Changquan Calvin Sun, Associate Professor & Director of Graduate Studies Sun, PhD

Director of Graduate Studies and Professor, Department of Pharmaceutics

Changquan Calvin Sun, Associate Professor & Director of Graduate Studies Sun

Contact Info

sunx0053@umn.edu

Office Phone 612-624-3722

Fax 612-626-2125

Office Address:
Room 9-127B
Weaver-Densford Hall

Mailing Address:
University of Minnesota
Department of Pharmaceutics
College of Pharmacy
308 Harvard St. SE
Room 9-177 WDH
Minneapolis, MN 55455

Director of Graduate Studies and Professor, Department of Pharmaceutics


Doctoral Degree, University of Minnesota (Pharmaceutics), 2000

Bachelors Degree, Shanghai Medical University, P.R. China (Pharmacy), 1994

Research

Research Summary/Interests

Our research focuses on manufacturing science of solid dosage forms, such as tablets and capsules. Formulation and process development is achieved by a clear scientific understanding of powders, including their flow and compaction properties. In this way, design replaces trial and error, and improved quality results.

We rely on three levels of control to attain the desired powder properties for successful manufacturing: (1) study and specification of the physico-mechanical properties of drugs; (2) incorporation of appropriate excipients for optimum mechanical properties; and (3) optimization of processes such as mixing, granulation, and compaction, based on a mechanistic understanding.

Our current research interests include:

  • Solubilization of poorly water-soluble drugs and other chemicals;
  • Crystal engineering for superior pharmaceutical properties of drugs (e.g., the development of a crystal structure–mechanical property relationship based on molecular modeling, crystallography, and nano-indentation);
  • Isolation and characterization of various solid forms, e.g., glasses, salts, cocrystals, and polymorphs, of drugs and excipients based on a thorough understanding of thermodynamics and kinetics of amorphization and crystallization phenomena;
  • Understanding and improving solid-state stability of drugs or excipients during processing and storage (e.g., glass to crystal, crystal to glass, and one polymorph to another);
  • Particle engineering for enhancing powder properties through controlled processes, such as crystallization, milling, and nano-coating;
  • Rational design of high-quality solid dosage forms based on mechanical properties of drug, excipients, and their interactions in a powder mixture (in addition to considering common criteria, such as chemical stability and hygroscopicity);
  • Mechanistic understanding of common pharmaceutical processes, such as granulation, milling, compaction, and coating, through both experimentation and computer modeling.

By systematically applying materials science principles to pharmaceutical systems, we will clearly define functionality of existing excipients and develop new types of excipient, including crystalline, polymeric, and co-processed powders.

Research Interests

  • Crystal Engineering
  • Particle Design
  • Formulation
  • Powder Technology
  • Drug Solubilization
  • Solid-state Science
  • Manufacturing Science

Publications

  • COVER ARTICLE Sathyanarayana Reddy Perumalla and Changquan Calvin Sun. A Synthon Preference in O-protonated Amide Crystals – Dominance of Short Strong Hydrogen Bonds. CrystEngComm, 15: 8941-8946, 2013.


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