Tretyakova Research Group Publications

Recent publications (2002-2009)

Tretyakova, N.Y., Matter, B., Jones, R., Shallop, A. (2002) Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach. Biochemistry 41, 9535-9544.
PubMed citation

Pfeifer, G.P., Denissenko, M.F., Olivier, M., Tretyakova, N.Y., Hecht, S.S., and Hainaut, P. (2002) Tobacco smoke carcinogens, DNA damage, and p53 mutations in smoking-associated cancers. Oncogene 21, 7435-51.
PubMed citation

Upadhyaya, P., Stirla, S.J., Tretyakova, N.Y., Ziegel, R., Villalta, P.W., Wang, M., and Hecht, S.S. (2002) Identification of adducts produced by the reactions of 4-(acetoxy methylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA. Chem. Res. Toxicol. 16, 180-190.
PubMed citation

Ziegel, R., Jones, R., Shallop, A. and Tretyakova, N.Y. (2002) K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts. Chem. Res. Toxicol. 16, 541-550.
PubMed citation

Park, S., Seethraman, M., Ogdie, A., Ferguson, D., Tretyakova, N.Y. (2003) 3'-Exonuclease resistance of DNA oligodeoxynucleotides containing O⁶-[4-oxo-4-(3-pyridyl)butyl] guanine. Nucleic Acids Res. 31, 1984-1994.
PubMed citation

Matter, B., Wang, G., Jones, R., Tretyakova, N.Y. (2004) Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences. Chem. Res. Toxicol.  17, 731-741.
PubMed citation

Ziegel, R., Shallop, A., Jones, R., Tretyakova, N. (2004) Endogenous 5-methylcytosine protects neighboring guanines from N7 and O⁶-methylation and O⁶-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Biochemistry 43, 540-549.
PubMed citation

Park, S. and Tretyakova, N. (2004) Structural characterization of the major DNA-DNA cross-link of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol. 17, 129-136.
PubMed citation

Balcome, S., Park, S., Quirk-Dorr, D.R., Hafner, L., Phillips, L., Tretyakova, N.Y. (2004) Adenine-containing DNA-DNA cross-links of antitumor nitrogen mustards. Chem. Res. Toxicol. 17, 950-962.
PubMed citation

Thomson, N.M., Mijal, R.S., Ziegel, R., Fleischer, N.L., Pegg, A.E., Tretyakova, N.Y., Peterson, L.A. (2004) Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O⁶-[4-oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine. Chem. Res. Toxicol. 17, 1600-1606.
PubMed citation

Park, S., Hodge, J., Anderson, C., Tretyakova, N.Y. (2004) Guanine-adenine DNA cross-linking by 1,2,3,4-diepoxybutane: potential basis for biological activity. Chem. Res. Toxicol. 17, 1638-1651.
PubMed citation

Rajesh, M., Wang, G., Jones, R., Tretyakova, N.Y. (2005) Stable Isotope Labeling-Mass Spectrometry Analysis of Methyl- and Pyridyloxobutyl-Guanine Adducts of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53 -Derived DNA Sequences. Biochemistry 44, 2197-2207.
PubMed citation

Park, S., Anderson, C.,Wang. G, Jones, R., and Tretyakova, N. (2005) Interstrand and intrastrand DNA-DNA cross-linking by 1,2,3,4-diepoxybutane: role of stereochemistry. J. Am. Chem. Soc., 127, 14355-14365.
PubMed citation

Kim, J., Park S., Tretyakova, N., Wagner, C.R. (2005) A method for quantitating the intracellular metabolism of AZT amino acid phosphoramidate pronucleotides by capillary high-performance liquid chromatography-electrospray ionization mass spectrometry. Mol. Pharm. 2, 233-241.
PubMed citation

Millard, J.T., Hanly, T.C., Murphy, K., and Tretyakova, N. (2006) The 5'-GNC Site for DNA Interstrand Cross-Linking is Conserved for Diepoxybutane Stereoisomers. Chem. Res. Toxicol., 19, 16-19.
PubMed citation

Guza, R., Rajesh, M., Fang, Q., Pegg, A.E., and Tretyakova, N. (2006) Kinetics of O6-Me-dG repair by O⁶ -alkylguanine DNA alkyltransferase within K-ras gene derived DNA sequences. Chem. Res. Toxicol., 19, 531-538.
PubMed citation

Malejka-Giganti, M. and Tretyakova, N. (2006) Molecular mechanisms of carcinogenesis. In Carcinogenic and anticarcinogenic food components. (Baer-Dubowska, W., Bartoszek, A., and Malejka-Giganti, D. Eds.), pp 13-36, CRC Press, Boca Raton, FL.

