Publications

Publications

SPR Bathena, IE Leppik, AM Kanner, AK Birnbaum, Changes in Antiseizure, Antidepressant, and Antipsychotic Medication Prescribing in Elderly Nursing Home Residents, Submitted 2015.

Lim CN, Birnbaum AK, Brundage RC, Leppik IE, Cloyd JC, Clark A,  Marino SE, Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling of Intravenous and Oral Topiramate and its Effect on the Symbol Digit Modalities Test in Adult Healthy Volunteers,  Journal Clinical Pharmacology, in press 2015.

Patel SI, Birnbaum AK, Cloyd JC, Leppik IE, IV and IM Formulations of Antiepileptic Drugs in the Treatment of Epilepsy, CNS Drugs, in press, 2015.

Polepally AR, Remmel RP, Brundage RC, Leppik IE, Rarick JO, Ramsay RE,  Birnbaum AK, Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology, J Clin Pharmacol. 2015 Apr 23. doi: 10.1002/jcph.522. [Epub ahead of print].

Pakhomov, S., Marino, S., Banks, S., Bernick, C. (2015). Using Automatic Speech Recognition to Assess Spoken Responses to Cognitive Tests of Semantic Verbal Fluency. Speech Communication. (in-press).

Ahmed, G.F., Marino, S.E., Brundage, R.C., Pakhomov, S.V., Leppik, I.E., Cloyd, J.C., Clark, A., Birnbaum, A.K. (2015). Pharmacokinetic-pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers. British Journal of Clinical Pharmacology; 79(5):820-30.

Pakhomov, S., Jones, D.T., Knopman, D. (2014). Language Networks Associated with Computerized Semantic Indices. NeuroImage; 104:125-37.

Pakhomov, S., Hemmy, L. (2014). A computational linguistic measure of clustering behavior on semantic verbal fluency task predicts risk of future dementia in the Nun Study. Cortex; 55:97-106.

Leppik IE, Birnbaum AK, Treating epilepsy in the elderly: more art than science, Cleveland Clinical Journal of Medicine (CCJM), 81(8):499-500, Aug 2014PMID: 25085988.

Polepally AR, Pennell PB, Brundage RC, Stowe ZN, Newport DJ, Viguera AC, Ritchie JC, Birnbaum AK, Model-Based Lamotrigine Clearance Changes During Pregnancy: Clinical Implication. Annals of Clinical and Translational Neurology 1(2):99-106, Feb 2014. PMID: 24883336, PMCID: PMC4038031.

Conway JM^, Birnbaum AK^*, Leppik IE, Pennell PB, White JR,  Rarick JO, Remmel RP, Safety of an Intravenous Formulation of Lamotrigine, Seizure. 23(5):390-392, May 2014. PMID: 24560492, PMCID:PMC4023538 .

Pakhomov, S., Marino, S., Birnbaum, AK. (2013). “Quantification of Speech Dysfluency as a Marker of Medication-Induced Cognitive Impairment: An Application of Computerized Speech Analysis in Neuropharmacology.” Computer Speech and Language. 27(1):116-134

Ghodke-Puranik Y, Thorn CF, Lamba JK, Leeder JS, Song W, Birnbaum AK, Altman RB, Klein TE. Valproic acid pathway: pharmacokinetics and pharmacodynamics Pharmacogenetics and Genomics. 23(4):236-241, Apr 2013. PMID:23407051 , PMCID: PMC3696515.

Ahmed GF, Brundage RC, Marino SE, Cloyd JC, Leppik IL, Pennell PB, RE Ramsay,  Birnbaum AK. Population Pharmacokinetics of Unbound and Total Drug Concentrations Following Intravenously Administered Carbamazepine in Adults and Elderly Patients. Journal of Clinical Pharmacology. 2013 Mar;53(3):276-84. doi: 10.1002/jcph.8. Epub 2013 Feb 13. PMID:23408495

Raleigh MD, Pravetoni M, Harris AC, Birnbaum AK, Pentel PR. Selective effects of a morphine conjugate vaccine on heroin and metabolite distribution and heroin-induced behaviors in rats. Journal of Pharmacology and Experimental Therapeutics 2013 Feb;344(2):397-406. doi: 10.1124/jpet.112.201194. Epub 2012 Dec 7.. PMID: 23220743, PMCID: PMC3558830.

Puranik YG^, Birnbaum AK^, Marino SE^, Ahmed G, Cloyd JC, Leppik IE, Remmel RP, Lamba JK. Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy, The Pharmacogenomics Journal. 2013 Jan;14(1):35-45. doi: 10.2217/pgs.12.180. PMID: 23252947, PMCID: PMC3570048.

Jones JM, Raleigh MD, Pentel PR, Harmon TM, Keyler DE, Remmel RP, Birnbaum AK. Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC-MS assay for delayed analyses of pharmacokinetic samples, Journal of Pharmaceutical and Biomedical Analysis. 2013 Feb 23;74:291-7. doi: 10.1016/j.jpba.2012.10.033. Epub 2012 Nov 15. PMID: 23245263, PMCID: PMC3789381.

Pakhomov, S., Hemmy, L., Lim, K. (2012). “Automated Semantic Indices Related to Cognitive Function and Rate of Cognitive Decline”. Neuropsychologia. 50(9):2165-2175.

Marino, S. Pakhomov, S., Han, S., Anderson, K, Ding, M., Eberly, L. et al. (2012). The Effect of Topiramate Plasma Concentration on Linguistic Behavior, Verbal Recall and Working Memory. Epilepsy and Behavior. 24(3):365-372.

