Pamala Jacobson

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Pamala Jacobson, Pharm.D.

Academic Title

Professor
Experimental and Clinical Pharmacology

ADDITIONAL TITLES:
Director of the Pathway Driven Pharmacogenomics U of M Alliance (PUMA-IPM) Institute of Personalized Medicine
Director of the Clinical Pharmacology Core of the Masonic Cancer Center

Education

Pharmacy School
Pharm.D., University of Nebraska
Residency
University of Michigan, Ann Arbor, MI
Other Education
Specialty Residency, Infectious Disease University of Michigan

Contact Info

Email
jacob117@umn.edu

Phone
612-624-6118

Fax
612-625-3927

Administrative Contact

Dede Johnston

Office Address

308 Harvard St SE, WDH 7-151

Mailing Address

University of Minnesota
College of Pharmacy
Department of Experimental and Clinical Pharmacology
7-115 Weaver-Densford Hall
308 Harvard St. SE
Minneapolis, MN 55455

Bio Statement

RECENT STUDIES:

- Fludarabine exposure-response relationships and pharmacogenetics in hematopoietic stem cell transplantation
- Pharmacogenetics of cyclosporine and tacrolimus related toxicity, exposure and clinical outcomes
- Pharmacokinetics of mycophenolate in hematopoietic stem cell transplantation, pharmacodynamics and pharmacogenetics.
- Busulfan pharmacokinetics, engraftment and veno-occlusive disease in patients undergoing allogenic transplantation.
- Population pharmacokinetics of tacrolimus and cyclosporine in stem cell transplantation.

Research Interests

  • Concentration and dose response relationships
  • Pharmacokinetics
  • Pharmacogenetics
  • Pharmacodynamics of immunosuppressants
  • Anticancer agents
  • Stem cell transplantation and organ transplant

 

Research Projects

Pharmacokinetics, pharmacodynamics and pharmacogenetics of immunosuppressants and anticancer agents.Clinical pharmacology of fludarabine, cyclophosphamide, doxorubicin, mycophenolate, cyclosporine, tacrolimus.

Leadership Roles

Director. Masonic Cancer Center Clinical Pharmacology Shared Resourse

Publications

PA Jacobson, WS Oetting, A Brearley, R. Leduc, W Guan, D Schladt, A Matas, V Lamba, A Israni for the DEKAF investigators. Novel Polymorphisms Associated with Tacrolimus Trough Concentrations: Results from a Multicenter Kidney Transplant Consortium. Transplantation. 2011 Feb 15; 91(3): 300-308. (PMID: 21206424, PMC Journal-In Process)

PA Jacobson, D Schladt, R Leduc, W Guan, AJ Matas, V Lamba, RB Mannon, BA Julian, A Israni for the DEKAF investigators. Genetic Determinants of Mycophenolate Related Anemia and Leukopenia Following Transplantation. Transplantation.2011 Feb 15; 91(3): 309-316. (PMID: 21107304, PMC Journal-In Process)

C Passey*, AK Birnbaum, RC Brundage, WS Oetting, PA Jacobson. Dosing Equation for Tacrolimus Using Genetic and Clinical Factors. Br J Clin Pharmacol. 2011 Dec; 72(6): 948-957. (PMID: 21671989, PMCID: PMC3244642)

Oetting WS, Schladt DP, Leduc RE, Jacobson PA, Guan W, Matas AJ, Israni A; DeKAF Investigators. Validation of single nucleotide polymorphisms associated with acute rejection in kidney transplant recipients using a large multi-center cohort. Transpl Int. 2011 Dec;24(12):1231-8. (PMID: 21955043, PMCID: PMC3208796, NIHMSID: NIHMS323689)

PA Jacobson, D Schladt, R Leduc, W Guan, AJ Matas, V Lamba, RB Mannon, BA Julian, A Israni for the DEKAF investigators. Reply to "genetic determinants of mycophenolate-related anemia and leukopenia after transplantation. Transplantation. 2012 Mar 27;93(6):624-31.

Johnson LA, Malayappan B, Tretyakova N, Campbell C, MacMillan ML, Wagner JE, Jacobson PA. Formation of cyclophosphamide specific DNA adducts in hematological diseases. Pediatr Blood Cancer. 2012 May;58(5):708-14. (PMID: 21793181, PMCID: PMC3204332, NIHMSID: NIHMS301541)

Jacobson PA, Schladt D, Israni A, Oetting WS, Lin Y*, Leduc R, Guan W, Lamba V, Matas AJ; DeKAF Investigators. Genetic and clinical determinants of early, acute calcineurin inhibitor-related nephrotoxicity: results from a kidney transplant consortium. Transplantation. 2012 Mar 27;93(6):624-31. (PMID: 22334041, PMCID: PMC3299910, NIHMSID: NIHMS349278)

