Mukesh Pandey, PhD, MRSC

Adjunct Pharmaceutics Faculty, Department of Pharmaceutics

Mukesh Pandey

Contact Info

Adjunct Pharmaceutics Faculty, Department of Pharmaceutics


Research Fellowship, Harvard Medical School, Brigham and Women's Hospital, Department of Radiology

Post-Doctoral Research, University of Massachusetts, Institute of Nano-Science and Engineering Technology

PhD in Synthetic Organic Chemistry, University of Delhi

MPhil in Organic Chemistry, University of Delhi

MSc in Organic Chemistry, Banaras Hindu University

BSc in Chemistry, Banaras Hindu University

Magnetic Resonance Safety Certified (MRSC)

Summary

Dr. Pandey’s research is primarily focused on Positron Emission Tomography (PET) based molecular Imaging for early and noninvasive diagnosis of various diseases. His research entails, design and development of novel Positron Emission Tomography probes for neurodegenerative diseases, psychiatric disorders, cardiac disorders and various cancers.

His research projects involve multi-step organic synthesis of various biomarkers, production of various radio isotopes like C-11, F-18, Ga-68, Zr-89 and Cu-64/61, automated labeling of biomarkers with appropriate radio-isotope to meet the biological half-life, extensive quality control analysis, and preclinical and clinical evaluation of developed probes in animal models and in humans.

Dr. Pandey is an Associate Professor of Radiology at Mayo Clinic in Rochester, MN.

Expertise

Organic Synthesis, Radio Synthesis, Isotope Production, Molecular Imaging

Awards & Recognition

Mayo Clinic Radiology Advanced Award by the Department of Radiology, Mayo Clinic, Rochester, MN, 2012, for alternative synthesis of 18F-FLT and 18F-FTHA PET probes for cancer and cardiac imaging, respectively. 

Outstanding Research Poster Award, 2015, by Society of Radiopharmaceutical Sciences, for the “Improved Production of Zr-89 in a Solution Target

Professional Associations

Society of Radiopharmaceutical Sciences, American Chemical Society, Royal Society of Chemistry and Society of Nuclear Medicine and Molecular Imaging

Research

Publications

1. Jain S C Kumar R, Goswami R, Pandey M K, Khurana S, Rohatgi L, Gyanda K. Synthesis of Novel Non-isoprenoid Phenolic Acids and 3-Alkylpyridines,. Pure and Applied Chemistry. 2005; 177:185-193.

2. Bhagat S Jain M, Pandey M K, Pragati, Saxena A, Jain S C. Synthesis of New Bridgehead Heterocycles: Pyrimido[3¢,2¢3,4]-1,2,4-triazino[5,6-b]indoles. Heteroatom Chemistry. 2006; 17(4):272-276.

3. Jain SC, Pandey MK, Upadhyay RK, Kumar R, Hundal G, Hundal MS. Alkaloids from Toddalia aculeata. Phytochemistry. 2006 May; 67(10):1005-10. Epub 2006 May 02. PMID:16647728 DOI:10.1016/j.phytochem.2006.03.012

4. Pandey M K, Tyagi R, Tomar S, Kumar J, Parmar V S, Watterson A C. Design, Synthesis of Novel Pegylated 4-MethylCoumarins. Journ, of Macr, Sci., Pure and applied chemistry. 2007; 44:1293-1298.

5. Tyagi R, Pandey M K, Kumar J, Parmar V S, Watterson A C. Synthesis, Characterization of Photoactive Amphiphillic Polymers. Journ, of Macr, Sci. Pure and applied chemistry. 2007; 44:1283-1287.

6. Kumar A, Singh BK, Sharma NK, Gyanda K, Jain SK, Tyagi YK, Baghel AS, Pandey M, Sharma SK, Prasad AK, Jain SC, Rastogi RC, Raj HG, Watterson AC, Van der Eycken E, Parmar VS. Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase. Eur J Med Chem. 2007 Apr; 42(4):447-55. Epub 2006 Dec 19. PMID:17182154 DOI:10.1016/j.ejmech.2006.09.008

7. Tyagi R, Kumar R, Pandey M K, Kumar J, Parmar V S, Watterson A C. Amino acid, Poly (ethylene glycol) based Self - Organizing Polymeric Systems: Chemo-enzymatic Synthesis, Characterization. Journ, of Macr, Sci., Pure and applied chemistry. 2008; 45:958-963.

