Poster Gallery & Presentations

Poster Gallery

Presented at 2017 Society of Biological Psychiatry annual meeting
Serotonin transporter relationships with treatment response to meditation interventions for PTSD
Bishop J, Thuras P, Lee A, Clancy D, Erbes C, Polusney M, Lamberty G, Lim K. Biological Psychiatry 2017; 81(10):S364-365.

Presented at 2017 American College of Neuropsychopharmacology annual meeting
Epigenetic relationships with response to mindfulness based stress reduction for PTSD
Bishop J, Lee A, Mills L, Thuras P, Erbes C, Polusny M, Lamberty G, Lim K. Neuropsychopharmacology 2017; 42 S111–S293.

Presented at 2017 International Congress on Schizophrenia Research annual meeting
Genetic analyses of cognitive performance in psychotic disorders from the bipolar-schizophrenia network on intermediate phenotypes (B-SNIP) consortium
Bishop JR, Hill SK, Mills LJ, Alliey-Rodriguez N, Reilly JL, Shafee R, McCarroll S, Keefe R, Pearlson G, Clementz B, Tamminga C, Keshavan M, Gershon E, Sweeney J. Schizophrenia Bulletin 2017 43(suppl_1):S245.

For the DeKAF Genomics Investigators Tacrolimus Dose Variability, CYP3A5 Genotype, and Acute Rejection in African American and European American Kidney Transplant Recipients. 
Seibert S, Schladt D, Wu B, Guan W, Dorr C, Berglund D, Remmel R, Matas A, Mannon R, Israni A, Oetting W, Jacobson P, Am J Transplant. 2017;17 (suppl 3).

For the DeKAF Genomics Investigators Personalized Tacrolimus (TAC) Dosing Using Genetic Variants in Caucasian Kidney Transplant (Tx) Recipients.
Margraf D, Brundage R, Schladt D, Guan W, Wu B, Remmel R, Dorr C, Berglund D, Mannon R, Matas A, Oetting W, Israni A, Jacobson P, Am J Transplant. 2017;17 (suppl 3).

 Identification of common genetic variants associated with variability in tacrolimus troughs using a genome wide association study.  
Oetting WS, Schladt DP, Guan W, Remmel RP, Wu B, Matas AJ, Mannon RB, Israni AK, Jacobson PA for DeKAF Genomics and GEN-03. Scientific Meeting of the Human Genome Variation Society, Copenhagen, Denmark, 2017. Oral Presentation.

Tacrolimus troughs in Caucasians with two CYP3A5 loss-of-function alleles: Evidence for additional genetic influences using a genome wide association study.  
Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Mannon RB, Matas AJ, Israni AK, Jacobson PA.  European Society of Human Genetics Annual Meeting, Copenhagen, Denmark, 2017. Poster.

Rare variation associated with immunosuppressant drug concentrations: Moving beyond common SNPs in predicting drug metabolism. 
Seyerle AA, Schladt D, Guan W, Remmel R, Oetting WS, Dorr C, Wu B, Israni A, Jacobson PA.  Annual Meeting of the American Society of Human Genetics, Orlando, FL, October 2017. Poster 1957w. 

Genome wide association study (GWAS) of tacrolimus trough concentrations in Caucasian kidney allograft recipients.  
Oetting WS, Wu B, Schladt DP, Guan W, Remmel RP, Mannon RB, Matas AJ, Israni AK, Jacobson PA.  Pharmacogenomics Research Network (PGRN) – Pharmacogenomics Poster Session at ASHG 2017.  Orlando, FL, 2017.

Personalizing Medication Decision Making: An Exploration of Commercial europsychiatric Pharmacogenomic Panels. 
Rivers Z, Jacobson PA, Schommer J, Zierhut H, Felton T, Bishop J.  Pharmacogenomics Research Network (PGRN) – Pharmacogenomics Poster Session at ASHG 2017.  Orlando, FL, 2017.