Jensen K*, Johnson LA, Jacobson PA, Kachler S, Kirstein MN, Lamba J, Klotz KN. Cytotoxic purine nucleoside analogues bind to A(1), A (2A), and A (3) adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):519-25. (PMID: 22249336, PMC Journal-In Process)

Kim H*, Long-Boyle J*, Rydholm N, Orchard PJ, Tolar J, Smith AR, Jacobson P, Brundage R. Population Pharmacokinetics of Unbound Mycophenolic Acid in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplantation. J Clin Pharmacol. 2012 Nov;52(11);1665-1675. (PMID:22110162)

Passey C*, Birnbaum A, Brundage R, Oetting W, Leduc R, Israni A, Guan W, Matas A, Jacobson PA. Validation of tacrolimus equation to predict troughs using genetic and clinical factors. Pharmacogenomics. 2012 Jul;13(10):1141-7. (PMID:22909204)

Abecassis M, Bridges ND, Clancy CJ, Dew MA, Eldadah B, Englesbe MJ, Flessner MF, Frank JC, Friedewald J, Gill J, Gries C, Halter JB, Hartmann EL, Hazzard WR, Horne FM, Hosenpud J, Jacobson P, Kasiske BL, Lake J, Loomba R, Malani PN, Moore TM, Murray A, Nguyen MH, Powe NR, Reese PP, Reynolds H, Samaniego MD, Schmader KE, Segev DL, Shah AS, Singer LG, Sosa JA, Stewart ZA, Tan JC, Williams WW, Zaas DW, High KP. Workshop Proceedings. Solid Organ Transplantation in Older Adults: Current Status and Future Research. Summarized the Workshop held on January 23-24, 2012. Am J Transplant. 2012 Oct;12(10):2608-22. (PMID:22958872).

Johnson LA, Tretyakova N, Jacobson PA. Obesity Effects on Cyclophosphamide-induced DNA Damage in Hematopoietic Cell Transplant Recipients. In Vivo. 2012 Sep;26(5):853-7. (PMID:22949601)

Jacobson PA, Schladt D, Oetting WS, Leduc R, Guan W, Matas AJ, Israni A. DeKAF Investigators. Lower Calcineurin Inhibitor Doses in Older Compared to Younger Kidney Transplant Recipients Yield Similar Troughs. Am J Transplant. 2012 Dec;12(12):3326-36. (PMID:22947444)

61. Oetting WS, Guan W, Schladt DP, Leduc RE, Jacobson PA, Matas AJ, Chinnakotla S, Schröppel B, Murphy BT, Israni AK. Donor polymorphisms of TLR4 associated with graft failure in liver transplant recipients. Liver Transpl. 2012 Dec;18(12); 1399-405. (PMID:22987288)

62. Frymoyer A, Verotta D, Jacobson P, Long-Boyle J. Population Pharmacokinetics of Unbound Mycophenolic Acid in Adult Allogeneic Hematopoietic Cell Transplantation: Effect of Pharmacogenetic Factors. Br J Clin Pharmacol. 2013 Feb;75; (2):463-75. (PMID:22765258)

Thyagarajan B, Jackson S, Basu S, Jacobson PA, Gross M, Weisdorf D, Arora M. Association between genetic variants in adhesion molecules and outcomes after hematopoietic cell transplantation. Int J Immunogenet. 2013 Apr;40(2):108-15 (PMID: 22646485)

64. A. Israni, R Leduc, P Jacobson, W Wildebush, W Guan, Schladt D, Matas A, Oetting W for the DEKAF investigators. Inflammation in the Setting of Chronic Allograft Dysfunction Post-Kidney Transplant: Phenotype & Genotype. Clin Transplant 2013 May-June 27(3):348-58 (PMID: 23350966)

65. Israni A, Riad S, Leduc R, Oetting W, Guan W, Schladt D, Matas A, Jacobson PA for the DEKAF investigators. Tacrolimus trough levels after month 3 as a predictor of acute rejection following kidney transplantation: a lesson learned from DeKAF Genomics. Transplant International. 2013 Oct;26(10):982-92 (PMID: 23879408)

Oetting W, Jacobson PA, Israni A. Editorial ; Transplant Rejection and Risk: In Search of the Genetic Dark Matter. J Gastrointestin Liver Dis. 2013 Jun;22(2):125-6 (PMID: 23799208)

Oetting WS, Guan, W, Schladt DP, Wildebush W, Becker J, Thyagarajan B, Jacobson P, Matas AJ, Israni AK. Telomere Length of Recipients and Living Kidney Donors and Chronic Graft Dysfunction in Kidney Transplants. Transplantation. 2013 Oct 24. [Epub ahead of print] (PMID:24162247)
 

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Links

Cancer Center Clinical Pharmacology Core

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  • Last modified on September 4, 2014