Research Projects

There is an urgent need for research into the mechanisms underlying cognition and for the development of strategies that predict the drug responses of individual patients.

Drug Effects on Cognition bubble map

Characterizing and Predicting Drug Effect on Cognition

The objective of this proposal is to elucidate the relationship among TPM exposure as measured by plasma drug levels, its neurophysiological effects, and consequent effect on cognition and linguistic behavior.

2012-2017 NH/NINDS R01NS076665
PI: Susan Marino

Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs

The proposed studies study several populations of women with and without epilepsy in order to compare the effect of antiepileptic drug exposure on the woman and child during pregnancy.  This is a multi clinical site proposal involving approximately 20 sites across the US. This is the clinical grant for MONEAD.

2012-2017 (MONEAD) (U01 NS038455-11A1)
PIs: Kimford Meador, Page Pennell, 2U01 NS050659-06A1 PI: Nancy Browning NINDS/NICHD - $13,105,969 Pharmacokinetics Core Director/U of MN PI: Angela Birnbaum,

Vaccines for Prescription Opioid and Heroin Abuse

The purpose of this proposal is to work toward submission of an IND toward a commercial vaccine product. Dr. Birnbaum's laboratory is involved in measurement of pharmacokinetic samples in this study and as the pharmacological core.

2015-2018
PI: Paul Pentel

Shimadzu Scientific Instruments Grant

2012
PI: Angela Birnbaum

Cognitive Effects of Vinpocetine in Healthy Adults & Epilepsy Patients: Assay Validation

2014-2016 Stanford University
PI: Susan Marino

Cognitive and Motor Effects of Treatment with a Calcineurin Inhibitor (Tacrolimus) versus Belatacept in Kidney Transplant Patients

2013-2015 Bristol Myers Squibb
PI: Marino

Longitudinal Analysis of Spoken Language Characteristics in the Nun Study

2013-2014 (NIH/NIA R03 AG045476)
Co-PI: Serguei Pakhomov

Professional Fighters Brain Health Study

2012-2014 (Center for Brain Health/Cleveland Clinic)
PI: Susan Marino

Automated Semantic Indices for Early Detection of Cognitive Changes

2012-2014 (Alzheimer’s Association DNCFI-12-242985)
PI: Serguei Pakhomov