Genome wide association meta-analysis for acute rejection of kidney transplants.  
Israni A, Jacobson PA, Guan W, Dorr C, DeBorst MH, Stapleton CP, Phelan PJ, Conlon PJ, Birdwell K, Bakker SJ, Cavalleri G, Oetting WS, Schladt DS, Van Setten J, Kwok P, Eikmans M, Snieder H, Wu B, Bassaganyas L, Yang J, Van der most P, Asselbergs FW, Keating B.  American Society Nephrology, 2017, Poster. October 18, 2017.ABSTRACT: SA-PO478

Coverage of Pharmacogenomic Tests among Minnesota Health Insurance Plans.
Fikru B, Salsabili M, Rivers Z, Jacobson P, Schondelmeyer SW. ISPOR 21st Annual International Meeting.  Washington DC. May 21-26, 2016.  Poster 

Differences in tacrolimus troughs and doses between Caucasians and African Americans with two CYP3A5 loss-of-function alleles: Looking beyond CYP3A5 expression.  
Oetting WS, Schladt DP, Guan W, Remmel RP, Dorr C, Sanghavi K, Matas AJ, Mannon RB, Israni AK, Jacobson PA for DeKAF Genomics & GEN-03 Investigators.  The American Transplant Congress, Boston, MA, 2016. American Journal of Transplantation Sup 3, 16:C251, 2016.  (Poster of Distinction)

Clinical outcomes of kidney allograft recipients with Apolipoprotein L1 (APOL1) risk alleles from living kidney donors.  
Dorr C, Hart A, Schladt D, Muthusamy A, Mannon RB, Oetting W, Matas A, Jacobson P, and Israni A for DeKAF Genomics & Gen-03 study.  The American Transplant Congress, Boston, MA, 2016. American Journal of Transplantation Sup 3, 16:C141, 2016.  (Poster of Distinction)

Marked alterations in gene expression in peripheral blood leukocytes of kidney transplant (tx) recipients following mycophenolic acid (MPA) treatment.  
Sanghavi K, Wu B, Dorr C, Muthuswamy A, Guan W, Schladt D, Remmel R, Ilke D, Matas A, Scherer S, Israni A, Oetting W, Jacobson P.  The American Transplant Congress, Boston, MA, 2016. American Journal of Transplantation Sup 3, 16:D264, 2016.  (Poster of Distinction)

High-Risk Pharmacogenetic Variants in Kidney Transplant (tx) Recipients.  
Berglund D, Schladt D, Sanghavi K, Guan W, Wu B, Dorr C, Remmel RP, Mannon RB, Matas AJ, Oetting WS, Israni A, Jacobson PA for DeKAF Genomics Investigators.  The American Transplant Congress, Boston, MA, 2016. American Journal of Transplantation Sup 3, 16:259, 2016.  (Oral Presentation)

Effect of genetic variants changes over time posttransplant on tacrolimus concentrations.  
Wu B, Guan W, Schladt D, Sanghavi K, Dorr C, Muthuswamy A, Remmel R, Mannon R, Matas A, Israni A, Oetting W, Jacobson PA.  Presented at the 66th Annual meeting of the American Society of Human Genetics, October 18, 2016. Vancouver CA. Poster.

Presented at 2015 American College of Neuropsychopharmacology
Antipsychotic pharmacogenomics: neuronal development, neurotransmission, and glutamate gene associations with treatment response
Jeffrey R. Bishop1, Matcheri S. Keshavan8, , James M. Stevenson2, James L. Reilly3, John A. Sweeney9

Presented at the 2015 Annual Meeting of the American Society of Clinical Pharmacology and Therapeutics, New Orleans, LA.
Single dose pharmacokinetics of atomoxetine in children with attention deficit hyperactivity disorder stratified by their CYP2D6 activity score.
Brown JT, Abdel-Rahman SM, van Haandel L, Gaedigk A, Leeder JS.

