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Pharmacy Practice and Pharmaceutical Sciences

 

Erin Sheets

cop bio pic erin sheets

Erin D. Sheets, Ph.D.
Associate Professor
Department of Pharmacy Practice and
  Pharmaceutical Sciences

Office:
121 Life Science, Duluth

Telephone Number:
218-726-6046

Fax Number:
218-726-6500

E-mail Address:
edsheets@d.umn.edu

Education:

Research Associate & NIH Postdoctoral Fellow, Chemistry & Chemical Biology, Cornell University
Ph.D. Chemistry, University of North Carolina at Chapel Hill
M.S. Chemistry, University of North Carolina at Chapel Hill
B.A. Chemistry, Juniata College, Pennsylvania

Additional Study:
Philipps-Universität, Marburg Germany

Honors & Awards:

Young Alumni Achievement Award, Juniata College (2006); NIH National Research Service Award (10/1997-9/2000); Charles N. Reilley Graduate Fellow, Department of Chemistry, University of North Carolina (8/1991-5/1992); Juniata College Honor Society (1991); Merck Index Chemistry Achievement Award, Department of Chemistry, Juniata College (1991); DuPont Chemistry Achievement Award, Department of Chemistry, Juniata College (1990) 

Research Interests:

Immunoreceptor signaling; spatiotemporal dynamics of cell surface phenomena; signal transduction; membrane structure and dynamics; quantitative fluorescence microscopy & spectroscopy.

Nanoscale dynamics of cell surface signaling
Research in the Sheets Group focuses on understanding quantitatively how critical molecular events in a variety of essential membrane-involved processes control biological function. Specifically, we study immunoglobulin E (IgE) receptor signaling, which initiates the allergic response in mast cells. We are developing new quantitative tools, particularly those exploiting fluorescence, to probe spatial and temporal dynamics of the molecular interactions involved in immunoreceptor signaling. Our multidisciplinary laboratory uses state-of-the-art fluorescence microscopy and spectroscopy, optical trapping and nanotechnology to manipulate and interrogate single molecules in living cells and biomimetic systems. Questions we are investigating range from the physical chemistry of functional interfacial lipid-lipid and lipid-protein interactions to the initiation of signal transduction and exocytosis.


Selected Publications:

Piehowski P, Davey AM, Kurczy ME, Sheets ED, Winograd N, Ewing AG, Heien ML. Time-of-flight secondary ion mass spectrometry imaging of subcellular lipid heterogeneity: Poisson counting and spatial resolution. Anal Chem. 2009;81:5593-5602.
 
Kyoung M and Sheets ED. Vesicle diffusion close to a membrane: intermembrane interactions measured with fluorescence correlation spectroscopy. Biophys J. 2008;95:5789-5797.
 
Vats K, Kyoung M, Sheets ED. Characterizing the chemical complexity of patterned biomimetic membranes. Bioch Biophys Acta. 2008;1778:2461-2468.
 
An A, Kumar S, Sheets ED, Benkovic SJ. Reversible compartmentalization of de novo purine biosynthetic complexes in living cells. Science. 2008;320:103-106.
 
Davey AM, Krise KM, Sheets ED, Heikal AA. Molecular perspective of antigen-mediated mast cell signaling. J Biol Chem. 2008;283:7117-7127.
 
Butler PJ, Dong C, Snyder AJ, Jones AD, Sheets ED. Bioengineering and Bioinformatics Summer Institutes: meeting modern challenges in undergraduate summer research. CBE--Life Sciences Education. 2008;7:45–53. 
 
Kyoung M, Karunwi K, Sheets ED. A versatile multi-mode microscope to probe and manipulate nanoparticles and biomolecules. J Microsc. 2007;225:137-146.
 
Davey AM, Liu Y, Walvick R, Heikal AA, Sheets ED. Membrane order and molecular dynamics associated with IgE receptor cross-linking in mast cells. Biophys J. 2007;92:343-355.
 
Kyoung M and Sheets ED. Manipulating and probing the spatio-temporal dynamics of nanoparticles near surfaces. Proceedings of SPIE. 2006;6326:63262L.
 
Holowka D, Sheets ED, Baird B. Interactions between FceRI and lipid raft components are regulated by the actin cytoskeleton. J Cell Sci. 2000;113:1009-1019.
 
Sheets ED, Holowka D, Baird B. Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FceRI and their association with detergent-resistant membranes. J Cell Biol. 1999;145:877-887.
 
Sheets ED, Lee GM, Simson R, Jacobson K. Transient confinement of a glycosylphosphatidylinositol-anchored protein in the plasma membrane. Biochem. 1997;36:12449-12458.
 
Jacobson K, Sheets ED, Simson R. Revisiting the fluid mosaic model of membranes. Science. 1995;268:1441-1442.
 
Professional Memberships:

  • American Chemical Society (ACS)
  • American Society for Biochemistry & Molecular Biology (ASBMB)
  • American Society for Cell Biology (ASCB)
  • Biophysical Society
    • Member, Committee on Professional Opportunities for Women, 2001-2006
    • Member, 50th Anniversary Committee, 2005-2006
    • Member, Early Career Committee, 2006–2009
    • Member, Membership Committee, 2006–present
    • Chair, Membership Committee, 2009–present
  • SPIE—The International Society for Optical Engineering