Henning Schroeder, PhD

Director of International Programs and Professor, Department of Pharmaceutics

Henning Schroeder

Contact Info

schro601@umn.edu

Office Phone 612-301-1702

Office Address:
9-127D Weaver-Densford Hall
308 Harvard St SE
Minneapolis, MN 55455-0353

Mailing Address:
College of Pharmacy
Room 5-130 WDH
1332A (Campus Delivery Code)
308 Harvard St SE
Minneapolis, MN 55455

Director of International Programs and Professor, Department of Pharmaceutics


Fellowship, Stanford University (Cell Signaling), 1986-1987

Doctoral Degree, Düsseldorf University (Pharmacology), 1985

Pharmacy Degree, Düsseldorf University (“Pharmazeutische Prüfung”), 1981

Summary

Positions and Employment:

  • Director of International Programs, College of Pharmacy, University of Minnesota, 2019
  • Special Assistant to the Provost for Professional Education, University of Minnesota, 2016
  • Vice Provost and Dean of Graduate Education, University of Minnesota, 2010
  • Associate Dean for Research and Graduate Studies, College of Pharmacy, University of Minnesota, Minneapolis, 2007
  • Professor, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, 2007
  • Visiting Professor, Division of Neonatology, Stanford University School of Medicine, California, 2005
  • Professor and Chair, Department of Pharmacology, Martin Luther University School of Pharmacy, Halle, FRG, 1995
  • Visiting Scholar, Division of Oncology, Stanford University School of Medicine, California, 1993
  • Assistant Professor (“Privatdozent”), Department of Pharmacology, Düsseldorf University School of Medicine, FRG, 1992

Awards & Recognition

  • Dean in Residence (NSF, Council of Graduate Schools), 2013
  • Phoenix Pharmaceutical Sciences Award, 2004
  • Fellow of the American Heart Association (F.A.H.A.), 2001
  • Innovation Prize of the Martin Luther University Halle Wittenberg, 1997
  • Heisenberg Fellowship (DFG), 1994
  • DFG visiting scholar fellowship, Stanford University School of Medicine, 1992
  • Edens Prize of the Heinrich Heine University Düsseldorf, 1991
  • DFG postdoctoral fellowship (German Research Foundation), Stanford University School of Medicine, 1986

Research

Research Summary/Interests

Dr. Schroeder’s research focuses on the regulation of antioxidant proteins and their potential role as therapeutic targets in atherosclerosis and other cardiovascular disorders. One of these candidate proteins is heme oxygenase-1 (HO-1) which degrades heme and generates bilirubin and carbon monoxide (CO). Both products have strong antioxidant and anti-inflammatory properties. CO, in addition, acts as a dilator of blood vessels. Dr. Schroeder’s group has shown that HO-1 is a target and mediator of established drugs such as aspirin, the statins, and organic nitrates (nitric oxide donors). More recent work has revealed that bioactive peptides and other micronutrients function as inducers of HO-1 which may explain their antioxidant and antihypertensive properties.

Publications

  • Schröder H(2019) Wilhelm von Humboldt's estranged American children and their obsession with leadership. Academe Blog, July 12, 2019
  • Schröder H (2019) The University needs more democracy and less royalty. Letter to the Editor, Minnesota Daily, April 4, 2019
  • Schröder H (2019) Donors, poets, paper-pushers – who deserves to have a building named after them? Opinion Exchange, Star Tribune, January 9, 2019
  • Schröder H (2018) A European view on doctoral education in the United States. The Doctoral Debate, European University Association – Council of Doctoral Education, November 23, 2018
  • Schröder H (2018) American exceptionalism needs another revolution. The Society Pages, February 12, 2018
  • Schröder H (2017) Flags, France and Freedom Fries – the changing flavor of American patriotism. The Society Pages, May 10, 2017 
  • Schröder H (2016) The unpredictable impacts of international graduate experiences. GradEdge 5 (3):3-4
  • Kartha RV, Zhou J, Basso L, Schröder H, Orchard PJ, Cloyd J (2015) Mechanisms of antioxidant induction with high-dose N-acetylcysteine in childhood cerebral adrenoleukodystrophy. CNS Drugs 29:1041-1047
  • Hetzel S, DeMets D, Schneider R, Borzak S, Schneider W, Serebruany V, Schröder H, Hennekens CH (2013) Aspirin increases nitric oxide formation in chronic stable coronary disease. J Cardiovasc Pharmacol Ther 18:217-221
  • Kartha RV, Zhou J, Hovde LB, Cheung BW and Schröder H. Enhanced detection of hydrogen sulfide generated in cell culture using an agar trap method. Anal. Biochem. 423: 102-108 (2012).
  • Hinkelmann U, Grosser N, Erdmann K, Schröder H and Immenschuh S. Simvastatin-dependent up-regulation of heme oxygenase-1 via mRNA stabilization in human endothelial cells. Eur. J. Pharm. Sci. 41: 118-124 (2010).
  • Sparatore A, Perrino E, Tazzari V, Giustarini D, Rossi R, Rossoni G, Erdmann K, Schröder H and Del Soldato P. Pharmacological profile of a novel hydrogen sulfide-releasing aspirin. Free Radic. Biol. Med. 46: 586-592 (2009).
  • Schröder H. No nitric oxide for HO-1 from sodium nitroprusside. Mol. Pharmacol. 69: 1507-1509 (2006).
  • Schmidt P, Schramm M, Schröder H, Wunder F and Stasch J-P. Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclase. J. Biol. Chem. 279: 3025-3032 (2004).
  • Stasch J-P, Becker EM, Alonso-Alija C, Apeler H, Dembowsky K, Feurer A, Gerzer R, Minuth T, Perzborn E, Pleiss U, Schröder H, Schroeder W, Stahl E, Steinke W, Straub A and Schramm M. NO-independent regulatory site on soluble guanylate cyclase and therapeutic implications. Nature 410: 212-215 (2001).
  • Polte T, Abate A, Dennery PA and Schröder H. Heme oxygenase-1 is a cyclic GMP-inducible endothelial protein and mediates the cytoprotective action of nitric oxide. Arterioscler. Thromb. Vasc. Biol. 20: 1209-1215 (2000).
  • Oberle S, Polte T, Abate A, Podhaisky H-P and Schröder H. Aspirin increases ferritin synthesis in endothelial cells: a novel antioxidant pathway. Circ. Res. 82: 1016-1020 (1998).
  • Schröder H, Leitman DC, Bennett BM, Waldman SA and Murad F. Glyceryl trinitrate-induced desensitization of guanylate cyclase in cultured rat lung fibroblasts. J. Pharmacol. Exp. Ther. 245: 413-418 (1988).