Presented at The American College of Clinical Pharmacy (ACCP) meeting 2015
Uric Acid Lowering Effect of Allopurinol in Minnesota Hmong Adults with Hyperuricemia or Gout
Youssef M. Roman, PharmD1, Kathleen A. Culhane-Pera, M.D.,M.A.2, Shoua Yang, B.S.2, John Yang, B.S.2, Muaj C. Lo, M.D.2, Robert J. Straka, PharmD1
1. Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN
2. West Side Community Health Services, St. Paul, MN

Scattome: A Single-Cell Analysis of Targeted Transcriptome Program to Predict Drug Sensitivity of Single Cells within Human Myeloma Tumors.
Amit Kumar Mitra, Ujjal Mukherjee, Taylor Harding, Holly Stessman, Ying Li, Jen Jin, Shaji K Kumar, S. Vincent Rajkumar, Brian G Van Ness (2015)Abstract. Blood 126:4249.

Single-Cell Transcriptomics Identifies Intra-Tumor Heterogeneity in Human Myeloma Cell Lines.
Amit Kumar Mitra, Holly Stessman, Michael A. Linden and Brian Van Ness. (2014) Abstract. Blood 124:3385.

Poster at American Transplant Congress, May 2015
Developing a tacrolimus dosing equation for African American kidney transplant recipients using genetic variants and clinical factors.
Kinjal Sanghavi1 MPharm, Richard Brundage1 PharmD, PhD, Michael Miller2 PhD, David Schladt3 MS, Ajay K. Israni3 MS, MD, Weihua Guan4 PhD, William S Oetting1 PhD, Rosalyn Mannon5 MD, Rory P Remmel1 PhD, Arthur Matas6 MD, Pamala A Jacobson1 PharmD for DeKAF Investigators. 1College of Pharmacy, University of Minnesota, 2 Dept. of Psychology, University of Minnesota, 3Hennepin County Medical Center, Minneapolis Medical Research Foundation and Dept. of Nephrology, University of Minnesota, 4Dept. of Biostatistics, University of Minnesota,5Dept. of Nephrology, University of Alabama, 6Dept. of Surgery, University of Minnesota. 

 

Variants associated with tacrolimus troughs in European American kidney transplant recipients: A genome wide association study
Jacobson PA1; Miller MB2, Schladt D3, Israni A4, Sanghavi K1, Dorr C4, Remmel RP5, Guan W6; Matas AJ7; Oetting WS1 for the DeKAF and GEN03 investigators. 1Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, 2Department of Psychology, University of Minnesota,  3Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minnesota,  4Department of Nephrology, Hennepin County Medical Center and University of Minnesota, 5Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota,  6Department of Biostatistics, University of Minnesota  7Department of Surgery, University of Minnesota. 

 
Poster at ACCP Global Conference on Clinical Pharmacy, Oct 2015
Pharmacodynamic Monitoring of Mycophenolic Acid in Allogeneic Nonmyeloablative Hematopoietic Cell Transplantation. Deeter R. Neumann, PharmD Candidate1, Kinjal Sanghavi, M Pharm1, Anthony C. Wiseman, MD2, and Pamala A. Jacobson, PharmD1. 1College of Pharmacy, University of Minnesota, Minneapolis, MN; 2Department of Internal Medicine, Baylor College of Medicine, Houston, TX. 


Creation of a Gene Expression Signature-Based Prediction Model Specific to Proteasome Inhibitor Response in Multiple Myeloma.
Amit Kumar Mitra, Ujjal Mukherjee, Taylor Harding, Snigdhansu Chatterjee, Brian G Van Ness (2015) Abstract. Blood 126:3053.

Comparative Analysis of in Vitro Chemosensitivity to Four Proteasome Inhibitors in Human Myeloma Cell Lines.
Amit Kumar Mitra, Taylor S Harding, Brian Van Ness (2014)Abstract. Blood 124:3436.

