Evgenyi Shalaev, PhD

Adjunct Pharmaceutics Faculty, Department of Pharmaceutics

Evgenyi Shalaev

Contact Info

shala002@umn.edu

Office Phone 714-246-3372

Office Address:
University of Minnesota
College of Pharmacy
Department of Pharmaceutics
9-177 Weaver Densford Hall
308 Harvard St. SE
Minneapolis, MN 55455

Mailing Address:
Allergan Inc
2525 DuPont St
Irvine, CA 92612
U.S.A.

Adjunct Pharmaceutics Faculty, Department of Pharmaceutics


Doctoral Degree, Institute of Molecular Biology, Russia (Chemistry), 1991

Bachelors Degree, Omsk State University, Russia (Chemistry), 1981

Summary

My research efforts are focused on applications of physical chemical principles to drug development and manufacturing, covering a broad range of pharmaceutical R&D such as pre-formulation and formulation development for immediate and controlled release dosage forms, lyophilization development and scale-up, and solid state characterization and stability of proteins and small molecular weight drugs. The current research interests include:

  • Role of water in solid-state chemical stability of proteins and small molecules
  • Advanced analytical methods (e.g., small-angle neutron and X-ray scattering) for characterization of various pharmaceuticals including small molecules and proteins, drug substance and drug product, and solutions, solids, and dispersed systems
  • Phase transitions during freezing and drying
  • Optimization of lyophilization processes

Research

Publications

  • Shalaev, EY, W Wang, LA Gatlin (2008). Rational choice of excipients for use in lyophilized formulations. in: EJ. McNally, JE. Hastedt, Eds, Drugs and the Pharmaceutical Sciences (2008), 175(Protein Formulation and Delivery (2nd Edition)), pp. 197-217.
  • Chou, SG, AK Soper, S Khodadadi, JE Curtis, S Krueger, MT Cicerone, A Fitch, EY Shalaev (2012) Pronounced Micro-Heterogeneity in a Sorbitol-Water Mixture Observed Through Variable Temperature Neutron Scattering, J Phys Chem B 116 (15) 4439–4447
  • Wu,C, S Shamblin, D Varshney, E Shalaev (2015) Advance Understanding of Buffer Behavior during Lyophilization. In: Lyophilized Biologics and Vaccines: Modality-Based Approaches, D Varshney, M Singh (Eds),Springer, pp. 25-42
    Shalaev, E, AK Soper (2016) Water in a Soft Confinement: Structure of Water in Amorphous Sorbitol. J Phys Chem B.DOI: 10.1021/acs.jpcb.6b06157.
    Shalaev, E, K Wu, S Shamblin, JF Krzyzaniak, M Descamps (2016) Crystalline mesophases: Structure, mobility, and pharmaceutical properties. Advanced Drug Delivery Reviews 100, 194–211