next-Generation Sequencing: The 2016 Scientific Meeting of the Human Genome Variation Society.
Oetting WS, Brookes AJ, Béroud C, Taschner PE. Hum Mutat. 2016 Oct;37(10):1110-3. doi: 10.1002/humu.23059. Epub 2016 Aug 21. PMID: 27492570

Pathogenicity Interpretation in the Age of Precision Medicine: The 2015 Annual Scientific Meeting of the Human Genome Variation Society.
Oetting WS, Brenner SE, Brookes AJ, Greenblatt MS, Hart RK, Karchin R, Sunyaev SR, Taschner PE. Hum Mutat. 2016 Apr;37(4):406-11. doi: 10.1002/humu.22958. Epub 2016 Feb 12. No abstract available. PMID: 26791113

Genotype-guided tacrolimus dosing in African-American kidney transplant recipients.
Sanghavi K, Brundage RC, Miller MB, Schladt DP, Israni AK, Guan W, Oetting WS, Mannon RB, Remmel RP, Matas AJ, Jacobson PA. Pharmacogenomics J. 2017 Jan;17(1):61-68. doi: 10.1038/tpj.2015.87. Epub 2015 Dec 15. PMID: 26667830

Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles. 
Oetting WS, Schladt DP, Guan W, Miller MB, Remmel RP, Dorr C, Sanghavi K, Mannon RB, Herrera B, Matas AJ, Salomon DR, Kwok PY, Keating BJ, Israni AK, Jacobson PA; DeKAF Investigators. Am J Transplant. 2016 Feb;16(2):574-82. doi: 10.1111/ajt.13495. Epub 2015 Oct 20.  PMID: 26485092


Pharmacogenetic Allele Nomenclature: International Workgroup Recommendations for Test Result Reporting.
Kalman LV, Agúndez JA, Appell ML, Black JL, Bell GC, Boukouvala S, Bruckner C, Bruford E, Bruckner C, Caudle K, Coulthard S, Daly AK, Del Tredici AL, den Dunnen JT, Drozda K, Everts R, Flockhart D, Freimuth R, Gaedigk A, Hachad H, Hartshorne T, Ingelman-Sundberg M, Klein TE, Lauschke VM, Maglott DR, McLeod HL, McMillin GA, Meyer UA, Müller DJ, Nickerson DA, Oetting WS, Pacanowski M, Pratt VM, Relling MV, Roberts A, Rubinstein WS, Sangkuhl K, Schwab M, Scott SA, Sim SC, Thirumaran RK, Toji LH, Tyndale R, van Schaik RH, Whirl-Carrillo M, Yeo KJ, Zanger UM.Clin Pharmacol Ther. 2015 Oct 19. doi: 10.1002/cpt.280. [Epub ahead of print] Review. PMID:26479518

Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies.
Li YR, van Setten J, Verma SS, Lu Y, Holmes MV, Gao H, Lek M, Nair N, Chandrupatla H, Chang B, Karczewski KJ, Wong C, Mohebnasab M, Mukhtar E, Phillips R, Tragante V, Hou C, Steel L, Lee T, Garifallou J, Guettouche T, Cao H, Guan W, Himes A, van Houten J, Pasquier A, Yu R, Carrigan E, Miller MB, Schladt D, Akdere A, Gonzalez A, Llyod KM, McGinn D, Gangasani A, Michaud Z, Colasacco A, Snyder J, Thomas K, Wang T, Wu B, Alzahrani AJ, Al-Ali AK, Al-Muhanna FA, Al-Rubaish AM, Al-Mueilo S, Monos DS, Murphy B, Olthoff KM, Wijmenga C, Webster T, Kamoun M, Balasubramanian S, Lanktree MB, Oetting WS, Garcia-Pavia P, MacArthur DG, de Bakker PI, Hakonarson H, Birdwell KA, Jacobson PA, Ritchie MD, Asselbergs FW, Israni AK, Shaked A, Keating BJ.
Genome Med. 2015 Oct 1;7(1):90. doi: 10.1186/s13073-015-0211-x.  PMID: 26423053

Multigene predictors of tacrolimus exposure in kidney transplant recipients.
Pulk RA, Schladt DS, Oetting WS, Guan W, Israni AK, Matas AJ, Remmel RP, Jacobson PA; DeKAF Investigators. Pharmacogenomics. 2015 Jul;16(8):841-54. doi: 10.2217/pgs.15.42. Epub 2015 Jun 12. PMID: 26067485

