Natalia Tretyakova

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Natalia Y. Tretyakova, Ph.D.

Academic Title

Medicinal Chemistry


Moscow State University, 1985
Moscow State University, 1990
University of North Carolina at Chapel Hill, 1997
Other Education
Postdoctoral Training, Massachusetts Institute of Technology, 1997-2000

Contact Info




Office Address

2-147 Cancer & Cardiovascular Research Building

Mailing Address

University of Minnesota
College of Pharmacy
Department of Medicinal Chemistry
2231 Sixth Street SE #2-147
Minneapolis, MN 55455

Bio Statement

The focus of our research is to investigate the structural basis for carcinogenic and anticancer activity of DNA- and protein-modifying agents. Synthetic methodologies are developed to prepare structurally modified nucleosides and amino acids representing carcinogen- and drug-induced DNA and protein adducts. The effects of nucleobase modifications on DNA structure and stability are determined by NMR spectroscopy, mass spectrometry, CD spectroscopy, and computer modeling of chemically altered DNA. Biological mass spectrometry techniques are employed to quantify the formation of DNA and protein adducts in vivo. These studies identify the molecular targets of exogenous and endogenous electrophiles and provide an insight into the origins of their biological activity. The following projects are currently underway:

Identification of DNA adducts produced by Bis-electrophiles: This research aims to identify the structures of novel DNA lesions generated by bifunctional electrophiles used in chemotherapy and generated from metabolism of xenobiotics.

Solid Phase Synthesis of DNA Oligonucleotides Containing Site- and Stereospecific DNA Adducts: Synthetic methodologies are developed to generate DNA strands containing site- and stereospecific nucleobase lesions for structural and biological studies (e.g. NMR, mutagenesis, and polymerase bypass).

Inter-individual Differences in Metabolism of Tobacco Carcinogens: Mass spectrometry based methodologies are employed to uncover inter-individual and ethic differences in metabolism of tobacco carcinogens.

DNA Sequence Effects on Reactivity: Isotope labeling approaches are used to map the reactivity of carcinogens and drugs towards DNA nucleobases as a function of local sequence context. Unnatural DNA bases are used to establish the mechanisms of sequence-dependent reactivity.

Novel Mass Spectrometry Methodologies for Quantitative Analyses of DNA damage: we are developing novel mass spectrometry methodologies for quantitative analyzes of DNA adducts in vivo (e.g. in laboratory animals and cancer patients undergoing treatment).

Proteomics Studies of DNA-protein Cross-linking: we are employing mass spectrometry based proteomics to characterize the protein targets of bis-electrophiles that cross-link proteins to DNA.

2002 –2013 "Sequence distribution of tobacco carcinogen-DNA adducts" (NCI 5R01 CA-095039) Research Project Grant from the NIH.

2003 –2013 "DNA cross-linking by diepoxybutane" (NIH NCI 2R01-CA100670) Research Project Grant from the NIH.

2010-2014 "Mechanisms of ethnic/racial differences in lung cancer due to cigarette smoking"(1 P01 CA138338-01A1) Program Project Grant from the NIH.

Research Interests

  • Chemical Biology
  • Nucleic Acids
  • Chemical Carcinogenesis
  • Nucleoside Synthesis
  • Mass Spectrometry
  • Proteomics


Peer Reviewed Publications

Kotandeniya, D., Murphy, D., Yan, S., Park, S., Seneviratne, U., Koopmeiners, J.S., Pegg, A., Kanugula, S., Kassie, F., Tretyakova, N.Y. (2013) Kinetics of O6-pyridyloxobutyl-2'-deoxyguanosine repair by human O6-alkylguanine DNA alkyltransferase. Biochemistry 52, 4075-4088. PubMed citation.

Tretyakova, N.Y., Villalta, P.W., Kotapati, S. (2013) Mass spectrometry of structurally modified DNA. Chem. Rev. 113, 2395-2436. PubMed citation.

Gherezghiher, T.B., Ming, X., Villalta, P.W., Campbell, C., Tretyakova, N.Y. (2013) 1,2,3,4-Diepoxybutane-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells. J. Proteome. Res. 12, 2151-2164. PubMed citation.

Wickramaratne, S., Mukherjee, S., Villalta, P.W., Scharer, O.D., Tretyakova, N.Y. (2013) Synthesis of sequence-specific DNA-protein conjugates via a reductive amination strategy. Bioconjug. Chem. 24, 1496-1506. PubMed citation.

