Jingshu Guo, PhD
Research Assistant Professor,
Research Assistant Professor
PhD, Chemistry, University of Toledo, Toledo OH
Liquid chromatography mass spectrometry, biomarker analysis
My research interest is on developing and analyzing biomolecules using Mass Spectrometry (MS)-based technologies. Currently, I focus on developing highly sensitive and selective high-resolution (HR) MS methods to biomonitor the exposure of carcinogens from environmental and dietary sources in human. Working with Dr. Turesky, my current projects include quantifying heterocyclic aromatic amines (HAAs), which are potential human carcinogens formed in well-done meat, and other environmental carcinogens in human hair; detecting DNA adducts of environmental and dietary carcinogens in fresh frozen or formalin-fixed paraffin-embedded animal and human tissues via targeted and untargeted approaches; and developing comprehensive screening methods to analyze the metabolome and proteome changes in cells treated with carcinogens.
1.Guo, J.; Villalta, P. W.; Weight, C. J.; Murugan, P.; Bonala, R.; Johnson, F. Rosenquist, T.; Turesky, R. J. Targeted and untargeted detection of DNA adducts of aromatic amine carcinogens in human bladder by ultra performance liquid chromatography-high resolution mass spectrometry. Chem. Res. Toxicol. 2018, 31, 1382-1397.
2.Guo, J.; Villalta, P. W.; Turesky, R. J. DNA adductomic analysis by data-independent mass spectrometry. LCGC Current Trends in MS. 2018, 37, 8-16.
3.Yun, B. H.; Guo, J; Turesky, R. J. Formalin fixed paraffin embedded tissues – an untapped biospecimen for biomonitoring DNA adducts by mass spectrometry. Toxics. 2018, 6, 30.
4.Yun, B. H.; Guo, J; Bellamri, M.; Turesky, R. J. DNA adducts: formation, biological effects, and new biospecimens for mass spectrometric measurements in humans. Mass Spectrom. Rev. 2018, 1-22.
5.Guo, J; Villalta, P. W.; Turesky, R. J. A data-independent mass spectrometry approach for screening and identification of DNA adducts. Anal. Chem. 2017, 89, 11728-11736.