Department of Medicinal Chemistry

Stephen Hecht, Ph.D.

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    Laboratory Medicine and Pathology (Graduate Faculty in Medicinal Chemistry)
    Wallin Land Grant Professor of Cancer Prevention, Department of Laboratory Medicine and Pathology
  • Professor of Laboratory Medicine and Pathology
  • Masonic Cancer Center Professor
  • Graduate Faculty Medicinal Chemistry
  • B.S.
    Duke University
  • Ph.D.
    Massachusetts Institute of Technology
  • PostDoc
    Massachusetts Institute of Technology
  • tobacco
  • carcinogens
  • metabolism
  • DNA adducts
  • biomarkers
  • 2-148 Cancer & Cardiovascular Research Building
  • University of Minnesota
    College of Pharmacy
    Department of Medicinal Chemistry
    8-101 Weaver-Densford Hall
    308 Harvard St. SE
    Minneapolis, MN 55455

About Stephen Hecht, Ph.D.


The goal of research in the Hecht laboratory is to understand mechanisms of metabolic activation and DNA modification by carcinogens in tobacco products and the human environment, and apply this knowledge to cancer prevention. The laboratory focuses on the properties of carcinogenic
nitrosamines, polycyclic aromatic hydrocarbons, and aldehydes. Using state of the art mass spectrometry and related techniques, analytical methods are developed for quantitation of carcinogen and toxicant metabolites and DNA adducts in human urine, blood and tissues. These biomarkers are
applied in collaborative clinical and epidemiologic studies to investigate human carcinogen exposure, metabolism, and susceptibility to cancer. Stable isotope labeled carcinogens and their analogues are employed in studies with users of tobacco products to track individual differences in metabolism.
The effects of naturally occurring potentially cancer chemopreventive compounds on carcinogen metabolism in humans are also investigated.

AWARDS:

1987-2001 Outstanding Investigator Grant, National Cancer Institute

2000-2009 American Cancer Society Research Professor

2001 Alton Ochsner Award Relating Smoking and Health

2002 Flight Attendant Medical Research Institute Dr. William Cahan Distinguished Professor
Award

2004 Merit Award, National Cancer Institute

1980-2004 Ninth most cited author in tobacco control; first in tobacco carcinogenesis (Byrne and
Chapman, Tobacco Control, 2005)

2006 Academy for Excellence in Health Research, Academic Health Center, University of
Minnesota

2006 AACR-Cancer Research and Prevention Foundation Award for Excellence in Cancer
Prevention Research

2009 Founders Award, Division of Chemical Toxicology, American Chemical Society

2009 Elected American Chemical Society Fellow

Published Works


Hecht, S.S. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nature Rev. Cancer, 3: 733-744, 2003.

Hecht, S.S., Yuan, J-Y., and Hatsukami, D. Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention. Chem. Res. Toxicol., 23: 1001-1008, 2010. PMCID: PMC2891118.

Zhong, Y., Carmella, S.G., Upadhyaya, P., Hochalter, J.B., Rauch, D., Oliver, A., Jensen, J., Hatsukami, D., Wang, J., Zimmerman, C., and Hecht. S.S. Immediate consequences of cigarette smoking: rapid
formation of polycyclic aromatic hydrocarbon diol epoxides, Chem. Res. Toxicol., 24: 246-252, 2011.  PMCID: PMC3042042.

Zhang, S., Balbo, S., Wang, M., and Hecht, S.S. Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human leukocyte DNA from smokers and non-smokers. Chem. Res.
Toxicol., 24: 119-124, 2010. PMCID: PMC3064499.

Thomas, J.L., Guo, H., Carmella, S.G., Balbo, S., Han, S., Davis, A., Murphy, S.E., An, L.C., Ahluwalia, J.S., and Hecht, S.S. Metabolites of a tobacco-specific lung carcinogen in children exposed to secondhand or thirdhand tobacco smoke in their homes. Cancer Epidemiol. Biomarkers & Prev., 20: 1213-1221, 2011.  PMCID: PMC3111852.

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  • Last modified on January 13, 2014