Gunda I. Georg, PhD

Professor and Head, Department of Medicinal Chemistry

Gunda I. Georg

Contact Info

Office Phone 612-626-6320

Fax 612-626-6318

Office Address:
717 Delaware St. SE, Room 452

Mailing Address:
University of Minnesota
College of Pharmacy
Department of Medicinal Chemistry
717 Delaware St. SE
Minneapolis, MN 55414

Lab Address:
717 Delaware Street SE
Minneapolis, MN 55414

Administrative Assistant Name
C. Leigh Allen, PhD

Administrative Phone

Administrative Email

Administrative Fax Number

Professor and Head, Department of Medicinal Chemistry

Robert Vince Endowed Chair

McKnight Presidential Chair

Director, Institute for Therapeutics Discovery and Development (ITDD)

PhD, Medicinal Chemistry, Philipps University Marburg, Germany, 1975

BS, Philipps Universitat Marburg, 1975

Postdoctoral, Philipps Universitat Marburg, 1981

Postdoctoral, University of Ottawa, 1982


Professor Georg and her group have published over 200 scientific articles and are involved in the design, semisynthesis, total synthesis, and evaluation of biologically active agents. Current therapeutic areas include cancer, male and female non-hormonal contraception, cancer, and epilepsy. 

These projects require the development of synthetic methods, synthesis of natural products, and structure-activity studies aimed at improving the therapeutic efficacy of lead compounds, including natural products, and hits from high throughput screening. 

Interdisciplinary projects are a main focus in the Georg group, involving medicinal chemistry, biochemistry, screening, structure-based drug design, pharmacology, pharmaceutical chemistry and reproductive biology. Active collaboration exists between the Contraception Research Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, several research groups at the University of Minnesota, and around the country.

Professor Georg is the PI of a NICHD U54 “Contraceptive Discovery, Development and Behavioral Research Center” that involves six institutions. She is the co-inventor of LusedraTM, which was marketed by Eisa Pharmaceuticals, of Minnelide, an anticancer agent in phase II clinical trials, and of Gamendazole, a male contraceptive agent in preclinical development.


Medicinal chemistry

Awards & Recognition

Professor Georg is the co-Editor-in-Chief of the Journal of Medicinal Chemistry of the American Chemical Society.

She has served as a member of review panels for the National Institutes of Health, the National Science Foundation, the American Cancer Society and others. 

In 2017 she was inducted into the Medicinal Chemistry Hall of Fame of the Division of Medicinal Chemistry of the American Chemical Society and named Research Exemplar by the Research Exemplar Project of Wahington University in St. Louis. 

She is a Fellow of the American Association for the Advancement of Science. 

In 2013 she received the Ernest H. Volwiler Research Achievement Award of the American Association of Colleges of Pharmacy, was named a Fellow of the American Chemical Society, and was the International Chair of Therapeutic Innovation, Paris, France (LERMIT). 

She was the 2000 Sato Memorial International Award recipient of the Pharmaceutical Society of Japan, and the 2001 Nolan and Gloria Sommer Award Winner (University of Nebraska).

Named Lectures:

  • 2005 Loyd E. Harris Lecturer of the School of Pharmacy, University of Oklahoma
  • 2005 Taito O. Soine Lecturer in Medicinal Chemistry at the University of Minnesota, 2005 George Lesher Lecturer in Bioorganic and Medicinal Chemistry in the Department of Chemistry at the Rensselear Polytechnic Institute
  • 2007 Stanford Distinguished Women in Science Colloquium
  • 2008 Pharmacological and Pharmaceutical Sciences Distinguished Lecture, University of Houston College of Pharmacy
  • 2009 Ohio State University, College of Pharmacy Distinguished Lecture Series
  • 2010 Henry A. Lardy Lecture, South Dakota State University Department of Chemistry
  • 2010 Sosnovsky Distinguished Lectureship, University of Wisconsin-Milwaukee, Department of Chemistry

