Reena Kartha, MS, PhD

Associate Director, Translational Pharmacology,

Reena Kartha

Contact Info

rvkartha@umn.edu

Office Phone 612-626-2436

Fax 612-624-7377

Mailing Address:
Center for Orphan Drug Research
4-500 McGuire Translational Research Facility
2001 - 6th St SE
Minneapolis, MN 55455

Associate Director, Translational Pharmacology


Summary

Reena Kartha is an Associate Director, Translational Pharmacology for the Center for Orphan Drug Research with a PhD in cellular and molecular biology from the Indian Institute of Science, Bangalore. She completed her post-doctoral training in translational research at Stanford University, California and in the University of Minnesota.

Research

Research Summary/Interests

Dr. Kartha's research interests are in deciphering the pathophysiological role of oxidative stress in disease conditions such as neurodegenerative disorders and ischemia/reperfusion injury. Her research involves understanding the molecular pharmacology of antioxidants and other drugs used to treat these conditions using cell culture and animal models and identification of novel protein- or miRNA-based biomarkers for early diagnosis of these conditions and as markers of response to therapy using patient derived samples.

Publications

Sunderbose K, Kartha RV and Subramanian S. MicroRNAs as biomarkers in cancer. Diagnostics, 2013; 3: 84-104

Subramanian S and Kartha RV. MicroRNA mediated gene regulations in human sarcomas. Cell Mol Life Sci, 2012; 69: 3571-3585

Thayanithy V, Park C, Sarver A, Kartha RV, Korpela DM, Graef AJ, Steer CJ, Modiano JF and Subramanian S. Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines. PLoS One, 2012; 7(9): e43720

Kartha RV*, Zhou J, Hovde LB, Cheung BW and Schröder H. Improved detection of hydrogen sulfide in cultured cells using an agar trapping method. Anal Biochem, 2012; 423, 102-108.

Thayanithy V, Sarver A, Kartha RV, Steer CJ, Modiano J and Subramanian S. Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma Bone, 2012; 50(1):171-81

Kartha RV and Subramanian S. MicroRNAs in cardiovascular diseases: biology and potential clinical applications. J Cardiovasc Transl Res, 2010; 3(3):256-70

Vanchinathan V, Marinelli EC, Kartha RV, Uzieblo A, Ranchod M and Sundram UN. A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating Neuroblastoma. Am J Dermatopathol, 2009; 31(2):193-196

Kambham N, Kartha RV, Grewal A, Lafayette R and Higgins J. Gene expression profiling of renal biopsies with IgA nephropathy suggest two distinct subgroups. J Am Soc Nephrol, 2008; 19: 665A.

Kartha RV, Subramanian S, Troxell ML, Higgins JP and Kambhan N Gene expression profiling of diabetic nephropathy using paraffin embedded nephrectomy samples. Mod Pathol, 2008; 21: 292A.

Cassarino DS, Cabral ES, Kartha RV and Swetter SM. Primary dermal melanoma: distinct immunohistochemical findings and clinical outcome compared with nodular and metastatic melanoma. Arch Dermatol, 2008; 144(1): 49-56.

Kartha RV and Sundram UN. Silent mutations in KIT and PDGFRA and coexpression of receptors with SCF and PDGFA in Merkel cell carcinoma: implications for tyrosine kinase-based tumorigenesis. Mod Pathol, 2008; 21(2): 96-104.

Arul V, Kartha RV and Jayakumar R. A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices. Life Sci, 2007; 80(4): 275-284.