Differentially expressed gene transcripts using RNA sequencing from the blood of immunosuppressed kidney allograft recipients.
Dorr C, Wu B, Guan W, Muthusamy A, Sanghavi K, Schladt DP, Maltzman JS, Scherer SE, Brott MJ, Matas AJ, Jacobson PA, Oetting WS, Israni AK.  PLoS One. 2015 May 6;10(5):e0125045. doi: 10.1371/journal.pone.0125045. eCollection 2015. PMID: 25946140

Germline & somatic mosaicism: the 2014 annual scientific meeting of the Human Genome Variation Society.
Oetting WS, Greenblatt MS, Brookes AJ, Karchin R, Mooney SD. Hum Mutat. 2015 Mar;36(3):390-3. doi: 10.1002/humu.22757. No abstract available. PMID: 25597405

Serguei Pakhomov

Serguei Pakhomov

Link to PubMed

Corpus Domain Effects on Distributional Semantic Modeling of Medical Terms 
Pakhomov, S., Finley, G., McEwan, R. Wang, Y. Melton, G. (2016) Bioinformatics, (in press).

Mining Biomedical Literature to Explore Interactions between Cancer Drugs and Dietary Supplements.
Zhang R, Adam TJ, Simon G, Cairelli MJ, Rindflesch T, Pakhomov S, Melton GB.
AMIA Jt Summits Transl Sci Proc. 2015 Mar 23;2015:69-73. eCollection 2015.
PMID: 26306241

Evaluation of Herbal and Dietary Supplement Resource Term Coverage.
Manohar N, Adam TJ, Pakhomov SV, Melton GB, Zhang R.
Stud Health Technol Inform. 2015;216:785-9.
PMID:26262159

Ease of adoption of clinical natural language processing software: An evaluation of five systems. Zheng K, Vydiswaran VG, Liu Y, Wang Y, Stubbs A, Uzuner O, Gururaj AE, Bayer S, Aberdeen J, Rumshisky A, Pakhomov S, Liu H, Xu H. J Biomed Inform. 2015 Jul 22. pii: S1532-0464(15)00148-3. doi: 10.1016/j.jbi.2015.07.008. [Epub ahead of print]
PMID:26210361

Zachary Rivers

Zachary Rivers

Link to Pubmed

 

David Stenehjem

David Stenehjem

Link to Pubmed

Predictive genomic markers of response to VEGF targeted therapy in metastatic renal cell carcinoma.
Stenehjem, D. D., Hahn, A. W., Gill, D. M., Albertson, D., Gowrishankar, B., Merriman, J., Agarwal, A. M., Thodima, V., Harrington, E. B., Au, T. H., Maughan, B. L., Houldsworth, J., Pal, S. K., & Agarwal, N. (2019).PLOS ONE, 14(1), e0210415. doi: 10.1371/journal.pone.0210415 doi: 10.1371/journal.pone.0210415

Pembrolizumab in advanced gastrointestinal malignancies with defective dna mismatch repair: A case series.
Stenehjem, D. D., Cavalieri, C., Swanson, E., Solomon, B., Whisenant, J., Tran, D., Weis, J., Gilcrease, G., Sharma, S., & Garrido-Laguna, I. (2018).J Immunother Precis Oncol, 1(1), 1--6. doi: 10.4103/JIPO.JIPO_5_18 doi: 10.4103/JIPO.JIPO_5_18 

Primary Care Clinicians Attitudes and Knowledge of Pharmacogenetics in a Large, Multi-state, Healthcare System.
Olander, M.*, Waring, S., Stenehjem, D. D., Taran, A., Raneli, P. L., & Brown, J. (2018). INNOVATIONS in pharmacy, 9(2), 6. doi: 10.24926/iip.v9i2.970 doi: 10.24926/iip.v9i2.970 

Impact of a genetic counseling requirement prior to genetic testing.
Stenehjem, D. D., Au, T., Sainski, A. M., Bauer, H., Brown, K., Lancaster, J., Stevens, V., & Brixner, D. I. (2018). BMC Health Services Research, 18(1). doi: 10.1186/s12913-018-2957-5 doi: 10.1186/s12913-018-2957-5 

Personalized treatment of women with early breast cancer: A risk-group specific cost-effectiveness analysis of adjuvant chemotherapy accounting for companion prognostic tests
Jahn, B., Rochau, U., Kurzthaler, C., Hubalek, M., Miksad, R., Sroczynski, G., Paulden, M., Bundo, M., Stenehjem, D., Brixner, D., Krahn, M., & Siebert, U. (2017). OncotypeDX and Adjuvant!Online. BMC Cancer, 17(1). doi: 10.1186/s12885-017-3603-z doi: 10.1186/s12885-017-3603-z 

Personalized and precision medicine: integrating genomics into treatment decisions in gastrointestinal malignancies.
Au, T. H., Wang, K., Stenehjem, D. D., & Garrido-Laguna, I. (2017). Journal of Gastrointestinal Oncology, 8(3), 387-404. doi: 10.21037/jgo.2017.01.04 doi: 10.21037/jgo.2017.01.04