8. Pandey M K, Chandekar A, Tyagi R, Parmar V S, Tucci V B, Smith K D, Westmoreland P R, Mosurkal R, Kumar J, Watterson A C. Design, Lipase Catalyzed Synthesis of 4-Methylcoumarin-siloxane Hybrid Copolymers. Journ, of Macr, Sci. Pure and applied chemistry. 2008; 45:926-931.

9. Pandey M K, Tyagi R, Gupta B, Parmar V S, Kumar J, Watterson A C. Synthesis and Characterization of Novel Amphiphilic Polymers as Drug Delivery Nano Carriers, Journ. of Macr Sci Pure and applied chemistry. 2008; 45:932-938.

10. Gupta S, Pandey MK, Levon K, Haag R, Watterson AC, Parmar VS, Sharma SK. Biocatalytic Approach for the Synthesis of Glycerol-Based Macroamphiphiles and their Self-Assembly to Micellar Nanotransporters Macromol. Chem. Phys. 2010, 211, 239–244..2009; 211:239–244. DOI:10.1002/macp.200900391

11. Pandey M K, Yang K, Pei C, Sharma P K, Viola J, Stromberg R, Kumar J, Parmar VS, Watterson AC. Design and Biocatalytic Synthesis of Pluronics based Nanomicellar Self-assembly Systems for Drug Encapsulation Applications. Journ of Macr Sci Pure and applied chemistry. 2010; 47(8):788-793.

12. Kumar V, Gupta B, Kumar G, Pandey M K, Aiazian E, Parmar V S, Kumar J, Watterson A C, Novel Pegylated Amphiphilic Copolymers. Novel PEGylated Amphiphilic Copolymers as Nanocarriers for Drug Delivery: Synthesis, Characterization and Curcumin Encapsulation. Journ of Macr Sci Pure and applied chemistry. 2010; 47(12):1154-1160.

13. Kumar A, Pandey M K, Anandakathir R, Mosurkal R, Parmar V S, Watterson A C, Kumar J. Sensory response of pegylated and siloxanated 4,8-dimethylcoumarins: A fluorescence quenching study by nitro aromatics. Sens. Actuators B: Chem.. 2010; 147: (1)105-110.

14. Pandey MK, Balwani S, Sharma PK, Parmar VS, Ghosh B, Watterson AC. Design, synthesis and anti-inflammatory evaluation of PEGylated 4-methyl and 4,8-dimethylcoumarins. Eur J Pharm Sci. 2010 Jan 31; 39(1-3):134-40. Epub 2009 Dec 03. PMID:19948217 DOI:10.1016/j.ejps.2009.11.008

15. DeGrado TR, Bhattacharyya F, Pandey MK, Belanger AP, Wang S. Synthesis and preliminary evaluation of 18-(18)F-fluoro-4-thia-oleate as a PET probe of fatty acid oxidation. J Nucl Med. 2010 Aug; 51(8):1310-7. Epub 2010 Jul 21. PMID:20660391 DOI:10.2967/jnumed.109.074245

16. Kancheva VD, Saso L, Boranova PV, Khan A, Saroj MK, Pandey MK, Malhotra S, Nechev JZ, Sharma SK, Prasad AK, Georgieva MB, Joseph C, DePass AL, Rastogi RC, Parmar VS. Structure-activity relationship of dihydroxy-4-methylcoumarins as powerful antioxidants: correlation between experimental & theoretical data and synergistic effect. Biochimie. 2010 Sep; 92(9):1089-100. Epub 2010 Jun 19. PMID:20600568 DOI:10.1016/j.biochi.2010.06.012

17. Pandey M K, Tyagi R, Yang K, Fisher R J, Colton C K, Parmar V S, Kumar J, Aiazian E, Watterson A C. Design, Synthesis of Perfluorinated Amphiphilic Copolymers: Smart Nanomicelles for Theronastic Applications. Polymer. 2011; 52(21):4727-4735.

18. Pandey MK, Bansal A, DeGrado TR. Fluorine-18 labeled Thia Fatty Acids for PET Imaging of Fatty Acid Oxidation in Heart and Cancer. Heart and Metabolism. 2011; 51:15-19.

