Preformulation Services

Contact CDD

612-626-3545

prabh025@umn.edu

  1. Solubility
  2. Chemical Stability Profile – Temperature, pH and solvent system
  3. Solid state stability
  4. Solution phase stability
  5. Excipient compatibility
    1. Thin layer chromatography
    2. Diffuse reflectance spectroscopy
    3. Differential scanning calorimetry and Thermogravimetric analysis
  6. Physical characterization – crystalline/amorphous, degree of crystallinity, polymorphic forms, state of solvation
  7. Particle size, shape and surface area
  8. Specifications for new drug substances and related substances
  9. Crystal engineering for superior pharmaceutical properties of drugs (e.g., the development of a crystal structure–mechanical property relationship based on molecular modeling, crystallography, and nano-indentation)
  10. Particle engineering for enhancing powder properties through controlled processes, such as crystallization, milling, and nano-coating
  11. Isolation and characterization of various solid forms, e.g., glasses, salts, cocrystals, and polymorphs, of drugs and excipients based on a thorough understanding of thermodynamics and kinetics of amorphization and crystallization phenomena
  12. Understanding and improving solid-state stability of drugs or excipients during processing and storage (e.g., glass to crystal, crystal to glass, and one polymorph to another)
  13. Rational design of high-quality solid dosage forms based on physico-mechanical properties of drug, excipients, and their interactions in a powder mixture.