Beshay Zordoky, MSc, PhD

My research focuses on cardio-oncology. Cardio-oncology has emerged as a novel scientific discipline that aims to mitigate the cardiovascular adverse effects of anti-cancer agents. Since the survival of cancer patients has significantly increased over the past two decades, it is very important to improve the quality of life of these cancer survivors.

Awards & Recognition

Above and Beyond Award for Research Productivity, University of Minnesota College of Pharmacy
K-R01 Transition to Independence Program Scholar, University of Minnesota Clinical and Translational Science Institute (CTSI)
Outstanding Junior Mentor Award, University of Minnesota Clinical and Translational Science Institute (CTSI)
Masonic Cancer Center Women’s Health Scholar
Outstanding Reviewer, Canadian Journal of Physiology and Pharmacology
Clinician Fellowship, Alberta Innovates – Health Solutions
Postdoctoral Fellowship, Canadian Institutes of Health Research (CIHR)
Dissertation Fellowship, University of Alberta
Vascular Pharmacology Top Cited Article Award

Languages

Research

Research Summary/Interests

Identifying the mechanisms of juvenile anthracycline-induced latent cardiotoxicity.
Determining the role of cellular senescence in cancer treatment-induced cardiovascular toxicity.
Defining sex-related differences in cardiovascular diseases.

Research Funding Grants

R01HL151740 - Psychosocial Stress Exacerbates Doxorubicin-induced Cardiovascular Aging Role: Principal Investigator Agency: NIH/NHLBI Date: 04/10/2020 – 03/31/2025
Combating Cellular Senescence to Prevent Anthracycline Cardiotoxicity Role: Principal Investigator Agency: St. Baldrick’s Foundation for Childhood Cancer Research Date: 07/01/2019 – 09/30/2020
Role of Galectin-3 in Juvenile Doxorubicin-induced Cardiotoxicity Role: Principal Investigator Agency: Rally Foundation for Childhood Cancer Research Date: 07/01/2017 – 06/30/2019

Publications

EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263. Abdelgawad IY, Agostinucci K, Ismail SG, Grant MKO, Zordoky BN. Cells 2022, 11(13), 1992.
Divergent Cardiac Effects of Angiotensin II and Isoproterenol Following Juvenile Exposure to Doxorubicin. Agostinucci K, Grant MKO, Seelig D, Yücel D, van Berlo J, Bartolomucci A, Dyck JRB, Zordoky BN. Front Cardiovasc Med. 2022 Mar 25;9:742193.
Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence. Abdelgawad IY, Sadak KT, Lone DW, Dabour MS, Niedernhofer LJ, Zordoky BN. Pharmacol Ther. 2021 May;221:107751.
Sexual Dimorphism in Doxorubicin-induced Systemic Inflammation: Implications for Hepatic Cytochrome P450 Regulation. Grant MKO, Abdelgawad IY, Lewis CA, Zordoky BN. Int J Mol Sci. 2020 Feb 14;21(4):1279.
Co-administration of resveratrol with doxorubicin in young mice attenuates detrimental late-occurring cardiovascular changes. Matsumura N, Zordoky BN, Robertson IM, Hamza SM, Parajuli N, Soltys CM, Beker DL, Grant MK, Razzoli M, Bartolomucci A, Dyck JRB. Cardiovasc Res. 2018 Aug 1;114(10):1350-1359.
Grant MKO, Seelig DM, Sharkey LC, Choi WSV, Abdelgawad IY, Zordoky BN. Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice. PLoS One. 2019 Feb 20;14(2):e0212486. PMID: 30785938.
Meiners B, Shenoy C, Zordoky BN. Clinical and preclinical evidence of sex-related differences in anthracycline-induced cardiotoxicity. Biology of Sex Differences. 2018 Aug 29;9(1):38. PMID: 30157941.
Matsumura N*, Zordoky BN *, Robertson IM*, Hamza SM, Parajuli N, Soltys CM, Beker DL, Grant MK, Razzoli M, Bartolomucci A, and Dyck JRB. Co-administration of resveratrol with doxorubicin in young mice attenuates detrimental late-occurring cardiovascular changes. Cardiovascular Research. 2018 1;114(10):1350-1359.PMID: 29566148. * Equally contributed to the manuscript.
Carlson A, Alderete KS, Grant MKO, Seelig DM, Sharkey LC, Zordoky BNM. Anticancer effects of resveratrol in canine hemangiosarcoma cell lines. Veterinary and Comparative Oncology. 2018 Jun 16(2):253-261. PMID: 29235249.
Grant MK, Seelig DM, Sharkey LC, Zordoky BN. Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice. Biology of Sex Differences. 2017 Jan 7;8:1. PMID: 28078076.
Zordoky BN, Radin J, Heller Lois, Tobias A, Matise Ilze, Apple Fred S, McCune SA, Sharkey LC. The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity. Cardio-Oncology. 2016 March 15; 2:4. PMID: 28758028.
Sung MM*, Zordoky BN*, Bujak AL, Lally JS, Fung D, Young ME, Horman S, Miller EJ, Light PE, Kemp BE, Steinberg GR, Dyck JR. AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism. Cardiovascular Research. 2015 Jul 15;107(2):235-45. PMID: 26023060.
Zordoky BN*, Nagendran J*, Pulinilkunnil T*, Kienesberger PC, Masson G, Waller TJ, Kemp BE, Steinberg GR, Dyck JR. AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation. Circulation Research. 2014 Aug 15;115(5):518-24. PMID: 25001074.

* Equally contributing co-authors.

Teaching

Courses

PHAR 6732: Medicinal Chemistry and Pharmacology of Cardiovascular Agents (Course Director).

Beshay Zordoky, MSc, PhD

Associate Professor, Department of Experimental and Clinical Pharmacology (ECP)

Contact Info

Summary

Expertise