Neutrophil-lymphocyte ratio as a predictive biomarker for response to high dose interleukin-2 in patients with renal cell carcinoma.
Kuzman JA, Stenehjem DD, Merriman J, Agarwal AM, Patel SB, Hahn AW, Alex A, Albertson D, Gill DM, Agarwal N. BMC Urol. 2017 Jan 5;17(1):1. doi: 10.1186/s12894-016-0192-0.PMID: 28056941

BRCA testing, treatment patterns and survival in platinum-sensitive recurrent ovarian cancer - an observational cohort study.
Unni SK, Schauerhamer MB, Deka R, Tyczynski JE, Fernandes AW, Stevens V, Brixner DI, Stenehjem DDJ Ovarian Res. 2016 Mar 22;9:18. doi: 10.1186/s13048-016-0227-x. PMID:27004793

Cost-Utility of a Prognostic Test Guiding Adjuvant Chemotherapy Decisions in Early-Stage Non-Small Cell Lung Cancer.
Stenehjem DD, Bellows BK, Yager KM, Jones J, Kaldate R, Siebert U, Brixner DI. Oncologist. 2016 Feb;21(2):196-204. doi: 10.1634/theoncologist.2015-0162. Epub 2015 Nov 27. PMID: 26614710

Assessment of HER2 testing patterns, HER2+ disease, and the utilization of HER2-directed therapy in early breast cancer.
Stenehjem DD, Yoo M, Unni SK, Singhal M, Bauer H, Saverno K, Quah C, Masaquel A, Brixner DI. Breast Cancer (Dove Med Press). 2014 Oct 29;6:169-77. doi: 10.2147/BCTT.S69416. eCollection 2014. PMID: 25378949

Application of decision-analytic models in personalized medicine for CML treatment decisions made by payers, providers, and patients. Saverno KR, Rochau U, Stenehjem DD, Morley K, Siebert U, Brixner DI.J Manag Care Pharm. 2012 Jul-Aug;18(6):457-63. No abstract available. PMID: 22839687

Robert Straka

Robert Straka

Link to PubMed

Engaging Hmong adults in genomic and pharmacogenomic research: Toward reducing health disparities in genomic knowledge using a community-based participatory research approach.
Culhane-Pera KA, Straka RJ, Moua M, Roman Y, Vue P, Xiaaj K, Lo MX, Lor M. J Community Genet. 2017 Apr;8(2):117-125. doi: 10.1007/s12687-017-0292-x. Epub 2017 Jan 10. PMID:28074382

Leaves imitate trees: Minnesota Hmong concepts of heredity and applications to genomics research.
Culhane-Pera KA, Moua M, Vue P, Xiaaj K, Lo MX, Straka RJJ Community Genet. 2017 Jan;8(1):23-34. doi: 10.1007/s12687-016-0284-2. Epub 2016 Nov 7. PMID:27822876

A genome-wide study of lipid response to fenofibrate in Caucasians: a combined analysis of the GOLDN and ACCORD studies.
Irvin MR, Rotroff DM, Aslibekyan S, Zhi D, Hidalgo B, Motsinger-Reif A, Marvel S, Srinivasasainagendra V, Claas SA, Buse JB, Straka RJ, Ordovas JM, Borecki IB, Guo X, Chen IY, Rotter JI, Wagner MJ, Arnett DK. Pharmacogenet Genomics. 2016 Jul;26(7):324-33. doi: 10.1097/FPC.0000000000000219. PMID: 27002377

A family-specific linkage analysis of blood lipid response to fenofibrate in the Genetics of Lipid Lowering Drug and Diet Network.
Hidalgo B, Aslibekyan S, Wiener HW, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Ordovas JM, Arnett DK. Pharmacogenet Genomics. 2015 Oct;25(10):511-4. doi: 10.1097/FPC.0000000000000162.PMID: 26203732

A family-specific linkage analysis of blood lipid response to fenofibrate in the Genetics of Lipid Lowering Drug and Diet Network. Hidalgo B, Aslibekyan S, Wiener HW, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins PN, Ordovas JM, Arnett DK. Pharmacogenet Genomics. 2015 Oct;25(10):511-4. doi: 10.1097/FPC.0000000000000162. PMID: 26203732

Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FA, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JM; CHARGE Nutrition Study Group. Diabetes Care. 2015 Aug;38(8):1456-66. doi: 10.2337/dc14-2709. Epub 2015 Jun 17. PMID: 26084345

