Tretyakova Research Group
| Dr. Natalia Tretyakova, Ph.D. 760E CCRB Cancer Center Email: trety001@umn.edu Main Lab Phone (790 CCRB) 612-624-0638 HPLC Room 1 (735C CCRB) 612-626-4879 HPLC Room 2 (735A CCRB) 612-625-6244 Natalia's Office (760E CCRB) 612-626-3432 Student Office (760G CCRB) 612-625-5132 Office Fax: 612-626-5135 Synthetic Lab (9-153 WDH) 612-624-4643 Molecular Biology Lab (Dr. Campbell's Lab in NHH) 612-625-8491 Natalia's C.V.: MS Word format or Adobe Acrobat | Related Links |
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| The majority of genetic changes observed in human cancer are not inherited, but have environmental causes. These genetic alterations originate when DNA is chemically altered by chemicals present in the environment, our diet, and also produced naturally as a result of normal metabolism. We are developing novel methods to chemically identify and map the location of carcinogen-induced DNA damage within genes often found mutated in cancer, those that control cell growth and differentiation. This research will help establish a link between specific DNA damaging agents and genetic changes observed in cancer, providing important insights into the origins of cancer and offering new strategies for cancer prevention and treatment. | |
| Lab News | |
April 2009 Best of luck to Rachel! Rachel Loeber recently graduated from our group to join the group of Prof. Deborah Ferrington, Ph.D. (U of M Department of Ophthalmology) as a postdoctoral associate. Rachel will be investigating how proteasome structure and function change with aging and disease. Erin Michalson-Richie presented a poster "DNA-PROTEIN CROSS-LINKING BY ANTITUMOR DNA ALKYLATING DRUGS" at the 100th national meeting of the American Association for Cancer Research in Denver on April 21, 2009. | |
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| December 2007 Our proposal "DNA-protein cross-linking in carcinogenesis and cancer therapy" is funded by the AHC. | |
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| September 2007 Brock's paper "Sequence distribution of acetaldehyde-derived N 2-ethyl-dG adducts along duplex DNA" is published in CRT. PubMed citation  | |
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| April 2007 First detection of diepoxybutane-specific DNA-DNA cross-links in vivo is reported. PubMed citation  | |
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| March 2007 Article describing the first synthesis of DNA oligonucleotides containing monoepoxide adducts of diepoxybutane appears in Chemical Research in Toxicology. PubMed citation  | |
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| January 2007 Novel DNA-DNA cross-link of diepoxybutane is identified. PubMed citation  | |
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May 2006 | |