Generation of a Predictive Score for Ixazomib Response in Multiple Myeloma.
Amit Kumar Mitra, Sanjoy Dey, Andrew Hangsleben, Michael Steinbach, Vipin Kumar and Brian Van Ness. (2014)  Abstract. Blood 124:5695.
Poster at annual meeting of American Society of Hematology (ASH)- Dec 2014.


Phosphoramide Mustard (PM) Population Pharmacokinetics to Estimate Inter-Individual Variability in Exposure and Identify Clinical Factors Associated with Variability After Reduced Intensity Conditioning (RIC). 
Kinjal Sanghavi, M Pharm1, Anthony C. Wiseman, MD2, Mark Kirstein, PharmD1, Richard Brundage, PharmD, PhD1, and Pamala A. Jacobson, PharmD1 1College of Pharmacy, University of Minnesota, Minneapolis, MN; 2Department of Internal Medicine, Baylor College of Medicine, Houston, TX .

Association of Phosphoramide (PM) and Fludarabine (FLU) Pharmacokinetics with Treatment Related Mortality (TRM) after Reduced Intensity Conditioning (RIC) Hematopoietic Cell Transplantation (HCT).  
Anthony C. Wiseman, MD1, Kinjal Sanghavi, M Pharm2, Qing Cao, MS3, Claudio G Brunstein, MD4,Erica D. Warlick, MD4, John Rogosheske, PharmD5, Andy Kurtzweil, PharmD5, Daniel J. Weisdorf, MD4 , and Pamala A. Jacobson, PharmD2 1Department of Internal Medicine, Baylor College of Medicine, Houston, TX; 2College of Pharmacy, University of Minnesota, Minneapolis, MN; 3Biostatistics, Masonic Cancer Center, Minneapolis, MN; 4Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN; 5Department of Pharmacy, U of MN Medical Center, Minneapolis, MN.

Pharmacokinetic Modeling of Fludarabine to Control Exposure and Improve Outcomes after Reduced Intensity Conditioning Transplantation.
 Kinjal Sanghavi, M Pharm1, Anthony C. Wiseman, MD2, Qing Cao, MS3, Claudio G Brunstein, MD4, Erica D. Warlick, MD4, Richard Brundage, PharmD PhD1, John Rogosheske, PharmD5, Andy Kurtzweil, PharmD5, John E. Wagner, MD6, Daniel J. Weisdorf, MD4 and Pamala A. Jacobson, PharmD1 1College of Pharmacy, University of MN, Minneapolis, MN; 2 Department of Internal Medicine, Baylor College of Medicine, Houston, TX; 3Biostatistics, Masonic Cancer Center; 4Hematology, Oncology and Transplantation, University of MN; 5Department of Pharmacy, U of MN Medical Center, Minneapolis, MN, 6Pediatric Blood and Marrow Transplant Program, University of MN.

Presented at American Society of Hematology, December 9, 2014
Single-Cell Transcriptomics Identifies Intra-Tumor Heterogeneity In Human Myeloma Cell Lines
Amit Kumar Mitra1, Holly Stessman2, Michael A. Linden3 and Brian G. Van Ness1,4

  1. Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN; 
  2. Department of Genome Sciences, University of Washington, Seattle, WA; 
  3. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN; 
  4. PUMA-Institute of Personalized Medicine, College of Pharmacy, University of Minnesota, Minneapolis, MN.

Comparative Analysis Of In Vitro Chemosensitivity To Four Proteasome Inhibitors In Human Myeloma Cell Lines
Amit Kumar Mitra, Taylor S. Harding, Brian G. Van Ness
Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN

Multi-gene Pharmacogenomics of Tacrolimus Troughs in Kidney Transplant Recipients
RA Pulk1, PA Jacobson1, D Schladt2, A Israni2, A Matas3, W Guan5, W Oetting1 for theDEKAF Investigators
1Expermimental and Clinical Pharmacology, U of MN, 2Minneapolis Medical Research Foundation, Hennepin County Medical Center 3Department of Nephrology, Hennepin County Medical Center, 5Biostatistics, U of MN, 4Department of Surgery, U of MN, Minneapolis, MN
Poster Presented at the World Transplant Congress, July 2014 San Francisco

Population pharmacokinetics of fludarabine (f-ara-a) in Hematopoietic cell transplant (hct) patients
Kinjal Sanghavi, M., Pamala Jacobson, Kyle Jensen, Richard Brundage, Janel Long Boyle, Mark Kirstein 
Department of Experimental And Clinical Pharmacology, University of Minnesota, Minneapolis.