Natalia Tretyakova

Natalia Tretyakova

Link to PubMed

Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells.
Pang J, Shen N, Yan F, Zhao N, Dou L, Wu LC, Seiler CL, Yu L, Yang K, Bachanova V, Weaver E, Tretyakova NY, Liu S.Oncotarget. 2017 May 23;8(21):34453-34467. doi: 10.18632/oncotarget.16431. PMID: 28415607

Mass Spectrometry Based Proteomics Study of Cisplatin-Induced DNA-Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells. Ming X, Groehler A 4th, Michaelson-Richie ED, Villalta PW, Campbell C, Tretyakova NYChem Res Toxicol. 2017 Apr 17;30(4):980-995. doi: 10.1021/acs.chemrestox.6b00389. Epub 2017 Mar 29. PMID: 28282121

Mass Spectrometry-Based Tools to Characterize DNA-Protein Cross-Linking by Bis-Electrophiles.  Groehler A 4th, Degner A, Tretyakova NYBasic Clin Pharmacol Toxicol. 2016 Dec 29. doi: 10.1111/bcpt.12751. [Epub ahead of print] Review. PMID: 28032943

Mutagenicity of a Model DNA-Peptide Cross-Link in Human Cells: Roles of Translesion Synthesis DNA Polymerases.
Pande P, Ji S, Mukherjee S, Schärer OD, Tretyakova NY, Basu AK. Chem Res Toxicol. 2017 Feb 20;30(2):669-677. doi: 10.1021/acs.chemrestox.6b00397. Epub 2016 Dec 21. PMID: 27951635

Synthesis of DNA Oligodeoxynucleotides Containing Site-Specific 1,3-Butadiene-Deoxyadenosine Lesions. Wickramaratne S, Seiler CL, Tretyakova NY.Curr Protoc Nucleic Acid Chem. 2015 Jun 3;61:4.61.1-22. doi: 10.1002/0471142700.nc0461s61. PMID:26344227

 

Brian Van Ness

Brian Van Ness

Link to PubMed

Development of expression-based biomarkers of dasatinib response in hematologic malignancies.
Akre, M, Mitra, A.,  Wang, W, Myers, C, and Van Ness, B. (2017) Blood Cancer J.  In press.

A gene expression signature distinguishes innate response and resistance to proteasome inhibitors in multiple myeloma.
Mitra AK, Harding T, Mukherjee UK, Jang JS, Li Y, HongZheng R, Jen J, Sonneveld P, Kumar S, Kuehl WM, Rajkumar V, Van Ness BBlood Cancer J. 2017 Jun 30;7(6):e581. doi: 10.1038/bcj.2017.56. PMID: 28665416

A de novo splice site mutation in EHMT1 resulting in Kleefstra syndrome with pharmacogenomics screening and behavior therapy for regressive behaviors.
Mitra AK, Dodge J, Van Ness J, Sokeye I, Van Ness BMol Genet Genomic Med. 2016 Dec 26;5(2):130-140. doi: 10.1002/mgg3.265. eCollection 2017 Mar. PMID:28361099

Fine-Mapping of 18q21.1 Locus Identifies Single Nucleotide Polymorphisms Associated with Nonsyndromic Cleft Lip with or without Cleft Palate.
Mitra AK, Stessman HA, Schaefer RJ, Wang W, Myers CL, Van Ness BG, Beiraghi S. Front Genet. 2016 May 23;7:88. doi: 10.3389/fgene.2016.00088. eCollection 2016. PMID: 27242896

PIAS1 Promotes Lymphomagenesis through MYC Upregulation.
Rabellino A, Melegari M, Tompkins VS, Chen W, Van Ness BG, Teruya-Feldstein J, Conacci-Sorrell M, Janz S, Scaglioni PP. Cell Rep. 2016 Jun 7;15(10):2266-78. doi: 10.1016/j.celrep.2016.05.015. Epub 2016 May 26. PMID: 27239040

Single-cell analysis of targeted transcriptome predicts drug sensitivity of single cells within human myeloma tumors. 
Mitra AK, Mukherjee UK, Harding T, Jang JS, Stessman H, Li Y, Abyzov A, Jen J, Kumar S, Rajkumar V, Van Ness BLeukemia. 2016 May;30(5):1094-102. doi: 10.1038/leu.2015.361. Epub 2015 Dec 29. PMID: 26710886

Polymerase Bypass of N(6)-Deoxyadenosine Adducts Derived from Epoxide Metabolites of 1,3-Butadiene. Kotapati S, Wickramaratne S, Esades A, Boldry EJ, Quirk Dorr D, Pence MG, Guengerich FP, Tretyakova NY. Chem Res Toxicol. 2015 Jul 20;28(7):1496-507. doi: 10.1021/acs.chemrestox.5b00166. Epub 2015 Jul 6. PMID: 26098310

