Mahmoud Al-Kofahi, DDS, PhD
Assistant Professor, Department of Experimental and Clinical Pharmacology (ECP)
Contact Info
Assistant Professor, Department of Experimental and Clinical Pharmacology (ECP)
Fellowship, Pharmacometrics, Dr. Richard Brundage, Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN
PhD, Physiology,Department of Molecular and Cellular Physiology at the Louisiana State University Health Sciences Center
DDS, Dentistry, Jordan University of Science and Technology, Faculty of Dentistry, Jordan
Summary
Dr. Al-Kofahi's research focus is in the analysis and simulation of the pharmacokinetics-pharmacodynamics of biologics; as well as modeling and simulation of circadian rhythms in particular adrenal steroids in children with Congenital Adrenal Hyperplasia.
Expertise
- Pharmacometrics
- Pharmacokinetics
- Pharmacodynamics
- Population pharmacokinetics-pharmacodynamics
- Modeling and Simulation
- Nonlinear Mixed Effects Modeling
- Model-based Drug Development
- Modeling Biologics
Awards & Recognition
Outstanding Teacher Award, Department of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center
Professional Associations
International Society of Pharmacometrics (ISoP)
Languages
Research
Research Summary/Interests
My research interests are in the area of analysis and simulation of the pharmacokinetics-pharmacodynamics of biologics in particular Antibody Drug Conjugates (ADCs). A second area of interest is the modeling and simulation of circadian rhythms in particular adrenal steroids.
Publications
Al-Kofahi M, Becker F, Gavins FN, Woolard M, Tsunoda I, Wang Y, Ostanin D, Zawieja DC, Muthuchamy M, von der Weid PY, Alexander JS. Interleukin-1 beta Reduces Tonic Contraction of Mesenteric Lymphatic Muscle Cells: Involvement of Cyclooxygenase-2 / Prostaglandin E2. British journal
of pharmacology (2015).
Al-Kofahi, M., Yun, J. W., Minagar, A. and Alexander, J. S., Anatomy and roles of lymphatics in inflammatory diseases. Clin Exp Neuroimmunol. (2017).
Teaching
Academic Interests and Focus
Teaching Areas
Pharmacometrics; Pharmacokinetics of Biologics; Model-based Drug Development of Biologics
Courses
ECP 8440 : "Biologics: Pharmacokinetics and Model-based Drug Development”