Narsihmulu Cheryala
Research Assistant Professor, Department of Medicinal Chemistry
Contact Info
Research Assistant Professor, Department of Medicinal Chemistry
PhD Organic Chemistry, Indian Institute of Chemical Technology, India, 2004
MS Organic Chemistry, Osmania University, India, 1996
Summary
I received my Ph.D. in Synthetic Organic Chemistry with the specialization of natural products synthesis and development new synthetic methodologies. I have over 15 years of experience in academic and CRO medicinal chemistry programs including anti-viral, anti-cancer, anti-microbial, epilepsy and male contraception with a focus of small molecules design and synthesis.
Professional Associations
American Chemical Society (ACS) – Organic and Medicinal Chemistry Division
Research
Research Summary/Interests
Organic and medicinal chemistry
Patents
Siegel, R. A.; Kapoor, M.; Cheryala, N.; Georg, G. I.; Cloyd, J. C. Therapeutic compounds and formulations for intranasal delivery. WO2016149540A1, 2016. Filed March 18, 2015. Published September 22, 2016.
Publications
- Rautiola, D.; Maglalang, P. D.; Cheryala, N.; Nelson, K. M.; Georg, G. I.; Fine, J. M.; Svitak, A. L.; Faltesek, K. A.; Hanson, L. R.; Mishra, U.; Coles, L. D.; Cloyd, J. C.; Siegel, R. A., Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats. J Pharmacol Exp Ther 2019, 370, 796-805.
- Kapoor, M.; Cheryala, N.; Rautiola, D.; Georg, G. I.; Cloyd, J. C.; Siegel, R. A., Chirally Pure Prodrugs and Their Converting Enzymes Lead to High Supersaturation and Rapid Transcellular Permeation of Benzodiazepines. J. Pharm. Sci. 2016, 105, 2365-2371.
- Siegel, R. A.; Kapoor, M.; Cheryala, N.; Georg, G. I.; Cloyd, J. C., Water-soluble benzodiazepine prodrug/enzyme combinations for intranasal rescue therapies. Epilepsy Behav 2015, 49, 347-350.