Passey C, Birnbaum AK, Brundage RC, Schladt DP, Oetting WS, Ledue RE, Israni AK,  Guan W, Matas AJ, Jacobson PA. Validation of tacrolimus clearance equation to predict troughs using genetic and clinical factors. The Pharmacogenomics Journal. 2012 Jul;13(10):1141-7. doi: 10.2217/pgs.12.98. PMID: 22909204; PMCID: PMC3579500.

Birnbaum AK, Conway JM, Strege MA, Leppik IE. Variability of carbamazepine and valproic acid concentrations in elderly nursing home residents, Epilepsy Research. 2012 Aug;101(1-2):22-7. doi: 10.1016/j.eplepsyres.2012.02.014. Epub 2012 Mar 30. PMID: 22464175.

Pakhomov SV, McInnes BT, Lamba J, Liu Y, Melton GB, Ghodke Y, Bhis Ne, Lamba V, Birnbaum AK. Using PharmGKB to Train Text Mining Approaches for identifying Potential Gene Targets for Pharmacogenomic Studies, Journal of Biomedical Informatics. 2012 Oct;45(5):862-9. doi: 10.1016/j.jbi.2012.04.007. Epub 2012 May 4. PMID: 22564551

Punyawudho B, Ramsay RE, Macias FM, Collins JF, Brundage RC, Birnbaum AK.  Population Pharmacokinetics of Carbamazepine in Elderly Patients. Therapeutic Drug Monitoring. 2012 Apr;34(2):176-81. doi: 10.1097/FTD.0b013e31824d6a4e. PMID: 22406657; PMCID: PMC3777257.

(Editorial in Pharmacy Times Aug. 9, 2012 – http://www.pharmacytimes.com/news/Does-Age-Change-Carbamazepine-Pharmacokinetics )

Marino SE, Birnbaum AK, Leppik IE, Conway JM, Musib LC, Brundage RC, Ramsay RE, Pennell PB, White JR, Gross CR, Rarick JO, Mishra U,  Cloyd JC. Steady-state Carbamazepine Pharmacokinetics following Oral and Stable-Labeled Intravenous Administration in Epilepsy Patients: Effects of Race and Sex, Clinical Pharmacology & Therapeutics, 2012 Mar;91(3):483-8. doi: 10.1038/clpt.2011.251. Epub 2012 Jan 25.  PMID: 22278332

Conway JM, Birnbaum AK, Marino SE, Remmel RP. A Sensitive Capillary GC-MS Method for Analysis of Topiramate from Plasma Obtained from Single Dose Studies, Biomed Chromatogr. Sep;26(9):1071-6 2012, PMID: 22223467; PMCID: PMC3776594.

 

Non-refereed Journal Articles, Essays, or Book Chapters

Marino G, Marino SE. Germanwings, suicide, and the hidden dangers of antidepressants.  Star Tribune (Commentary), April 10, 2015.

Marino SE.  Medication and memory loss:  It’s not necessarily dementia. Minnesota Health Care News.  March 2015.

Birnbaum AK and Marino SE.  Valproate.  In Wyllie E, Gidal B., Goodkin H, Loddenkempe T., Sirven JI, eds. Wyllie’s Treatment of Epilepsy: Principles and Practice. 6th ed. Philadelphia PA: Lippincott William & Wilkens. March 2015.

Marino GD and Marino SE. Paying Homage to the Silence of Suffering. In: Green RM, Palpant N, eds. Suffering and Bioethics. Oxford, United Kingdom: Oxford University Press; 2014;chap 4

Marino S, Birnbaum A, Pakhomov S. "Assessing the Side Effects." International Innovation. 2014, issue 162, Pages 42-44.

 

Selected Conference Posters

Marino SE, Brittain ST, Pakhomov S.  Topiramate and impaired verbal fluency:  Observations from three different formulations with different input rates.  Presented at: The American Epilepsy Society Annual Meeting, 2014 December 4-8; Seattle WA.

Pakhomov S, Marek-Spartz K, Bill R, Knoll B, Christie T, Birnbaum AK, Leppik I, Marino SE.  Computerized language and speech analysis to measure effects of anti-epileptic drugs on cognition.  Presented at: Third International Congress on Epilepsy “Brain & Mind”, 2014 April 3-5, Brno, Czech Republic

Lim CN, Marino SE, Brundage RC, Leppik IE, Cloyd JC, Clark A, Birnbaum AK.  Pharmacokinetics-pharmacodynamics modeling of topiramate’s effect on working memory in healthy volunteers.  Presented at: Rho Chi Research Symposium, 2014 March 24, Minneapolis MN.  (Award:  Rho Chi Prize for Best Poster)

Marino SE, Wang C, Han SM, Babu I, Samuel H, Birnbaum AK, Cibula J, Ding M. The brain’s response to cognitive demand under drug-induced impairment: A topiramate study. Presented at: The Society for Neuroscience Annual Meeting; 2013 November 12; San Diego CA.

Marino SE, Ahmed G, Brundage RC, Leppik IE, Pakhomov SVS, Birnbaum AK. Prediction of cognitive response from a model-based simulation of generative verbal fluency scores after a single dose of topiramate in healthy volunteers. Presented at: The American Epilepsy Society Annual Meeting; 2012 December 3; San Diego, CA.

Ahmed GF, Marino SE, Brundage RC, Pakhomov SVS, Leppik IE, Cloyd JC, Clark A, Kriel R, Birnbaum AK. Pharmacokinetic/pharmacodynamic (PK/PD) modeling of intravenous and oral topiramate and its effects on phonemic fluency in adult healthy volunteers. Presented at: The Interdisciplinary Pharmaceutical Research Retreat; 2012 May; Minneapolis, MN. (Award: Best Poster by a Graduate Student – Ghada Ahmed)