Kotapati, S., Maddukuri, L., Wickramaratne, S., Seneviratne, U., Goggin, M., Pence, M., Villalta, P., Guengerich, F. Marnett, L., Tretyakova, N.Y. (2012) Translesion synthesis across 1,N6-(2-Hydroxy-3-hydroxy-methylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases. J. Biol. Chem. 287, 38800-38811. PubMed citation.

Tretyakova, N.Y., Goggin, M., Sangaraju, D, Janis, G. (2012) Quantitation of DNA adducts by stable isotope dilution mass spectrometry. Chem. Res. Toxicol. 25, 2007-2035. PubMed citation

Sangaraju, D., Goggin, M., Walker, V., Swenberg, J., Tretyakova, N.Y. (2012) NanoHPLC-nanoESI+-MS/MS quantitation of bis-N7-guanine DNA-DNA cross-links in tissues of B6C3F1 mice exposed to sub-ppmlevels of 1,3-butadiene. Anal. Chem., 84(3), 1732-1739. PubMed citation

Kotandeniya, D., Murphy, D., Seneviratne, U., Guza, R., Pegg, A., Kanugula, S., Tretyakova, N.Y. (2011) Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA. Chem. Res. Toxicol. 24(11), 1966-1975. PubMed citation

Kotapati, S., Matter, B.A., Grant, A.L., Tretyakova, N.Y. (2011) Quantitative analysis of trihydroxybutyl mercapturic acid, a urinary metabolite of 1,3-butadiene, in human. Chem. Res. Toxicol. 24(9), 1516-1526. PubMed citation

Goggin, M., Sangaraju, D., Walker, V.E., Wickliffe, J., Swenberg, J.A., Tretyakova, N.Y. (2011) Persistence and repair of bifunctional DNA adducts in tissues of laboratory animals exposed to 1,3-butadiene by inhalation. Chem. Res. Toxicol. 24, 809-817.
PubMed citation

Swenberg, J.A., Bordeerat, N.K., Boysen, G., Carro, S., Georgieva, N.I., Nakamura, J., Troutman, J.M., Upton, P.B., Albertini, R.J., Vacek, P.M., Walker, V.E., Sram, R.J., Goggin, M., Tretyakova, N.Y. (2011) 1,3-Butadiene: Biomarkers and application to risk assessment. Chem. Biol. Interact. 192, 150-154.
PubMed citation

Kotandeniya, D., Murphy, D., Seneviratne, U., Guza, R., Pegg, A., Kanugula, S., Tretyakova N.Y. (2011) Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA. Chem. Res. Toxicol. 24, 1966-75.
PubMed citation

Johnson, L,A., Malayappan, B., Tretyakova, N.Y., Campbell, C., Macmillan, M.L., Wagner, J.E., Jacobson, P.A. (2012) Formation of cyclophosphamide specific DNA adducts in hematological diseases. Pediatr. Blood Cancer. 58, 708-14.
PubMed citation

Kotapati, S., Matter, B.A., Grant, A.L., Tretyakova, N.Y. (2011) Quantitative analysis of trihydroxybutyl mercapturic acid, a urinary metabolite of 1,3-butadiene, in humans. Chem. Res. Toxicol. 24, 1516-1526.
PubMed citation

Michaelson-Richie, E,D., Ming. X., Codreanu, S.G., Loeber, R.L., Liebler, D.C., Campbell, C., Tretyakova, N.Y. (2011) Mechlorethamine-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells. J. Proteome Res. 10, 2785-2796.
PubMed citation

Guza, R., Kotandeniya, D., Murphy, K., Dissanayake, T., Lin, C., Giambasu, G.M., Lad, R.R., Wojciechowski, F., Amin, S., Sturla, S.J., Hudson, R.H., York, D.M., Jankowiak, R., Jones, R., Tretyakova, N.Y. (2011) Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA. Nucleic Acids Res. 39, 3988-4006.
PubMed citation

Seneviratne, U., Antsypovich, S., Quirk Dorr, D., Dissanayake, T., and Tretyakova, N.Y. (2010) DNA oligomers containing site- and stereospecific exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, characterization, and effects on DNA structure. Chem. Res. Toxicol. 23, 1556-1567.
PubMed citation