Pharmacogenomic Investigations in the Hmong: CYP2C19 Single Nucleotide Polymorphisms (SNPs) as Predictors of Drug Response
Jenny Xiong1, Youssef Roman1, Kathleen Culhane-Pera2, Robert Straka1
1Experimental and Clinical Pharmacology Department, College of Pharmacy, University of Minnesota, Minneapolis MN; 2East Side Family Clinic, West Side Community Health Services, St. Paul MN

Higher Prevalence of Risk Alleles for Hyperuricemia Parallels Elevated Incidence of Gout and Growing Risk for Cardiovascular Diseases in a Hmong Population
Youssef Roman1, Jenny Xiong1, Kathleen Culhane-Pera2, Robert Straka1
1Experimental and Clinical Pharmacology, College of Pharmacy, Minneapolis, MN,2 East Side Family Clinic, St. Paul, MN

Pathway-Based Pharmacogenomics Of Gemcitabine Pharmacokinetics In Patients With Solid Tumors
Amit K. Mitra1, Mark N. Kirstein1,2,4, Amit Khatri1, Keith M. Skubitz3,4, Arkadiusz Z. Dudek3,4, Edward W. Greeno3,4, Robert A. Kratzke3,4, Jatinder K. Lamba1,2,4
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN; 2. PUMA-Institute of Personalized Medicine, College of Pharmacy, University of Minnesota, Minneapolis, MN; 3. Division of Hematology, Oncology and Transplantation, School of Medicine, University of Minnesota, Minneapolis, MN; 4..Masonic Comprehensive Cancer Center, University of Minnesota Minneapolis, Minnesota

Identification And Functional Genomic Analysis Of Genetic Variants Of Nt5c2
Amit K Mitra1, Kristine Crews2, Christine Hartford2, Stanley Pounds2, Xueyuan Cao2, Jeffrey Rubnitz2, Raul Ribeiro2, M. Eileen Dolan3, and Jatinder K Lamba1 
1University of Minnesota, Minneapolis, MN, United States, 2St. Jude Children's Research Hospital, Memphis, TN, United States and 3University of Chicago, Chicago, IL, United States.

Association Of Carbamazepine Metabolism Pathway Gene Polymorphisms And Pharmacokinetics In Patients With Epilepsy
Yogita Ghodke Puranik, Angela K Birnbaum, Susan E Marino, Ghada Ahmed, James C Cloyd, Rory P Remmel, Ilo E Leppik, and Jatinder K Lamba, International Society for the Study of Xenobiotics 18th North American Regional Meeting, Dallas TX.

Oral Presentations

Ajay Israni: "Pharmacogenomics of transplant immunosuppression and association with transplant outcomes.”  The American Transplant Congress,  Boston, MA.  6/15/2016

Jeffrey Bishop: "Psychiatry pharmacogenomics." University of Florida Precision Medicine Conference 3/11/2016

Jeffrey Bishop: "Pharmacogenomics: insights and opportunities." University of Minnesota Clinical and Translational Science Institute 4/14/2016

Jeffrey Bishop: Psychiatry and neurology pharmacogenomics: implications for patient care and resources for implementation. College of Psychiatric and Neurologic Pharmacists Annual Meeting 4/19/2016

Jacob Brown: Pharmacogenomics and Public Health. Duluth Area Pharmacists Meetings, Duluth, MN, April 21st, 2015

Jacob Brown: Clinical Perspectives of Pharmacogenetics. Minnesota Society of Health-System Pharmacists, Duluth, MN, November 13th, 2014.