William Oetting, PhD

Professor, Department of Experimental and Clinical Pharmacology (ECP)

William Oetting

Contact Info

oetti001@umn.edu

Office Phone 612-624-1139

Fax 612-624-6645

Lab Phone 612-625-5628

Office Address:
14-255 Moos Tower

Mailing Address:
University of Minnesota
College of Pharmacy
Department of Experimental and Clinical Pharmacology
7-115 Weaver-Densford Hall
308 Harvard St. SE
Minneapolis, MN 55455

Biochemistry, University of California-Riverside

PhD, Genetics, University of Nebraska-Lincoln

Genetics, University of Nebraska-Lincoln

Microbiology, University of Kansas

Summary

My expertise is in identifying genetic variants associated with complex human phenotypes and disease. I have created methodology, utilizing fluorescent-based detection systems, to identify genes and genetic variation. My initial work was to identify mutations associated with defects in pigmentation. This research utilized linkage analysis, gene identification and DNA sequencing for mutation identification. I have using different analytical methods to identify alterations in proteins and metabolites associated with different kidney transplant outcomes. I have identified several urinary proteins to create a profile associated with acute rejection in kidney allografts. The goal of this work is to identify a set of biomarkers that can be used to determine disease status, especially in the sub-acute phase. Currently, my primary work is in the identification of genetic variation with transplant outcomes in kidney allograft recipients, including pharmacogenomic related outcomes. This work includes creating a large cohort of DNA samples from both kidney allograft recipients and living kidney donors, collecting clinical outcomes, genotyping variants and associating these variants with different outcomes. Additional work in complex disease includes identification of variants associated with behavioral phenotypes, asthma, and novel single gene disorders. I am also working with whole exome sequencing (WES) and whole genome sequencing (WGS) to identify variants associated with single gene disorders and predisposing variants associated with glioblastoma.

Expertise

Genetics, Genomics

Awards & Recognition

  • The Vitiligo Research Award (Skin Disease Society, Inc.)
  • Young Investigator Award (PanAmerican Society for Pigment Cell Research)
  • Honorary Member, (PanAmerican Society for Pigment Cell Research)

Professional Associations

American Society of Human Genetics (ASHG)
American Society of Transplantation (AST) 
Human Genome Organization (HUGO) 
Human Genome Variation Society (HGVS) 
Human Variome Project (HVP) 
PanAmerican Society for Pigment Cell Research (PASPCR) 

Research

Research Summary/Interests

  • Genetic analysis of genes and gene polymorphisms associated with solid organ transplant outcome
  • Genetics of behavioral disorders
  • Proteomic and metabolomic analysis of kidney disease

Publications

  • Jackola DR, Basu S, Liebeler CL, Willaert R, Luah SS, Oetting W, King RA, Blumenthal MN. 2006. Inheritance of CD14 promoter polymorphisms in atopic families: Implications for modulated allergen-specific IgE and IgG1 responses. International Archives of Allergy & Immunology 139:217-24. [PMID: 16446545]
  • Oetting WS, Rogers TB, Krick TP, Matas AJ, Ibrahim H. 2006. ?2-microglobulin is a urine biomarker associated with acute kidney allograft rejection. American Journal of Kidney Disease 47:898-904. [PMID: 16632030]
  • Argikar UA, Cloyd JC, Birnbaum AK, Leppik IE, Conday J, Kshirsagar S, Oetting WS, Klein EC, Remmel RP, 2006, .Parodoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients. Epilepsy Research 71:54-63. [PMID: 16815679]
  • Wahlstrom D, White T, Hooper CJ, Vrshek-Schallhorn S, Oetting WS, Luciana M. 2007. Variations in the catechol O-methyltransferase polymerase and prefrontally-guided behaviors in adolescents. Biological Psychiatry. 61:626-632. [PMID: 17014828]
  • Chan PA, Duraisamy S, Newell JA, Miller PJ, McBride C, Bond JP, Raevaara T, Ollila S, Nyström M, Grimm A, Christodoulou J, Oetting WS, Greenblatt MS. 2007. Interpreting missense variants: validation of comparative sequence analyses in human disease genes CDKN2A, MLH1, MSH2, MECP2, and Tyrosinase. Human Mutation 28:683-693. [PMID: 17370310]
  • Reilly C, Miller MB, Liu Y, Oetting WS, King R, Blumenthal M. 2007. Linkage analysis of a cluster-based quantitative phenotype constructed from pulmonary function test data in 27 multigenerational families with multiple family members. Human Heredity 64:136-145. [PMID: 17476113]
  • Irons, DE, McGue M, Iacono WG, Oetting WS. 2007. Mendelian randomization: A novel test of the gateway hypothesis. Development and Psychopathology 19:1181-1195. [PMID: 17931442]
  • Kumar, V, Brundage RC, Oetting WS, Leppik IE, Tracy TS. 2008. Differential Genotype Dependent Inhibition of CYP2C9 in Humans. Drug Metabolism and Disposition 36:1242-8. [PMID: 18378563]
  • Oetting WS. 2008. Large scale sequencing – New challenges emerge. The 2007 Human Genome Variation Society Scientific Meeting. Human Mutation 29:765-768 [PMID: 18348287]
  • Johnson LA, Oetting WS, Basu S, Prausa S, Matas A, Jacobson P. 2008. Pharmacogenetic effect of the UGT polymorphisms on mycophenolate is modified by calcineurin inhibitors. European Journal of Clinical Pharmacology 64:1047-1056. [PMID: 18568343]
  • Akkina S, Zhang Y, Nelsestuen G, Oetting WS, Ibrahim HN. 2009. Temporal stability of the urinary proteome after kidney transplant: more sensitive than protein composition? Journal of Proteome Research 8:94-103. [PMID: 19012427]
  • Oetting WS, Pietsch, J, Brott, MJ, Savage S, Fryer JP, Summers CG, King, RA. 2009. The R402Q tyrosinase variant does not cause autosomal recessive ocular albinism. American Journal of Medical Genetics 149A:466-469. [PMID: 19208379]
  • Zhang Y, Oetting WS, Harvey SB, Stone MD, Monkkonen T, Matas AJ, Nelsestuen GL. 2009 Urinary protein profiles: diagnosis and prognosis of kidney transplant outcomes. Transplantation 87:1807-1813. [PMID: 19543057]
  • Oetting WS. 2009. Clinical Genetics & Human Genome Variation. The 2008 Human Genome Variation Society Scientific Meeting. Human Mutation 30:852-856. [PMID: 19260058]
  • He H, Oetting WS, Brott MJ and Basu S. 2009. Power of multifactor dimensionality reduction and penalized logistic regression for detecting gene-gene interaction in a case-control study. BMC Medical Genetics 10:127. [PMID: 19961594]
  • He H, Oetting WS, Brott MJ and Basu S. 2010. Pair-wise multifactor dimensionality reduction method to detect gene-gene interactions in a case control study. Human Heredity 69:60-70. [PMID: 19797910]
  • Oetting WS. 2010. Impact of next generation sequencing: The 2009 Human Genome Variation Society scientific meeting. Human Mutation 31:500-503 [PMID: 20127974]

Teaching

Teaching Areas

Human Genetics, Molecular Biology

Courses

  • BIOL 1101 Genetics and Society
  • GCD 4143 Human Genetics 
  • PHAR 6702 Integrated Biochemical Sciences 
  • PHAR 6224 Pharmacogenomics