DNA-Protein Cross-Links: Formation, Structural Identities, and Biological Outcomes. Tretyakova NY, Groehler A 4th, Ji S. Acc Chem Res. 2015 Jun 16;48(6):1631-44. doi: 10.1021/acs.accounts.5b00056. Epub 2015 Jun 2. PMID:26032357

Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide. McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD. Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29. PMID:26025730

High throughput HPLC-ESI--MS/MS methodology for mercapturic acid metabolites of 1,3-butadiene: Biomarkers of exposure and bioactivation. Kotapati S, Esades A, Matter B, Le C, Tretyakova N. Chem Biol Interact. 2015 Feb 26. pii: S0009-2797(15)00071-X. doi: 10.1016/j.cbi.2015.02.009. [Epub ahead of print] PMID: 25727266

Single-cell analysis of targeted transcriptome (SCATTome) predicts drug sensitivity of single cells within human myeloma tumors.  
Mitra, A, Mukherjee, U, Jang, J, Harding, T, Stessman, H, Li, Y, Abyzov, A, Jen, J, Kumar, S, Rajkumar, V, Van Ness, B.  (2016)  Leukemia.  In press.

Risk of multiple myeloma in a case-spouse study.
Andrrotti, G, Katz, M, Hoering, A, Van Ness, B, Crowley, J, Morgan, G, Hoover RN, Baris D, Durie, B. (2015) Leuk Lymphoma DOI: 10.3109/10428194.2015.1094693

Returning a Research Participant's Genomic Results to Relatives: Perspectives from Managers of Two Distinct Research Biobanks.
Petersen GM, Ness BV. J Law Med Ethics. 2015 Sep;43(3):523-8. doi: 10.1111/jlme.12294. PMID: 26479561

Returning a Research Participant's Genomic Results to Relatives: Analysis and Recommendations.
Wolf SM, Branum R, Koenig BA, Petersen GM, Berry SA, Beskow LM, Daly MB, Fernandez CV, Green RC, LeRoy BS, Lindor NM, O'Rourke PP, Breitkopf CR, Rothstein MA, Van Ness B, Wilfond BS. J Law Med Ethics. 2015 Sep;43(3):440-63. doi: 10.1111/jlme.12288. PMID: 26479555

Applications and limitations in translating genomics to clinical practice.
Van Ness B. Transl Res. 2015 May 4. pii: S1931-5244(15)00138-3. doi: 10.1016/j.trsl.2015.04.012. [Epub ahead of print] Review. PMID:26001594

Catherine McCarthy

Catherine McCarthy

Link to PubMed

A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers.

Mosley JD, Feng Q, Wells QS, Van Driest SL, Shaffer CM, Edwards TL, Bastarache L, Wei WQ, Davis LK, McCarty CA, Thompson W, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, Carrell DS, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Namjou B, Williams MS, Ritchie MD, Borthwick KM, Verma SS, Karnes JH, Weiss ST, Wang TJ, Stein CM, Denny JC, Roden DM.
Nat Commun. 2018 Aug 30;9(1):3522. doi: 10.1038/s41467-018-05624-4.

Implementation, adoption, and utility of family health history risk assessment in diverse care settings: evaluating implementation processes and impact with an implementation framework.
Wu RR, Myers RA, Sperber N, Voils CI, Neuner J, McCarty CA, Haller IV, Harry M, Fulda KG, Cross D, Dimmock D, Rakhra-Burris T, Buchanan AH, Ginsburg GS, Orlando LA.
Genet Med. 2018 Jun 6. doi: 10.1038/s41436-018-0049-x

How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration?
McCarty CA, Fuchs MJ, Lamb A, Conway P.
Optom Vis Sci. 2018 Mar;95(3):166-170. doi: 10.1097/OPX.0000000000001188.

PLATO software provides analytic framework for investigating complexity beyond genome-wide association studies.
Hall MA, Wallace J, Lucas A, Kim D, Basile AO, Verma SS, McCarty CA, Brilliant MH, Peissig PL, Kitchner TE, Verma A, Pendergrass SA, Dudek SM, Moore JH, Ritchie MD.
Nat Commun. 2017 Oct 27;8(1):1167. doi: 10.1038/s41467-017-00802-2.

Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes.
Mosley JD, Shoemaker MB, Wells QS, Darbar D, Shaffer CM, Edwards TL, Bastarache L, McCarty CA, Thompson W, Chute CG, Jarvik GP, Crosslin DR, Larson EB, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Witte JS, Denny JC, Roden DM.
Circ Cardiovasc Genet. 2017 Apr;10(2). pii: e001482. doi: 10.1161/CIRCGENETICS.116.001482.

