Changquan Calvin Sun, PhD

Director of Graduate Studies and Professor, Department of Pharmaceutics

Changquan Calvin Sun

Contact Info

sunx0053@umn.edu

Office Phone 612-624-3722

Fax 612-626-2125

Office Address:
Room 9-127B
Weaver-Densford Hall

Mailing Address:
University of Minnesota
Department of Pharmaceutics
College of Pharmacy
308 Harvard St. SE
Room 9-177 WDH
Minneapolis, MN 55455

Administrative Assistant Name
Katie James

Administrative Email
kmjames@umn.edu

Director of Graduate Studies and Professor, Department of Pharmaceutics


PhD, Pharmaceutics, University of Minnesota

BS, Pharmacy, Shanghai Medical University, P.R. China

Summary

Expertise

Formulation, Solid-state chemistry, Powder technology, Crystal engineering, Materials science and engineering

Awards & Recognition

  • 1999 – 2000 AFPE Pre-doctoral Fellowship
  • 11/2008 AAPS New Investigator Award
  • 2009 Top reviewer for Molecular Pharmaceutics
  • 2009, 2013, 2016 Top reviewer for Journal of Pharmaceutical Sciences
  • 07/2014 PhRMA Foundation Sabbatical Fellowship
  • 09/2014 China 100 distinguished Chinese alumni of the University of Minnesota
  • 11/2016 Fellow of American Association of Pharmaceutical Scientists

Professional Associations

  • Royal Society of Chemistry
  • American Association for the Advancement of Science
  • American Association of Pharmaceutical Scientists
  • American Association of Colleges of Pharmacy
  • American Chemical Society

Research

Research Summary/Interests

Our research focuses on manufacturing science of solid dosage forms, such as tablets and capsules. Formulation and process development is achieved by a clear scientific understanding of powders, including their flow and compaction properties. In this way, design replaces trial and error, and improved quality results.

We rely on three levels of control to attain the desired powder properties for successful manufacturing: (1) study and specification of the physico-mechanical properties of drugs; (2) incorporation of appropriate excipients for optimum mechanical properties; and (3) optimization of processes such as mixing, granulation, and compaction, based on a mechanistic understanding.

Our current research interests include:

  • Solubilization of poorly water-soluble drugs and other chemicals;
  • Crystal engineering for superior pharmaceutical properties of drugs (e.g., the development of a crystal structure–mechanical property relationship based on molecular modeling, crystallography, and nano-indentation);
  • Isolation and characterization of various solid forms, e.g., glasses, salts, cocrystals, and polymorphs, of drugs and excipients based on a thorough understanding of thermodynamics and kinetics of amorphization and crystallization phenomena;
  • Understanding and improving solid-state stability of drugs or excipients during processing and storage (e.g., glass to crystal, crystal to glass, and one polymorph to another);
  • Particle engineering for enhancing powder properties through controlled processes, such as crystallization, milling, and nano-coating;
  • Rational design of high-quality solid dosage forms based on mechanical properties of drug, excipients, and their interactions in a powder mixture (in addition to considering common criteria, such as chemical stability and hygroscopicity);
  • Mechanistic understanding of common pharmaceutical processes, such as granulation, milling, compaction, and coating, through both experimentation and computer modeling.

By systematically applying materials science principles to pharmaceutical systems, we will clearly define functionality of existing excipients and develop new types of excipient, including crystalline, polymeric, and co-processed powders.

Research Interests

  • Crystal Engineering
  • Particle Design
  • Formulation
  • Powder Technology
  • Drug Solubilization
  • Solid-state Science
  • Manufacturing Science

Publications

  • COVER ARTICLE Sathyanarayana Reddy Perumalla and Changquan Calvin Sun. A Synthon Preference in O-protonated Amide Crystals – Dominance of Short Strong Hydrogen Bonds. CrystEngComm, 15: 8941-8946, 2013.


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