Sunil David, MD, PhD

Professor, Department of Medicinal Chemistry

Sunil David

Contact Info

sdavid@umn.edu

Fax 612-624-4996

Office Address:
Cancer & Cardiovascular Research Building

Mailing Address:
University of Minnesota
College of Pharmacy
Department of Medicinal Chemistry
2-163 Cancer & Cardiovascular Research Building
2231 Sixth Street SE
Minneapolis, MN 55455

MD, Christian Medical College in Vellore

PhD, Madras University, 1995

MBBS, Madras University, 1986

Summary

David Lab Research

Sunil David received his M.D. and PhD degrees from the Christian Medical College in Vellore, India. Following postdoctoral training stints at the Forschungszentrum, Borstel, Germany, Indian Institute of Science, Bangalore, and the University of Kansas Medical Center, he joined the faculty at KU before being recruited by the Department of Medicinal Chemistry at the University of Minnesota. His research focuses on the discovery and development of endotoxin-sequestering molecules as potential anti-sepsis agents, modulation of innate immune pathways, and host responses to infectious agents.

Expertise

Vaccine Adjuvants, Vaccines, Innate Immunity

Research

Research Summary/Interests

  • Vaccine adjuvant design and development
  • Immunogen design
  • Molecular mechanisms of host responses to pathogens with emphasis on innate immunity
  • Molecular recognition
  • Proteomics
  • Protein structure and function

Publications

Pubmed Bibliography

  • Human Toll-like Receptor 8-Selective Agonistic Activities in 1-Alkyl-1H-benzimidazol-2-amines. M Beesu, SS Malladi, CD Jones & SA David. J. Med. Chem. (2014) 57:7325-7341.
  • Determinants of Activity at Human Toll-like Receptors 7 and 8: QSAR of Diverse Heterocyclic Scaffolds. E Yoo, DB Salunke, D Sil, X Guo, ACD Salyer, AR Hermanson, M Kumar, SS Malladi, R Balakrishna, WH Thompson, H Tanji, U Ohto, T Shimizu & SA David. J. Med. Chem. (2014) 57:7955-7970.
  • Structure-based Ligand Design of Novel Human Toll-like Receptor 8 Agonists. HP Kokatla, D Sil, H Tanji, U Ohto, SS Malladi, LM Fox, T Shimizu & SA David. ChemMedChem. (2014) 9:719-723.
  • Structure-Activity Relationships in Toll-like Receptor 7 Agonistic 1H-Imidazo[4,5-c]pyridines. E Yoo, BM Crall, LM Fox, R Balakrishna, SS Malladi, AR Hermanson & SA David. Org. Biomol. Chem. (2013) 11:6526-6545.
  • Design and Development of Hydrolytically-stable, Water-soluble, Human Toll-like Receptor 2-Specific, Monoacyl Lipopeptides as Candidate Vaccine Adjuvants. DB Salunke, SW Connelly, NM Shukla, AR Hermanson, LM Fox & SA David. J. Med. Chem. (2013) 56:5885-5900
  • Exquisite Selectivity For Human Toll-like Receptor 8 in Substituted Furo[2,3-c]quinolines. HP Kokatla, D Sil, SS Malladi, R Balakrishna, AR Hermanson, LM Fox, X Wang, A Dixit & SA David. J. Med. Chem. (2013) 56:6871-6885.
  • Toll-like receptor-8 agonistic activities in C2, C4, and C8 modified thiazolo[4,5-c]quinolines HP Kokatla, E Yoo, DB Salunke, D Sil, CF Ng, R Balakrishna, SS Malladi, LM Fox & SA David. Org. Biomol. Chem. (2013) 11:1179-1198.