Rory Remmel, PhD

Dr. Remmel is a Distinguished Teaching Professor in the College of Pharmacy.

He is well known as a collaborative investigator in drug metabolism research, with an emphasis on glucuronidation. His research has included studies in basic enzymology, work with hepatocytes, animal studies, and clinical studies in AIDS patients, in patients with epilepsy, and in patients with tuberculosis. He has received multiple teaching awards (including highest teaching award given at the University of Minnesota), especially for teaching antimicrobial agents to pharmacy students.

• Teacher of the Graduating Class of 2012, College of Pharmacy
• Professor of the Year, Pharm. D III Class in 2001, 2003, 2005, 2007 2008, 2009, 2011
• Minnesota Alumni Association Outstanding Contributions to Professional and Graduate Education, 2010
• Outstanding Faculty Award, Council of Graduate Students, 2010

Research Interests

Drug Metabolism and Disposition, Development of Prodrugs of Carbapenems for Tuberculosis, Metabolism, pharmacokinetics, and pharmacogenomics of antiepileptic Agents, Kinetics of UDP-glucuronosyl transferases, Effect of obesity on drug metabolism and disposition.

Research Projects

Meropenem Prodrugs for Treatment of Multi-Drug-Resistant Tuberculosis, Maternal and Childhood Outcomes of Children Borne by Mothers taking antiepileptic agents during pregnancy, Effect of Obesity on Drug Metabolism and Glucuronidation

PubMed

1.Mohamed, M. E.; Schladt, D. P.; Guan, W.; Wu, B.; van Setten, J.; Keating, B.; Ikle, D.; Remmel, R. P.; Dorr, C. R.; Mannon, R. B.; Matas, A. J.; Israni, A. K.; Oetting, W. S.; Jacobson, P. A.; De, K. A. F. G.; Investigators, G. E. N. Tacrolimus troughs and genetic determinants of metabolism in kidney transplant recipients: a comparison of four ancestry groups. Am. J. Transplant. 2019.

2.Oetting, W. S.; Wu, B.; Schladt, D. P.; Guan, W.; van Setten, J.; Keating, B. J.; Ikle, D.; Remmel, R. P.; Dorr, C. R.; Mannon, R. B.; Matas, A. J.; Israni, A. K.; Jacobson, P. A.; De, K. A. F. G.; Investigators, G. E. N. Genetic variants associated with immunosuppressant pharmacokinetics and adverse effects in the DeKAF genomics genome wide association studies. Transplantation 2019.

3.Oetting, W. S.; Schladt, D. P.; Dorr, C. R.; Wu, B.; Guan, W.; Remmel, R. P.; Ikle, D.; Mannon, R. B.; Matas, A. J.; Israni, A. K.; Jacobson, P. A.; De, K. A. F. G.; Investigators, G. E. N. Analysis of 75 candidate SNPs associated with acute rejection in kidney transplant recipients: validation of rs2910164 in microRNA MIR146A. Transplantation 2019.

4.Roslawski, M. J.; Remmel, R. P.; Karanam, A.; Leppik, I. E.; Marino, S. E.; Birnbaum, A. K. Simultaneous quantification of thirteen cannabinoids and metabolites in human plasma by liquid chromatography tandem mass spectrometry in adult epilepsy patients. Ther. Drug Monit. 2019, 41, 357-370.

5.Dorr, C. R.; Wu, B.; Remmel, R. P.; Muthusamy, A.; Schladt, D. P.; Abrahante, J. E.; Guan, W.; Mannon, R. B.; Matas, A. J.; Oetting, W. S.; Jacobson, P. A.; Israni, A. K.; for De, K. A. F. G. Identification of genetic variants associated with tacrolimus metabolism in kidney transplant recipients by extreme phenotype sampling and next generation sequencing. Pharmacogenomics J. 2018.