Michaelson-Richie, E., Loeber, R., Fang, Q., Campbell, C., Pegg, A., and Tretyakova, N.Y. (2010) DNA-protein cross-linking by 1,2,3,4-diepoxybutane. J. Proteome Res. 9, 4356-4367.
PubMed citation

Seneviratne U., Antsypovich S., Goggin M., Dorr D.Q., Guza R., Moser A., Thompson C., York D.M. and Tretyakova, N.Y. (2010) Exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, structural characterization, and mechanistic studies. Chem. Res. Toxicol. 23, 118-133 (highlighted article).
PubMed citation

Goggin, M., Seneviratne, U., Swenberg, J.A., Walker, V., and Tretyakova, N.Y. (2010) Column switching HPLC-ESI+-MS/MS methods for quantitative analysis of exocyclic dA adducts in the DNA of laboratory animals exposed to 1,3-butadiene. Chem. Res. Toxicol. 23, 808-812.
PubMed citation

Malayappan, B., Johnson, L., Nie, B., Panchal, D., Matter, B., Jacobson, P., and Tretyakova, N.Y. (2010) Quantitative HPLC-ESI-MS/MS analysis of bis-N7-Guanine cross-Links in blood of cancer patients receiving cyclophosphamide therapy. Analytical Chemistry 82, 3650-3658.
PubMed citation

Guza, R., Ma, L., Fang, Q., Pegg, A., and Tretyakova, N.Y. (2009) Cytosine methylation effects on the repair of O6-methylguaines within CG dinucleotides, J. Biol. Chem. 284, 22601-22610.
PubMed citation

Moser, A., Guza, B., Tretyakova, N.Y., and York, D. (2009) Density functional study of the influence of C5 cytosine substitution in base pairs with guanine. Theor. Chem. Accounts. 122, 179-188.
SpringerLink citation

Loeber, R.L., Michaelson-Richie, E.D., Codreanu, S.G., Liebler, D.C., Campbell, C.R., Tretyakova, N.Y. (2009) Proteomic analysis of DNA-protein cross-linking by antitumor nitrogen mustards. Chem. Res. Toxicol. 22, 1151-1162. 
PubMed citation

Goggin, M., Swenberg, J.A., Walker, V., and Tretyakova, N.Y. (2009) Molecular dosimetry of 1,2,3,4-diepoxybutane-induced DNA-DNA cross-links in B6C3F1 mice and F344 rats exposed to 1,3-butadiene by inhalation. Cancer Res. 69, 2479-2486.
PubMed citation

Tretyakova, N.Y., Guza, R., and Matter, B. (2008) Endogenous cytosine methylation and the formation of carcinogen carcinogen-DNA adducts. Nucleic Acids Symp. Ser. 52, 49-50.
PubMed citation

Goggin, M., Anderson, C., Park, S., Walker, V., and Tretyakova, N.Y. (2008) Quantitative HPLC-ESI+ MS/MS analysis of adenine-guanine cross-links of 1,2,3,4-diepoxybutane in vitro and in vivo. Chem. Res. Toxicol., 21, 1163-1170.
PubMed citation

Loeber, R., Michaelson, E., Fang, Q., Campbell, C., Pegg, A.E., and Tretyakova, N.Y. (2008) Cross-linking of the DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards. Chem. Res. Toxicol. 21, 787-795.
PubMed citation

Quirk-Dorr, D., Murphy, K., and Tretyakova, N.Y. (2007) Synthesis of DNA oligodeoxynucleotides containing structurally defined N6 -(2'-hydroxy-3',4'-buten-1'-yl)-adenine adducts of 3,4-epoxy-1-butene. Chemico-Biol. Interact. 166, 104-111.
PubMed citation

Matter, B., Guza, R., Zhao, J., Li, Z., Jones, R., and Tretyakova, N.Y. (2007) Sequence distribution of acetaldehyde-derived N2-ethyl-dG adducts along duplex DNA. Chem. Res. Toxicol. 20, 1379-1387.
PubMed citation

Miksa, B., Chinnapann, R., Dang, N.C., Reppert, M., Matter, B., Tretyakova, N.Y., Grubor, N., and Jankowiak, R. (2007) Spectral differentiation and immunoaffinity capillary electrophoresis separation of enantiomeric benzo(a)pyrene diol epoxide-derived DNA adducts. Chem. Res. Toxicol. 20, 1192-1199.
PubMed citation

