Erin D. Sheets, Ph.D.
Research Associate & NIH Postdoctoral Fellow, Chemistry & Chemical Biology, Cornell University
Ph.D. Chemistry, University of North Carolina at Chapel Hill
M.S. Chemistry, University of North Carolina at Chapel Hill
B.A. Chemistry, Juniata College, Pennsylvania
Philipps-Universität, Marburg Germany
Honors & Awards:
Young Alumni Achievement Award, Juniata College (2006); NIH National Research Service Award (10/1997-9/2000); Charles N. Reilley Graduate Fellow, Department of Chemistry, University of North Carolina (8/1991-5/1992); Juniata College Honor Society (1991); Merck Index Chemistry Achievement Award, Department of Chemistry, Juniata College (1991); DuPont Chemistry Achievement Award, Department of Chemistry, Juniata College (1990)
Immunoreceptor signaling; spatiotemporal dynamics of cell surface phenomena; signal transduction; membrane structure and dynamics; quantitative fluorescence microscopy & spectroscopy.
Nanoscale dynamics of cell surface signaling
Research in the Sheets Group focuses on understanding quantitatively how critical molecular events in a variety of essential membrane-involved processes control biological function. Specifically, we study immunoglobulin E (IgE) receptor signaling, which initiates the allergic response in mast cells. We are developing new quantitative tools, particularly those exploiting fluorescence, to probe spatial and temporal dynamics of the molecular interactions involved in immunoreceptor signaling. Our multidisciplinary laboratory uses state-of-the-art fluorescence microscopy and spectroscopy, optical trapping and nanotechnology to manipulate and interrogate single molecules in living cells and biomimetic systems. Questions we are investigating range from the physical chemistry of functional interfacial lipid-lipid and lipid-protein interactions to the initiation of signal transduction and exocytosis.