Department of Medicinal Chemistry

Gunda Georg, Ph.D.

COP - Image - Size 3 - COP - georg gunda
    Medicinal Chemistry
    Professor and Head
  • Robert Vince Endowed Chair
  • McKnight Presidential Chair in Medicinal Chemistry
  • Director - Institute for Therapeutics Discovery & Development
  • B.S. 1975
    Philipps Universität Marburg, Germany
  • Ph.D. 1980
    Philipps Universität Marburg
  • Postdoctoral 1981
    Philipps Universität Marburg
  • Postdoctoral 1982
    University of Ottawa, Canada
  • synthetic medicinal agents
  • natural products chemistry
  • new synthetic methods
  • 717 Delaware St SE, Room 452
  • University of Minnesota
    College of Pharmacy
    Department of Medicinal Chemistry
    717 Delaware St. SE, Room 477
    Minneapolis, MN 55414

About Gunda Georg, Ph.D.


Professor Georg and her group have published 180 scientific articles and are involved in the design, semisynthesis, total synthesis, and evaluation of biologically active agents. Current therapeutic areas include cancer, male contraception, epilepsy, and Alzheimer's disease. These projects require the development of synthetic methods, synthesis of natural products, and structure-activity studies aimed at improving the therapeutic efficacy of lead compounds, including natural products, and hits from high throughput screening.

Interdisciplinary projects are a main focus in the Georg group, involving medicinal chemistry, biochemistry, pharmacology, pharmaceutical chemistry and reproductive biology. Active collaboration exists between the Reproductive Branch of the National Institute of Child Health and Human Development, the Chemical Biology Consortium of the National Cancer Institute, several research groups at the University of Minnesota, and around the country. Professor Georg is the co-inventor of LusedraTM, which is marketed by Eisa Pharmaceuticals. She is also a co-inventor of Minnelide, an anticancer agent in phase I clinical trials, and of Gamedazol, a male contraceptive agent in preclinical development.

PATENTS:
Stella, V.; Krise, J.; Zygmunt, J. J.; Georg, G. I. Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof.

Stella, V.; Zygmunt, J. J.; Georg, G.I.; Safadi, M. S. Water-soluble prodrugs of hindered alcohols.

Georg, G. I.; Tash, J.; Chakrasali, R.; Jakkaraj, S. R. Lonidamine Analogues and their Use in Male Contraception and Cancer Treatment.

Michaelis, M. L.; Georg, G. I.; Himes, R. H.; Audus, K. Neuroprotective Agents.

Georg, G. I.; Saluja, A,; Patil, S. Vickers, S.; Chugh, R. Triptolide Prodrugs (patent pending).

AWARDS:
Professor Georg is the co-Editor-in-Chief of the Journal of Medicinal Chemistry of the American Chemical Society. She has served as a member of review panels for the National Institutes of Health, the National Science Foundation, the American Cancer Society and others. She is a Fellow of the American Association for the Advancement of Science. She was the 2000 Sato Memorial International Award recipient of the Pharmaceutical Society of Japan and the 2001 Nolan and Gloria Sommer Award Winner (University of Nebraska). Named Lectures: 2005 Loyd E. Harris Lecturer of the School of Pharmacy, University of Oklahoma, 2005 Taito O. Soine Lecturer in Medicinal Chemistry at the University of Minnesota, 2005 George Lesher Lecturer in Bioorganic and Medicinal Chemistry in the Department of Chemistry at the Rensselear Polytechnic Institute. 2007 Stanford Distinguished Women in Science Colloquium. 2008 Pharmacological and Pharmaceutical Sciences Distinguished Lecture. University of Houston College of Pharmacy, 2009 Ohio State University, College of Pharmacy Distinguished Lecture Series, 2010 Henry A. Lardy Lecture, South Dakota State University Department of Chemistry, 2010 Sosnovsky Distinguished Lectureship,University of Wisconsin-Milwaukee, Department of Chemistry.

Published Works


Tash. J. S.; Attardi, B.; Hild, S. A.; Chakrasali, R.; Jakkaraj, S. R.; Georg, G. I. A Novel Potent Indazole Carboxylic Acid Derivative Blocks Spermatogenesis and is Contraceptive in
Rats after a Single Oral Dose. Biology of Reproduction 2008, 78, 1127-1138.

Desino, K. E.; Ansar, S.; Georg, G. I.; Himes, R. H.; Michaelis, M. L.; Powell, D. R.; Reiff, E. A.; Telikepalli, H.; Audus, K. L. (3R,5S,7as)-(3,5-bis(4-Fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl) methanol: A Novel Neuroprotective Agent. J. Med. Chem. 2009, 52, 7537-7543.

Reiff, E. A.; Nair, S. N.; Henri, J. T.; Greiner, J. F.; Reddy, B. S.; Chakrasali, R.; David, S.;Chiu, T.-L.; Amin, E. A.; Himes, R. H.; VanderVelde, D. G.; Georg, G. I. Total Synthesis and
Evaluation of C26-Hydroxyepothilone D Derivatives for Photoaffinity Labeling of β-Tubulin. J. Org. Chem. 2010, 75, 86-94.

Niphakis, M. J.; Georg, G. I. Synthesis of Tylocrebrine and Related Phenanthroindolizidines by VOF3-Mediated Oxidative Aryl-Alkene Coupling. Org. Lett. 2011, 13, 196-199.

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  • Last modified on February 15, 2013