19. Belanger AP, Pandey MK, DeGrado TR. Microwave-assisted radiosynthesis of [18F]fluorinated fatty acid analogs. Nucl Med Biol. 2011 Apr; 38(3):435-41. Epub 2010 Dec 03. PMID:21492792 PMCID:3078335 DOI:10.1016/j.nucmedbio.2010.10.001

20. Pandey MK, Kumar S, Thimmulappa RK, Parmar VS, Biswal S, Watterson AC. Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells. Eur J Pharm Sci. 2011 May 18; 43(1-2):16-24. Epub 2011 Mar

21. PMID:21426935 DOI:10.1016/j.ejps.2011.03.003 21. Kumar S, Reddy L CS, Kumar Y, Kumar A, Singh BK, Kumar V, Malhotra S, Pandey MK, Jain R, Thimmulappa R, Sharma SK, Prasad AK, Biswal S, Van der Eycken E, DePass AL, Malhotra SV, Ghosh B, Parmar VS. Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-alpha induced expression of ICAM-1: structure-activity analysis. Arch Pharm (Weinheim). 2012 May; 345(5):368-77. Epub 2011 Dec 20. PMID:22190402 DOI:10.1002/ardp.201100279

22. Pandey MK, Belanger AP, Wang S, DeGrado TR. Structure dependence of long-chain [18F]fluorothia fatty acids as myocardial fatty acid oxidation probes. J Med Chem. 2012 Dec 13; 55: (23)10674-84. PMID:23153307 PMCID:3533245 DOI:10.1021/jm301345v

23. Pandey MK, Kumar A, Ravichandran S, Parmar VS, Watterson AC, Kumar J. Chemo-enzymatic synthesis of polydimethylsiloxane curcumin copolymer for detection of nitro-aromatics. Journal of Macromolecular Science, Part A: Pure and Applied Chemistry. 2014; 51(5):399-404.

24. Pandey MK, Byrne JF, Jiang H, Packard AB, DeGrado TR. Cyclotron production of (68)Ga via the (68)Zn(p,n)(68)Ga reaction in aqueous solution. Am J Nucl Med Mol Imaging. 2014; 4: (4)303-10. PMID:24982816 PMCID:4074496

25. Pandey MK, Engelbrecht HP, Byrne JP, Packard AB, DeGrado TR. Production of 89Zr via the 89Y(p,n)89Zr reaction in aqueous solution: effect of solution composition on in-target chemistry. Nucl Med Biol. 2014 Apr; 41: (4)309-16. PMID:24607433 DOI:10.1016/j.nucmedbio.2014.01.006

26. DeGrado TR, Pandey MK, Byrne JF, Engelbrecht HP, Jiang H, Packard AB, Thomas KA, Jacobson MS, Curran GL, Lowe VJ. Preparation and preliminary evaluation of 63Zn-zinc citrate as a novel PET imaging biomarker for zinc. J Nucl Med. 2014 Aug; 55(8):1348-54. Epub 2014 Jul 21. PMID:25047329 DOI:10.2967/jnumed.114.141218

27. Pandey MK, DeGrado TR, Qian K, Jacobson MS, Hagen CE, Duclos RI Jr, Gatley SJ. Synthesis and preliminary evaluation of N-(16-18F-fluorohexadecanoyl)ethanolamine (18F-FHEA) as a PET probe of N-acylethanolamine metabolism in mouse brain. ACS Chem Neurosci. 2014 Sep 17; 5: (9)793-802. PMID:25003845 DOI:10.1021/cn400214j

28. Bansal A, Pandey MK, Demirhan YE, Nesbitt JJ, Crespo-Diaz RJ, Terzic A, Behfar A, DeGrado TR. Novel (89)Zr cell labeling approach for PET-based cell trafficking studies. EJNMMI Res. 2015; 5: 19. PMID:25918673 PMCID:4401478 DOI:10.1186/s13550-015-0098-y

29. DeGrado TR, Kemp BJ, Pandey MK, Jiang H, Gunderson TM, Linscheid LR, Woodwick AR, McConnell DM, Fletcher JG, Johnson GB, Petersen RC, Knopman DS, Lowe VJ. First PET Imaging Studies With 63Zn-Zinc Citrate in Healthy Human Participants and Patients With Alzheimer Disease. Mol Imaging. 2016; 15: (). PMID:27941122 PMCID:5469518 DOI:10.1177/1536012116673793