Loeber, R., Rajesh, M., Fang, Q., Pegg, A.E., and Tretyakova, N. (2006) Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol., 19, 645-654.
PubMed citation

Quirk-Dorr, D., Murphy, K., and Tretyakova, N. (2006) Synthesis of DNA oligodeoxynucleotides containing structurally defined N⁶-(2'-hydroxy-3',4'-buten-1'-yl)-adenine adducts of 3,4-epoxy-1-butene. Chemico-Biol. Interact., 166, 104-11.
PubMed citation

Matter, B., Malejka-Giganti D., Csallany, A.S., and Tretyakova, N. (2006) Quantitative analysis of the oxidative DNA lesion, 2,2-diamino-4-(2-deoxy-beta-D-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), in vitro and in vivo by isotope dilution-capillary HPLC-ESI-MS/MS.  Nuc. Acids. Res., 34, 5449-5460.
PubMed citation

Tretyakova, N.Y., Livshits, A., Park, S., Bisht, B., and Goggin, M. (2007) Structural elucidation of a novel DNA-DNA cross-link of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol., 20, 284-289.
PubMed citation

Antsypovich, S., Quirk Dorr, D., Pitts, C., and Tretyakova, N.Y. (2007) Site specific N⁶-(2-hydroxy-3,4-epoxybut-1-yl)adenine oligodeoxynucleotide adducts of 1,2,3,4 diepoxybutane: synthesis and stability at physiological pH. Chem. Res. Toxicol., 20, 641-649.
PubMed citation

Kim, M.Y., Park, S., Tretyakova, N.Y., and Wogan, G. (2007) Mutagenesis of the supF gene by stereoisomers of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol., 20, 790-797.
PubMed citation

Goggin, M., Loeber, R., Park, S., and Tretyakova, N.Y. (2007) HPLC-ESI⁺-MS/MS analysis of N7-guanine-N7-guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene. Chem. Res. Toxicol., 20, 839-847.
PubMed citation

Miksa, B., Chinnapann, R., Dang, N.C., Reppert, M., Matter, B., Tretyakova, N.Y., Grubor, N., and Jankowiak, R. (2007) Spectral differentiation and immunoaffinity capillary electrophoresis separation of enantiomeric benzo(a)pyrene diol epoxide-derived DNA adducts. Chem. Res. Toxicol. 20, 1192-1199.
PubMed citation

Matter, B., Guza, R., Zhao, J., Li, Z., Jones, R., and Tretyakova, N.Y. (2007) Sequence distribution of acetaldehyde-derived N²-ethyl-dG adducts along duplex DNA. Chem. Res. Toxicol. 20, 1379-1387.
PubMed citation

Quirk-Dorr, D., Murphy, K., and Tretyakova, N.Y. (2007) Synthesis of DNA oligodeoxynucleotides containing structurally defined N⁶ -(2'-hydroxy-3',4'-buten-1'-yl)-adenine adducts of 3,4-epoxy-1-butene. Chemico-Biol. Interact. 166, 104-111.
PubMed citation

Loeber, R., Michaelson, E., Fang, Q., Campbell, C., Pegg, A.E., and Tretyakova, N.Y. (2008) Cross-linking of the DNA repair protein O⁶-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards. Chem. Res. Toxicol. 21, 787-795.
PubMed citation

Goggin, M., Anderson, C., Park, S., Walker, V., and Tretyakova, N.Y. (2008) Quantitative HPLC-ESI⁺ MS/MS analysis of adenine-guanine cross-links of 1,2,3,4-diepoxybutane in vitro and in vivo. Chem. Res. Toxicol., 21, 1163-70.
PubMed citation

Tretyakova, N.Y., Guza, R., and Matter, B. (2008) Endogenous cytosine methylation and the formation of carcinogen carcinogen-DNA adducts. Nucleic Acids Symp. Ser. 52, 49-50.
PubMed citation

Goggin, M., Swenberg, J.A., Walker, V., and Tretyakova, N.Y. (2009) Molecular dosimetry of 1,2,3,4-diepoxybutane-induced DNA-DNA cross-links in B6C3F1 mice and F344 rats exposed to 1,3-butadiene by inhalation. Cancer Res. 69, 2479-2486.
PubMed citation

Loeber, R.L., Michaelson-Richie, E.D., Codreanu, S.G., Liebler, D.C., Campbell, C.R., Tretyakova, N.Y. (2009) Proteomic analysis of DNA-protein cross-linking by antitumor nitrogen mustards. Chem. Res. Toxicol. 22, 1151-1162. 
PubMed citation

Guza, R., Ma, L., Fang, Q., Pegg, A.E., and Tretyakova, N.Y. (2009) Cytosine methylation effects on the repair of O⁶-methylgunaines within CG dinucleotides. J. Biol. Chem. 284, 22601-22610.
PubMed citation

Moser, A., Guza, B., Tretyakova, N.Y., and York, D. (2009) Density functional study of the influence of C5 cytosine substitution in base pairs with guanine. Theor. Chem. Accounts. 122, 179-188.
SpringerLink citation

Seneviratne, U., Antsypovich, S., Quirk Dorr, D., Guza, R., and Tretyakova, N.Y. (2009) Exocyclic deoxyadenosine adducts of 1,3-butadiene: synthesis, structural elucidation, and effects of DNA structure. Submitted.

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