William C. Pomerantz, PhD

Assistant Professor and McKnight Landgrant Professor, Department of Chemistry

William C. Pomerantz

Contact Info

wcp@umn.edu

Office Phone 612-624-9091

Fax 612-626-7541

Office Address:
312 Smith Hall

Mailing Address:
Univ. of Minnesota
Dept. of Chemistry
A-16, 139 Smith Hall
207 Pleasant St. SE
Minneapolis, MN 55455-0431

Assistant Professor and McKnight Landgrant Professor, Department of Chemistry

Graduate Faculty, Department of Medicinal Chemistry


Fulbright Fellow, ETH, Zürich, 2002-2003

PhD, University of Wisconsin-Madison, 2008

BS, Chemistry, Ithaca College, 2002

Summary

Awards & Recognition

  • NIH NRSA Postdoctoral Fellowship, University of Michigan, Ann Arbor, 2009
  • Goering student fellowship, University of Wisconsin-Madison Chem. Department, 2008
  • Fulbright Fellowship, Zürich, Switzerland, 2002-2003

Research

Research Summary/Interests

Research in our group focuses on modulating protein-protein interactions through the use of small molecules and bio-inspired peptide scaffolds. By controlling such processes using synthetic molecules that we make in the laboratory, we seek to develop new chemical probes for understanding the underlying biology of protein-protein interactions in disease and ultimately novel therapeutics. Within this interdisciplinary research program, we combine techniques in organic synthesis, biophysics, biochemistry and molecular biology to investigate the folding/misfolding and disease pathways of intrinsically disordered proteins (IDPs). Our research program exploits the bio-orthogonality and the hypersensitivity of fluorine as an NMR probe for exploring important protein-protein interactions of IDPs. Our ultimate goal is to study these proteins in their native environment – whole cells – using 19F NMR. This research is complemented with established spectroscopic techniques, organic synthesis of chemical probes, and new peptide-based strategies for pre-organization and cellular delivery for studying challenging IDPs under physiological conditions.