Kathryn Nelson, PhD

Research Assistant Professor, Institute for Therapeutics Discovery and Development (ITDD)

Kathryn Nelson

Contact Info

kmnelson@umn.edu

Office Phone 612-626-6364

Lab Phone 612-626-6364

Office Address:
717 Delaware Street SE, RM 611
Minneapolis, MN 55414

Mailing Address:
717 Delaware Street SE, RM 611
Minneapolis, MN 55414

Lab Address:
717 Delaware Street SE, RM 611
Minneapolis, MN 55414

PhD in Medicinal Chemistry, University of Minnesota

BS in Chemistry, St. Cloud State University

Summary

I am a project and laboratory leader in a highly multidisciplinary and collaborative team designing new tools and therapeutics against neurological diseases. I strive to continue to learn new techniques from the latest research to apply toward the development of practical tools and effective therapies.

Expertise

Medicinal chemistry, analytical chemistry, organic chemistry, drug design, including: NMR, HPLC, LC-MS, TEM imaging, enzyme assays, chemical probes

Awards & Recognition

Outstanding Contribution to Drug Discovery: Emerging Biology Award, Eli Lilly, 2017
3M Science and Technology Fellowship, 2008-2012
NSF Research Experiences for Undergraduates (REU), 2007

Professional Associations

American Chemical Society, MEDI Division
Graduate Women in Science, Twin Cities Chapter
Society for Neuroscience

Research

Research Summary/Interests

Publications

1.Rautiola, D.; Maglalang, P. D.; Cheryala, N.; Nelson, K. M.; Georg, G. I.; Fine, J. M.; Svitak, A. L.; Faltesek, K. A.; Hanson, L. R.; Mishra, U.; Coles, L. D.; Cloyd, J. C.; Siegel, R. A. Intranasal co-administration of a diazepam prodrug with a converting enzyme results in rapid absorption of diazepam in rats. J. Pharmacol. Exp. Ther. 2019.

2.Dahlin, J. L.; Cuellar, M.; Singh, G.; Nelson, K. M.; Strasser, J.; Rappe, T.; Xia, Y.; Veglia, G.; Walters, M. A. ALARM NMR for HTS triage and chemical probe validation. Curr. Protoc. Chem. Biol. 2018, 10, 91-117.

3.Dahlin, J. L.; Nelson, K. M.; Strasser, J. M.; Barsyte-Lovejoy, D.; Szewczyk, M. M.; Organ, S.; Cuellar, M.; Singh, G.; Shrimp, J. H.; Nguyen, N.; Meier, J. L.; Arrowsmith, C. H.; Brown, P. J.; Baell, J. B.; Walters, M. A. Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors. Nat. Commun. 2017, 8, 1527.

4.Nelson, K. M.; Dahlin, J. L.; Bisson, J.; Graham, J.; Pauli, G. F.; Walters, M. A. The essential medicinal chemistry of curcumin. J. Med. Chem. 2017, 60, 1620-1637.

5.Nelson, K. M.; Viswanathan, K.; Dawadi, S.; Duckworth, B. P.; Boshoff, H. I.; Barry, C. E., 3rd; Aldrich, C. C. Synthesis and pharmacokinetic evaluation of siderophore biosynthesis inhibitors for Mycobacterium tuberculosis. J. Med. Chem. 2015, 58, 5459-5475.