Goggin, M., Loeber, R., Park, S., and Tretyakova, N.Y. (2007) HPLC-ESI+-MS/MS analysis of N7-guanine-N7-guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene. Chem. Res. Toxicol., 20, 839-847.
PubMed citation

Kim, M.Y., Park, S., Tretyakova, N.Y., and Wogan, G. (2007) Mutagenesis of the supF gene by stereoisomers of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol., 20, 790-797.
PubMed citation

Antsypovich, S., Quirk Dorr, D., Pitts, C., and Tretyakova, N.Y. (2007) Site specific N6-(2-hydroxy-3,4-epoxybut-1-yl)adenine oligodeoxynucleotide adducts of 1,2,3,4 diepoxybutane: synthesis and stability at physiological pH. Chem. Res. Toxicol., 20, 641-649.
PubMed citation

Tretyakova, N.Y., Livshits, A., Park, S., Bisht, B., and Goggin, M. (2007) Structural elucidation of a novel DNA-DNA cross-link of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol., 20, 284-289.
PubMed citation

Matter, B., Malejka-Giganti D., Csallany, A.S., and Tretyakova, N.Y. (2006) Quantitative analysis of the oxidative DNA lesion, 2,2-diamino-4-(2-deoxy-beta-D-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), in vitro and in vivo by isotope dilution-capillary HPLC-ESI-MS/MS.  Nuc. Acids. Res., 34, 5449-5460.
PubMed citation

Loeber, R., Rajesh, M., Fang, Q., Pegg, A.E., and Tretyakova, N.Y. (2006) Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol., 19, 645-654.
PubMed citation

Guza, R., Rajesh, M., Fang, Q., Pegg, A.E., and Tretyakova, N.Y. (2006) Kinetics of O6-Me-dG repair by O6 -alkylguanine DNA alkyltransferase within K-ras gene derived DNA sequences. Chem. Res. Toxicol., 19, 531-538.
PubMed citation

Millard, J.T., Hanly, T.C., Murphy, K., and Tretyakova, N.Y. (2006) The 5'-GNC site for DNA interstrand cross-linking is conserved for diepoxybutane stereoisomers. Chem. Res. Toxicol., 19, 16-19.
PubMed citation

Kim, J., Park S., Tretyakova, N.Y., Wagner, C.R. (2005) A method for quantitating the intracellular metabolism of AZT amino acid phosphoramidate pronucleotides by capillary high-performance liquid chromatography-electrospray ionization mass spectrometry. Mol. Pharm. 2, 233-241.
PubMed citation

Park, S., Anderson, C.,Wang. G, Jones, R., and Tretyakova, N.Y. (2005) Interstrand and intrastrand DNA-DNA cross-linking by 1,2,3,4-diepoxybutane: role of stereochemistry. J. Am. Chem. Soc., 127, 14355-14365.
PubMed citation

Rajesh, M., Wang, G., Jones, R., Tretyakova, N.Y. (2005) Stable Isotope Labeling-Mass Spectrometry Analysis of Methyl- and Pyridyloxobutyl-Guanine Adducts of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53 -Derived DNA Sequences. Biochemistry 44, 2197-2207.
PubMed citation

Park, S., Hodge, J., Anderson, C., Tretyakova, N.Y. (2004) Guanine-adenine DNA cross-linking by 1,2,3,4-diepoxybutane: potential basis for biological activity. Chem. Res. Toxicol. 17, 1638-1651.
PubMed citation

Thomson, N.M., Mijal, R.S., Ziegel, R., Fleischer, N.L., Pegg, A.E., Tretyakova, N.Y., Peterson, L.A. (2004) Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine. Chem. Res. Toxicol. 17, 1600-1606.
PubMed citation

Balcome, S., Park, S., Quirk-Dorr, D.R., Hafner, L., Phillips, L., Tretyakova, N.Y. (2004) Adenine-containing DNA-DNA cross-links of antitumor nitrogen mustards. Chem. Res. Toxicol. 17, 950-962.
PubMed citation

Park, S. and Tretyakova, N.Y. (2004) Structural characterization of the major DNA-DNA cross-link of 1,2,3,4-diepoxybutane. Chem. Res. Toxicol. 17, 129-136.
PubMed citation

