Krzysztof W. Pankiewicz, Ph.D. Senior Research Associate, Center for Drug Design Research Professor, Department of Medicinal Chemistry Office: 7-215 Philips-Wangensteen Building Telephone Number: 612-625-7968 FAX Number: 612-625-8252 E-mail Address: panki001@umn.edu

Education:

M.Sc., Warsaw Polytechnic, Warsaw, Poland, 1966
Ph.D., Polish Academy of Sciences, Center of Molecular and Macromolecular Studies, Lodz, Poland, 1979
Postdoctoral Research Associate, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, NY. 1980-1982.

Research Interests:

Research is focused on the discovery and development of novel compounds with anticancer, antiviral, antimicrobial, and immunosuppressive activity based on inhibition of NAD-dependent enzymes including IMP-dehydrogenase, the key enzyme in de novo synthesis of purine nucleosides. One lead compound is now in advanced pre-clinical studies against Gleevec-resistant leukemia (CML). Research also concerns synthesis of nucleosides and nucleotides as antiviral agents against HCV, HBV, HIV, WNV, and SARS.

Publications:

Pankiewicz KW, Lesiak-Watanabe KB, Watanabe, Patterson S, KA, Jayaram HN, Yalowitz JA, Miller MD, Seidman M, Majumdar A, Prehna G, Goldstein BM. Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemias. J. Med. Chem. 2002, 45, 703-712.

Pankiewicz KW, Goldstein BM. Inosine monophosphate dehydrogenase and its inhibitors. An overview. Inosine Monophosphate Dehydrogenase A Major Therapeutic Target, Pankiewicz KW, Goldstein BM Eds., ACS Symposium Series No. 839, 2003, 1- 20.

Stuyver LJ, Lostia S, Patterson SE, Watanabe KA, Otto MJ, Pankiewicz KW. Inhibitors of the IMPDH enzyme as potential anti-bovine viral diarrhea virus agents. Antiviral Chem. Chemother. 2003, 13, 345-352.