Rory Remmel

cop_content_359647_Rory Remmel

Rory Remmel, Ph.D.

Academic Title

Professor
Medicinal Chemistry

Education

Pharmacy School
University of Wyoming, 1977
Bachelor's
Pharmacy, University of Wyoming, Laramie
Ph.D.
Medicinal Chemistry, University of Washington, Seattle
Other Education
Postodoctoral Fellow, Harvard Medical School, Boston

Contact Info

Email
remme001@umn.edu

Phone
612-624-0472

Fax
612-624-0139

Office Address

8-174 Weaver-Densford Hall

Mailing Address

University of Minnesota
College of Pharmacy
Department of Medicinal Chemistry
8-101 Weaver-Densford Hall
308 Harvard St. SE
Minneapolis, MN 55455

Bio Statement

Dr. Remmel is a Distinguished Teaching Professor in the College of Pharmacy.

He is well known as a collaborative investigator in drug metabolism research, withan emphasis on glucuronidation. His research has included studies in basic enzymology, work with hepatocytes, animal studies, and clinical studies in AIDS patients, in patients with epilepsy, and in patients with tuberculosis. He has received multiple teaching awards (including highest teaching award given at the University of Minnesota), especially for teaching antimicrobial agents to pharmacy students.

Research Interests

Drug Metabolism and Disposition, Development of Prodrugs of Carbapenems for Tuberculosis, Metabolism, pharmacokinetics, and pharmacogenomics of antiepileptic Agents, Kinetics of UDP-glucuronosyl transferases, Effect of obesity on drug metabolism and dispositio

 

Research Projects

Meropenem Prodrugs for Treatment of Multi-Drug-Resistant Tuberculosis, Maternal and Childhood Outcomes of Children Borne by Mothers taking antiepileptic agents during pregnancy, Effect of Obesity on Drug Metabolism and Glucuronidation
 

Leadership Roles
  • Division Head, Experimental and Clinical Pharmacology, 1998-2000
  • Chair of Curricular Revision Committee, 2011
     
Awards
  • Minnesota Alumni Association Outstanding Contributions to Professional and Graduate Education 2010
  • Outstanding Faculty Award, Council of Graduate Students, 2010
  • Professor of the Year, Pharm. D III Class in 2001, 2003, 2005, 2007 2008, 2009, 2011
  • Teacher of the Graduating Class of 2012, College of Pharmacy
Publications

Argikar UA, Remmel RP, Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UGT1A4, UGT1A8, and UGT1A10. Drug Metab. Disp. (in press).

Brophy CM, Luebke-Wheeler J, Amiot B, Remmel RP, Rinaldo P, Nyberg SL, Rat hepatocyte spheroids formed by a rocked technique maintain differentiated structure and function. Hepatology (in press).

Gupte A, Subramanian M, Remmel RP, Aldrich CC, Synthesis of Deuterium Labeled 5’-O-[N-(Salicyl)sulfamoyl]adenosine (Sal-AMS-d4) as an Internal Standard for Quantitation of Sal-AMS, J. Labeled Comp. Radiolab..(in press).

Johnson L, Baker KS, Orchard PJ, Remmel RP, Jacobson P. Glutathione-S-Transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantation. J. Clin. Pharmacol. 48(9):1052-62 (2008).

Goodell JR, Ougolkov AV, Hiasa H, Kaur H, Remmel R, Billadeau DD, Ferguson DM. Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis. J Med Chem. 51(2):179-82 (2008).

Subramanian M, Birnbaum AK, Remmel RP High Speed Simultaneous Determination of Nine Antiepileptic Drugs by Liquid Chromatography-Mass Spectrometry. Therap. Drug Monitor. 30:347-356 (2008).

Clemens PL, Cloyd JC, Kriel RL, Remmel RP. Bioavailability, metabolism, and tolerability of rectally administered oxcarbazepine suspension. Clin, Pharmacok. 27(4):243-50 (2007).

Kumar A, Mann HJ, Remmel RP, Simultaneous analysis of cytochrome P450 probes dextromethorphan, flurbiprofen and midazolam and their major metabolites by HPLC-Mass-spectrometry/Fluorescence after single-step extraction from plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 853(1-2):287-93 (2007).

Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. Expression of the human UGT1 Locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic Acid (WY-14643) and implications on drug metabolism through Peroxisome Proliferator-Activated Receptor ? activation. Drug Metab Dispos. 35(3):419-27 (2007).

Kumar A, Mann HJ, Remmel RP, Pharmacokinetics of tiletamine and zolazepam (Telazol®) in anesthesized pigs. J. Vet. Pharmacol. Ther. 29:587-589 (2006).

Argikar UA, Cloyd JC, Birnbaum, AK, Leppik IE, Conway J, Kshirsagar S, Oetting WS, Klein EC, Remmel RP, Paradoxical urinary phenytoin metabolic (S)/(R) ratios in CYP2C19*1/*2 patients. Epilepsy Research 71(1):54-63 (2006).

Nyberg SL, Hardin J, Amiot B, Argikar UA, Remmel RP, Rinaldo P. Rapid, large-scale formation of porcine hepatocyte spheroids in a novel spheroid reservoir bioartificial liver. Liver Transpl. 11(8):901-910 (2005).

 

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  • Last modified on April 24, 2013