Pharmacogenomics Conference 2018

Genomic Testing to Individualize Drug Therapy

The 2018 Pharmacogenomics Confernece on June 22 was at capacity with over 310 registrants in attendance.  Topics included: cancer somatic mutations and selection of targeted therapies, emerging PGx areas such as analgesics and how to apply PGx in minority populations, clinical PGx guidelines, use of PGx in children, implementation of PGx in practice settings, insurance reimbursement, and evidence for cost effectiveness and improved quality of care.  Participants were given the opportunity to have personal PGx testing done by OneOme and received their results at check-in.

Stay tuned for information on our next PGx Conference - date TBD.

Introductions and Keynote

Pamala JacobsonIntroduction to the Day (link to video)
Pamala Jacobson, PharmD, FCCP, Conference Chair
Professor and Director of the Institute of Personalized Medicine
College of Pharmacy, University of Minnesota, Minneapolis

Dean Lynda WelageWelcome (link to video)
Lynda Welage, PharmD
Professor and Dean
College of Pharmacy, University of Minnesota, Minneapolis

Julie JohnsonKeynote
Improving Clinical Outcomes Through Pharmacogenomics (link to video)
Julie A. Johnson, PharmD
Dean and Distinguished Professor, College of Pharmacy
University of Florida, Gainesville

Morning Sessions

Precision Medicine in Cancer

The last decade has been an exciting era for cancer medicine. Speakers will discuss how genetic markers have transformed the treatment of breast cancer. They will also address how somatic tumor mutation information is powerfully guiding targeted drug therapy selection for patients and showing tumor responses in diseases never thought possible. Immunotherapies have emerged into clinical care nearly overnight and biomarkers predicting response are moving into clinical care.   


Mark KirsteinMark Kirstein, PharmD, Associate Professor,
Experimental and Clinical Pharmacology,
College of Pharmacy, University of Minnesota, Minneapolis



Douglas Yee"Precision Medicine In Early Stage Breast Cancer: The I-SPY 2 Experience (link to video)
Douglas Yee, MD
Director of the Masonic Cancer Center
Professor of Medicine and Pharmacology
Medical Oncologist, University of Minnesota, Minneapolis

David StenehjemUsing Genetic Biomarkers for Selection of Targeted Cancer Therapies (link to video)
David Stenehjem, PharmD, BCOP
Assistant Professor,
Department of Pharmacy Practice and Pharmaceutical Sciences
College of Pharmacy, University of Minnesota, Duluth

Shilpa GuptaImmunotherapy in the Precision Medicine Era; Profiling to Predict Responsiveness (link to video)
Shilpa Gupta, MD
Assistant Professor of Medicine
Division of Hematology, Oncology and Transplantation
Lead, Phase 1 Interdisciplinary Solid Tumor Program
Medical School, University of Minnesota, Minneapolis

Emerging Areas in Pharmacogenomics

Amidst the backdrop of a nationwide opioid epidemic, the need for improving pain management medicine has never been greater. Our first speaker will discuss of the role of  pharmacogenomics to advance precision medicine in pain management with considerations for research and clinical care.  Additionally, our growing understanding of genetic diversity has raised awareness about the importance of conducting discovery and clinical pharmacogenomic studies in diverse populations. Our second speaker will talk about this important area and how to advance the field by appropriately examining data from multiethnic study samples.


Jeffrey BishopModeratorJeffrey Bishop, PharmD, FCCP,
Associate Professor, Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis


Gillian BellChallenges of Studying Pharmacogenomics in Pain Management; Navigating the Genetic and Behavioral Determinants of Analgesia (link to video)
Gillian C. Bell, PharmD
Clinical Pharmacist, Personalized Medicine Program
Fullerton Genetics Center, Mission Health
Asheville, NC

Jason KarnesMultiethnic Populations and Precision Medicine:  Managing the Lack of Genetic Data and Clinical Studies (link to video)
Jason Karnes, PharmD, PhD, BCPS
Assistant Professor, Pharmacy Practice and Science
University of Arizona, College of Pharmacy Tucson, AZ


Lunch Session

Lunch and Review of Conference Participant Pharmacogenomic Test Results

Who would have predicted 30 years ago that genetic information would predict response or toxicity to medications? It is well-known that drug failure is high for many classes of agents.  PGx research has made progress in addressing this problem and now dozens of companies offer PGx testing for clinical care.

