Raj Suryanarayanan, PhD

Professor and William & Mildred Peters Endowed Chair, Department of Pharmaceutics

Raj Suryanarayanan

Contact Info

surya001@umn.edu

Office Phone 612-624-9626

Office Address:
9-157 Weaver-Densford Hall

Mailing Address:
University of Minnesota
College of Pharmacy
Department of Pharmaceutics
9-177 Weaver-Densford Hall
308 Harvard St. SE
Minneapolis, MN 55455
USA

Administrative Assistant Name
Jody Tracy

Administrative Phone
612-625-2718

Administrative Email
tracy122@umn.edu

Professor and William & Mildred Peters Endowed Chair, Department of Pharmaceutics


PhD in Pharmaceutics, University of British Columbia

MPharm in Pharmaceutics, Banaras Hindu University

BPharm in Pharmaceutics, Banaras Hindu University

Research

Research Summary/Interests

A large fraction of pharmaceutical products are administered as solids. We are interested in the material science of pharmaceutical solids with a specific emphasis on their physical characterization. In drugs and excipients we investigate the polymorphic form, degree of crystallinity, and the nature and extent of interaction with water.

In addition to X-ray powder diffractometry, thermoanalytical, spectroscopic and microscopic techniques are used for this purpose. We are specifically interested in monitoring and quantifying phase transitions at various stages of pharmaceutical processing. While the active ingredient is of predominant concern, there are cases where phase transitions of excipients may be of relevance and importance. The goal is to ensure reproducible and predictable performance of solid dosage forms with minimum batch-to-batch variations.

Our current research interests are in the following areas: (1) Monitor phase transitions during the entire freeze-drying cycle using specialinstrumentation built in-house. The ultimate goal is the optimization of the freeze-drying cycles of protein pharmaceuticals. (2) Simultaneous quantification of reactant, product, and intermediate phases of very rapid reactions (time resolution of 40 msec) using high intensity X-rays. (3) Use of a microdiffractometer to map tablet surfaces and also to characterize specific regions of a powder bed (or of a tablet). (4) Identify new excipients or modify the physical state of current excipients with the object of expanding their utility in freeze-dried formulations.

Publications

  • S. Thakral, N.K. Thakral, R. Suryanarayanan. Estimation of drug particle size in intact tablets by two dimensional X-ray diffractometry. J. Pharm. Sci., 107(1), 231-238, (2018).
  • N.K. Duggirala, A. Vyas, J.F. Krzyzaniak, K.K. Arora, R. Suryanarayanan. Mechanistic insight into caffeine-oxalic cocrystal dissociation in formulations: Role of excipients. Mol. Pharm., 14(11), 3879-3887 (2017).
  • S. Koranne, S. Thakral, R. Suryanarayanan. Effect of Formulation and Process Parameters on the Disproportionation of Indomethacin Sodium in Buffered Lyophilized Formulations. Pharm. Res., 35(1), 21 (2018).
  • S. Thakral, A. Wolf, G.J. Beilman, R. Suryanarayanan. Development and in vivo evaluation of a novel lyophilized formulation for the treatment of hemorrhagic shock. Int. J. Pharm., 537(1-2), 162-171 (2018).
  • K. B?rzi?š, R. Suryanarayanan. Compression-induced crystallization in sucrose-polyvinylpyrrolidone amorphous solid dispersions. Cryst. Growth Des., 18(2), 839-848 (2018).
  • M.H. Fung, M. DeVault, K.T. Kuwata, R. Suryanarayanan. Drug-excipient interactions: Effect on molecular mobility and physical stability of ketoconazole-organic acid coamorphous systems. Mol. Pharm., 15(3), 1052-1061 (2018).
  • M.H. Fung, K. B?rzi?š, R. Suryanarayanan. Physical stability and dissolution behavior of ketoconazole-organic acid coamorphous systems. Mol. Pharm. 15(5), 1862-1869 (2018).
  • S.A. Koranne, A. Sahoo, J.F. Krzyzaniak, S. Luthra, R. Suryanarayanan. Challenges in transitioning cocrystals from bench to bedside: Dissociation in prototype drug product environment. Mol. Pharm, 15(8), 3297-3307 (2018).
  • A. Wolf, S. Thakral, K.E. Mulier, R. Suryanarayanan, G.J. Beilman. Evaluation of novel formulations of d-?-hydroxybutyrate and melatonin in a rat model of hemorrhagic shock. Int. J. Pharm., 548(1), 104-112 (2018).
  • S.S. Kulkarni, R. Suryanarayanan, J.V. Rinella Jr., R.H. Bogner. Mechanisms by which crystalline mannitol improves the reconstitution time of high concentration lyophilized protein formulations. Eur. J. Biopharm., 130, 70-81 (2018).
  • S. Thakral, S. Koranne, R. Suryanarayanan. Intra-vial heterogeneity in physical form of mannitol in colyophilized binary systems. Pharm. Res., 35(11), 214 (2018).
  • M.H. Fung, R. Suryanarayanan. Effect of organic acids on molecular mobility, physical stability and dissolution of ternary ketoconazole spray dried dispersions. Mol. Pharm. DOI: 10.1021/acs.molpharmaceut.8b00593, PMID: 30359037 [Epub ahead of print] (2018).
  • N.K. Thakral, S. Thakral, G.A. Stephenson, R. Sedlock, R. Suryanarayanan. Compression-induced polymorphic transformation in tablets: Role of shear stress and development of mitigation strategies. J. Pharm. Sci., 108(1), 476-484 (2019).
  • N.K. Duggirala, J. Li, N.S.K. Kumar, T. Gopinath, R. Suryanarayanan. A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability. Chem Commun. DOI: 10.1039/c9cc02021g. PMID: 30972394 [Epub ahead of print] (2019).
  • S. Koranne, J.F. Krzyzaniak, S. Luthra, K.K. Arora, R. Suryanarayanan. Role of conformer and excipient properties on the solid-state stability of theophylline cocrystals. Cryst. Growth Des., 19(2), 868-875 (2019).
  • J.R. Snell, N.K. Kumar, R. Suryanarayanan, T.W. Randolph. Nanobubbles in reconstituted lyophilized formulations: Interaction with proteins and mechanism of formation. J. Pharm. Sci., in press (2019).
  • N. Kaur, N.K. Duggirala, R. Suryanarayanan. The role of lattice disorder in water mediated dissociation of pharmaceutical cocrystal systems. Mol. Pharm., in press. PMID 31117742 (2019).
  • A.A. Thorat, R. Suryanarayanan. Characterization of phosphate buffered saline (PBS) in frozen state and after freeze-drying. Pharm. Res., in press. PMID 31087169 (2019).
  • S. Jena, N.S.K. Kumar, A. Aksan, R. Suryanarayanan. Stability of lyophilized albumin formulations: Role of excipient crystallinity and molecular mobility. Int J Pharm, 569, 118568 (2019).
  • A. Sahoo, N.S.K. Kumar, R. Suryanarayanan. Crosslinking: An avenue to develop stable amorphous solid dispersion with high drug loading and tailored physical stability. J Control Release, in press. PMID 31299085 (2019).
  • R. Tanaka, N.K. Duggirala, Y. Hattori, M. Otsuka, R. Suryanarayanan. Formation of Indomethacin-Saccharin Cocrystals during wet granulation: Role of Polymeric Excipients. Mol. Pharm., in press. PMID 31756100 (2019).