Strategies for integrating personalized medicine into healthcare practice.
Pritchard DE, Moeckel F, Villa MS, Housman LT, McCarty CA, McLeod HL.
Per Med. 2017 Mar;14(2):141-152. doi: 10.2217/pme-2016-0064. Epub 2017 Jan 19.

Genome-wide study of resistant hypertension identified from electronic health records.
Dumitrescu L, Ritchie MD, Denny JC, El Rouby NM, McDonough CW, Bradford Y, Ramirez AH, Bielinski SJ, Basford MA, Chai HS, Peissig P, Carrell D, Pathak J, Rasmussen LV, Wang X, Pacheco JA, Kho AN, Hayes MG, Matsumoto M, Smith ME, Li R, Cooper-DeHoff RM, Kullo IJ, Chute CG, Chisholm RL, Jarvik GP, Larson EB, Carey D, McCarty CA, Williams MS, Roden DM, Bottinger E, Johnson JA, de Andrade M, Crawford DC.
PLoS One. 2017 Feb 21;12(2):e0171745. doi: 10.1371/journal.pone.0171745. eCollection 2017

Public Attitudes toward Consent and Data Sharing in Biobank Research: A Large Multi-site Experimental Survey in the US.
Sanderson SC, Brothers KB, Mercaldo ND, Clayton EW, Antommaria AHM, Aufox SA, Brilliant MH, Campos D, Carrell DS, Connolly J, Conway P, Fullerton SM, Garrison NA, Horowitz CR, Jarvik GP, Kaufman D, Kitchner TE, Li R, Ludman EJ, McCarty CA, McCormick JB, McManus VD, Myers MF, Scrol A, Williams JL, Shrubsole MJ, Schildcrout JS, Smith ME, Holm IA.
Am J Hum Genet. 2017 Mar 2;100(3):414-427. doi: 10.1016/j.ajhg.2017.01.021. Epub 2017 Feb 9.

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.
Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, Hartwig FP, Horta BL, Hyppönen E, Power C, Moldovan M, van Iperen E, Hovingh GK, Demuth I, Norman K, Steinhagen-Thiessen E, Demuth J, Bertram L, Liu T, Coassin S, Willeit J, Kiechl S, Willeit K, Mason D, Wright J, Morris R, Wanamethee G, Whincup P, Ben-Shlomo Y, McLachlan S, Price JF, Kivimaki M, Welch C, Sanchez-Galvez A, Marques-Vidal P, Nicolaides A, Panayiotou AG, Onland-Moret NC, van der Schouw YT, Matullo G, Fiorito G, Guarrera S, Sacerdote C, Wareham NJ, Langenberg C, Scott R, Luan J, Bobak M, Malyutina S, Pająk A, Kubinova R, Tamosiunas A, Pikhart H, Husemoen LL, Grarup N, Pedersen O, Hansen T, Linneberg A, Simonsen KS, Cooper J, Humphries SE, Brilliant M, Kitchner T, Hakonarson H, Carrell DS, McCarty CA, Kirchner HL, Larson EB, Crosslin DR, de Andrade M, Roden DM, Denny JC, Carty C, Hancock S, Attia J, Holliday E, O'Donnell M, Yusuf S, Chong M, Pare G, van der Harst P, Said MA, Eppinga RN, Verweij N, Snieder H; LifeLines Cohort study group, Christen T, Mook-Kanamori DO, Gustafsson S, Lind L, Ingelsson E, Pazoki R, Franco O, Hofman A, Uitterlinden A, Dehghan A, Teumer A, Baumeister S, Dörr M, Lerch MM, Völker U, Völzke H, Ward J, Pell JP, Smith DJ, Meade T, Maitland-van der Zee AH, Baranova EV, Young R, Ford I, Campbell A, Padmanabhan S, Bots ML, Grobbee DE, Froguel P, Thuillier D, Balkau B, Bonnefond A, Cariou B, Smart M, Bao Y, Kumari M, Mahajan A, Ridker PM, Chasman DI, Reiner AP, Lange LA, Ritchie MD, Asselbergs FW, Casas JP, Keating BJ, Preiss D, Hingorani AD; UCLEB consortium, Sattar N.
Lancet Diabetes Endocrinol. 2017 Feb;5(2):97-105. doi: 10.1016/S2213-8587(16)30396-5. Epub 2016 Nov 29.