Participants will be given the opportunity to obtain personal PGx testing for some of the commonly tested variants.  Conference participants will be tested prior to the conference and receive the results at conference check-in.  The clinical implications for the most common variants identified in conference participants will be discussed over lunch.

Moderators: Pamala Jacobson, PharmD, Jacob Brown, PharmD and Brian VanNess, PhD

Afternoon Sessions

Translating Pharmacogenomic Research into Evidence Based Medication and Dose Recommendations

Speakers will discuss the process of developing Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines and pharmacogenomic information found in the package insert.  CPIC is an international consortium facilitating the use of pharmacogenetic tests for children and adults. The FDA Table of Pharmacogenomic Biomarkers in Drug Labeling also contains drug-gene information for nearly 200 drug-gene pairs. However, for many medications or patient populations no guidelines exist. Our speakers will discuss the guidelines and how to apply PGx when no guideline exists.  


Jacob BrownJacob Brown, PharmD, Assistant Professor,
Dept of Pharmacy Practice and Pharmaceutical Sciences
College of Pharmacy, University of Minnesota, Duluth


Kelly CaudleCreation of CPIC Guidelines and Drug Labeling Information to Guide PGx Prescribing and How to Approach Drugs Without Formal Guidelines (link to video)
Kelly Caudle, PharmD, PhD, BCPS
CPIC Director, St Jude Children’s Research Hospital
Department of Pharmaceutical Sciences Memphis, TN

GregornikApplying Pharmacogenomic Testing to Children; Overcoming Limited Pediatric Data and Adult Centered Guidelines (link to video)
David Gregornik, PharmD, BCOP
Pharmacogenomics Program Leader
Childrens Hospitals and Clinics Minnesota, Minneapolis

Implementation of Pharmacogenomics in the Real World Setting

As the evidence supporting the clinical significance of genomic-guided drug therapy grows, the importance of establishing the genoeconomic value increases.  Studies which explore the cost-effectiveness or cost-utility of implementing pharmacogenomics will become central determinants of the rate and extent of uptake and implementation of pharmacogenomics in the real-world setting. This section of the program will review key issues to be considered when evaluating the feasibility and impact of implementing pharmacogenomic-guided drug therapy.  


Robert StrakaRobert Straka, PharmD, FCCP, Professor and Department Head Experimental and Clinical Pharmacology,
College of Pharmacy, University of Minnesota, Minneapolis


Mark DunnenbergerImplementation of Pharmacogenomic Testing and a Clinical Service; The NorthShore Experience (link to video)         
Henry ‘Mark’ Dunnenberger, PharmD
Director - Pharmacogenomics
NorthShore University HealthSystem
Center for Molecular Medicine Evanston, Illinois

Diana BrixnerInsurance Reimbursement and the Payer Perspective on Pharmacogenomics (link to video)
Diana I. Brixner, PhD, RPh, FAMCP
Professor, Department of Pharmacotherapy
Executive Director, Outcomes Research Center
Director of Outcomes, Program in Personalized Health Care
University of Utah, Salt Lake City

Concluding Remarks (link to video)

Pamala Jacobson, PharmD, FCCP

Precision Medicine Conference 2018

Conference Presentation Videos and Program


OneOme conducted PGx testing and results of PGx panels were available for pickup on the day of the conference.

Target Audience

Healthcare providers and translational and clinical scientists


Department of Experimental and Clinical Pharmacology and College of Pharmacy, University of Minnesota

Planning Committee

Graduate Students and Staff

Samuel Callisto, BA, Experimental and Clinical Pharmacology Graduate Program

Zachary Rivers, PharmD, Social and Administrative Graduate Program

Summer (Dao) Tran, PharmD, Social and Administrative Pharmacy Program (SAPH)

Jay (Ya-Feng) Wen, PharmD, Experimental and Clinical Pharmacology Graduate Program

Mary Moreno Lien, PGx Conference Coordinator

Danielle Carrigan, E-Communications Specialist

Jessica Ward-Dennison, Coordinator, College of Pharmacy