Esam El-Fakahany, PhD

Associate Dean for Faculty Affairs and Graduate Education, College of Pharmacy

Esam El-Fakahany

Contact Info

elfak001@umn.edu

Office Phone 612-625-5695

Fax 612-624-6695

Office Address:
7-152 Weaver-Densford Hall

Mailing Address:
University of Minnesota
College of Pharmacy
Department of Experimental and Clinical Pharmacology
7-115 Weaver-Densford Hall
308 Harvard St. SE
Minneapolis, MN 55455

Associate Dean for Faculty Affairs and Graduate Education, College of Pharmacy

Professor, Department of Experimental and Clinical Pharmacology (ECP)

Professor, Department of Neuroscience

Adjunct Professor, Department of Psychiatry


PhD of Pharmacology, University of Minnesota, Mayo Graduate School

MS of Pharmacology, Alexandria University

Bachelor of Pharmacy, University of Alexandria

Research

Research Summary/Interests

Dr. El-Fakahany's research interests are focused in the areas of neuronal receptor modulation, mechanisms of receptor coupling to second messenger signal transduction pathways, and Alzheimer's disease. One of the main ongoing research areas is the investigation of the cellular pathways that link muscarinic acetylcholine receptors to the generation of nitric oxide in neurons, particularly in relation to hydrolysis of membrane phospholipids and calcium signaling. The laboratory is also interested in elucidating the mechanisms of feedback regulation of nitric oxide. Nitric oxide plays major roles in the regulation of cerebral blood flow, memory and neurotoxicity. Another area of interest is the investigation of the molecular mechanisms of action of drugs used for the treatment of Alzheimer's dementia. All of these questions are addressed by applying a combination of pharmacological and molecular biology techniques in mammalian brain, cultured neurons, or genetically engineered cells.

Research Interest

  • Alzheimer's therapy
  • Psychiatry

Research Project

  • Cholinergic replacement therapy for Alzheimer's

Publications

Jakubík, J, Randáková, A, El-Fakahany, EE & Doležal, V 2019, ‘Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators’ PLoS One, vol. 14, no. 3, pp. e0214255. https://doi.org/10.1371/journal.pone.0214255

Jakubík, J, Randáková, A, Rudajev, V, Zim?ík, P, El-Fakahany, EE & Doležal, V 2019, ‘Applications and limitations of fitting of the operational model to determine relative efficacies of agonists’ Sci Rep, vol. 9, no. 1, p. 4637. https://doi.org/10.1038/s41598-019-40993-w

Randáková, A, Dolejší, E, Rudajev, V, Zim?ík, P, Doležal, V, El-Fakahany, EE & Jakubík, J 2018, ‘Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline’ Neuropharmacology, vol. 133, pp. 129-144. https://doi.org/10.1016/j.neuropharm.2018.01.027

Jakubík, J, Randáková, A, Zim?ík, P, El-Fakahany, EE & Doležal, V 2017, ‘Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors’ Sci Rep, vol. 7, p. 40381. https://doi.org/10.1038/srep40381

Janickova, H, Rudajev, V, Dolejsi, E, Koivisto, H, Jakubik, J, Tanila, H, El-Fakahany, EE & Dolezal, V 2015, ‘Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic APPswe/PS1dE9 Mice’ Curr Alzheimer Res, vol. 12, no. 10, pp. 923-31.

Jakubík, J, El-Fakahany, EE & Doležal, V 2015, ‘Towards predictive docking at aminergic G-protein coupled receptors’ J Mol Model, vol. 21, no. 11, p. 284. https://doi.org/10.1007/s00894-015-2824-9

Randáková, A, Dolejší, E, Rudajev, V, Zim?ík, P, Doležal, V, El-Fakahany, EE & Jakubík, J 2015, ‘Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms’ Pharmacol Res, vol. 97, pp. 27-39. https://doi.org/10.1016/j.phrs.2015.04.002

Jakubík, J, Zim?ík, P, Randáková, A, Fuksová, K, El-Fakahany, EE & Doležal, V 2014, ‘Molecular mechanisms of methoctramine binding and selectivity at muscarinic acetylcholine receptors’ Mol Pharmacol, vol. 86, no. 2, pp. 180-92. https://doi.org/10.1124/mol.114.093310

Michal, P, El-Fakahany, EE & Doležal, V 2015, ‘Changes in Membrane Cholesterol Differentially Influence Preferential and Non-preferential Signaling of the M1 and M3 Muscarinic Acetylcholine Receptors’ Neurochem Res, vol. 40, no. 10, pp. 2068-77. https://doi.org/10.1007/s11064-014-1325-z

Šantr??ková, E, Doležal, V, El-Fakahany, EE & Jakubík, J 2014, ‘Long-term activation upon brief exposure to xanomleline is unique to M1 and M4 subtypes of muscarinic acetylcholine receptors’ PLoS One, vol. 9, no. 2, p. e88910.https://doi.org/10.1371/journal.pone.0088910