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci.
Jones GT, Tromp G, Kuivaniemi H, Gretarsdottir S, Baas AF, Giusti B, Strauss E, Van't Hof FN, Webb TR, Erdman R, Ritchie MD, Elmore JR, Verma A, Pendergrass S, Kullo IJ, Ye Z, Peissig PL, Gottesman O, Verma SS, Malinowski J, Rasmussen-Torvik LJ, Borthwick KM, Smelser DT, Crosslin DR, de Andrade M, Ryer EJ, McCarty CA, Böttinger EP, Pacheco JA, Crawford DC, Carrell DS, Gerhard GS, Franklin DP, Carey DJ, Phillips VL, Williams MJ, Wei W, Blair R, Hill AA, Vasudevan TM, Lewis DR, Thomson IA, Krysa J, Hill GB, Roake J, Merriman TR, Oszkinis G, Galora S, Saracini C, Abbate R, Pulli R, Pratesi C, Saratzis A, Verissimo AR, Bumpstead S, Badger SA, Clough RE, Cockerill G, Hafez H, Scott DJ, Futers TS, Romaine SP, Bridge K, Griffin KJ, Bailey MA, Smith A, Thompson MM, van Bockxmeer FM, Matthiasson SE, Thorleifsson G, Thorsteinsdottir U, Blankensteijn JD, Teijink JA, Wijmenga C, de Graaf J, Kiemeney LA, Lindholt JS, Hughes A, Bradley DT, Stirrups K, Golledge J, Norman PE, Powell JT, Humphries SE, Hamby SE, Goodall AH, Nelson CP, Sakalihasan N, Courtois A, Ferrell RE, Eriksson P, Folkersen L, Franco-Cereceda A, Eicher JD, Johnson AD, Betsholtz C, Ruusalepp A, Franzén O, Schadt EE, Björkegren JL, Lipovich L, Drolet AM, Verhoeven EL, Zeebregts CJ, Geelkerken RH, van Sambeek MR, van Sterkenburg SM, de Vries JP, Stefansson K, Thompson JR, de Bakker PI, Deloukas P, Sayers RD, Harrison SC, van Rij AM, Samani NJ, Bown MJ.
Circ Res. 2017 Jan 20;120(2):341-353. doi: 10.1161/CIRCRESAHA.116.308765. Epub 2016 Nov 29.

Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data.
Mosley JD, van Driest SL, Wells QS, Shaffer CM, Edwards TL, Bastarache L, McCarty CA, Thompson W, Chute CG, Jarvik GP, Crosslin DR, Larson EB, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Denny JC, Roden DM.
Circ Cardiovasc Genet. 2016 Dec;9(6):521-530. doi: 10.1161/CIRCGENETICS.116.001530. Epub 2016 Oct 25.

Analysis of CYP1B1 in pediatric and adult glaucoma and other ocular phenotypes.
Reis LM, Tyler RC, Weh E, Hendee KE, Kariminejad A, Abdul-Rahman O, Ben-Omran T, Manning MA, Yesilyurt A, McCarty CA, Kitchner TE, Costakos D, Semina EV.
Mol Vis. 2016 Oct 17;22:1229-1238. eCollection 2016.

Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium.
Verma SS, Cooke Bailey JN, Lucas A, Bradford Y, Linneman JG, Hauser MA, Pasquale LR, Peissig PL, Brilliant MH, McCarty CA, Haines JL, Wiggs JL, Vrabec TR, Tromp G, Ritchie MD; eMERGE Network; NEIGHBOR Consortium.
PLoS Genet. 2016 Sep 13;12(9):e1006186. doi: 10.1371/journal.pgen.1006186. eCollection 2016 Sep.

Identification of Four Novel Loci in Asthma in European American and African American Populations.
Almoguera B, Vazquez L, Mentch F, Connolly J, Pacheco JA, Sundaresan AS, Peissig PL, Linneman JG, McCarty CA, Crosslin D, Carrell DS, Lingren T, Namjou-Khales B, Harley JB, Larson E, Jarvik GP, Brilliant M, Williams MS, Kullo IJ, Hysinger EB, Sleiman PM, Hakonarson H.
Am J Respir Crit Care Med. 2017 Feb 15;195(4):456-463. doi: 10.1164/rccm.201604-0861OC.