Professional Associations

  • American Chemical Society
  • Division of Medicinal Chemistry
  • Division of Organic Chemistry
  • American Association for the Advancement of Science
  • American Association for Cancer Research
  • International Society of Heterocyclic Chemistry
  • Deutsche Pharmazeutische Gesellschaft
  • Gesellschaft Deutscher Chemiker
  • Division of Medicinal Chemistry
  • American Association of Pharmaceutical Scientists
  • Iota Sigma Pi
  • Phi Lambda Upsilon
  • Phi Beta Kappa


  • German


Research Summary/Interests

Medicinal Chemistry

Research Funding Grants

NICHD U54 HD093540, NICHD HHSN275201300017C, U01 HD080423 (Blanco), U01 HD080431 (Tash)


  • US7,514,463
  • WO2010129918 A8
  • US20140323748 A1
  • WO 2015/117024A1
  • WO 2016/149540 A1



Hawkinson, J. E.; Sinville, R.; Mudaliar, D.; Shetty, J.; Ward, T.; Herr, J. C.; Georg, G. I. Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2). ChemMedChem 2017, (accepted). DOI: 10.1002/cmdc.201700503.

Ayoub, A.; Hawk, M. L.; Herzig, R. J.; Wisniewski, A. J.; Gee, C. Zhu, J.-Y.; Berndt, N.; Scott, T. G.; Qi, J.; Jun, Q.; Bradner, J. E.; Ward, T. R.; Schönbrunn, E.; Georg, G. I.; Pomerantz, W. C. K. BET Bromodomain Inhibitors with One-step Synthesis Discovered from a Virtual Screen. J. Med. Chem. 2017, 60, 4805-4817.

Syeda, S. S.; Carlson, E. J.; Miller, M. R.; Francis, R.; David E. Clapham, D. E.; Lishko, P. V.; Hawkinson, J. E.; Hook, D.; Georg, G. I. The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex. ACS Chem. Biol. 2016, 11, 452-459.

Patil, S.; Lis, L. G.; Schumacher, R. J.; Norris, B. J.; Morgan, M. L.; Cuellar, R. A. D.; Blazar, B. R.; Suryanarayanan, R.; Gurvich, V. J.; Georg, G. I. Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficay in Human Colon adenocarcinoma and Ovarian Cancer. J. Med. Chem. 2015, 58, 9334-9344.

Syeda, S. S.; Jakkaraj, S.; Georg, G. I. Scalable synthesis of the BET bromodomain inhibitor JQ1. Tetrahedron Lett. 2015, 56, 3454-3457.

Tash. J. S.; Attardi, B.; Hild, S. A.; Chakrasali, R.; Jakkaraj, S. R.; Georg, G. I. A Novel Potent Indazole Carboxylic Acid Derivative Blocks Spermatogenesis and is Contraceptive in Rats after a Single Oral Dose. Biology of Reproduction 2008, 78, 1127-1138.

Desino, K. E.; Ansar, S.; Georg, G. I.; Himes, R. H.; Michaelis, M. L.; Powell, D. R.; Reiff, E. A.; Telikepalli, H.; Audus, K. L. (3R,5S,7as)-(3,5-bis(4-Fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl) methanol: A Novel Neuroprotective Agent. J. Med. Chem. 2009, 52, 7537-7543.

Reiff, E. A.; Nair, S. N.; Henri, J. T.; Greiner, J. F.; Reddy, B. S.; Chakrasali, R.; David, S.;Chiu, T.-L.; Amin, E. A.; Himes, R. H.; VanderVelde, D. G.; Georg, G. I. Total Synthesis and
Evaluation of C26-Hydroxyepothilone D Derivatives for Photoaffinity Labeling of ?-Tubulin. J. Org. Chem. 2010, 75, 86-94.

Niphakis, M. J.; Georg, G. I. Synthesis of Tylocrebrine and Related Phenanthroindolizidines by VOF3-Mediated Oxidative Aryl-Alkene Coupling. Org. Lett. 2011, 13, 196-199.



The Institute for Therapeutics Discovery and Development