Lisa Coles, MS, PhD

Associate Director, Clinical Pharmacology and Pharmacometrics,

Lisa Coles

Contact Info

durh0016@umn.edu

Office Phone 612-624-1861

Fax 612-624-7377

Mailing Address:
University of Minnesota
Center for Orphan Drug Research
4-226 McGuire Translational Research Facility
2001 - 6th St SE
Minneapolis, MN 55455

Associate Director, Clinical Pharmacology and Pharmacometrics


Summary

Dr. Coles is an Associate Director of Clinical Pharmacology and Pharmacometrics at the Center for Orphan Drug Research (CODR) at the University of Minnesota College of Pharmacy.

Dr. Coles earned a BS in Chemical Engineering from Iowa State University in 1996 and a MS in Biomedical Engineering from the University of Minnesota in 1998. Upon graduation, she accepted a position as a biochemical pharmacologist at 3M Pharmaceuticals where she worked for over 4 years conducting pharmacokinetic and drug metabolism studies. In 2003, Dr. Coles was accepted into the Pharmaceutical Sciences Department at the University of Maryland and received a PhD in 2008 in pharmacokinetics and pharmacodynamics. Her focus of her project was to evaluate the effect of pregnancy on drug distribution using a gravid mouse model and in vitro cell-based assays.

Research

Research Summary/Interests

Dr. Coles research focuses on pharmacokinetics and pharmacodynamics of drugs for the treatment of rare neurological disorders such as neurodegenerative diseases and epilepsy syndromes.

Publications

Holmay M, Terpstra M, Coles L, Mishra U, Ahlskog, M, Oz G, Cloyd J, Tuite P. N-acetylcysteine Boosts Brain and Blood Glutathione in Gaucher and Parkinson’s Diseases. Clinical Neuropharmacology. 2013.

KK Radtke, LD Coles, U Mishra, PJ Orchard, M Holmay, JC Cloyd. Interaction of N-acetylcysteine and Cysteine in Human Plasma. J Pharm Sci. 2012. Sep 27. Epub..

LD Coles, JC Cloyd. Role of Academic Organizations in the discovery and development of orphan drugs. Clin Pharm & Therapeutics. 2012. Aug 92(2): 193-202.

IE Leppik, EE Patterson, LD Coles, EM Craft, JC Cloyd. Canine status epilepticus: a translational platform for human therapeutic trials. Epilepsia. 2011 Oct;52 Suppl 8:31-4.

L Scherkenbach, LD Coles, L Krach, N Patterson, JC Cloyd, R Kriel. Clinical tolerance and toxicity of intravenous baclofen: A pilot study in a canine model. J Pediatr Rehabil Med. 2011 Jan 1;4(2):89-98.

LD Coles, PJ Voulalas, ND Eddington. Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells (NCI-ADR-RES) and placental cells (JAR). Mol Pharm. 2009 Nov-Dec;6(6):1816-25.

LD Coles, I Lee, H Hassan, ND Eddington. Distribution of Saquinavir, Methadone and Buprenorphine in Maternal Brain, Placenta and Fetus During Two Different Gestational Stages of Pregnancy in Mice. J Pharm Sci. 2009. Aug;98(8):2832-46.

LD Coles, ND Eddington. Pharmacotherapy and Pregnancy: The Dynamics of Pharmacokinetics, Drug Metabolism and Transporters. American Association of Pharmaceutical Scientists Magazine. Nov 2006.