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Marnie Peterson

COP pharmacy image of Marnie Peterson

Marnie Peterson, PhD, PharmD, BCPS
Assistant Professor
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota
Infectious Diseases & Microbiology Translational Research

Office:
4-212 McGuire Translational Research Facility, 2001 6th Street S.E., Minneapolis, MN 55455

Telephone Number:
612-626-4388 (office)
612-626-6114 (laboratory)

E-mail Address:
peter377@umn.edu

 

 

Education:

  • BS Pharmacy, University of Minnesota College of Pharmacy
  • PharmD, University of Minnesota College of Pharmacy
  • Residency in Clinical Pharmacy, Antibiotic Pharmacodynamic Research Institute, University of Minnesota
  • Fellowship American College of Clinical Pharmacy Fellowship Infectious Disease Antibiotic Pharmacodynamic Research Institute, University of Minnesota
  • Post Graduate Visiting Scientist Anti microbial Agents Research Group, The Medical School, University of Birmingham, Birmingham, UK
  • PhD in Infection, Division of Infection and Immunity, The Medical School, University of Birmingham, Birmingham, UK
  • Post Doctoral Fellowship National Research Service Award Fellow, Department of Microbiology, Dept of Pediatric Infectious Diseases, Medical School, University of Minnesota

Research Interests Include: Characterization of interactions between Staphylococcus aureus and mucosal surfaces for the development of novel drug therapies including topical microbicides, anti-inflammatory agents as well as mucosal vaccine strategies.

Research Focus Areas:

  1. Prevention of Staphylococcal Infections & Toxic Shock Syndrome:  Hypothesis: Staphylococcal exoproteins (hemolysins) enhance mucosal transport of superantigens (toxic shock syndrome toxin -1 (TSST-1) & staphylococcal enterotoxins) via inflammatory activation of epithelial cells.
  2. Development of a Topical Microbicides.  Hypotheses:  Fatty acids, such as glycerol monolaurate (GML) are effective antimicrobials in the treatment of infections (vaginal and staphylococcal) as well as effective topical anti-inflammatory agents.

Recent Publications (Publications listed at PubMed):

  1. Schlievert, P.M., T.J. Tripp, T.J.,  and Peterson, M.L. Reemergence of staphylococcal toxic shock syndrome in Minneapolis-St. Paul, Minnesota, during the 2000-2003 surveillance period. J. Clin. Microbiol. 2004; 42(6):2875-2876.
  2. Peterson, M.L., Ault, K., Klingelhutz, A.J., Davis, C.C., and Schlievert, P.M. The innate immune system is activated by stimulation of vaginal epithelial cells with Staphylococcus aureus and toxic shock syndrome toxin-1. Infect. Immun. 2005; 73(4):2164-2174. 
  3. Kravitz, G.R., Dries, D.J., Peterson, M.L., and Schlievert, P.M. Purpura fulminans due to Staphylococcus aureus. Clin. Infect. Dis. 2005; 40(7):941-947.
  4. Peterson, M.L., and Schlievert, P.M. Glycerol monolaurate inhibits the effects of gram-positive select agents on eukaryotic cells.  Biochemistry. 2006; Feb 21; 45(7):2387-97.
  5. Buonpane, R.A.,  Churchill, H.R.,  Moza, B.,  Sundberg, E.J., Peterson, M.L.,  Schlievert, P.M., and  Kranz, D.M. Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists. Nat. Med. 2007; Jun;13(6):725-9.

  6. Schlievert, P.M.,  Case, L.C.,  Strandberg, K.L.,  Tripp, T.J.,  Lin, Y.C., and Peterson M.L. Vaginal Staphylococcus aureus superantigen profile shift from 1980-81 to 2003-05. J. Clin. Microbiol. 2007; 45(8):2704-7.

  7. Schlievert, P. M., Case, L. C., Nemeth, K. A., Davis, C. C., Sun, Y., Qin, W., Wang, F., Brosnahan, A. J., Mleziva, J. A., Peterson, M. L. and B. E. Jones. Alpha and beta chains of hemoglobin inhibit production of Staphylococcus aureus exotoxins. Biochemistry 2007; 46(50):14349-58.