30. Pandey MK, DeGrado TR. Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging. Theranostics. 2016; 6: (4)571-93. PMID:26941849 PMCID:4775866 DOI:10.7150/thno.14334

31. Pandey MK, Bansal A, Engelbrecht HP, Byrne JF, Packard AB, DeGrado TR. Improved production and processing of (8)(9)Zr using a solution target. Nucl Med Biol. 2016 Jan; 43: (1)97-100. PMID:26471714 DOI:10.1016/j.nucmedbio.2015.09.007

32. Yang B, Brahmbhatt A, Nieves Torres E, Thielen B, McCall DL, Engel S, Bansal A, Pandey MK, Dietz AB, Leof EB, DeGrado TR, Mukhopadhyay D, Misra S. Tracking and Therapeutic Value of Human Adipose Tissue-derived Mesenchymal Stem Cell Transplantation in Reducing Venous Neointimal Hyperplasia Associated with Arteriovenous Fistula. Radiology. 2016 May; 279: (2)513-22. PMID:26583911 PMCID:4836988 DOI:10.1148/radiol.2015150947 

33. Lowe VJ, Curran G, Fang P, Liesinger AM, Josephs KA, Parisi JE, Kantarci K, Boeve BF, Pandey MK, Bruinsma T, Knopman DS, Jones DT, Petrucelli L, Cook CN, Graff-Radford NR, Dickson DW, Petersen RC, Jack CR Jr, Murray ME. An autoradiographic evaluation of AV-1451 Tau PET in dementia. Acta Neuropathol Commun. 2016 Jun 13; 4 (1):58 Epub 2016 June 13 PMID:27296779 PMCID:4906968 DOI:10.1186/s40478-016-0315-6

34. Jiang H, Bansal A, Pandey MK, Peng KW, Suksanpaisan L, Russell SJ, DeGrado TR. Synthesis of 18F-Tetrafluoroborate via Radiofluorination of Boron Trifluoride and Evaluation in a Murine C6-Glioma Tumor Model. J Nucl Med. 2016 Sep; 57: (9)1454-9. PMID:27103021 DOI:10.2967/jnumed.115.170894 

35. Kumar A, Khan A, Malhotra S, Mosurkal R, Dhawan A, Pandey MK, Singh BK, Kumar R, Prasad AK, Sharma SK, Samuelson LA, Cholli AL, Len C, Richards NG, Kumar J, Haag R, Watterson AC, Parmar VS. Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives. Chem Soc Rev. 2016 Dec 21; 45: (24)6855-6887. PMID:27785498 DOI:10.1039/c6cs00147e

36. Bruinsma TJ, Johnson DR, Fang P, Senjem M, Josephs KA, Whitwell JL, Boeve BF, Pandey MK, Kantarci K, Jones DT, Vemuri P, Murray M, Graff-Radford J, Schwarz CG, Knopman DS, Petersen RC, Jack CR Jr, Lowe VJ. Uptake of AV-1451 in meningiomas. Ann Nucl Med. 2017 Sep 08 Epub 2017 Sept 08 PMID:28887599 DOI:10.1007/s12149-017-1205-0

Book Chapters

1. Kumar R, Pandey M K, Tyagi R, Parmar V S, Watterson A C, Kumar J. Enzymatically Synthesized Pegylated Polymers as Nano-Miceller Drug Delivery Systems. In: Polymers for Biomedical applications Vol. 977. Oxford University Press; 2008. p. 204-224.

2. Pandey MK, Rangarajan S, a chapter written as a review in a book entitled “Curcumin: Biosynthesis, Medicinal Uses and Health Benefits” ISBN: 978-1-61942-487-6, on “PEGylated Curcumin: A Potent Drug Candidate 2012, 155-176” by Nova Science Publication, New York

3. Pandey MK, Parmar VS, Watterson AC. Transformation of Natural Products into Synthetic Copolymers In: Shivendu Ranjan, Nandita Dasgupta, Eric Lichtfouse . Nanoscience in Food and Agriculture

4. Volume 24. Springer International Publishing; 2017.24:247-262p.