Shameem Sultana Syeda

Research Assistant Professor, Department of Medicinal Chemistry

Shameem Sultana Syeda

Contact Info

Office Phone 612-626-6350

Office Address:
475 717 Delaware St SE

Mailing Address:
475 717 Delaware St SE
Minneapolis, MN 55414

Research Assistant Professor, Department of Medicinal Chemistry

Organic Chemistry, Indian Institute of Chemical Technology, India, 2006

Chemistry, Osmania University, India, 2000

Chemistry and Biology, Osmania University, India, 1998


I received a PhD in Synthetic Organic Chemistry specializing in natural products synthesis and development of new reactions. My current research focuses on the development of Na,K-ATPase a4 inhibitors as male contraceptive agents. My areas of expertise include multi-step synthesis, natural products-based drug design, contract research, development of medicinal chemistry strategies and execution of tactics to generate lead molecules.

Professional Associations

American Chemical Society (ACS) – Organic and Medicinal Chemistry Division


Research Summary/Interests

Synthesis and development of new methodologies, medicinal chemistry.


Gustavo Blanco, Gunda Georg, Shameem Syeda. Contraceptive agents. US20140005132 A1. Filed07/02/2013. Published January 2, 2014. Issued June 6, 2017.


Syeda, S. S.; Hong, K. H.; Georg, G. I.; Sanchez, G.; McDermott, J. P.; Blanco, G., The Na+ and K+ transport system of sperm (ATP1A4) is essential for male fertility and an attractive target for male contraception†. Biol Reprod 2020, 103 (2), 343-356.

Syeda, S. S.; Sánchez, G.; Hong, K. H.; Hawkinson, J. E.; Georg, G. I.; Blanco, G. Design, Synthesis, and in Vitro and in Vivo Evaluation of Ouabain Analogues as Potent and Selective Na,K-ATPase ?4 Isoform Inhibitors for Male Contraception. J. Med. Chem. 2018, 61, 1800-1820. DOI: 10.1021/acs.jmedchem.7b00925

Most read article: Article views between January 1 and July 31st, 2019: 6,899 (Source ACS).

Selected for 2018 ACS PressPac: “Prospective birth control pill for men has its origin in an arrow poison.”

Selected for cover page: Syeda, S. S.; Carlson, E. J.; Miller, M. R.; Francis, R.; Clapham, D. E.; Lishko, P. V.; Hawkinson, J. E.; Hook, D.; Georg, G. I. The Fungal Sexual Hormone Sirenin Activates the Human CatSper Channel Complex. ACS Chem. Biol. 2016, 11, 452-459. DOI: 10.1021/acschembio.5b00748

Recommended in F1000Prime as being of special significance in its field: Syeda, S. S.; Rice, D.; Hook, D. J.; Heckert, L. L.; Georg, G. I. Synthesis of Arylazide- and Diazirine-Containing CrAsH-EDT2 Photoaffinity Probes. Arch. Pharm. 2016, 349, 233-241.DOI: 10.1002/ardp.201500440

Among the top 20 downloaded articles in Arch. Pharm (one year after publication): Syeda, S.S.; Jakkaraj, S.; Georg, G.I. Scalable syntheses of the BET bromodomain inhibitor JQ1. Tet. Lett. 2015, 56, 3454-3457.DOI: 10.1016/j/tetlet.2015.02.062