William C. Pomerantz, PhD

Assistant Professor, Department of Chemistry

William C. Pomerantz

Contact Info

wcp@umn.edu

Office Phone 612-624-9091

Fax 612-626-7541

Office Address:
328 Smith Hall
207 Pleasant St SE
Minneapolis MN 55455

Mailing Address:
Univ. of Minnesota
Dept. of Chemistry
A-16, 139 Smith Hall
207 Pleasant St. SE
Minneapolis, MN 55455-0431

Lab Address:
Smith 408, 439, 445

Assistant Professor, Department of Chemistry

Land-Grant McKnight Assistant Professor

Graduate Faculty, Department of Medicinal Chemistry


Fulbright Fellow, ETH, Zürich, 2002-2003

PhD, University of Wisconsin-Madison, 2008

BS, Chemistry, Ithaca College, 2002

Summary

Pomerantz Lab Group

Research in our group focuses on modulating protein-protein interactions through the use of small molecules and bio-inspired peptide scaffolds. By controlling such processes using synthetic molecules that we make in the laboratory, we seek to develop new chemical probes for understanding the underlying biology of protein-protein interactions in disease and ultimately novel therapeutics. Within this interdisciplinary research program, we combine techniques in organic synthesis, biophysics, biochemistry and molecular biology to study the role epigenetic regulatory proteins play in disease.Our current focus is on developing chemical probes for modulating protein-protein interactions of bromodomain-containing proteins, Brd4 and BPTF.

Our research program exploits the bio-orthogonality and the hypersensitivity of fluorine as an NMR probe for providing structural inforatmion of protein interfaces and for use as a tool for small molecule screening in the area of fragment-based drug discovery. As a new direction, we have also begun to use highly fluorinated molecules for design of new imaging agents for 19F MRI. Beyond 19F NMR, This research is complemented with established spectroscopic techniques, organic synthesis of chemical probes, and new peptide-based strategies for pre-organization and cellular delivery for studying challenging epigenetic proteins under physiological conditions.

Expertise

Chemical biology, biophysics, epigenetics, medicinal chemistry

Awards & Recognition

  • F32 NIH postdoctoral Research Fellow
  • 2016 Chemical Biology Rising Star Award
  • McKnight Land Grant Assistant Professor

Professional Associations

  • American Chemical Society
  • American Peptide Society

Research

Research Summary/Interests

Research in our group focuses on modulating protein-protein interactions through the use of small molecules and bio-inspired peptide scaffolds. By controlling such processes using synthetic molecules that we make in the laboratory, we seek to develop new chemical probes for understanding the underlying biology of protein-protein interactions in disease and ultimately novel therapeutics. Within this interdisciplinary research program, we combine techniques in organic synthesis, biophysics, biochemistry and molecular biology to investigate the folding/misfolding and disease pathways of intrinsically disordered proteins (IDPs). Our research program exploits the bio-orthogonality and the hypersensitivity of fluorine as an NMR probe for exploring important protein-protein interactions of IDPs. Our ultimate goal is to study these proteins in their native environment – whole cells – using 19F NMR. This research is complemented with established spectroscopic techniques, organic synthesis of chemical probes, and new peptide-based strategies for pre-organization and cellular delivery for studying challenging IDPs under physiological conditions.

Publications