Mahmoud Al-Kofahi, DDS, PhD

Assistant Professor, Department of Experimental and Clinical Pharmacology (ECP)

Mahmoud Al-Kofahi

Contact Info

malkofah@umn.edu

Office Phone 612-624-1161

Office Address:
Room 467
717 Delaware St. S.E.
Minneapolis, MN 55414

Mailing Address:
Room 464
717 Delaware St. S.E.
Minneapolis, MN 55414

Fellowship, Pharmacometrics, Dr. Richard Brundage, Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN

PhD, Physiology,Department of Molecular and Cellular Physiology at the Louisiana State University Health Sciences Center

DDS, Dentistry, Jordan University of Science and Technology, Faculty of Dentistry, Jordan

Summary

Dr. Al-Kofahi's research focus is in the analysis and simulation of the pharmacokinetics-pharmacodynamics of biologics; as well as modeling and simulation of circadian rhythms in particular adrenal steroids in children with Congenital Adrenal Hyperplasia.

Expertise

  • Pharmacometrics
  • Pharmacokinetics
  • Pharmacodynamics
  • Population pharmacokinetics-pharmacodynamics 
  • Modeling and Simulation
  • Nonlinear Mixed Effects Modeling
  • Model-based Drug Development
  • Modeling Biologics

Awards & Recognition

Outstanding Teacher Award, Department of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center

Professional Associations

International Society of Pharmacometrics (ISoP)

Languages

  • Arabic

Research

Research Summary/Interests

My research interests are in the area of analysis and simulation of the pharmacokinetics-pharmacodynamics of biologics in particular Antibody Drug Conjugates (ADCs). A second area of interest is the modeling and simulation of circadian rhythms in particular adrenal steroids.

Publications

Al-Kofahi M, Becker F, Gavins FN, Woolard M, Tsunoda I, Wang Y, Ostanin D, Zawieja DC, Muthuchamy M, von der Weid PY, Alexander JS. Interleukin-1 beta Reduces Tonic Contraction of Mesenteric Lymphatic Muscle Cells: Involvement of Cyclooxygenase-2 / Prostaglandin E2. British journal
of pharmacology (2015).

Al-Kofahi, M., Yun, J. W., Minagar, A. and Alexander, J. S., Anatomy and roles of lymphatics in inflammatory diseases. Clin Exp Neuroimmunol. (2017).

Teaching

Academic Interests and Focus

Pharmacometrics; Biologics; Physiology

Teaching Areas

Pharmacometrics; Pharmacokinetics of Biologics; Model-based Drug Development of Biologics

Courses

ECP 8440 : "Biologics: Pharmacokinetics and Model-based Drug Development”