Ziegel, R., Shallop, A., Jones, R., Tretyakova, N.Y. (2004) Endogenous 5-methylcytosine protects neighboring guanines from N7 and O6-methylation and O6-pyridyloxobutylation by the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Biochemistry 43, 540-549.
PubMed citation

Matter, B., Wang, G., Jones, R., Tretyakova, N.Y. (2004) Formation of diastereomeric benzo[a]pyrene diol epoxide-guanine adducts in p53 gene-derived DNA sequences. Chem. Res. Toxicol.  17, 731-741.
PubMed citation

Park, S., Seethraman, M., Ogdie, A., Ferguson, D., Tretyakova, N.Y. (2003) 3'-Exonuclease resistance of DNA oligodeoxynucleotides containing O6-[4-oxo-4-(3-pyridyl)butyl] guanine. Nucleic Acids Res. 31, 1984-1994.
PubMed citation

Ziegel, R., Jones, R., Shallop, A. and Tretyakova, N.Y. (2002) K-ras gene sequence effects on the formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-DNA adducts. Chem. Res. Toxicol. 16, 541-550.
PubMed citation

Upadhyaya, P., Sturla, S.J., Tretyakova, N.Y., Ziegel, R., Villalta, P.W., Wang, M., and Hecht, S.S. (2002) Identification of adducts produced by the reactions of 4-(acetoxy methylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA. Chem. Res. Toxicol. 16, 180-190.
PubMed citation

Pfeifer, G.P., Denissenko, M.F., Olivier, M., Tretyakova, N.Y., Hecht, S.S., and Hainaut, P. (2002) Tobacco smoke carcinogens, DNA damage, and p53 mutations in smoking-associated cancers. Oncogene 21, 7435-51.
PubMed citation

Tretyakova, N.Y., Matter, B., Jones, R., Shallop, A. (2002) Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach. Biochemistry 41, 9535-9544.
PubMed citation

Tretyakova, N.Y., Matter, B., Ogdie, A., Wishnok, J.S., and Tannenbaum, S.R. (2001) Locating nucleobase lesions within DNA sequences by MALDI-TOF mass spectral analysis of exonuclease ladders. Chem. Res. Toxicol. 14, 1058-1070.
PubMed citation

Tretyakova, N.Y., Wishnok, J.S., and Tannenbaum, S.R. (2000) Peroxynitrite-induced secondary oxidative lesions at guanine nucleobases: chemical stability and recognition by the Fpg repair enzyme. Chem. Res. Toxicol. 13, 658-664.
PubMed citation

Tretyakova, N.Y., Burney, S., Pamir, B., Wishnok, J.S., Dedon, P.C., Wogan, G.N., and Tannenbaum, S.R. (2000) Peroxynitrite-induced DNA damage in the supF gene: correlation with the mutational spectrum. Mutation Research 447, 287-303.
PubMed citation

Vatsadze, S.Z., Lebedev, A.T., Zyk, N.V., Zefirov, N.S., Tretyakova, N.Y., Hass, J.R. (2000) Fragmentation of 3,7-dialkyl-1,5-diphenyl-3,7-diazabicyclo[3.3.1]nonan-9-ones under electron ionization. Rapid Commun. Mass Spectrom. 14, 1949-1953.
PubMed citation

Swenberg, J.A., Ham, A., Koc, H., Morinello, E., Ranasinghe, A., Tretyakova, N.Y., Upton, P.B., Wu, K.Y. (2000) DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene. Mutation Research 464, 77-86.
PubMed citation

Tretyakova, N.Y., Niles, J., Burney, S., Wishnok, J.S. and Tannenbaum, S.R. (1999) Peroxynitrite-induced reactions of synthetic oligonucleotides containing 8-oxoguanine. Chem. Res. Toxicol. 12, 459-466.
PubMed citation

Koc, H., Tretyakova, N.Y., Walker, V.E., Henderson, R.F., and Swenberg, J.A. (1999) Molecular dosimetry of N-7-guanine adduct formation in mice and rats exposed to 1,3-butadiene. Chem. Res. Toxicol. 12, 566-574.
PubMed citation