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.
van 't Hof FN, Ruigrok YM, Lee CH, Ripke S, Anderson G, de Andrade M, Baas AF, Blankensteijn JD, Böttinger EP, Bown MJ, Broderick J, Bijlenga P, Carrell DS, Crawford DC, Crosslin DR, Ebeling C, Eriksson JG, Fornage M, Foroud T, von Und Zu Fraunberg M, Friedrich CM, Gaál EI, Gottesman O, Guo DC, Harrison SC, Hernesniemi J, Hofman A, Inoue I, Jääskeläinen JE, Jones GT, Kiemeney LA, Kivisaari R, Ko N, Koskinen S, Kubo M, Kullo IJ, Kuivaniemi H, Kurki MI, Laakso A, Lai D, Leal SM, Lehto H, LeMaire SA, Low SK, Malinowski J, McCarty CA, Milewicz DM, Mosley TH, Nakamura Y, Nakaoka H, Niemelä M, Pacheco J, Peissig PL, Pera J, Rasmussen-Torvik L, Ritchie MD, Rivadeneira F, van Rij AM, Santos-Cortez RL, Saratzis A, Slowik A, Takahashi A, Tromp G, Uitterlinden AG, Verma SS, Vermeulen SH, Wang GT; Aneurysm Consortium; Vascular Research Consortium of New Zealand, Han B, Rinkel GJ, de Bakker PI.
J Am Heart Assoc. 2016 Jul 14;5(7). pii: e002603. doi: 10.1161/JAHA.115.002603. Erratum in: J Am Heart Assoc. 2018 Feb 2;7(3):.

Identification of genetic interaction networks via an evolutionary algorithm evolved Bayesian network.
Li R, Dudek SM, Kim D, Hall MA, Bradford Y, Peissig PL, Brilliant MH, Linneman JG, McCarty CA, Bao L, Ritchie MD.
BioData Min. 2016 May 10;9:18. doi: 10.1186/s13040-016-0094-4. eCollection 2016.

ePhenotyping for Abdominal Aortic Aneurysm in the Electronic Medical Records and Genomics (eMERGE) Network: Algorithm Development and Konstanz Information Miner Workflow.
Borthwick KM, Smelser DT, Bock JA, Elmore JR, Ryer EJ, Ye Z, Pacheco JA, Carrell DS, Michalkiewicz M, Thompson WK, Pathak J, Bielinski SJ, Denny JC, Linneman JG, Peissig PL, Kho AN, Gottesman O, Parmar H, Kullo IJ, McCarty CA, Böttinger EP, Larson EB, Jarvik GP, Harley JB, Bajwa T, Franklin DP, Carey DJ, Kuivaniemi H, Tromp G.
Int J Biomed Data Min. 2015 Dec;4(1). pii: 113. Epub 2015 Jul 30.

Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network.
Bush WS, Crosslin DR, Owusu-Obeng A, Wallace J, Almoguera B, Basford MA, Bielinski SJ, Carrell DS, Connolly JJ, Crawford D, Doheny KF, Gallego CJ, Gordon AS, Keating B, Kirby J, Kitchner T, Manzi S, Mejia AR, Pan V, Perry CL, Peterson JF, Prows CA, Ralston J, Scott SA, Scrol A, Smith M, Stallings SC, Veldhuizen T, Wolf W, Volpi S, Wiley K, Li R, Manolio T, Bottinger E, Brilliant MH, Carey D, Chisholm RL, Chute CG, Haines JL, Hakonarson H, Harley JB, Holm IA, Kullo IJ, Jarvik GP, Larson EB, McCarty CA, Williams MS, Denny JC, Rasmussen-Torvik LJ, Roden DM, Ritchie MD.
Clin Pharmacol Ther. 2016 Aug;100(2):160-9. doi: 10.1002/cpt.350. Epub 2016 Jun 1.

KNOWLEDGE DRIVEN BINNING AND PHEWAS ANALYSIS IN MARSHFIELD PERSONALIZED MEDICINE RESEARCH PROJECT USING BIOBIN.
Basile AO, Wallace JR, Peissig P, McCarty CA, Brilliant M, Ritchie MD.
Pac Symp Biocomput. 2016;21:249-60

Protocol for the "Implementation, adoption, and utility of family history in diverse care settings" study.
Wu RR, Myers RA, McCarty CA, Dimmock D, Farrell M, Cross D, Chinevere TD, Ginsburg GS, Orlando LA; Family Health History Network.
Implement Sci. 2015 Nov 24;10:163. doi: 10.1186/s13012-015-0352-8.

Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration.
Brilliant MH, Vaziri K, Connor TB Jr, Schwartz SG, Carroll JJ, McCarty CA, Schrodi SJ, Hebbring SJ, Kishor KS, Flynn HW Jr, Moshfeghi AA, Moshfeghi DM, Fini ME, McKay BS.
Am J Med. 2016 Mar;129(3):292-8. doi: 10.1016/j.amjmed.2015.10.015. Epub 2015 Oct 30.

Comparing Mammography Abnormality Features to Genetic Variants in the Prediction of Breast Cancer in Women Recommended for Breast Biopsy.
Burnside ES, Liu J, Wu Y, Onitilo AA, McCarty CA, Page CD, Peissig PL, Trentham-Dietz A, Kitchner T, Fan J, Yuan M.
Acad Radiol. 2016 Jan;23(1):62-9. doi: 10.1016/j.acra.2015.09.007. Epub 2015 Oct 26.