  8. Schlievert P.M., Strandberg, K.L., Brosnahan, A.J., Peterson, M.L., Pambuccian, S.E., Nephew, K.R., Brunner, K.G., Schultz-Darken, N.J., and Haase, A.T. Glycerol Monolaurate Does Not Alter Rhesus Macaque (Macaca mulatta) Vaginal Lactobacilli and Is Safe for Chronic Use. Antimicrob. Agents Chemother. 2008 Oct 6. [Epub ahead of print]

Research Support:
The laboratory is supported via grants from the The Graduate School, U of MN, National Institutes of Health (NIH/NIAID), foundations, and industrial partners.

Awards:
3M Non-Tenured Faculty Grant Award

Current Laboratory Members:
Marnie L. Peterson, Pharm.D., Ph.D.- Principal Investigator; peter377@umn.edu
Michele Anderson, Ph.D. – Research Associate; ande8303@umn.edu
Ying-Chi Lin, B.S., M.S. – 4rd yr Ph.D. student; linxx290@umn.edu
Matthew Schaefers, B.S. – 3rd yr Ph.D. student; scha0607@umn.edu

Conferences-Scientific Abstracts: (recently attended or to be attended)

  1. M.M. Schaefers, A.M. Walz, P. Southern, P.M. Schlievert, M.L. Peterson. B-023 Effects of toxic shock syndrome toxin-1 on human vaginal and cervical epithelial cells and the role of major histocompatibility complex class II molecules. American Society for Microbiology, 106th General Meeting, Orlando, FLA May 21-25, 2006.
  2.  M.L. Peterson, P.M. Schlievert, M.M. Schaefers. P-211 Studies to explore human vaginal epithelial cell receptors that bind staphylococcal toxic shock syndrome toxin-1 and induce inflammation.  12th International Symposium on Staphylococci & Staphylococcal Infections, Maastricht, The Netherlands. Sept. 3 to 6, 2006.
  3. C. Fair, M.M. Schaefers, D. Simonsen, R. Muthylala, P.M. Schlievert, ML Peterson. F2-505 Effects of dodecylglycerol against methicillin-sensitive and methicillin-resistant Staphylococcus aureus. 46th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA, Sept. 27-30, 2006.
  4. M.M. Schaefers, P.M. Schlievert, P. Southern, M. L. Peterson. Exploration for epithelial receptor(s) that bind staphylococcal superantigens & induce cytokines. 3M Science and Engineering Faculty Day (SEFD) event, June 20, 2007, 3M Center in St. Paul, MN.
  5. B.L. Harlow, A.F. Vitonis, R.N.Fichorova, A. Onderdonk, W.H., M. Peterson, and E. G. Stewart. Assessment of clinical and epidemiological markers related to altered immuno-inflammatory response among women with and without vulvodynia. International Society for the Study of Vulvovaginal Disease World Congress, July 28-Aug. 4, 2007, Alaska (cruise).
  6. M.M. Schaefers, P.M. Schlievert, M. L. Peterson. Toxic Shock Syndrome Toxin-1 binding to CD40 induces cytokine production by Vaginal Epithelial Cells. Gordon Research Conference, Staphylococcal Diseases. Les Diablerets, Switzerland September 2-7, 2007.
  7. M.L. Peterson, P.M. Schlievert, K.L. Strandberg, L.C. Case, Y.C. Lin, M.C. Pack, D.J. Chase. L-616 (slide presentation). Staphylococcus aureus Exotoxin Production In Vivo is Reduced by Glycerol Monolaurate (GML) Tampons. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL, Sept. 17-20, 2007.
  8. M.L. Peterson. Simulating Anaerobic Infection (invited speaker). Symposium Session: When the pharmacokinetic/pharmacodynamic paradigm doesn’t fit. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL, Sept. 17-20, 2007.
  9. M.L. Peterson. Simulating Anaerobic Infection (invited speaker). Symposium Session: When the pharmacokinetic/pharmacodynamic paradigm doesn't fit. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, IL, Sept. 17-20, 2007.
  10. Lin, Y.C., Schlievert, P.M., Fair, C., Schaefers, M.M., Muthyala, R, and M.L. Peterson. Dodecylglycerol and glycerol monolaurate inhibit Staphylococcus aureus growth and toxin production. Gordon Research Conferences: New Antibacterial Discovery and Development. Lucca, Italy, March 9 to 14, 2008.