Tretyakova, N.Y., Chiang, S-Y., Walker, V. and Swenberg, J.A. (1998) Quantitative analysis of 1,3-butadiene-induced DNA adducts in vivo and in vitro using liquid chromatography-electrospray ionization tandem mass spectrometry, Journal of Mass Spectrometry 33, 363-376.
PubMed citation

Tretyakova, N.Y., Sangaiah, R., Yen, T-Y. and Swenberg, J.A. (1997) Synthesis, characterization and in vitro quantitation of N-7-guanine adducts of diepoxybutane. Chem. Res. Toxicol. 10, 779-785.
PubMed citation

Tretyakova, N.Y., Lin, Y-P, Sangaiah, R., Upton, P.B. and Swenberg, J.A. (1997) Identification and quantification of DNA adducts from calf thymus DNA exposed to 3,4-epoxy-1-butene. Carcinogenesis 18, 137-147.
PubMed citation

Tretyakova, N.Y., Sangaiah, R., Yen, T-Y., and Swenberg, J.A. (1997) Adenine adducts with diepoxybutane: isolation and analysis in exposed calf thymus DNA. Chem. Res. Toxicol. 10, 1171-1179. 9348440.

Tretyakova, N.Y., Hass, J.R., Saginova, L.G. and Lebedev, A.T. (1997) Decomposition of 3,5-diaryl-oxathiolane-2-oxides under the electron impact. International Journal of Mass Spectrometry and Ion Processes 165/166, 595-607.

Sangaiah, R., Christova-Georgieva, N.I., Ranasighe, A., Tretyakova, N.Y., Gold, A., Ball, L.M., and Swenberg, J.A. (1997) Synthesis of perdeuterated analogues of the epoxide metabolites of butadiene: 1,2-epoxybut-3-ene-d6 and 1,2,3,4-diepoxybutane-d6. Journal of Labeled Compounds and Radiopharmaceuticals 39, 731-739.

Lebedev, A.T., Karakhanova, N.K., Sipyaguin, A.M., Efremov, I.V., Tretyakova, N.Y., and Hass, J.R. (1997) Comparative study of the cyclization of dithiocarbamate derivatives of polyhalopyridines induced by electron impact and carried out in solution. Journal of Mass Spectrometry 32, 728-738.

Lebedev, A.T., Predein, E., Bakulev, V., Tretyakova, N.Y., Hass, J.R. (1997) Isomerization of thioamidomethylpyridine ylides and isoquinoline ylides under electron impact. European Mass Spectrometry3, 217-223.

Tretyakova, N.Y., Lin, Y-P, Upton, P.B., Sangaiah, R. and Swenberg, J.A. (1996) Macromolecular adducts of butadiene. Toxicology 113, 70-76.
PubMed citation

Tretyakova, N.Y., Lebedev, A.T. and Petrosyan, V.S.(1994) Degradative pathways of the aqueous chlorination of orcinol. Environmental Science and Technology 28, 606-613.



Books and book chapters

Guza, R., Pegg, A., and Tretyakova, N.Y. (2010) Effects of sequence context on O6-alkylguanine DNA alkyltransferase repair of O6-alkylguanine-deoxyguanosine adducts. In ACS Symposium Series, Volume 1041, Structural Biology of DNA Damage and Repair (Stone, M.P., Ed.) pp 73-101, American Chemical Society, Washington, D.C.

Tretyakova, N.Y. (2009) Sequence distribution of nucleobase adducts studied by isotope labeling of DNA-mass spectrometry. In Mass Spectrometry of Nucleosides and Nucleic Acids (Banoub, J.H. and Limbach, P.A., Eds.), CRC Press, Boca Raton, FL.

Malejka-Giganti, M. and Tretyakova, N.Y. (2006) Molecular mechanisms of carcinogenesis. In Carcinogenic and anticarcinogenic food components. (Baer-Dubowska, W., Bartoszek, A., and Malejka-Giganti, D. Eds.), pp 13-36, CRC Press, Boca Raton, FL.


Active Collaborations

  Prof. Colin Campbell (Pharmacology) - DNA-protein cross-linking by bis-electrophiles
  Prof. Darrin York - (Chemistry) Molecular modeling of chemically modified nucleic acids
  Prof. D. Malejka-Giganti (VA Medical Center) - Oxidative DNA damage and cancer
  Prof. Roger Jones (Rutgers) - Stable isotope labeling of DNA


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